<?xml version="1.0" encoding="US-ASCII"?>
<!--XBRL Document Created with Wdesk from Workiva-->
<!-- -->
<linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <roleRef roleURI="http://www.regeneron.com/role/AccountsPayableAndAccruedExpenses" xlink:href="regn-20151231.xsd#AccountsPayableAndAccruedExpenses" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/AccountsPayableAndAccruedExpensesDetails" xlink:href="regn-20151231.xsd#AccountsPayableAndAccruedExpensesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/AccountsPayableAndAccruedExpensesTables" xlink:href="regn-20151231.xsd#AccountsPayableAndAccruedExpensesTables" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/BusinessOverviewAndSummaryOfSignificantAccountingPolicies" xlink:href="regn-20151231.xsd#BusinessOverviewAndSummaryOfSignificantAccountingPolicies" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/BusinessOverviewAndSummaryOfSignificantAccountingPoliciesDetails" xlink:href="regn-20151231.xsd#BusinessOverviewAndSummaryOfSignificantAccountingPoliciesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/BusinessOverviewAndSummaryOfSignificantAccountingPoliciesPolicies" xlink:href="regn-20151231.xsd#BusinessOverviewAndSummaryOfSignificantAccountingPoliciesPolicies" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/BusinessOverviewAndSummaryOfSignificantAccountingPoliciesTables" xlink:href="regn-20151231.xsd#BusinessOverviewAndSummaryOfSignificantAccountingPoliciesTables" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/CollaborationAgreements" xlink:href="regn-20151231.xsd#CollaborationAgreements" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/CollaborationAgreementsBayerHealthcareLlcDetails" xlink:href="regn-20151231.xsd#CollaborationAgreementsBayerHealthcareLlcDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/CollaborationAgreementsEyleaDetails" xlink:href="regn-20151231.xsd#CollaborationAgreementsEyleaDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/CollaborationAgreementsMitsubishiTanabePharmaDetails" xlink:href="regn-20151231.xsd#CollaborationAgreementsMitsubishiTanabePharmaDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/CollaborationAgreementsPdgfrBetaAntibodyDetails" xlink:href="regn-20151231.xsd#CollaborationAgreementsPdgfrBetaAntibodyDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/CollaborationAgreementsSanofiDetails" xlink:href="regn-20151231.xsd#CollaborationAgreementsSanofiDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/CollaborationAgreementsTables" xlink:href="regn-20151231.xsd#CollaborationAgreementsTables" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/CommitmentsAndContingencies" xlink:href="regn-20151231.xsd#CommitmentsAndContingencies" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/CommitmentsAndContingenciesCapitalLeasesDetails" xlink:href="regn-20151231.xsd#CommitmentsAndContingenciesCapitalLeasesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/CommitmentsAndContingenciesFacilityLeasesDetails" xlink:href="regn-20151231.xsd#CommitmentsAndContingenciesFacilityLeasesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/CommitmentsAndContingenciesOperatingLeasesDetails" xlink:href="regn-20151231.xsd#CommitmentsAndContingenciesOperatingLeasesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/CommitmentsAndContingenciesResearchCollaborationAndLicensingAgreementsDetails" xlink:href="regn-20151231.xsd#CommitmentsAndContingenciesResearchCollaborationAndLicensingAgreementsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/CommitmentsAndContingenciesTables" xlink:href="regn-20151231.xsd#CommitmentsAndContingenciesTables" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/ConsolidatedBalanceSheets" xlink:href="regn-20151231.xsd#ConsolidatedBalanceSheets" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:href="regn-20151231.xsd#ConsolidatedBalanceSheetsParenthetical" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/ConsolidatedStatementsOfCashFlows" xlink:href="regn-20151231.xsd#ConsolidatedStatementsOfCashFlows" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/ConsolidatedStatementsOfOperationsAndComprehensiveIncome" xlink:href="regn-20151231.xsd#ConsolidatedStatementsOfOperationsAndComprehensiveIncome" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/ConsolidatedStatementsOfStockholdersEquity" xlink:href="regn-20151231.xsd#ConsolidatedStatementsOfStockholdersEquity" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/Debt" xlink:href="regn-20151231.xsd#Debt" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/DebtDetails" xlink:href="regn-20151231.xsd#DebtDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/DebtTables" xlink:href="regn-20151231.xsd#DebtTables" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/DeferredRevenue" xlink:href="regn-20151231.xsd#DeferredRevenue" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/DeferredRevenueDetails" xlink:href="regn-20151231.xsd#DeferredRevenueDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/DeferredRevenueTables" xlink:href="regn-20151231.xsd#DeferredRevenueTables" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/DocumentAndEntityInformation" xlink:href="regn-20151231.xsd#DocumentAndEntityInformation" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/EmployeeSavingsPlan" xlink:href="regn-20151231.xsd#EmployeeSavingsPlan" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/EmployeeSavingsPlanDetails" xlink:href="regn-20151231.xsd#EmployeeSavingsPlanDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/ExecutiveStockPurchasePlan" xlink:href="regn-20151231.xsd#ExecutiveStockPurchasePlan" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/ExecutiveStockPurchasePlanDetails" xlink:href="regn-20151231.xsd#ExecutiveStockPurchasePlanDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/FairValueMeasurements" xlink:href="regn-20151231.xsd#FairValueMeasurements" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/FairValueMeasurementsDetails" xlink:href="regn-20151231.xsd#FairValueMeasurementsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/FairValueMeasurementsTables" xlink:href="regn-20151231.xsd#FairValueMeasurementsTables" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/IncomeTaxes" xlink:href="regn-20151231.xsd#IncomeTaxes" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/IncomeTaxesDetails" xlink:href="regn-20151231.xsd#IncomeTaxesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/IncomeTaxesTables" xlink:href="regn-20151231.xsd#IncomeTaxesTables" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/Inventory" xlink:href="regn-20151231.xsd#Inventory" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/InventoryDetails" xlink:href="regn-20151231.xsd#InventoryDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/InventoryTables" xlink:href="regn-20151231.xsd#InventoryTables" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/LegalMatters" xlink:href="regn-20151231.xsd#LegalMatters" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/LongTermIncentivePlans" xlink:href="regn-20151231.xsd#LongTermIncentivePlans" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/LongTermIncentivePlansDetails" xlink:href="regn-20151231.xsd#LongTermIncentivePlansDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/LongTermIncentivePlansTables" xlink:href="regn-20151231.xsd#LongTermIncentivePlansTables" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/MarketableSecurities" xlink:href="regn-20151231.xsd#MarketableSecurities" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/MarketableSecuritiesDetails" xlink:href="regn-20151231.xsd#MarketableSecuritiesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/MarketableSecuritiesTables" xlink:href="regn-20151231.xsd#MarketableSecuritiesTables" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/NetIncomeLossPerShare" xlink:href="regn-20151231.xsd#NetIncomeLossPerShare" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/NetIncomeLossPerShareDetails" xlink:href="regn-20151231.xsd#NetIncomeLossPerShareDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/NetIncomeLossPerShareTables" xlink:href="regn-20151231.xsd#NetIncomeLossPerShareTables" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/NetProductSales" xlink:href="regn-20151231.xsd#NetProductSales" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/NetProductSalesDetails" xlink:href="regn-20151231.xsd#NetProductSalesDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/NetProductSalesTables" xlink:href="regn-20151231.xsd#NetProductSalesTables" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/PropertyPlantAndEquipment" xlink:href="regn-20151231.xsd#PropertyPlantAndEquipment" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/PropertyPlantAndEquipmentDetails" xlink:href="regn-20151231.xsd#PropertyPlantAndEquipmentDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/PropertyPlantAndEquipmentTables" xlink:href="regn-20151231.xsd#PropertyPlantAndEquipmentTables" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/StatementOfCashFlows" xlink:href="regn-20151231.xsd#StatementOfCashFlows" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/StatementOfCashFlowsDetails" xlink:href="regn-20151231.xsd#StatementOfCashFlowsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/StockholdersEquity" xlink:href="regn-20151231.xsd#StockholdersEquity" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/StockholdersEquityDetails" xlink:href="regn-20151231.xsd#StockholdersEquityDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/TechnologyLicensingAgreements" xlink:href="regn-20151231.xsd#TechnologyLicensingAgreements" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/TechnologyLicensingAgreementsDetails" xlink:href="regn-20151231.xsd#TechnologyLicensingAgreementsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/UnauditedQuarterlyResults" xlink:href="regn-20151231.xsd#UnauditedQuarterlyResults" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/UnauditedQuarterlyResultsDetails" xlink:href="regn-20151231.xsd#UnauditedQuarterlyResultsDetails" xlink:type="simple" />
  <roleRef roleURI="http://www.regeneron.com/role/UnauditedQuarterlyResultsTables" xlink:href="regn-20151231.xsd#UnauditedQuarterlyResultsTables" xlink:type="simple" />
  <roleRef roleURI="http://www.xbrl.org/2009/role/negatedLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedLabel" xlink:type="simple" />
  <roleRef roleURI="http://www.xbrl.org/2009/role/negatedNetLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedNetLabel" xlink:type="simple" />
  <roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodEndLabel" xlink:type="simple" />
  <roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodStartLabel" xlink:type="simple" />
  <roleRef roleURI="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTerseLabel" xlink:type="simple" />
  <roleRef roleURI="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTotalLabel" xlink:type="simple" />
  <roleRef roleURI="http://www.xbrl.org/2009/role/netLabel" xlink:href="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd#netLabel" xlink:type="simple" />
  <presentationLink xlink:role="http://www.regeneron.com/role/AccountsPayableAndAccruedExpenses" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PayablesAndAccrualsAbstract" xlink:label="loc_us-gaap_PayablesAndAccrualsAbstract_B1B8E2284D03ED18EB38B238AEA0BBBF" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsPayableAccruedLiabilitiesAndOtherLiabilitiesDisclosureCurrentTextBlock" xlink:label="loc_us-gaap_AccountsPayableAccruedLiabilitiesAndOtherLiabilitiesDisclosureCurrentTextBlock_9F60D0C9CAEA2D952454B238AEA06789" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PayablesAndAccrualsAbstract_B1B8E2284D03ED18EB38B238AEA0BBBF" xlink:to="loc_us-gaap_AccountsPayableAccruedLiabilitiesAndOtherLiabilitiesDisclosureCurrentTextBlock_9F60D0C9CAEA2D952454B238AEA06789" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/AccountsPayableAndAccruedExpensesDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PayablesAndAccrualsAbstract" xlink:label="loc_us-gaap_PayablesAndAccrualsAbstract_3E74F77A119D757C1A46B238AE91EF5F" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_ABDE1904C22FF90814DEB238AE91CA8E" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PayablesAndAccrualsAbstract_3E74F77A119D757C1A46B238AE91EF5F" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_ABDE1904C22FF90814DEB238AE91CA8E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsPayableTradeCurrent" xlink:label="loc_us-gaap_AccountsPayableTradeCurrent_C56B847D31A57F5A1559B238AE96AD9E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_ABDE1904C22FF90814DEB238AE91CA8E" xlink:to="loc_us-gaap_AccountsPayableTradeCurrent_C56B847D31A57F5A1559B238AE96AD9E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_246DF4EFDDBCF78397D6B238AE968BE5" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_ABDE1904C22FF90814DEB238AE91CA8E" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_246DF4EFDDBCF78397D6B238AE968BE5" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_AccruedClinicalTrialExpenseCurrent" xlink:label="loc_regn_AccruedClinicalTrialExpenseCurrent_633CBF1BA6D8D967088FB238AE96F1F7" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_ABDE1904C22FF90814DEB238AE91CA8E" xlink:to="loc_regn_AccruedClinicalTrialExpenseCurrent_633CBF1BA6D8D967088FB238AE96F1F7" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Accruedsalesrelatedchargesdeductionsandroyalties" xlink:label="loc_regn_Accruedsalesrelatedchargesdeductionsandroyalties_5562C7D59EFA4575F834B238AE962ED0" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_ABDE1904C22FF90814DEB238AE91CA8E" xlink:to="loc_regn_Accruedsalesrelatedchargesdeductionsandroyalties_5562C7D59EFA4575F834B238AE962ED0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_4FB1901B7CC022114604B238AE97A89C" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_ABDE1904C22FF90814DEB238AE91CA8E" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_4FB1901B7CC022114604B238AE97A89C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_AF8D6EA1844167E42407B238AE97DA2C" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_ABDE1904C22FF90814DEB238AE91CA8E" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_AF8D6EA1844167E42407B238AE97DA2C" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/AccountsPayableAndAccruedExpensesTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PayablesAndAccrualsAbstract" xlink:label="loc_us-gaap_PayablesAndAccrualsAbstract_A7595BA25504AAAF3FA2B238AE99B8CC" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock_F9CC7700388A5524F69EB238AE99F378" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PayablesAndAccrualsAbstract_A7595BA25504AAAF3FA2B238AE99B8CC" xlink:to="loc_us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock_F9CC7700388A5524F69EB238AE99F378" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/BusinessOverviewAndSummaryOfSignificantAccountingPolicies" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_E1C79070A05FA7D9D105B238B0481427" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SignificantAccountingPoliciesTextBlock" xlink:label="loc_us-gaap_SignificantAccountingPoliciesTextBlock_39CE62309B261688B8C3B238B048708D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_E1C79070A05FA7D9