Date Name Title Type Shares Traded Price
Dec 30, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 130,714 $483.25
Dec 30, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 86,096 $483.25
Mar 09, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 50,545 $476.42
Mar 09, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 78,376 $476.42
Dec 12, 2019
Director, President and CSO
Director, President and CSO Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 49,405 $377.16
Dec 12, 2019
Director, President and CSO
Director, President and CSO Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 77,767 $377.16
Dec 13, 2018
Director, President and Chief Scientific
Director, President and Chief Scientific Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 76,863 $377.31
Dec 13, 2018
Director, President and Chief Scientific
Director, President and Chief Scientific Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 48,192 $377.31
Dec 18, 2017
Director, President & CSO
Director, President & CSO Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 257,850 $386.90
Dec 13, 2017
Director, President & CSO
Director, President & CSO Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 11,124 $385.08

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.