Date Name Title Type Shares Traded Price
Aug 05, 2022
EVP Research and Development
EVP Research and Development Open market or private sale of non-derivative or derivative security 100 $621.11
Aug 05, 2022
EVP Research and Development
EVP Research and Development Open market or private sale of non-derivative or derivative security 177 $620.11
Aug 05, 2022
EVP Research and Development
EVP Research and Development Open market or private sale of non-derivative or derivative security 502 $619.64
Aug 05, 2022
EVP Research and Development
EVP Research and Development Open market or private sale of non-derivative or derivative security 521 $618.27
Aug 05, 2022
EVP Research and Development
EVP Research and Development Open market or private sale of non-derivative or derivative security 424 $617.43
Aug 05, 2022
EVP Research and Development
EVP Research and Development Open market or private sale of non-derivative or derivative security 535 $616.40
Aug 05, 2022
EVP Research and Development
EVP Research and Development Open market or private sale of non-derivative or derivative security 1,610 $615.49
Aug 05, 2022
EVP Research and Development
EVP Research and Development Open market or private sale of non-derivative or derivative security 4,112 $614.35
Aug 05, 2022
EVP Research and Development
EVP Research and Development Open market or private sale of non-derivative or derivative security 3,218 $613.49
Aug 04, 2022
EVP Research and Development
EVP Research and Development Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 71,218 $613.00

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.