D105B238B0481427" xlink:to="loc_us-gaap_SignificantAccountingPoliciesTextBlock_39CE62309B261688B8C3B238B048708D" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/BusinessOverviewAndSummaryOfSignificantAccountingPoliciesDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_D1F11BA106834D7F297DC721245D9D16" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_D7D932A469AD809D1DF6C721245D016E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_D1F11BA106834D7F297DC721245D9D16" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_D7D932A469AD809D1DF6C721245D016E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_CEF6C8C10C0BD694CDB7C721245DA0CB" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_D7D932A469AD809D1DF6C721245D016E" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_CEF6C8C10C0BD694CDB7C721245DA0CB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_850412593219C51F5DF3C721245DC4CF" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_CEF6C8C10C0BD694CDB7C721245DA0CB" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_850412593219C51F5DF3C721245DC4CF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BuildingAndBuildingImprovementsMember" xlink:label="loc_us-gaap_BuildingAndBuildingImprovementsMember_20CE83833EF866E4966BC721245D3AD4" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_850412593219C51F5DF3C721245DC4CF" xlink:to="loc_us-gaap_BuildingAndBuildingImprovementsMember_20CE83833EF866E4966BC721245D3AD4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquipmentMember" xlink:label="loc_us-gaap_EquipmentMember_BC099102B750CA2100BEC721245D0DE9" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_850412593219C51F5DF3C721245DC4CF" xlink:to="loc_us-gaap_EquipmentMember_BC099102B750CA2100BEC721245D0DE9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FurnitureAndFixturesMember" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_CF57505ADC83CD9CE28CC721245DB584" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_850412593219C51F5DF3C721245DC4CF" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_CF57505ADC83CD9CE28CC721245DB584" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_6FE20E6DF015BDFFB892C721245D6211" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_D7D932A469AD809D1DF6C721245D016E" xlink:to="loc_us-gaap_RangeAxis_6FE20E6DF015BDFFB892C721245D6211" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_49C222F68B4D9AAD67D8C721245D0755" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeAxis_6FE20E6DF015BDFFB892C721245D6211" xlink:to="loc_us-gaap_RangeMember_49C222F68B4D9AAD67D8C721245D0755" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_DA3DC8A38F382FA71E92C721245D8A67" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_49C222F68B4D9AAD67D8C721245D0755" xlink:to="loc_us-gaap_MinimumMember_DA3DC8A38F382FA71E92C721245D8A67" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_919D2D854DE824E0B796C721245D3140" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_49C222F68B4D9AAD67D8C721245D0755" xlink:to="loc_us-gaap_MaximumMember_919D2D854DE824E0B796C721245D3140" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_F7320517C0761548CF8CC721245D20E9" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_D7D932A469AD809D1DF6C721245D016E" xlink:to="loc_us-gaap_StatementLineItems_F7320517C0761548CF8CC721245D20E9" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Deferredtaxassetreclassification" xlink:label="loc_regn_Deferredtaxassetreclassification_4CC927BF2E9AF62B06FCC727280F5562" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_F7320517C0761548CF8CC721245D20E9" xlink:to="loc_regn_Deferredtaxassetreclassification_4CC927BF2E9AF62B06FCC727280F5562" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Reductionindeferredrevenue" xlink:label="loc_regn_Reductionindeferredrevenue_A5C755CD38CF6A372C87C721245D9ADF" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_F7320517C0761548CF8CC721245D20E9" xlink:to="loc_regn_Reductionindeferredrevenue_A5C755CD38CF6A372C87C721245D9ADF" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Decreaseintotalcashfromfinancing" xlink:label="loc_regn_Decreaseintotalcashfromfinancing_167BCB00C05FA0C518F4C721245DAF20" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_F7320517C0761548CF8CC721245D20E9" xlink:to="loc_regn_Decreaseintotalcashfromfinancing_167BCB00C05FA0C518F4C721245DAF20" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Reductioninaccountsreceivable" xlink:label="loc_regn_Reductioninaccountsreceivable_44EAB37C52F6B617CFB2C721245DF30A" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_F7320517C0761548CF8CC721245D20E9" xlink:to="loc_regn_Reductioninaccountsreceivable_44EAB37C52F6B617CFB2C721245DF30A" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Reductioninincometaxassetsnet" xlink:label="loc_regn_Reductioninincometaxassetsnet_DECC4C48515EC95C167CC721245DE038" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_F7320517C0761548CF8CC721245D20E9" xlink:to="loc_regn_Reductioninincometaxassetsnet_DECC4C48515EC95C167CC721245DE038" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConcentrationRiskPercentage1" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_64554D8CC775D3054CE4C721245D858C" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_F7320517C0761548CF8CC721245D20E9" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_64554D8CC775D3054CE4C721245D858C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_1DCD613D315C14FD0EA9C721245D0371" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_F7320517C0761548CF8CC721245D20E9" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_1DCD613D315C14FD0EA9C721245D0371" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Increaseintotalcashfromoperating" xlink:label="loc_regn_Increaseintotalcashfromoperating_BE0F7014C74CD1E8535BC721245DD649" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_F7320517C0761548CF8CC721245D20E9" xlink:to="loc_regn_Increaseintotalcashfromoperating_BE0F7014C74CD1E8535BC721245DD649" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ReductioninAPIC" xlink:label="loc_regn_ReductioninAPIC_DF4369B68A13FA9D1A16C721245DC136" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_F7320517C0761548CF8CC721245D20E9" xlink:to="loc_regn_ReductioninAPIC_DF4369B68A13FA9D1A16C721245DC136" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RevenueRecognitionAbstract" xlink:label="loc_us-gaap_RevenueRecognitionAbstract_309F0F7F85526963B49DC721245DC2A5" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_D1F11BA106834D7F297DC721245D9D16" xlink:to="loc_us-gaap_RevenueRecognitionAbstract_309F0F7F85526963B49DC721245DC2A5" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_PercentageOfPromptPayDiscountCompanyAccrues" xlink:label="loc_regn_PercentageOfPromptPayDiscountCompanyAccrues_BC68E46CCFD99DAF8C51C721245D8A59" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueRecognitionAbstract_309F0F7F85526963B49DC721245DC2A5" xlink:to="loc_regn_PercentageOfPromptPayDiscountCompanyAccrues_BC68E46CCFD99DAF8C51C721245D8A59" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentExpenseAbstract" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseAbstract_C0614B034AF279F269FDC721245DC6CE" xlink:type="locator" />
    <presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_D1F11BA106834D7F297DC721245D9D16" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseAbstract_C0614B034AF279F269FDC721245DC6CE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConcentrationRisksTypesNoConcentrationPercentageAbstract" xlink:label="loc_us-gaap_ConcentrationRisksTypesNoConcentrationPercentageAbstract_A1300F4B21DF89893C62C721245DA75A" xlink:type="locator" />
    <presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_D1F11BA106834D7F297DC721245D9D16" xlink:to="loc_us-gaap_ConcentrationRisksTypesNoConcentrationPercentageAbstract_A1300F4B21DF89893C62C721245DA75A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_08A9416A05EF2AFCD5E5C721245DFB79" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRisksTypesNoConcentrationPercentageAbstract_A1300F4B21DF89893C62C721245DA75A" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_08A9416A05EF2AFCD5E5C721245DFB79" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProvisionForDoubtfulAccounts" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_44B05A8D08788B68FD1CC721245DFACB" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRisksTypesNoConcentrationPercentageAbstract_A1300F4B21DF89893C62C721245DA75A" xlink:to="loc_us-gaap_ProvisionForDoubtfulAccounts_44B05A8D08788B68FD1CC721245DFACB" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/BusinessOverviewAndSummaryOfSignificantAccountingPoliciesPolicies" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_68A8C8AABF029D3C7AFEB238B040EE66" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConsolidationPolicyTextBlock" xlink:label="loc_us-gaap_ConsolidationPolicyTextBlock_D31D1FEE734E955E7DA3B238B040B3DA" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_68A8C8AABF029D3C7AFEB238B040EE66" xlink:to="loc_us-gaap_ConsolidationPolicyTextBlock_D31D1FEE734E955E7DA3B238B040B3DA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UseOfEstimates" xlink:label="loc_us-gaap_UseOfEstimates_B4893493C267477F1D39B238B0406B09" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_68A8C8AABF029D3C7AFEB238B040EE66" xlink:to="loc_us-gaap_UseOfEstimates_B4893493C267477F1D39B238B0406B09" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CashAndCashEquivalentsPolicyTextBlock" xlink:label="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_81794D495EC3B0A2A8EEB238B040C0B1" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_68A8C8AABF029D3C7AFEB238B040EE66" xlink:to="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_81794D495EC3B0A2A8EEB238B040C0B1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MarketableSecuritiesAvailableForSaleSecuritiesPolicy" xlink:label="loc_us-gaap_MarketableSecuritiesAvailableForSaleSecuritiesPolicy_A885888486CC1EDF8722B238B0406F35" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_68A8C8AABF029D3C7AFEB238B040EE66" xlink:to="loc_us-gaap_MarketableSecuritiesAvailableForSaleSecuritiesPolicy_A885888486CC1EDF8722B238B0406F35" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TradeAndOtherAccountsReceivablePolicy" xlink:label="loc_us-gaap_TradeAndOtherAccountsReceivablePolicy_2C3DF396346D3DC76DC3B238B040B305" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_68A8C8AABF029D3C7AFEB238B040EE66" xlink:to="loc_us-gaap_TradeAndOtherAccountsReceivablePolicy_2C3DF396346D3DC76DC3B238B040B305" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryPolicyTextBlock" xlink:label="loc_us-gaap_InventoryPolicyTextBlock_AFAEDFF991875CAF11AFB238B0408F95" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_68A8C8AABF029D3C7AFEB238B040EE66" xlink:to="loc_us-gaap_InventoryPolicyTextBlock_AFAEDFF991875CAF11AFB238B0408F95" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentPolicyTextBlock" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_611CDEE36D9A6D5970C1B238B04098AD" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_68A8C8AABF029D3C7AFEB238B040EE66" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_611CDEE36D9A6D5970C1B238B04098AD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RevenueRecognitionSalesOfGoods" xlink:label="loc_us-gaap_RevenueRecognitionSalesOfGoods_3D8139FDD31204E7BA72B238B040974B" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_68A8C8AABF029D3C7AFEB238B040EE66" xlink:to="loc_us-gaap_RevenueRecognitionSalesOfGoods_3D8139FDD31204E7BA72B238B040974B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CollaborativeArrangementAccountingPolicy" xlink:label="loc_us-gaap_CollaborativeArrangementAccountingPolicy_F0797A71A114BB92C8DBB238B040B31D" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_68A8C8AABF029D3C7AFEB238B040EE66" xlink:to="loc_us-gaap_CollaborativeArrangementAccountingPolicy_F0797A71A114BB92C8DBB238B040B31D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentExpensePolicy" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_618349B31D194C74B148B238B0403951" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_68A8C8AABF029D3C7AFEB238B040EE66" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_618349B31D194C74B148B238B0403951" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy" xlink:label="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_6D0B2ED38A611957AD3CB238B0400EB2" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_68A8C8AABF029D3C7AFEB238B040EE66" xlink:to="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_6D0B2ED38A611957AD3CB238B0400EB2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxPolicyTextBlock" xlink:label="loc_us-gaap_IncomeTaxPolicyTextBlock_8711A25FCCB0371ABF70B238B040F713" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_68A8C8AABF029D3C7AFEB238B040EE66" xlink:to="loc_us-gaap_IncomeTaxPolicyTextBlock_8711A25FCCB0371ABF70B238B040F713" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerSharePolicyTextBlock" xlink:label="loc_us-gaap_EarningsPerSharePolicyTextBlock_830E2DE3157C41A8B08FB238B040EDE0" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_68A8C8AABF029D3C7AFEB238B040EE66" xlink:to="loc_us-gaap_EarningsPerSharePolicyTextBlock_830E2DE3157C41A8B08FB238B040EDE0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConcentrationRiskCreditRisk" xlink:label="loc_us-gaap_ConcentrationRiskCreditRisk_06835D45F582E11A571FB238B04570AE" xlink:type="locator" />
    <presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_68A8C8AABF029D3C7AFEB238B040EE66" xlink:to="loc_us-gaap_ConcentrationRiskCreditRisk_06835D45F582E11A571FB238B04570AE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:label="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_01A55FA6082F7893889EB238B045E9B7" xlink:type="locator" />
    <presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_68A8C8AABF029D3C7AFEB238B040EE66" xlink:to="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_01A55FA6082F7893889EB238B045E9B7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LegalCostsPolicyTextBlock" xlink:label="loc_us-gaap_LegalCostsPolicyTextBlock_53ECC140CC1BA6E4C322B238B04654F5" xlink:type="locator" />
    <presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_68A8C8AABF029D3C7AFEB238B040EE66" xlink:to="loc_us-gaap_LegalCostsPolicyTextBlock_53ECC140CC1BA6E4C322B238B04654F5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueTransferPolicyPolicyTextBlock" xlink:label="loc_us-gaap_FairValueTransferPolicyPolicyTextBlock_FE66D0A8F3C852E5BE7BB238B0468C34" xlink:type="locator" />
    <presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_68A8C8AABF029D3C7AFEB238B040EE66" xlink:to="loc_us-gaap_FairValueTransferPolicyPolicyTextBlock_FE66D0A8F3C852E5BE7BB238B0468C34" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/BusinessOverviewAndSummaryOfSignificantAccountingPoliciesTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_C81C8CC9BD87A665F093B238B03110CA" xlink:type="locator" />
    <loc xlink:href="regn-20151231.xsd#regn_EstimatedUsefulLivesOfPropertyPlantAndEquipmentTableTextBlock" xlink:label="loc_regn_EstimatedUsefulLivesOfPropertyPlantAndEquipmentTableTextBlock_017984EED0DAF7AD6DADB238B031153A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_C81C8CC9BD87A665F093B238B03110CA" xlink:to="loc_regn_EstimatedUsefulLivesOfPropertyPlantAndEquipmentTableTextBlock_017984EED0DAF7AD6DADB238B031153A" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/CollaborationAgreements" xlink:type="extended">
