Date Name Title Filing Type Shares Traded Price Total Held
Dec 16, 2011
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 248,079 -- 248,079
Jun 23, 2004
Director
Director Form 4 Bona fide gift 245,682 -- 851
Jun 23, 2004
Director
Director Form 4 Bona fide gift 245,682 -- 245,682
Dec 19, 2017
Director, President and CSO
Director, President and CSO Form 4 Bona fide gift 242,150 -- 847
Dec 19, 2017
Director, President and CSO
Director, President and CSO Form 4 Bona fide gift 242,150 -- 486,820
Aug 06, 2021
Director, President & CEO
Director, President & CEO Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 240,000 $52.03 573,321
Aug 06, 2021
Director, President & CEO
Director, President & CEO Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 240,000 -- 160,000
Dec 30, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 240,000 $52.03 880,938
Dec 30, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 240,000 -- 158,079
Dec 16, 2014
Director, President & CEO
Director, President & CEO Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 240,000 -- 400,000

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.