Date Name Title Filing Type Shares Traded Price Total Held
Dec 15, 2003
VP, Regulatory Development
VP, Regulatory Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 15,000 -- 15,000
Sep 16, 2014
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 15,031 $349.12 22,364,543
Jan 05, 2005
VP, Gen Counsel & Secretary
VP, Gen Counsel & Secretary Form 4 Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) 15,035 -- --
Jan 05, 2005
SVP, PreclinDevel & Biomol Sci
SVP, PreclinDevel & Biomol Sci Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 15,066 -- 16,666
Dec 23, 2014
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 15,104 $389.17 22,713,305
Aug 01, 2011
SVP Clinical Development
SVP Clinical Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 15,144 $15.64 15,144
Aug 01, 2011
SVP Clinical Development
SVP Clinical Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 15,144 -- 10,428
May 13, 2019
EVP Research and Development
EVP Research and Development Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 15,147 $304.20 32,303
Apr 27, 2009
VP Regul Devel & Clin Safety
VP Regul Devel & Clin Safety Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 15,160 $6.50 82,116
Apr 27, 2009
VP Regul Devel & Clin Safety
VP Regul Devel & Clin Safety Form 4 Open market or private sale of non-derivative or derivative security 15,160 $12.74 66,956

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.