    <loc xlink:href="regn-20151231.xsd#regn_CollaborationAgreementAbstract" xlink:label="loc_regn_CollaborationAgreementAbstract_D09DBB008D26FCAB355BB238AFEFB546" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CollaborativeArrangementDisclosureTextBlock" xlink:label="loc_us-gaap_CollaborativeArrangementDisclosureTextBlock_AAFC80E67AB3C65A34EEB238AFEFD9BC" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_CollaborationAgreementAbstract_D09DBB008D26FCAB355BB238AFEFB546" xlink:to="loc_us-gaap_CollaborativeArrangementDisclosureTextBlock_AAFC80E67AB3C65A34EEB238AFEFD9BC" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/CollaborationAgreementsBayerHealthcareLlcDetails" xlink:type="extended">
    <loc xlink:href="regn-20151231.xsd#regn_CollaborationAgreementAbstract" xlink:label="loc_regn_CollaborationAgreementAbstract_0DF8DCF37DC6E16463F7B238AFA18128" xlink:type="locator" />
    <loc xlink:href="regn-20151231.xsd#regn_Contingentreimbursementobligation" xlink:label="loc_regn_Contingentreimbursementobligation_1F24F6B99CE4DC868042B238AFA1E87D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_CollaborationAgreementAbstract_0DF8DCF37DC6E16463F7B238AFA18128" xlink:to="loc_regn_Contingentreimbursementobligation_1F24F6B99CE4DC868042B238AFA1E87D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable" xlink:label="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_58E763C2062ED3B6620BB238AFA2A329" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_CollaborationAgreementAbstract_0DF8DCF37DC6E16463F7B238AFA18128" xlink:to="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_58E763C2062ED3B6620BB238AFA2A329" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="loc_us-gaap_TypeOfArrangementAxis_CC68BA9A444346EA3861B238AFA29BC6" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_58E763C2062ED3B6620BB238AFA2A329" xlink:to="loc_us-gaap_TypeOfArrangementAxis_CC68BA9A444346EA3861B238AFA29BC6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_E7ADB3AF155335172773B238AFA2637D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_CC68BA9A444346EA3861B238AFA29BC6" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_E7ADB3AF155335172773B238AFA2637D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_68EE6519663DBDF49B3FB238AFA2C7F2" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_58E763C2062ED3B6620BB238AFA2A329" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_68EE6519663DBDF49B3FB238AFA2C7F2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_ADDC04AB807494182711B238AFA21887" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_68EE6519663DBDF49B3FB238AFA2C7F2" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_ADDC04AB807494182711B238AFA21887" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_CollaborationAgreementWithBayerHealthcareLlcMember" xlink:label="loc_regn_CollaborationAgreementWithBayerHealthcareLlcMember_9BA4D7AAC305A7B168DBB238AFA2E8A3" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_ADDC04AB807494182711B238AFA21887" xlink:to="loc_regn_CollaborationAgreementWithBayerHealthcareLlcMember_9BA4D7AAC305A7B168DBB238AFA2E8A3" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_EYLEAMember" xlink:label="loc_regn_EYLEAMember_0F34438B2E4EF07C4C24B238AFA2DB5D" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_ADDC04AB807494182711B238AFA21887" xlink:to="loc_regn_EYLEAMember_0F34438B2E4EF07C4C24B238AFA2DB5D" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_PDGFRbetaoutsidetheUSMember" xlink:label="loc_regn_PDGFRbetaoutsidetheUSMember_E644514E6212EB2A6E5BB238AFA22716" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_ADDC04AB807494182711B238AFA21887" xlink:to="loc_regn_PDGFRbetaoutsidetheUSMember_E644514E6212EB2A6E5BB238AFA22716" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_438CD5E1AFCBE4E6A51FB238AFA2A4A6" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_58E763C2062ED3B6620BB238AFA2A329" xlink:to="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_438CD5E1AFCBE4E6A51FB238AFA2A4A6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueAdditions" xlink:label="loc_us-gaap_DeferredRevenueAdditions_FF440C9664216C53BE27B238AFA26D87" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_438CD5E1AFCBE4E6A51FB238AFA2A4A6" xlink:to="loc_us-gaap_DeferredRevenueAdditions_FF440C9664216C53BE27B238AFA26D87" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsAndNotesReceivableNet" xlink:label="loc_us-gaap_AccountsAndNotesReceivableNet_6DE978DBFC39622CDFD2B238AFA27C86" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_438CD5E1AFCBE4E6A51FB238AFA2A4A6" xlink:to="loc_us-gaap_AccountsAndNotesReceivableNet_6DE978DBFC39622CDFD2B238AFA27C86" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueCurrent" xlink:label="loc_us-gaap_DeferredRevenueCurrent_AF8F1E2E2CBC19E2E9A9B238AFA25B52" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_438CD5E1AFCBE4E6A51FB238AFA2A4A6" xlink:to="loc_us-gaap_DeferredRevenueCurrent_AF8F1E2E2CBC19E2E9A9B238AFA25B52" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_RoyaltyRateMinimum" xlink:label="loc_regn_RoyaltyRateMinimum_0B5CAB8B212FEED8C79BB238AFA217D8" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_438CD5E1AFCBE4E6A51FB238AFA2A4A6" xlink:to="loc_regn_RoyaltyRateMinimum_0B5CAB8B212FEED8C79BB238AFA217D8" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_RoyaltyRateMaximum" xlink:label="loc_regn_RoyaltyRateMaximum_6727F53A717B3B3723DDB238AFA31EDE" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_438CD5E1AFCBE4E6A51FB238AFA2A4A6" xlink:to="loc_regn_RoyaltyRateMaximum_6727F53A717B3B3723DDB238AFA31EDE" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Netprofitlossfromcommercializationofproductsundercollaborationagreement" xlink:label="loc_regn_Netprofitlossfromcommercializationofproductsundercollaborationagreement_994838847662E2CEB7C8B238AFA320B7" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_438CD5E1AFCBE4E6A51FB238AFA2A4A6" xlink:to="loc_regn_Netprofitlossfromcommercializationofproductsundercollaborationagreement_994838847662E2CEB7C8B238AFA320B7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized" xlink:label="loc_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_3DF3DBD21047206DB2FFB238AFA39F69" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_438CD5E1AFCBE4E6A51FB238AFA2A4A6" xlink:to="loc_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_3DF3DBD21047206DB2FFB238AFA39F69" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersCompensationEarned" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersCompensationEarned_C968EF0F5AD0C38E29A3B238AFA3D887" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_438CD5E1AFCBE4E6A51FB238AFA2A4A6" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersCompensationEarned_C968EF0F5AD0C38E29A3B238AFA3D887" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ContractsRevenue" xlink:label="loc_us-gaap_ContractsRevenue_02576CC22B1BD72C778EB238AFA3A091" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_438CD5E1AFCBE4E6A51FB238AFA2A4A6" xlink:to="loc_us-gaap_ContractsRevenue_02576CC22B1BD72C778EB238AFA3A091" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_OtherCollaborationRevenue" xlink:label="loc_regn_OtherCollaborationRevenue_2C302F85B3F4B57AFE30B238AFA3819E" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_438CD5E1AFCBE4E6A51FB238AFA2A4A6" xlink:to="loc_regn_OtherCollaborationRevenue_2C302F85B3F4B57AFE30B238AFA3819E" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/CollaborationAgreementsEyleaDetails" xlink:type="extended">
    <loc xlink:href="regn-20151231.xsd#regn_CollaborationAgreementAbstract" xlink:label="loc_regn_CollaborationAgreementAbstract_722A03324DB446F1C136B238AF8C27C9" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable" xlink:label="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_7980BE318DE738EB8705B238AF8CC9F9" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_CollaborationAgreementAbstract_722A03324DB446F1C136B238AF8C27C9" xlink:to="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_7980BE318DE738EB8705B238AF8CC9F9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_64B37B15018012F1785EB238AF8C1999" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_7980BE318DE738EB8705B238AF8CC9F9" xlink:to="loc_us-gaap_RangeAxis_64B37B15018012F1785EB238AF8C1999" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_6F1ADD16663EEF8BDFD7B238AF8C75D7" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeAxis_64B37B15018012F1785EB238AF8C1999" xlink:to="loc_us-gaap_RangeMember_6F1ADD16663EEF8BDFD7B238AF8C75D7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_C6993C0314A852AB7586B238AF8C4BDB" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_6F1ADD16663EEF8BDFD7B238AF8C75D7" xlink:to="loc_us-gaap_MinimumMember_C6993C0314A852AB7586B238AF8C4BDB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_035571EA29D85D41F6DDB238AF8CCED1" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_6F1ADD16663EEF8BDFD7B238AF8C75D7" xlink:to="loc_us-gaap_MaximumMember_035571EA29D85D41F6DDB238AF8CCED1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="loc_us-gaap_TypeOfArrangementAxis_0F41AF68B3DCB03FCCE5B238AF8C99ED" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_7980BE318DE738EB8705B238AF8CC9F9" xlink:to="loc_us-gaap_TypeOfArrangementAxis_0F41AF68B3DCB03FCCE5B238AF8C99ED" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_23CE2A0B3C04E51C0B53B238AF9192C9" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_0F41AF68B3DCB03FCCE5B238AF8C99ED" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_23CE2A0B3C04E51C0B53B238AF9192C9" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_MarketingApprovalMember" xlink:label="loc_regn_MarketingApprovalMember_4275883D8D41FECBC8ECB238AF911581" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_23CE2A0B3C04E51C0B53B238AF9192C9" xlink:to="loc_regn_MarketingApprovalMember_4275883D8D41FECBC8ECB238AF911581" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_PricingApprovalMember" xlink:label="loc_regn_PricingApprovalMember_5CBF7C681F49187E484FB238AF912368" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_23CE2A0B3C04E51C0B53B238AF9192C9" xlink:to="loc_regn_PricingApprovalMember_5CBF7C681F49187E484FB238AF912368" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Salesachievement1sttierMember" xlink:label="loc_regn_Salesachievement1sttierMember_E53C8E3FB73853CD0DE3B238AF91B6A6" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_23CE2A0B3C04E51C0B53B238AF9192C9" xlink:to="loc_regn_Salesachievement1sttierMember_E53C8E3FB73853CD0DE3B238AF91B6A6" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Salesachievement500millionMember" xlink:label="loc_regn_Salesachievement500millionMember_C2F9656D0C84A56E7FC6B238AF927541" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_23CE2A0B3C04E51C0B53B238AF9192C9" xlink:to="loc_regn_Salesachievement500millionMember_C2F9656D0C84A56E7FC6B238AF927541" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Salesachievement200millionMember" xlink:label="loc_regn_Salesachievement200millionMember_EE75B175DF332006AA1CB238AF92CA24" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_23CE2A0B3C04E51C0B53B238AF9192C9" xlink:to="loc_regn_Salesachievement200millionMember_EE75B175DF332006AA1CB238AF92CA24" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Salesachievement100millionMemberMember" xlink:label="loc_regn_Salesachievement100millionMemberMember_159F1B15F282C6A94ED6B238AF920B19" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_23CE2A0B3C04E51C0B53B238AF9192C9" xlink:to="loc_regn_Salesachievement100millionMemberMember_159F1B15F282C6A94ED6B238AF920B19" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_43F42B75A62DF174FAA9B238AF92156D" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_7980BE318DE738EB8705B238AF8CC9F9" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_43F42B75A62DF174FAA9B238AF92156D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_6951C5EC54B4FC021B19B238AF9230AF" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_43F42B75A62DF174FAA9B238AF92156D" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_6951C5EC54B4FC021B19B238AF9230AF" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_CollaborationAgreementWithBayerHealthcareLlcMember" xlink:label="loc_regn_CollaborationAgreementWithBayerHealthcareLlcMember_C91DCC3666B175C6C13AB238AF921FCC" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_6951C5EC54B4FC021B19B238AF9230AF" xlink:to="loc_regn_CollaborationAgreementWithBayerHealthcareLlcMember_C91DCC3666B175C6C13AB238AF921FCC" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_BRVOMember" xlink:label="loc_regn_BRVOMember_3544582CCF979F41C29DB238AF92F356" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_6951C5EC54B4FC021B19B238AF9230AF" xlink:to="loc_regn_BRVOMember_3544582CCF979F41C29DB238AF92F356" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_C44C1031A242FFB1F0A9B238AF92ECAF" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_7980BE318DE738EB8705B238AF8CC9F9" xlink:to="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_C44C1031A242FFB1F0A9B238AF92ECAF" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Percentageofrepaymentofdevelopmentbalanceoutofprofits" xlink:label="loc_regn_Percentageofrepaymentofdevelopmentbalanceoutofprofits_D11D69FA6BA9B3664861B238AF92ED80" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_C44C1031A242FFB1F0A9B238AF92ECAF" xlink:to="loc_regn_Percentageofrepaymentofdevelopmentbalanceoutofprofits_D11D69FA6BA9B3664861B238AF92ED80" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Contingentreimbursementobligation" xlink:label="loc_regn_Contingentreimbursementobligation_F516CDC0E06DDCE70CF0B238AF92DD85" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_C44C1031A242FFB1F0A9B238AF92ECAF" xlink:to="loc_regn_Contingentreimbursementobligation_F516CDC0E06DDCE70CF0B238AF92DD85" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized" xlink:label="loc_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_1314EF3ED89BEF39197FB238AF9250AE" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_C44C1031A242FFB1F0A9B238AF92ECAF" xlink:to="loc_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_1314EF3ED89BEF39197FB238AF9250AE" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_PeriodForAchievingSalesTargetForMilestonePaymentRollingBasis" xlink:label="loc_regn_PeriodForAchievingSalesTargetForMilestonePaymentRollingBasis_982F5A75509D5D6D035AB238AF923954" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_C44C1031A242FFB1F0A9B238AF92ECAF" xlink:to="loc_regn_PeriodForAchievingSalesTargetForMilestonePaymentRollingBasis_982F5A75509D5D6D035AB238AF923954" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Levelsoftwelvemonthsalesatwhichsalesmilestonepaymentswerereceived500million" xlink:label="loc_regn_Levelsoftwelvemonthsalesatwhichsalesmilestonepaymentswerereceived500million_421AC60715E06939EC59B238AF92E63B" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_C44C1031A242FFB1F0A9B238AF92ECAF" xlink:to="loc_regn_Levelsoftwelvemonthsalesatwhichsalesmilestonepaymentswerereceived500million_421AC60715E06939EC59B238AF92E63B" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