Date Name Title Filing Type Shares Traded Price Total Held
May 17, 2021
EVP Research and Development
EVP Research and Development Form 4 Open market or private sale of non-derivative or derivative security 3,379 $518.63 38,422
May 17, 2021
EVP Research and Development
EVP Research and Development Form 4 Open market or private sale of non-derivative or derivative security 10,336 $519.47 28,086
May 17, 2021
EVP Research and Development
EVP Research and Development Form 4 Open market or private sale of non-derivative or derivative security 3,806 $520.17 24,280
May 14, 2021
EVP Research and Development
EVP Research and Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 40,000 $179.13 64,280
May 14, 2021
EVP Research and Development
EVP Research and Development Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 27,775 $516.69 36,505
May 14, 2021
EVP Research and Development
EVP Research and Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 12,500 $52.03 49,005
May 14, 2021
EVP Research and Development
EVP Research and Development Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 7,204 $516.69 41,801
May 14, 2021
EVP Research and Development
EVP Research and Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 12,500 -- --
May 14, 2021
EVP Research and Development
EVP Research and Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 40,000 -- 72,500
Feb 25, 2021
EVP Research and Development
EVP Research and Development Form 4 Bona fide gift 435 -- 24,280

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.