Date Name Title Filing Type Shares Traded Price Total Held
Nov 29, 2012
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Open market or private sale of non-derivative or derivative security 19,733 $179.60 86,101
Feb 03, 2014
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 19,805 $283.17 16,073,557
Mar 27, 2014
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 19,807 $308.75 19,442,105
Jan 05, 2005
VP, Regulatory Development
VP, Regulatory Development Form 4 Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) 19,853 -- --
Jan 11, 2017
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 19,858 $365.20 23,459,618
Jun 21, 2021
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 19,911 $541.44 14,898
Sep 04, 2012
VP Regulat Dev & Med Safety
VP Regulat Dev & Med Safety Form 4 Bona fide gift 19,947 -- 19,947
Sep 04, 2012
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Bona fide gift 19,947 -- 3
Jul 24, 2012
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Bona fide gift 19,947 -- 59,844
Jul 24, 2012
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Bona fide gift 19,947 -- 39,897

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.