_MaximumAmountOfSalesMilestonePaymentsIfTotalSalesAchieveSpecificLevels" xlink:label="loc_regn_MaximumAmountOfSalesMilestonePaymentsIfTotalSalesAchieveSpecificLevels_042D8B1BDB7C558A1DF6B238AF92627D" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_C44C1031A242FFB1F0A9B238AF92ECAF" xlink:to="loc_regn_MaximumAmountOfSalesMilestonePaymentsIfTotalSalesAchieveSpecificLevels_042D8B1BDB7C558A1DF6B238AF92627D" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Levelsoftwelvemonthssalesatwhichsalesmilestonepaymentswerereceived200million" xlink:label="loc_regn_Levelsoftwelvemonthssalesatwhichsalesmilestonepaymentswerereceived200million_A17F14CF34BF3B287A97B238AF92F602" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_C44C1031A242FFB1F0A9B238AF92ECAF" xlink:to="loc_regn_Levelsoftwelvemonthssalesatwhichsalesmilestonepaymentswerereceived200million_A17F14CF34BF3B287A97B238AF92F602" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Leveloftwelvemonthssalesatwhichsalesmilestonepaymentsmaybereceived100million" xlink:label="loc_regn_Leveloftwelvemonthssalesatwhichsalesmilestonepaymentsmaybereceived100million_2A70FA7D9DC2C469DC5CB238AF924CD3" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_C44C1031A242FFB1F0A9B238AF92ECAF" xlink:to="loc_regn_Leveloftwelvemonthssalesatwhichsalesmilestonepaymentsmaybereceived100million_2A70FA7D9DC2C469DC5CB238AF924CD3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersCompensationEarned" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersCompensationEarned_5F8B383B5D99678A67DCB238AF9297C6" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_C44C1031A242FFB1F0A9B238AF92ECAF" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersCompensationEarned_5F8B383B5D99678A67DCB238AF9297C6" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Minimumadvancenoticerequiredtoterminatecollaborationagreement" xlink:label="loc_regn_Minimumadvancenoticerequiredtoterminatecollaborationagreement_ECDB6A577F3BAC1E234DB238AF93EFF4" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_C44C1031A242FFB1F0A9B238AF92ECAF" xlink:to="loc_regn_Minimumadvancenoticerequiredtoterminatecollaborationagreement_ECDB6A577F3BAC1E234DB238AF93EFF4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProceedsFromCollaborators" xlink:label="loc_us-gaap_ProceedsFromCollaborators_602DF8043AE5B440C95FB238AF93930C" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_C44C1031A242FFB1F0A9B238AF92ECAF" xlink:to="loc_us-gaap_ProceedsFromCollaborators_602DF8043AE5B440C95FB238AF93930C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherResearchAndDevelopmentExpense" xlink:label="loc_us-gaap_OtherResearchAndDevelopmentExpense_BAFA2DB63E0A235599B4B238AF938AE3" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_C44C1031A242FFB1F0A9B238AF92ECAF" xlink:to="loc_us-gaap_OtherResearchAndDevelopmentExpense_BAFA2DB63E0A235599B4B238AF938AE3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsAndNotesReceivableNet" xlink:label="loc_us-gaap_AccountsAndNotesReceivableNet_2FAB50375006527DB671B238AF9347AB" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_C44C1031A242FFB1F0A9B238AF92ECAF" xlink:to="loc_us-gaap_AccountsAndNotesReceivableNet_2FAB50375006527DB671B238AF9347AB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueAdditions" xlink:label="loc_us-gaap_DeferredRevenueAdditions_5E4C2570A9CE8854E0C4B238AF931D08" xlink:type="locator" />
    <presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_C44C1031A242FFB1F0A9B238AF92ECAF" xlink:to="loc_us-gaap_DeferredRevenueAdditions_5E4C2570A9CE8854E0C4B238AF931D08" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/CollaborationAgreementsMitsubishiTanabePharmaDetails" xlink:type="extended">
    <loc xlink:href="regn-20151231.xsd#regn_CollaborationAgreementAbstract" xlink:label="loc_regn_CollaborationAgreementAbstract_7EDD7191099DD3F2FF45B238AF5D8912" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_A942751DCA789EDC9CA7B238AF5DCE78" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_CollaborationAgreementAbstract_7EDD7191099DD3F2FF45B238AF5D8912" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_A942751DCA789EDC9CA7B238AF5DCE78" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_F9CBCEF2A1C3C18F8BE8B238AF5EC11A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_A942751DCA789EDC9CA7B238AF5DCE78" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_F9CBCEF2A1C3C18F8BE8B238AF5EC11A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_AD13AC1CAE298A59BFA0B238AF5E060F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_F9CBCEF2A1C3C18F8BE8B238AF5EC11A" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_AD13AC1CAE298A59BFA0B238AF5E060F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_27548FAC91EC23F69C75B238AF5E4191" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_AD13AC1CAE298A59BFA0B238AF5E060F" xlink:to="loc_us-gaap_SubsequentEventMember_27548FAC91EC23F69C75B238AF5E4191" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CounterpartyNameAxis" xlink:label="loc_us-gaap_CounterpartyNameAxis_2EC56D3886998FE6129EB238AF5EDE98" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_A942751DCA789EDC9CA7B238AF5DCE78" xlink:to="loc_us-gaap_CounterpartyNameAxis_2EC56D3886998FE6129EB238AF5EDE98" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RepurchaseAgreementCounterpartyNameDomain" xlink:label="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_4A643E704A389F8A05CAB238AF5E19F6" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CounterpartyNameAxis_2EC56D3886998FE6129EB238AF5EDE98" xlink:to="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_4A643E704A389F8A05CAB238AF5E19F6" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_MitsubishiTanabePharmaCorporationMTPCMember" xlink:label="loc_regn_MitsubishiTanabePharmaCorporationMTPCMember_E89BD769C049C89980E6B238AF5EF28D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RepurchaseAgreementCounterpartyNameDomain_4A643E704A389F8A05CAB238AF5E19F6" xlink:to="loc_regn_MitsubishiTanabePharmaCorporationMTPCMember_E89BD769C049C89980E6B238AF5EF28D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="loc_us-gaap_TypeOfArrangementAxis_3386668DDB2DB5DC22D9B238AF5E46FE" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_A942751DCA789EDC9CA7B238AF5DCE78" xlink:to="loc_us-gaap_TypeOfArrangementAxis_3386668DDB2DB5DC22D9B238AF5E46FE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_9CBCE40D0E5A71932B53B238AF5EF52D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_3386668DDB2DB5DC22D9B238AF5E46FE" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_9CBCE40D0E5A71932B53B238AF5EF52D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CollaborativeArrangementMember" xlink:label="loc_us-gaap_CollaborativeArrangementMember_6E675690A9803F3B79CFB238AF5EE721" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_9CBCE40D0E5A71932B53B238AF5EF52D" xlink:to="loc_us-gaap_CollaborativeArrangementMember_6E675690A9803F3B79CFB238AF5EE721" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_00EE47A2EC67ECD4D462B238AF5E1CF8" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_A942751DCA789EDC9CA7B238AF5DCE78" xlink:to="loc_us-gaap_RangeAxis_00EE47A2EC67ECD4D462B238AF5E1CF8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_82A0B4FAA2C8AFEAC065B238AF5E5E58" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeAxis_00EE47A2EC67ECD4D462B238AF5E1CF8" xlink:to="loc_us-gaap_RangeMember_82A0B4FAA2C8AFEAC065B238AF5E5E58" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_A27686ACA04A07B0EE2EB238AF5E9A8B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_82A0B4FAA2C8AFEAC065B238AF5E5E58" xlink:to="loc_us-gaap_MaximumMember_A27686ACA04A07B0EE2EB238AF5E9A8B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_9F103D6A2C6DA4C01BE1B238AF5E5CD4" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_82A0B4FAA2C8AFEAC065B238AF5E5E58" xlink:to="loc_us-gaap_MinimumMember_9F103D6A2C6DA4C01BE1B238AF5E5CD4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_31E76FA60CF75FD84D7FB238AF5EC117" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_A942751DCA789EDC9CA7B238AF5DCE78" xlink:to="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_31E76FA60CF75FD84D7FB238AF5EC117" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueAdditions" xlink:label="loc_us-gaap_DeferredRevenueAdditions_A9263BF563C211B72496B238AF5E2EEC" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_31E76FA60CF75FD84D7FB238AF5EC117" xlink:to="loc_us-gaap_DeferredRevenueAdditions_A9263BF563C211B72496B238AF5E2EEC" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_FuturedevelopmentmilestonepaymenttheCompanyiseligibletoreceive" xlink:label="loc_regn_FuturedevelopmentmilestonepaymenttheCompanyiseligibletoreceive_07FBB63B3BFA6ED00019B238AF5F7B85" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_31E76FA60CF75FD84D7FB238AF5EC117" xlink:to="loc_regn_FuturedevelopmentmilestonepaymenttheCompanyiseligibletoreceive_07FBB63B3BFA6ED00019B238AF5F7B85" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ContingentpaymentsCompanycouldreceive" xlink:label="loc_regn_ContingentpaymentsCompanycouldreceive_23E5F31E25AA0F7A70DEB238AF5F5176" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_31E76FA60CF75FD84D7FB238AF5EC117" xlink:to="loc_regn_ContingentpaymentsCompanycouldreceive_23E5F31E25AA0F7A70DEB238AF5F5176" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_CollaborativeArrangementPurchasePricePercentageofNetProductSales" xlink:label="loc_regn_CollaborativeArrangementPurchasePricePercentageofNetProductSales_587ACBB5C18FCC4B9CBFB238AF5F60E5" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_31E76FA60CF75FD84D7FB238AF5EC117" xlink:to="loc_regn_CollaborativeArrangementPurchasePricePercentageofNetProductSales_587ACBB5C18FCC4B9CBFB238AF5F60E5" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_CollaborativeArrangementAdditionalEligibleAggregatePayments" xlink:label="loc_regn_CollaborativeArrangementAdditionalEligibleAggregatePayments_7DEA853CBFAE6CAB00C3B238AF5F1124" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_31E76FA60CF75FD84D7FB238AF5EC117" xlink:to="loc_regn_CollaborativeArrangementAdditionalEligibleAggregatePayments_7DEA853CBFAE6CAB00C3B238AF5F1124" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Startingspecifiedlevelsofannualsalesatwhichsalesmilestonepaymentsmaybereceived" xlink:label="loc_regn_Startingspecifiedlevelsofannualsalesatwhichsalesmilestonepaymentsmaybereceived_58FDBF5E89DE3C66DDC3B238AF5F9397" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_31E76FA60CF75FD84D7FB238AF5EC117" xlink:to="loc_regn_Startingspecifiedlevelsofannualsalesatwhichsalesmilestonepaymentsmaybereceived_58FDBF5E89DE3C66DDC3B238AF5F9397" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/CollaborationAgreementsPdgfrBetaAntibodyDetails" xlink:type="extended">
    <loc xlink:href="regn-20151231.xsd#regn_CollaborationAgreementAbstract" xlink:label="loc_regn_CollaborationAgreementAbstract_B16FB14AE9CB0891E3E3B238AF74AA61" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable" xlink:label="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_78AE0FA2A17AA3B2F6FBB238AF74E564" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_CollaborationAgreementAbstract_B16FB14AE9CB0891E3E3B238AF74AA61" xlink:to="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_78AE0FA2A17AA3B2F6FBB238AF74E564" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_7CC5DDBEF6C349B0700DB238AF741D4D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_78AE0FA2A17AA3B2F6FBB238AF74E564" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_7CC5DDBEF6C349B0700DB238AF741D4D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_1BAED25A4A9B36DC7ED0B238AF74B448" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_7CC5DDBEF6C349B0700DB238AF741D4D" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_1BAED25A4A9B36DC7ED0B238AF74B448" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_PDGFMember" xlink:label="loc_regn_PDGFMember_813995D959544A619624B238AF74779B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_1BAED25A4A9B36DC7ED0B238AF74B448" xlink:to="loc_regn_PDGFMember_813995D959544A619624B238AF74779B" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_PDGFRbetaoutsidetheUSMember" xlink:label="loc_regn_PDGFRbetaoutsidetheUSMember_C4A33F6544DD2250C904B238AF74DD3C" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_1BAED25A4A9B36DC7ED0B238AF74B448" xlink:to="loc_regn_PDGFRbetaoutsidetheUSMember_C4A33F6544DD2250C904B238AF74DD3C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_291C240D1E11DBE3629BB238AF74A14A" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_78AE0FA2A17AA3B2F6FBB238AF74E564" xlink:to="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_291C240D1E11DBE3629BB238AF74A14A" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_MaximumPercentageOfOutstandingSharesThatMayBeAcquiredUnderStandstillProvisions" xlink:label="loc_regn_MaximumPercentageOfOutstandingSharesThatMayBeAcquiredUnderStandstillProvisions_7D3099DD178B1F7C5573B238AF74FBBC" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_291C240D1E11DBE3629BB238AF74A14A" xlink:to="loc_regn_MaximumPercentageOfOutstandingSharesThatMayBeAcquiredUnderStandstillProvisions_7D3099DD178B1F7C5573B238AF74FBBC" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Percentageofglobaldevelopmentcosttobepaidbythecollaborationpartnerunderthecollaboration" xlink:label="loc_regn_Percentageofglobaldevelopmentcosttobepaidbythecollaborationpartnerunderthecollaboration_8F05EFC2B951BBDB808AB238AF74F6C1" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_291C240D1E11DBE3629BB238AF74A14A" xlink:to="loc_regn_Percentageofglobaldevelopmentcosttobepaidbythecollaborationpartnerunderthecollaboration_8F05EFC2B951BBDB808AB238AF74F6C1" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_PercentageofdevelopmentcostfortheterritoryoutsidetheUnitedStatespreviouslyrequiredtobepaidforunderthecollaboration" xlink:label="loc_regn_PercentageofdevelopmentcostfortheterritoryoutsidetheUnitedStatespreviouslyrequiredtobepaidforunderthecollaboration_77AA67F07873B92880BBB238AF7401D4" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_291C240D1E11DBE3629BB238AF74A14A" xlink:to="loc_regn_PercentageofdevelopmentcostfortheterritoryoutsidetheUnitedStatespreviouslyrequiredtobepaidforunderthecollaboration_77AA67F07873B92880BBB238AF7401D4" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Percentageofdevelopmentmilestonepaymentstobereimbursed" xlink:label="loc_regn_Percentageofdevelopmentmilestonepaymentstobereimbursed_4409D9A47A1A43160659B238AF74BA4F" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_291C240D1E11DBE3629BB238AF74A14A" xlink:to="loc_regn_Percentageofdevelopmentmilestonepaymentstobereimbursed_4409D9A47A1A43160659B238AF74BA4F" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_NumberofdevelopmentmilestonepaymentstheCompanyreceived" xlink:label="loc_regn_NumberofdevelopmentmilestonepaymentstheCompanyreceived_F69FCD633E38771F0D7BB238AF75E2B0" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_291C240D1E11DBE3629BB238AF74A14A" xlink:to="loc_regn_NumberofdevelopmentmilestonepaymentstheCompanyreceived_F69FCD633E38771F0D7BB238AF75E2B0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueAdditions" xlink:label="loc_us-gaap_DeferredRevenueAdditions_9ED1E6A4E2D351EB27FDB238AF75CBFE" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_291C240D1E11DBE3629BB238AF74A14A" xlink:to="loc_us-gaap_DeferredRevenueAdditions_9ED1E6A4E2D351EB27FDB238AF75CBFE" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_SubstantiveMilestonePaymentToCompany" xlink:label="loc_regn_SubstantiveMilestonePaymentToCompany_E542C26AAF49DC674011B238AF75CA72" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_291C240D1E11DBE3629BB238AF74A14A" xlink:to="loc_regn_SubstantiveMilestonePaymentToCompany_E542C26AAF49DC674011B238AF75CA72" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized" xlink:label="loc_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_CD60AF93AAD8F9D34C17B238AF755F15" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_291C240D1E11DBE3629BB238AF74A14A" xlink:to="loc_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_CD60AF93AAD8F9D34C17B238AF755F15" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_FuturedevelopmentmilestonepaymenttheCompanyiseligibletoreceive" xlink:label="loc_regn_FuturedevelopmentmilestonepaymenttheCompanyiseligibletoreceive_6AADAFE7F7BC01B2FD75B238AF75807B" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_291C240D1E11DBE3629BB238AF74A14A" xlink:to="loc_regn_FuturedevelopmentmilestonepaymenttheCompanyiseligibletoreceive_6AADAFE7F7BC01B2FD75B238AF75807B" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Optinpayment" xlink:label="loc_regn_Optinpayment_8AB0435DF36D693EA315B238AF75457B" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_291C240D1E11DBE3629BB238AF74A14A" xlink:to="loc_regn_Optinpayment_8AB0435DF36D693EA315B238AF75457B" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Amountofmilestonepaymentsthatmaybereceivedrelatingtomarketingapproval" xlink:label="loc_regn_Amountofmilestonepaymentsthatmaybereceivedrelatingtomarketingapproval_5D6F09C95E366EF09E78B238AF7523F5" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_291C240D1E11DBE3629BB238AF74A14A" xlink:to="loc_regn_Amountofmilestonepaymentsthatmaybereceivedrelatingtomarketingapproval_5D6F09C95E366EF09E78B238AF7523F5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsAndNotesReceivableNet" xlink:label="loc_us-gaap_AccountsAndNotesReceivableNet_929C025D380DFC29CCD7B238AF7594A5" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_291C240D1E11DBE3629BB238AF74A14A" xlink:to="loc_us-gaap_AccountsAndNotesReceivableNet_929C025D380DFC29CCD7B238AF7594A5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProceedsFromCollaborators" xlink:label="loc_us-gaap_ProceedsFromCollaborators_DB3AE07B7C323FD9BDFEB238AF75E010" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_291C240D1E11DBE3629BB238AF74A14A" xlink:to="loc_us-gaap_ProceedsFromCollaborators_DB3AE07B7C323FD9BDFEB238AF75E010" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/CollaborationAgreementsSanofiDetails" xlink:type="extended">
    <loc xlink:href="regn-20151231.xsd#regn_CollaborationAgreementAbstract" xlink:label="loc_regn_CollaborationAgreementAbstract_14A782FF1BAC352DEED6C7100025BBA8" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable" xlink:label="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_20492D59C70DCF4A9D7BC710002550DE" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_CollaborationAgreementAbstract_14A782FF1BAC352DEED6C7100025BBA8" xlink:to="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_20492D59C70DCF4A9D7BC710002550DE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_63DED5CA0E5870880364C7100025D506" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_20492D59C70DCF4A9D7BC710002550DE" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_63DED5CA0E5870880364C7100025D506" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_EBD4ADFA7F78333845C1C7100025422F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_63DED5CA0E5870880364C7100025D506" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_EBD4ADFA7F78333845C1C7100025422F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_1636872680751604F6B1C71000254BA4" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_EBD4ADFA7F78333845C1C7100025422F" xlink:to="loc_us-gaap_SubsequentEventMember_1636872680751604F6B1C71000254BA4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_03F97699917518D22671C71000346768" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_20492D59C70DCF4A9D7BC710002550DE" xlink:to="loc_us-gaap_StatementScenarioAxis_03F97699917518D22671C71000346768" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_CD2C738E51441A98362AC710003486FC" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementScenarioAxis_03F97699917518D22671C71000346768" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_CD2C738E51441A98362AC710003486FC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScenarioForecastMember" xlink:label="loc_us-gaap_ScenarioForecastMember_4185532CB74742AFBF43C71000342BB9" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScenarioUnspecifiedDomain_CD2C738E51441A98362AC710003486FC" xlink:to="loc_us-gaap_ScenarioForecastMember_4185532CB74742AFBF43C71000342BB9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_49423DC522270FCCF038C71000349F7D" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_20492D59C70DCF4A9D7BC710002550DE" xlink:to="loc_us-gaap_RangeAxis_49423DC522270FCCF038C71000349F7D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_56FAAEA69067B98930B3C710003415CC" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeAxis_49423DC522270FCCF038C71000349F7D" xlink:to="loc_us-gaap_RangeMember_56FAAEA69067B98930B3C710003415CC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_8D4BE4065ADC5EC6691DC7100034793C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_56FAAEA69067B98930B3C710003415CC" xlink:to="loc_us-gaap_MinimumMember_8D4BE4065ADC5EC6691DC7100034793C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_2946A4024111EC8A5C7AC7100034CD05" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_56FAAEA69067B98930B3C710003415CC" xlink:to="loc_us-gaap_MaximumMember_2946A4024111EC8A5C7AC7100034CD05" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProductOrServiceAxis" xlink:label="loc_us-gaap_ProductOrServiceAxis_1F2F98E687F21E748C14C710003460CC" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_20492D59C70DCF4A9D7BC710002550DE" xlink:to="loc_us-gaap_ProductOrServiceAxis_1F2F98E687F21E748C14C710003460CC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_A8800E2D9D616ABC0D90C71000345EB5" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductOrServiceAxis_1F2F98E687F21E748C14C710003460CC" xlink:to="loc_us-gaap_ProductsAndServicesDomain_A8800E2D9D616ABC0D90C71000345EB5" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_PD1Member" xlink:label="loc_regn_PD1Member_D64981B636B990CF665FC71000345735" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_A8800E2D9D616ABC0D90C71000345EB5" xlink:to="loc_regn_PD1Member_D64981B636B990CF665FC71000345735" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TypeOfArrangementAxis" xlink:label="loc_us-gaap_TypeOfArrangementAxis_E6322212B7CDC740C120C71000348E61" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_20492D59C70DCF4A9D7BC710002550DE" xlink:to="loc_us-gaap_TypeOfArrangementAxis_E6322212B7CDC740C120C71000348E61" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_5D66B12FE6CF0E26148EC7100034A9CA" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_E6322212B7CDC740C120C71000348E61" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_5D66B12FE6CF0E26148EC7100034A9CA" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_NewFundingMember" xlink:label="loc_regn_NewFundingMember_EA57789A189B1C5E7544C7100034D437" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_5D66B12FE6CF0E26148EC7100034A9CA" xlink:to="loc_regn_NewFundingMember_EA57789A189B1C5E7544C7100034D437" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_PreviousFundingunderAntibodyDiscoveryAgreementMember" xlink:label="loc_regn_PreviousFundingunderAntibodyDiscoveryAgreementMember_BB2D7672335E5D0734A5C710003413BC" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_5D66B12FE6CF0E26148EC7100034A9CA" xlink:to="loc_regn_PreviousFundingunderAntibodyDiscoveryAgreementMember_BB2D7672335E5D0734A5C710003413BC" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductAxis" xlink:label="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductAxis_B8A076C0A5185D861B3EC71000348A43" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_20492D59C70DCF4A9D7BC710002550DE" xlink:to="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductAxis_B8A076C0A5185D861B3EC71000348A43" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain" xlink:label="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_FFA9A84071DC7248219BC7100034AB9D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductAxis_B8A076C0A5185D861B3EC71000348A43" xlink:to="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_FFA9A84071DC7248219BC7100034AB9D" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_IOAgreementMember" xlink:label="loc_regn_IOAgreementMember_C333F6EB4401D7614905C7100034EC19" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_FFA9A84071DC7248219BC7100034AB9D" xlink:to="loc_regn_IOAgreementMember_C333F6EB4401D7614905C7100034EC19" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_AntibodyCollaborationMember" xlink:label="loc_regn_AntibodyCollaborationMember_A4B290183731265DC247C71000341F88" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_FFA9A84071DC7248219BC7100034AB9D" xlink:to="loc_regn_AntibodyCollaborationMember_A4B290183731265DC247C71000341F88" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ImmunooncologyAgreementMember" xlink:label="loc_regn_ImmunooncologyAgreementMember_906E8899D22A0CF1AC2FC71000345332" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_FFA9A84071DC7248219BC7100034AB9D" xlink:to="loc_regn_ImmunooncologyAgreementMember_906E8899D22A0CF1AC2FC71000345332" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_SanofiMember" xlink:label="loc_regn_SanofiMember_CFE037ADB25D8D63EA82C71000343CB4" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_FFA9A84071DC7248219BC7100034AB9D" xlink:to="loc_regn_SanofiMember_CFE037ADB25D8D63EA82C71000343CB4" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_VelocigeneAgreementMember" xlink:label="loc_regn_VelocigeneAgreementMember_A7B3650143B33DDDF247C7100034B753" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_FFA9A84071DC7248219BC7100034AB9D" xlink:to="loc_regn_VelocigeneAgreementMember_A7B3650143B33DDDF247C7100034B753" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_PDGFMember" xlink:label="loc_regn_PDGFMember_960FE4E26F1192F1E0F1C71000343713" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_FFA9A84071DC7248219BC7100034AB9D" xlink:to="loc_regn_PDGFMember_960FE4E26F1192F1E0F1C71000343713" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Ang2Member" xlink:label="loc_regn_Ang2Member_0DC4A849B147674C8872C7100034E02C" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_FFA9A84071DC7248219BC7100034AB9D" xlink:to="loc_regn_Ang2Member_0DC4A849B147674C8872C7100034E02C" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_AfliberceptAgreementMember" xlink:label="loc_regn_AfliberceptAgreementMember_261C537140BE82FD7C43C71000341357" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_FFA9A84071DC7248219BC7100034AB9D" xlink:to="loc_regn_AfliberceptAgreementMember_261C537140BE82FD7C43C71000341357" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_IODiscoveryAgreementMember" xlink:label="loc_regn_IODiscoveryAgreementMember_1D6B1C95F0E1B15B4DE6C7100034DCB0" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_FFA9A84071DC7248219BC7100034AB9D" xlink:to="loc_regn_IODiscoveryAgreementMember_1D6B1C95F0E1B15B4DE6C7100034DCB0" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_IOLicenseandCollaborationAgreementMember" xlink:label="loc_regn_IOLicenseandCollaborationAgreementMember_8A4282EA3F093D0D820DC71000343734" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_FFA9A84071DC7248219BC7100034AB9D" xlink:to="loc_regn_IOLicenseandCollaborationAgreementMember_8A4282EA3F093D0D820DC71000343734" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_98A8B84DD02CF550E611C7100034080A" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_20492D59C70DCF4A9D7BC710002550DE" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_98A8B84DD02CF550E611C7100034080A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_627E6B86FB3669B1B494C71000349B4C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_98A8B84DD02CF550E611C7100034080A" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_627E6B86FB3669B1B494C71000349B4C" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_CollaborationAgreementWithSanofiMember" xlink:label="loc_regn_CollaborationAgreementWithSanofiMember_2F6E68B5144F5FA0F3EAC71000342010" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_627E6B86FB3669B1B494C71000349B4C" xlink:to="loc_regn_CollaborationAgreementWithSanofiMember_2F6E68B5144F5FA0F3EAC71000342010" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfResearchAndDevelopmentArrangementContractToPerformForOthersTable_20492D59C70DCF4A9D7BC710002550DE" xlink:to="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_6279E0B62ADF79F7C60FC71000346057" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_6279E0B62ADF79F7C60FC71000346057" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_DeferredRevenueFromRelatedPartyCurrent" xlink:label="loc_regn_DeferredRevenueFromRelatedPartyCurrent_09FBC22D3B7F1450D107C71000349E4F" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_DeferredRevenueFromRelatedPartyCurrent_09FBC22D3B7F1450D107C71000349E4F" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Contingentreimbursementobligation" xlink:label="loc_regn_Contingentreimbursementobligation_831A3EC98276223BFCE5C71000345261" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_Contingentreimbursementobligation_831A3EC98276223BFCE5C71000345261" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RecognitionOfDeferredRevenue" xlink:label="loc_us-gaap_RecognitionOfDeferredRevenue_9ECF26A1F6B3601721EBC7100034BB20" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_us-gaap_RecognitionOfDeferredRevenue_9ECF26A1F6B3601721EBC7100034BB20" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="loc_us-gaap_CommonStockSharesIssued_2246A4FD26A2B5C199BDC7100034EADD" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_us-gaap_CommonStockSharesIssued_2246A4FD26A2B5C199BDC7100034EADD" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Netprofitlossfromcommercializationofproductsundercollaborationagreement" xlink:label="loc_regn_Netprofitlossfromcommercializationofproductsundercollaborationagreement_DFAC37F79A0D8950F067C7100034C33E" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_Netprofitlossfromcommercializationofproductsundercollaborationagreement_DFAC37F79A0D8950F067C7100034C33E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized" xlink:label="loc_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_922EABFABDBBEE229907C710003481A4" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_922EABFABDBBEE229907C710003481A4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersCompensationEarned" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersCompensationEarned_71CA98842932763FA96BC7100034E19B" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersCompensationEarned_71CA98842932763FA96BC7100034E19B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ContractsRevenue" xlink:label="loc_us-gaap_ContractsRevenue_A2EFD21E1CF928C84E7BC7100034528B" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_us-gaap_ContractsRevenue_A2EFD21E1CF928C84E7BC7100034528B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff" xlink:label="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_DA818AED00F8B4C9B7FEC7100034D604" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_DA818AED00F8B4C9B7FEC7100034D604" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Licenseagreementterm" xlink:label="loc_regn_Licenseagreementterm_EA30E3CF706FBC27C378C7100034A0CD" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_Licenseagreementterm_EA30E3CF706FBC27C378C7100034A0CD" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Levelsoftwelvemonthsalesatwhichsalesmilestonepaymentswouldbereceived" xlink:label="loc_regn_Levelsoftwelvemonthsalesatwhichsalesmilestonepaymentswouldbereceived_D8BBE974DD80F84215EBC7100034941D" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_Levelsoftwelvemonthsalesatwhichsalesmilestonepaymentswouldbereceived_D8BBE974DD80F84215EBC7100034941D" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_PercentageofdevelopmentcostfortheterritoryoutsidetheUnitedStatespreviouslyrequiredtobepaidforunderthecollaboration" xlink:label="loc_regn_PercentageofdevelopmentcostfortheterritoryoutsidetheUnitedStatespreviouslyrequiredtobepaidforunderthecollaboration_492019C3A62AF58996DBC71000345DF6" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_PercentageofdevelopmentcostfortheterritoryoutsidetheUnitedStatespreviouslyrequiredtobepaidforunderthecollaboration_492019C3A62AF58996DBC71000345DF6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueRevenueRecognized" xlink:label="loc_us-gaap_DeferredRevenueRevenueRecognized_4583982B6411E764D562C71000346DDD" xlink:type="locator" />
    <presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_us-gaap_DeferredRevenueRevenueRecognized_4583982B6411E764D562C71000346DDD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_CCE4D9AF3F12CAAB7B6CC7100034C59B" xlink:type="locator" />
    <presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_CCE4D9AF3F12CAAB7B6CC7100034C59B" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_CollaborativeArrangementPurchasePricePercentageofNetProductSales" xlink:label="loc_regn_CollaborativeArrangementPurchasePricePercentageofNetProductSales_D364BFC6C59F51DAE2E6C7100034D53A" xlink:type="locator" />
    <presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_CollaborativeArrangementPurchasePricePercentageofNetProductSales_D364BFC6C59F51DAE2E6C7100034D53A" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_CollaborativeArrangementAdditionalEligibleAggregatePayments" xlink:label="loc_regn_CollaborativeArrangementAdditionalEligibleAggregatePayments_D91230EA5464A8AA8187C71000340316" xlink:type="locator" />
    <presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_CollaborativeArrangementAdditionalEligibleAggregatePayments_D91230EA5464A8AA8187C71000340316" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueAdditions" xlink:label="loc_us-gaap_DeferredRevenueAdditions_0C3746E5BEA2D6CA77CDC710003460F8" xlink:type="locator" />
    <presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_us-gaap_DeferredRevenueAdditions_0C3746E5BEA2D6CA77CDC710003460F8" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_PotentialfutureRDexpenses" xlink:label="loc_regn_PotentialfutureRDexpenses_2A9087CA24630FDC5D80C7100034448F" xlink:type="locator" />
    <presentationArc order="19" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_PotentialfutureRDexpenses_2A9087CA24630FDC5D80C7100034448F" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_FuturedevelopmentmilestonepaymenttheCompanyiseligibletoreceive" xlink:label="loc_regn_FuturedevelopmentmilestonepaymenttheCompanyiseligibletoreceive_B82EB76EC3B7B703E58EC7100034D3DF" xlink:type="locator" />
    <presentationArc order="20" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_FuturedevelopmentmilestonepaymenttheCompanyiseligibletoreceive_B82EB76EC3B7B703E58EC7100034D3DF" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ContingentpaymentsCompanycouldreceive" xlink:label="loc_regn_ContingentpaymentsCompanycouldreceive_8B4434E94027F7F27F7EC7100034E22B" xlink:type="locator" />
    <presentationArc order="21" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_ContingentpaymentsCompanycouldreceive_8B4434E94027F7F27F7EC7100034E22B" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Maximumamountofshareddevelopmentcosts" xlink:label="loc_regn_Maximumamountofshareddevelopmentcosts_25688AE754CB183F2A7EC7100034C28F" xlink:type="locator" />
    <presentationArc order="22" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_Maximumamountofshareddevelopmentcosts_25688AE754CB183F2A7EC7100034C28F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RevenueFromRelatedParties" xlink:label="loc_us-gaap_RevenueFromRelatedParties_C1BA6F8BDFBAF7777D0DC7100034ACEC" xlink:type="locator" />
    <presentationArc order="23" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_us-gaap_RevenueFromRelatedParties_C1BA6F8BDFBAF7777D0DC7100034ACEC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProceedsFromCollaborators" xlink:label="loc_us-gaap_ProceedsFromCollaborators_6BCB6A59DB369E886479C7100034DB4D" xlink:type="locator" />
    <presentationArc order="24" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_us-gaap_ProceedsFromCollaborators_6BCB6A59DB369E886479C7100034DB4D" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Amountofmilestonepaymentsthatmaybereceivedrelatingtomarketingapproval" xlink:label="loc_regn_Amountofmilestonepaymentsthatmaybereceivedrelatingtomarketingapproval_55E8B340B1B6853680DBC71000346E66" xlink:type="locator" />
    <presentationArc order="25" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_Amountofmilestonepaymentsthatmaybereceivedrelatingtomarketingapproval_55E8B340B1B6853680DBC71000346E66" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Percentageofrepaymentofdevelopmentbalanceoutofprofits" xlink:label="loc_regn_Percentageofrepaymentofdevelopmentbalanceoutofprofits_DDA48290EA58BE0006AEC71000346457" xlink:type="locator" />
    <presentationArc order="26" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_Percentageofrepaymentofdevelopmentbalanceoutofprofits_DDA48290EA58BE0006AEC71000346457" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Minimumadvancenoticerequiredtoterminatecollaborationagreement" xlink:label="loc_regn_Minimumadvancenoticerequiredtoterminatecollaborationagreement_75A7045F05B258C7959EC7100034F637" xlink:type="locator" />
    <presentationArc order="27" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_Minimumadvancenoticerequiredtoterminatecollaborationagreement_75A7045F05B258C7959EC7100034F637" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Minimumpaymentreceivedundertheagreement" xlink:label="loc_regn_Minimumpaymentreceivedundertheagreement_AD6A0870034FF1830625C71000341B43" xlink:type="locator" />
    <presentationArc order="28" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_Minimumpaymentreceivedundertheagreement_AD6A0870034FF1830625C71000341B43" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_AnnualFundingMaximumOfResearchActivitiesPerAmendedAgreement" xlink:label="loc_regn_AnnualFundingMaximumOfResearchActivitiesPerAmendedAgreement_0EC5D897E491BFAE12C5C71000342D4A" xlink:type="locator" />
    <presentationArc order="29" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_AnnualFundingMaximumOfResearchActivitiesPerAmendedAgreement_0EC5D897E491BFAE12C5C71000342D4A" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ReductionofFundingforResearchActivitiesPerAgreement" xlink:label="loc_regn_ReductionofFundingforResearchActivitiesPerAgreement_1FF438602E98A426BEB0C7100034F5E1" xlink:type="locator" />
    <presentationArc order="30" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_ReductionofFundingforResearchActivitiesPerAgreement_1FF438602E98A426BEB0C7100034F5E1" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_FundingMaximumofResearchActivitiesPerAgreement" xlink:label="loc_regn_FundingMaximumofResearchActivitiesPerAgreement_50AF3547568CB3847911C7100034CED7" xlink:type="locator" />
    <presentationArc order="31" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_FundingMaximumofResearchActivitiesPerAgreement_50AF3547568CB3847911C7100034CED7" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Additionalyearstoextendtheagreement" xlink:label="loc_regn_Additionalyearstoextendtheagreement_4C8755074FF9BD6E2741C7100034BE74" xlink:type="locator" />
    <presentationArc order="32" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_Additionalyearstoextendtheagreement_4C8755074FF9BD6E2741C7100034BE74" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_SubstantiveMilestonePaymentToCompany" xlink:label="loc_regn_SubstantiveMilestonePaymentToCompany_3AD8C1C08E24A2E99F60C710003493D8" xlink:type="locator" />
    <presentationArc order="33" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_SubstantiveMilestonePaymentToCompany_3AD8C1C08E24A2E99F60C710003493D8" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_PercentageOfTrialCostsBorneByCollaboratingParty" xlink:label="loc_regn_PercentageOfTrialCostsBorneByCollaboratingParty_18A45F0DA757349D872EC710003429F0" xlink:type="locator" />
    <presentationArc order="34" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_PercentageOfTrialCostsBorneByCollaboratingParty_18A45F0DA757349D872EC710003429F0" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_PercentageOfTrialCostsBorneByEntity" xlink:label="loc_regn_PercentageOfTrialCostsBorneByEntity_282F330CF76E3E3ED19EC710003409CB" xlink:type="locator" />
    <presentationArc order="35" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_PercentageOfTrialCostsBorneByEntity_282F330CF76E3E3ED19EC710003409CB" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_PercentageOfTrialCostsToBeReimbursedDueToProfitabilityOfAgreement" xlink:label="loc_regn_PercentageOfTrialCostsToBeReimbursedDueToProfitabilityOfAgreement_BBB6FC7A459BB113560BC71000348E86" xlink:type="locator" />
    <presentationArc order="36" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_PercentageOfTrialCostsToBeReimbursedDueToProfitabilityOfAgreement_BBB6FC7A459BB113560BC71000348E86" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ExcessShareOfProfitNotRequiredToToBeAppliedToReimburseDevelopmentCost" xlink:label="loc_regn_ExcessShareOfProfitNotRequiredToToBeAppliedToReimburseDevelopmentCost_EA68D3BF5EF3669F3F04C71000342A06" xlink:type="locator" />
    <presentationArc order="37" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_ExcessShareOfProfitNotRequiredToToBeAppliedToReimburseDevelopmentCost_EA68D3BF5EF3669F3F04C71000342A06" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_StartingShareOfProfitsOutsideUnitedStatesBasedOnSalesForCollaboratingParty" xlink:label="loc_regn_StartingShareOfProfitsOutsideUnitedStatesBasedOnSalesForCollaboratingParty_FF3947386105DF1222F0C7100034EA5C" xlink:type="locator" />
    <presentationArc order="38" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_StartingShareOfProfitsOutsideUnitedStatesBasedOnSalesForCollaboratingParty_FF3947386105DF1222F0C7100034EA5C" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_StartingShareOfProfitsOutsideUnitedStatesBasedOnSalesForCompany" xlink:label="loc_regn_StartingShareOfProfitsOutsideUnitedStatesBasedOnSalesForCompany_580968114C68C48D87DCC71000341080" xlink:type="locator" />
    <presentationArc order="39" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_StartingShareOfProfitsOutsideUnitedStatesBasedOnSalesForCompany_580968114C68C48D87DCC71000341080" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_EndingShareOfProfitsOutsideUnitedStatesBasedOnSalesForCollaboratingParty" xlink:label="loc_regn_EndingShareOfProfitsOutsideUnitedStatesBasedOnSalesForCollaboratingParty_9817117FDD3BE7F6FCC1C710003416FC" xlink:type="locator" />
    <presentationArc order="40" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_EndingShareOfProfitsOutsideUnitedStatesBasedOnSalesForCollaboratingParty_9817117FDD3BE7F6FCC1C710003416FC" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_EndingShareOfProfitsOutsideUnitedStatesBasedOnSalesForCompany" xlink:label="loc_regn_EndingShareOfProfitsOutsideUnitedStatesBasedOnSalesForCompany_B640CC782349FF0F94B0C710003477F5" xlink:type="locator" />
    <presentationArc order="41" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_EndingShareOfProfitsOutsideUnitedStatesBasedOnSalesForCompany_B640CC782349FF0F94B0C710003477F5" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ShareOfLossesOutsideUnitedStatesForCollaboratingParty" xlink:label="loc_regn_ShareOfLossesOutsideUnitedStatesForCollaboratingParty_103153A95E50BC199117C7100034BBC7" xlink:type="locator" />
    <presentationArc order="42" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_ShareOfLossesOutsideUnitedStatesForCollaboratingParty_103153A95E50BC199117C7100034BBC7" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ShareOfLossesOutsideUnitedStatesForCompany" xlink:label="loc_regn_ShareOfLossesOutsideUnitedStatesForCompany_39B4AE30B9F54C7F72ECC7100034488F" xlink:type="locator" />
    <presentationArc order="43" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_ShareOfLossesOutsideUnitedStatesForCompany_39B4AE30B9F54C7F72ECC7100034488F" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_MaximumAmountOfSalesMilestonePaymentsIfTotalSalesAchieveSpecificLevels" xlink:label="loc_regn_MaximumAmountOfSalesMilestonePaymentsIfTotalSalesAchieveSpecificLevels_091E0F6FC761004B3BABC7100034F2C2" xlink:type="locator" />
    <presentationArc order="44" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_MaximumAmountOfSalesMilestonePaymentsIfTotalSalesAchieveSpecificLevels_091E0F6FC761004B3BABC7100034F2C2" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Startingspecifiedlevelsofannualsalesatwhichsalesmilestonepaymentsmaybereceived" xlink:label="loc_regn_Startingspecifiedlevelsofannualsalesatwhichsalesmilestonepaymentsmaybereceived_766669CF8DE02D1968C9C7100034E13B" xlink:type="locator" />
    <presentationArc order="45" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_Startingspecifiedlevelsofannualsalesatwhichsalesmilestonepaymentsmaybereceived_766669CF8DE02D1968C9C7100034E13B" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_PeriodForAchievingSalesTargetForMilestonePaymentRollingBasis" xlink:label="loc_regn_PeriodForAchievingSalesTargetForMilestonePaymentRollingBasis_CB491436E32D3AC46E99C71000344587" xlink:type="locator" />
    <presentationArc order="46" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_PeriodForAchievingSalesTargetForMilestonePaymentRollingBasis_CB491436E32D3AC46E99C71000344587" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Percentageofaggregatenetsalestobepaidbytherelatedpartyinsuchcalendaryear" xlink:label="loc_regn_Percentageofaggregatenetsalestobepaidbytherelatedpartyinsuchcalendaryear_A2C8E9056B70505056FAC71000340F0D" xlink:type="locator" />
    <presentationArc order="47" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_Percentageofaggregatenetsalestobepaidbytherelatedpartyinsuchcalendaryear_A2C8E9056B70505056FAC71000340F0D" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_AmountOfFundingOfAgreedUponCostIncurredToExpandManufacturingCapacity" xlink:label="loc_regn_AmountOfFundingOfAgreedUponCostIncurredToExpandManufacturingCapacity_FD46579C24C74877A46CC7100034F63D" xlink:type="locator" />
    <presentationArc order="48" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_AmountOfFundingOfAgreedUponCostIncurredToExpandManufacturingCapacity_FD46579C24C74877A46CC7100034F63D" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Maximumamountofreimbursementrelatedtocapitalexpenditures" xlink:label="loc_regn_Maximumamountofreimbursementrelatedtocapitalexpenditures_CED205EC888D69749375C7100034AEDA" xlink:type="locator" />
    <presentationArc order="49" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_Maximumamountofreimbursementrelatedtocapitalexpenditures_CED205EC888D69749375C7100034AEDA" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Amountofcapitalexpenditureswhichhasbeenreceivedorisreceivable" xlink:label="loc_regn_Amountofcapitalexpenditureswhichhasbeenreceivedorisreceivable_C55ED33C93200D8A44FDC71000342F5E" xlink:type="locator" />
    <presentationArc order="50" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_Amountofcapitalexpenditureswhichhasbeenreceivedorisreceivable_C55ED33C93200D8A44FDC71000342F5E" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_PeriodOfNoticeToOptOutOfFurtherDevelopmentAndOrCommercialization" xlink:label="loc_regn_PeriodOfNoticeToOptOutOfFurtherDevelopmentAndOrCommercialization_F23FDFD0E49549E2D827C710003412BB" xlink:type="locator" />
    <presentationArc order="51" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_PeriodOfNoticeToOptOutOfFurtherDevelopmentAndOrCommercialization_F23FDFD0E49549E2D827C710003412BB" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_PeriodOfNoticeToOptOutOfFurtherDevelopmentUponEnteringOfJointDevelopmentProduct" xlink:label="loc_regn_PeriodOfNoticeToOptOutOfFurtherDevelopmentUponEnteringOfJointDevelopmentProduct_FD05C2C2053E71BD3D7EC71000343D67" xlink:type="locator" />
    <presentationArc order="52" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_PeriodOfNoticeToOptOutOfFurtherDevelopmentUponEnteringOfJointDevelopmentProduct_FD05C2C2053E71BD3D7EC71000343D67" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Numberoffamiliesofnovelantibodies" xlink:label="loc_regn_Numberoffamiliesofnovelantibodies_38D97CD717E00A67BA18C7100034C549" xlink:type="locator" />
    <presentationArc order="53" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_Numberoffamiliesofnovelantibodies_38D97CD717E00A67BA18C7100034C549" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_NumberofPaymentstheCompanymade" xlink:label="loc_regn_NumberofPaymentstheCompanymade_9203A51668891C814726C710003437E0" xlink:type="locator" />
    <presentationArc order="54" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_NumberofPaymentstheCompanymade_9203A51668891C814726C710003437E0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherResearchAndDevelopmentExpense" xlink:label="loc_us-gaap_OtherResearchAndDevelopmentExpense_D1BB894419425C2E1B1AC7100034B0D3" xlink:type="locator" />
    <presentationArc order="55" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_us-gaap_OtherResearchAndDevelopmentExpense_D1BB894419425C2E1B1AC7100034B0D3" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Potentialfuturemilestonepayments" xlink:label="loc_regn_Potentialfuturemilestonepayments_1627653B556557699CFFC7100034ABC8" xlink:type="locator" />
    <presentationArc order="56" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_regn_Potentialfuturemilestonepayments_1627653B556557699CFFC7100034ABC8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsForPurchaseOfOtherAssets1" xlink:label="loc_us-gaap_PaymentsForPurchaseOfOtherAssets1_4C97213D46CA1C36AC5CC7100034A0A8" xlink:type="locator" />
    <presentationArc order="57" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_us-gaap_PaymentsForPurchaseOfOtherAssets1_4C97213D46CA1C36AC5CC7100034A0A8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherSalesRevenueNet" xlink:label="loc_us-gaap_OtherSalesRevenueNet_1C75D20EC46ABF419BF5C7100034FF58" xlink:type="locator" />
    <presentationArc order="58" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_0E93B5BB03687B768B64C7100034A7DA" xlink:to="loc_us-gaap_OtherSalesRevenueNet_1C75D20EC46ABF419BF5C7100034FF58" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/CollaborationAgreementsTables" xlink:type="extended">
    <loc xlink:href="regn-20151231.xsd#regn_CollaborationAgreementAbstract" xlink:label="loc_regn_CollaborationAgreementAbstract_E2BBB9C420EB92EEC478B238AFED4A9F" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsTableTextBlock_89D1D65E10143E5844EEB238AFEDF781" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_CollaborationAgreementAbstract_E2BBB9C420EB92EEC478B238AFED4A9F" xlink:to="loc_us-gaap_ScheduleOfRelatedPartyTransactionsTableTextBlock_89D1D65E10143E5844EEB238AFEDF781" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_CollaborationRevenueTableTextBlock" xlink:label="loc_regn_CollaborationRevenueTableTextBlock_667D1AB24BCCFCB1AFC3B238AFED09BE" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_CollaborationAgreementAbstract_E2BBB9C420EB92EEC478B238AFED4A9F" xlink:to="loc_regn_CollaborationRevenueTableTextBlock_667D1AB24BCCFCB1AFC3B238AFED09BE" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ScheduleofSelectedFinancialInformationSanofiTableTextBlock" xlink:label="loc_regn_ScheduleofSelectedFinancialInformationSanofiTableTextBlock_37E8E5EC9E4ED85ED451B238AFED7766" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_CollaborationAgreementAbstract_E2BBB9C420EB92EEC478B238AFED4A9F" xlink:to="loc_regn_ScheduleofSelectedFinancialInformationSanofiTableTextBlock_37E8E5EC9E4ED85ED451B238AFED7766" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ScheduleofSelectedFinancialInformationBayerTableTextBlock" xlink:label="loc_regn_ScheduleofSelectedFinancialInformationBayerTableTextBlock_71C3EE55EA2A1CDCF20DB238AFEDB764" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_CollaborationAgreementAbstract_E2BBB9C420EB92EEC478B238AFED4A9F" xlink:to="loc_regn_ScheduleofSelectedFinancialInformationBayerTableTextBlock_71C3EE55EA2A1CDCF20DB238AFEDB764" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/CommitmentsAndContingencies" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_3DA3137561EC9D796F53B238AE269957" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommitmentsDisclosureTextBlock" xlink:label="loc_us-gaap_CommitmentsDisclosureTextBlock_E2E0795BA3EAB8A92B89B238AE26997E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_3DA3137561EC9D796F53B238AE269957" xlink:to="loc_us-gaap_CommitmentsDisclosureTextBlock_E2E0795BA3EAB8A92B89B238AE26997E" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/CommitmentsAndContingenciesCapitalLeasesDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_B6637D08D355F5408EFAB238ADF83B50" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfCapitalLeasedAsssetsTable" xlink:label="loc_us-gaap_ScheduleOfCapitalLeasedAsssetsTable_30C2548C1528E4C6E04BB238ADF8E790" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_B6637D08D355F5408EFAB238ADF83B50" xlink:to="loc_us-gaap_ScheduleOfCapitalLeasedAsssetsTable_30C2548C1528E4C6E04BB238ADF8E790" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_42DE8E969D73685A5B45B238ADF873A1" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCapitalLeasedAsssetsTable_30C2548C1528E4C6E04BB238ADF8E790" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_42DE8E969D73685A5B45B238ADF873A1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_302C4F0977F1A525DE5BB238ADF845BC" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_42DE8E969D73685A5B45B238ADF873A1" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_302C4F0977F1A525DE5BB238ADF845BC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquipmentMember" xlink:label="loc_us-gaap_EquipmentMember_512D6BB1B4B16E463AE5B238ADF8A401" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_302C4F0977F1A525DE5BB238ADF845BC" xlink:to="loc_us-gaap_EquipmentMember_512D6BB1B4B16E463AE5B238ADF8A401" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CapitalLeasedAssetsLineItems" xlink:label="loc_us-gaap_CapitalLeasedAssetsLineItems_060151B2CD5BC88DC188B238ADFDF907" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCapitalLeasedAsssetsTable_30C2548C1528E4C6E04BB238ADF8E790" xlink:to="loc_us-gaap_CapitalLeasedAssetsLineItems_060151B2CD5BC88DC188B238ADFDF907" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/CommitmentsAndContingenciesFacilityLeasesDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_2AA6775682D173DD34FFB238ADEFDFA3" xlink:type="locator" />
    <loc xlink:href="regn-20151231.xsd#regn_ScheduleOfFacilityLeasesTable" xlink:label="loc_regn_ScheduleOfFacilityLeasesTable_F92CBA489AA9EB948F12B238ADEFB69B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_2AA6775682D173DD34FFB238ADEFDFA3" xlink:to="loc_regn_ScheduleOfFacilityLeasesTable_F92CBA489AA9EB948F12B238ADEFB69B" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_FacilityLeaseObligationsAxis" xlink:label="loc_regn_FacilityLeaseObligationsAxis_C26F361B355624B0A6A3B238ADEF79E4" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ScheduleOfFacilityLeasesTable_F92CBA489AA9EB948F12B238ADEFB69B" xlink:to="loc_regn_FacilityLeaseObligationsAxis_C26F361B355624B0A6A3B238ADEF79E4" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_FacilityLeaseObligationsNameDomain" xlink:label="loc_regn_FacilityLeaseObligationsNameDomain_30605FC6BEF39E49298EB238ADEF4C35" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_FacilityLeaseObligationsAxis_C26F361B355624B0A6A3B238ADEF79E4" xlink:to="loc_regn_FacilityLeaseObligationsNameDomain_30605FC6BEF39E49298EB238ADEF4C35" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_FacilitiesBuildingsAndBMember" xlink:label="loc_regn_FacilitiesBuildingsAndBMember_75B95486D72EC00FBD7DB238ADEFE7E7" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_FacilityLeaseObligationsNameDomain_30605FC6BEF39E49298EB238ADEF4C35" xlink:to="loc_regn_FacilitiesBuildingsAndBMember_75B95486D72EC00FBD7DB238ADEFE7E7" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_FacilitiesBuildingCMember" xlink:label="loc_regn_FacilitiesBuildingCMember_4407A73536F84F7CD88CB238ADEF9BCF" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_FacilityLeaseObligationsNameDomain_30605FC6BEF39E49298EB238ADEF4C35" xlink:to="loc_regn_FacilitiesBuildingCMember_4407A73536F84F7CD88CB238ADEF9BCF" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_FacilitiesBuildingDandEMember" xlink:label="loc_regn_FacilitiesBuildingDandEMember_B89C870934FC1A75D9C8B238ADEF6831" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_FacilityLeaseObligationsNameDomain_30605FC6BEF39E49298EB238ADEF4C35" xlink:to="loc_regn_FacilitiesBuildingDandEMember_B89C870934FC1A75D9C8B238ADEF6831" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ScheduleOfFacilityLeasesLineItems" xlink:label="loc_regn_ScheduleOfFacilityLeasesLineItems_A8DAD4B80109859E752AB238ADEFA777" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ScheduleOfFacilityLeasesTable_F92CBA489AA9EB948F12B238ADEFB69B" xlink:to="loc_regn_ScheduleOfFacilityLeasesLineItems_A8DAD4B80109859E752AB238ADEFA777" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDueCurrent" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueCurrent_3C500B4561925B0E98ADB238ADEFF67A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ScheduleOfFacilityLeasesLineItems_A8DAD4B80109859E752AB238ADEFA777" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueCurrent_3C500B4561925B0E98ADB238ADEFF67A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDueInTwoYears" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInTwoYears_97739E81F9747CFFA61FB238ADEF2DED" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ScheduleOfFacilityLeasesLineItems_A8DAD4B80109859E752AB238ADEFA777" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInTwoYears_97739E81F9747CFFA61FB238ADEF2DED" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDueInThreeYears" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInThreeYears_EA344B6EA355361D5128B238ADEF80AB" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ScheduleOfFacilityLeasesLineItems_A8DAD4B80109859E752AB238ADEFA777" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInThreeYears_EA344B6EA355361D5128B238ADEF80AB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDueInFourYears" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInFourYears_9380734D5FE8B2C93CF8B238ADEF1D26" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ScheduleOfFacilityLeasesLineItems_A8DAD4B80109859E752AB238ADEFA777" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInFourYears_9380734D5FE8B2C93CF8B238ADEF1D26" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDueInFiveYears" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInFiveYears_2BB64C6C3286E4279B79B238ADEFBC99" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ScheduleOfFacilityLeasesLineItems_A8DAD4B80109859E752AB238ADEFA777" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInFiveYears_2BB64C6C3286E4279B79B238ADEFBC99" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDueThereafter" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueThereafter_E0AA0B11ECADB8294EF4B238ADF0DD42" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ScheduleOfFacilityLeasesLineItems_A8DAD4B80109859E752AB238ADEFA777" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueThereafter_E0AA0B11ECADB8294EF4B238ADF0DD42" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDue" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDue_F1F2D3D68C25DF9554E8B238ADF0C0EF" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ScheduleOfFacilityLeasesLineItems_A8DAD4B80109859E752AB238ADEFA777" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDue_F1F2D3D68C25DF9554E8B238ADF0C0EF" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_FacilityLeaseObligationsAbstract" xlink:label="loc_regn_FacilityLeaseObligationsAbstract_2AC04957636431AF192BB238ADF06FA9" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ScheduleOfFacilityLeasesLineItems_A8DAD4B80109859E752AB238ADEFA777" xlink:to="loc_regn_FacilityLeaseObligationsAbstract_2AC04957636431AF192BB238ADF06FA9" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ImputedInterestRateApplicableToFacilityLeaseObligation" xlink:label="loc_regn_ImputedInterestRateApplicableToFacilityLeaseObligation_9B3BA0FE25FA3D5A3FE0B238ADF06D4E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_FacilityLeaseObligationsAbstract_2AC04957636431AF192BB238ADF06FA9" xlink:to="loc_regn_ImputedInterestRateApplicableToFacilityLeaseObligation_9B3BA0FE25FA3D5A3FE0B238ADF06D4E" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_InterestExpenseInConnectionWithFacilityLeaseObligation" xlink:label="loc_regn_InterestExpenseInConnectionWithFacilityLeaseObligation_B62B4B0E29B1D6151E34B238ADF0F37D" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_FacilityLeaseObligationsAbstract_2AC04957636431AF192BB238ADF06FA9" xlink:to="loc_regn_InterestExpenseInConnectionWithFacilityLeaseObligation_B62B4B0E29B1D6151E34B238ADF0F37D" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_FacilityLeasesFutureMinimumPaymentsDueAbstract" xlink:label="loc_regn_FacilityLeasesFutureMinimumPaymentsDueAbstract_5186DB2EC2FC4600FE4AB238ADF067EB" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ScheduleOfFacilityLeasesLineItems_A8DAD4B80109859E752AB238ADEFA777" xlink:to="loc_regn_FacilityLeasesFutureMinimumPaymentsDueAbstract_5186DB2EC2FC4600FE4AB238ADF067EB" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_FacilityLeaseObligationIncludingReimbursements" xlink:label="loc_regn_FacilityLeaseObligationIncludingReimbursements_4AE750C21FF5C8B92443B238ADF02A15" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ScheduleOfFacilityLeasesLineItems_A8DAD4B80109859E752AB238ADEFA777" xlink:to="loc_regn_FacilityLeaseObligationIncludingReimbursements_4AE750C21FF5C8B92443B238ADF02A15" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/CommitmentsAndContingenciesOperatingLeasesDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_17103D151AAE16EF8B35B238AE0D61EE" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfOperatingLeasedAssetsTable" xlink:label="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_3B5F094E8A38234A6464B238AE0D4C8A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_17103D151AAE16EF8B35B238AE0D61EE" xlink:to="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_3B5F094E8A38234A6464B238AE0D4C8A" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_NameOfLeaseAxis" xlink:label="loc_regn_NameOfLeaseAxis_2A11A75DD879CB27AEF7B238AE0D111F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_3B5F094E8A38234A6464B238AE0D4C8A" xlink:to="loc_regn_NameOfLeaseAxis_2A11A75DD879CB27AEF7B238AE0D111F" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_NameOfLeaseDomain" xlink:label="loc_regn_NameOfLeaseDomain_08143F6452C4E247BCB3B238AE0E9039" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_NameOfLeaseAxis_2A11A75DD879CB27AEF7B238AE0D111F" xlink:to="loc_regn_NameOfLeaseDomain_08143F6452C4E247BCB3B238AE0E9039" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_FacilitiesBuildingsAndBMember" xlink:label="loc_regn_FacilitiesBuildingsAndBMember_82F5B682C41318B3B9CFB238AE0E4A39" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_NameOfLeaseDomain_08143F6452C4E247BCB3B238AE0E9039" xlink:to="loc_regn_FacilitiesBuildingsAndBMember_82F5B682C41318B3B9CFB238AE0E4A39" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_FacilitiesBuildingDandEMember" xlink:label="loc_regn_FacilitiesBuildingDandEMember_A80D7EE21FA45728E8D2B238AE0EB2DB" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_NameOfLeaseDomain_08143F6452C4E247BCB3B238AE0E9039" xlink:to="loc_regn_FacilitiesBuildingDandEMember_A80D7EE21FA45728E8D2B238AE0EB2DB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_8F902655343A7C34024DB238AE0EB105" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_3B5F094E8A38234A6464B238AE0D4C8A" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_8F902655343A7C34024DB238AE0EB105" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_FEAC9877B6334F9B2CB4B238AE0EB2D4" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_8F902655343A7C34024DB238AE0EB105" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_FEAC9877B6334F9B2CB4B238AE0EB2D4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BuildingMember" xlink:label="loc_us-gaap_BuildingMember_3E1D1A8EA9CEC20BED51B238AE0EAB14" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_FEAC9877B6334F9B2CB4B238AE0EB2D4" xlink:to="loc_us-gaap_BuildingMember_3E1D1A8EA9CEC20BED51B238AE0EAB14" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquipmentMember" xlink:label="loc_us-gaap_EquipmentMember_9857A81B0B1C37044D71B238AE1376E4" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_FEAC9877B6334F9B2CB4B238AE0EB2D4" xlink:to="loc_us-gaap_EquipmentMember_9857A81B0B1C37044D71B238AE1376E4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingLeasedAssetsLineItems" xlink:label="loc_us-gaap_OperatingLeasedAssetsLineItems_25F9B3AF421C75256B18B238AE13B375" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_3B5F094E8A38234A6464B238AE0D4C8A" xlink:to="loc_us-gaap_OperatingLeasedAssetsLineItems_25F9B3AF421C75256B18B238AE13B375" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_RentChargesForUtilitiesRealEstateTaxesAndOperatingExpense" xlink:label="loc_regn_RentChargesForUtilitiesRealEstateTaxesAndOperatingExpense_CEDFE0B968B6737F33F5B238AE14BBC4" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_25F9B3AF421C75256B18B238AE13B375" xlink:to="loc_regn_RentChargesForUtilitiesRealEstateTaxesAndOperatingExpense_CEDFE0B968B6737F33F5B238AE14BBC4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LeasesOperatingAbstract" xlink:label="loc_us-gaap_LeasesOperatingAbstract_14E7B11596B3CE9A96E0B238AE14DF84" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_25F9B3AF421C75256B18B238AE13B375" xlink:to="loc_us-gaap_LeasesOperatingAbstract_14E7B11596B3CE9A96E0B238AE14DF84" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_NumberOfNewBuildingsLeased" xlink:label="loc_regn_NumberOfNewBuildingsLeased_E5291994D76F2E0FF656B238AE14339C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesOperatingAbstract_14E7B11596B3CE9A96E0B238AE14DF84" xlink:to="loc_regn_NumberOfNewBuildingsLeased_E5291994D76F2E0FF656B238AE14339C" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Annualrentescalationpercentage" xlink:label="loc_regn_Annualrentescalationpercentage_AD32A387710B0079A37BB238AE14D6FC" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesOperatingAbstract_14E7B11596B3CE9A96E0B238AE14DF84" xlink:to="loc_regn_Annualrentescalationpercentage_AD32A387710B0079A37BB238AE14D6FC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_342F9639968B7C8BDED5B238AE1407B4" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_25F9B3AF421C75256B18B238AE13B375" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_342F9639968B7C8BDED5B238AE1407B4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_DA10043B9DA80AB14CA1B238AE1478E8" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_342F9639968B7C8BDED5B238AE1407B4" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_DA10043B9DA80AB14CA1B238AE1478E8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_5FD40DFAF39C475F6013B238AE146FEE" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_342F9639968B7C8BDED5B238AE1407B4" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_5FD40DFAF39C475F6013B238AE146FEE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_5C54D7DC5D908AE043A6B238AE14F692" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_342F9639968B7C8BDED5B238AE1407B4" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_5C54D7DC5D908AE043A6B238AE14F692" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_ECCFEE11CC05D6F7F803B238AE1427BD" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_342F9639968B7C8BDED5B238AE1407B4" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_ECCFEE11CC05D6F7F803B238AE1427BD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_4C3E62DE9166653D1A51B238AE1515F6" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_342F9639968B7C8BDED5B238AE1407B4" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_4C3E62DE9166653D1A51B238AE1515F6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter_41CE290D7C4B52BD9D9EB238AE15DB08" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_342F9639968B7C8BDED5B238AE1407B4" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter_41CE290D7C4B52BD9D9EB238AE15DB08" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_CB5DE62494076FE84D4DB238AE159DE8" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueAbstract_342F9639968B7C8BDED5B238AE1407B4" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_CB5DE62494076FE84D4DB238AE159DE8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingLeasesRentExpenseAbstract" xlink:label="loc_us-gaap_OperatingLeasesRentExpenseAbstract_66962D09C0DAE974CADBB238AE15C84F" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_25F9B3AF421C75256B18B238AE13B375" xlink:to="loc_us-gaap_OperatingLeasesRentExpenseAbstract_66962D09C0DAE974CADBB238AE15C84F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingLeasesRentExpenseNet" xlink:label="loc_us-gaap_OperatingLeasesRentExpenseNet_A9EF76ABC60FA59AD4A1B238AE15AA1F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasesRentExpenseAbstract_66962D09C0DAE974CADBB238AE15C84F" xlink:to="loc_us-gaap_OperatingLeasesRentExpenseNet_A9EF76ABC60FA59AD4A1B238AE15AA1F" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_TarrytownleaseAbstract" xlink:label="loc_regn_TarrytownleaseAbstract_8A2900C3849C33C2DD16B238AE156E73" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_25F9B3AF421C75256B18B238AE13B375" xlink:to="loc_regn_TarrytownleaseAbstract_8A2900C3849C33C2DD16B238AE156E73" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/CommitmentsAndContingenciesResearchCollaborationAndLicensingAgreementsDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_947512A2B5B5C1741486B238ADD793A2" xlink:type="locator" />
    <loc xlink:href="regn-20151231.xsd#regn_ResearchCollaborationAndLicensingArrangementsTable" xlink:label="loc_regn_ResearchCollaborationAndLicensingArrangementsTable_4626D44AADD60D8E8846B238ADD740E9" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_947512A2B5B5C1741486B238ADD793A2" xlink:to="loc_regn_ResearchCollaborationAndLicensingArrangementsTable_4626D44AADD60D8E8846B238ADD740E9" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ResearchCollaborationAndLicensingAgreementsAxis" xlink:label="loc_regn_ResearchCollaborationAndLicensingAgreementsAxis_D3C6F2B7C64432B30134B238ADD7844D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchCollaborationAndLicensingArrangementsTable_4626D44AADD60D8E8846B238ADD740E9" xlink:to="loc_regn_ResearchCollaborationAndLicensingAgreementsAxis_D3C6F2B7C64432B30134B238ADD7844D" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ResearchCollaborationAndLicensingAgreementsDomain" xlink:label="loc_regn_ResearchCollaborationAndLicensingAgreementsDomain_EC73D2B570BE36E6DA0CB238ADD72EAA" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchCollaborationAndLicensingAgreementsAxis_D3C6F2B7C64432B30134B238ADD7844D" xlink:to="loc_regn_ResearchCollaborationAndLicensingAgreementsDomain_EC73D2B570BE36E6DA0CB238ADD72EAA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RoyaltyAgreementTermsMember" xlink:label="loc_us-gaap_RoyaltyAgreementTermsMember_DF9DDF39784F8E8F4BF2B238ADD82C79" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchCollaborationAndLicensingAgreementsDomain_EC73D2B570BE36E6DA0CB238ADD72EAA" xlink:to="loc_us-gaap_RoyaltyAgreementTermsMember_DF9DDF39784F8E8F4BF2B238ADD82C79" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_LicenseagreementwithGenentechEYLEAMember" xlink:label="loc_regn_LicenseagreementwithGenentechEYLEAMember_88FFFBE93A086996A683B238ADD832C4" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchCollaborationAndLicensingAgreementsDomain_EC73D2B570BE36E6DA0CB238ADD72EAA" xlink:to="loc_regn_LicenseagreementwithGenentechEYLEAMember_88FFFBE93A086996A683B238ADD832C4" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ResearchCollaborationAndLicensingArrangementsLineItems" xlink:label="loc_regn_ResearchCollaborationAndLicensingArrangementsLineItems_29E73DFB27BFA734781BB238ADD8D55F" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchCollaborationAndLicensingArrangementsTable_4626D44AADD60D8E8846B238ADD740E9" xlink:to="loc_regn_ResearchCollaborationAndLicensingArrangementsLineItems_29E73DFB27BFA734781BB238ADD8D55F" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_RoyaltyRateMinimum" xlink:label="loc_regn_RoyaltyRateMinimum_E9827C4C530A2B2AFE2DB238ADD82CC8" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchCollaborationAndLicensingArrangementsLineItems_29E73DFB27BFA734781BB238ADD8D55F" xlink:to="loc_regn_RoyaltyRateMinimum_E9827C4C530A2B2AFE2DB238ADD82CC8" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_RoyaltyRateMaximum" xlink:label="loc_regn_RoyaltyRateMaximum_9751F06BE301BF68878AB238ADD835F2" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchCollaborationAndLicensingArrangementsLineItems_29E73DFB27BFA734781BB238ADD8D55F" xlink:to="loc_regn_RoyaltyRateMaximum_9751F06BE301BF68878AB238ADD835F2" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Firstpaymentmadeormaybemadeuponreachingminimumsalestarget" xlink:label="loc_regn_Firstpaymentmadeormaybemadeuponreachingminimumsalestarget_3AD88436F7425E7BE8A5B238ADD88A6F" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchCollaborationAndLicensingArrangementsLineItems_29E73DFB27BFA734781BB238ADD8D55F" xlink:to="loc_regn_Firstpaymentmadeormaybemadeuponreachingminimumsalestarget_3AD88436F7425E7BE8A5B238ADD88A6F" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Cumulativerelevantsalesminimumsalestarget" xlink:label="loc_regn_Cumulativerelevantsalesminimumsalestarget_0578C48F68773EB7C670B238ADD898D9" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchCollaborationAndLicensingArrangementsLineItems_29E73DFB27BFA734781BB238ADD8D55F" xlink:to="loc_regn_Cumulativerelevantsalesminimumsalestarget_0578C48F68773EB7C670B238ADD898D9" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Salesrangeminimum1sttier" xlink:label="loc_regn_Salesrangeminimum1sttier_F46AE58A29EA3B0B52AEB238ADD894A4" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchCollaborationAndLicensingArrangementsLineItems_29E73DFB27BFA734781BB238ADD8D55F" xlink:to="loc_regn_Salesrangeminimum1sttier_F46AE58A29EA3B0B52AEB238ADD894A4" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Cumulativesalesrange1sttiermaximum" xlink:label="loc_regn_Cumulativesalesrange1sttiermaximum_1BC44C635AE966B9260FB238ADD884EA" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchCollaborationAndLicensingArrangementsLineItems_29E73DFB27BFA734781BB238ADD8D55F" xlink:to="loc_regn_Cumulativesalesrange1sttiermaximum_1BC44C635AE966B9260FB238ADD884EA" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Cumulativesalesrange2ndtier" xlink:label="loc_regn_Cumulativesalesrange2ndtier_E65A54C855DCB5566B5AB238ADD8A002" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchCollaborationAndLicensingArrangementsLineItems_29E73DFB27BFA734781BB238ADD8D55F" xlink:to="loc_regn_Cumulativesalesrange2ndtier_E65A54C855DCB5566B5AB238ADD8A002" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Royaltypaymentpercentageofcumulativesale1sttier" xlink:label="loc_regn_Royaltypaymentpercentageofcumulativesale1sttier_81EAADA91E8DD6243827B238ADD8289F" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchCollaborationAndLicensingArrangementsLineItems_29E73DFB27BFA734781BB238ADD8D55F" xlink:to="loc_regn_Royaltypaymentpercentageofcumulativesale1sttier_81EAADA91E8DD6243827B238ADD8289F" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Royaltypaymentpercentageofsales2ndtier" xlink:label="loc_regn_Royaltypaymentpercentageofsales2ndtier_C846FCA5AE16C29A7D42B238ADD8A998" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchCollaborationAndLicensingArrangementsLineItems_29E73DFB27BFA734781BB238ADD8D55F" xlink:to="loc_regn_Royaltypaymentpercentageofsales2ndtier_C846FCA5AE16C29A7D42B238ADD8A998" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RoyaltyExpense" xlink:label="loc_us-gaap_RoyaltyExpense_F6C99A694D9F019CE689B238ADD8F07F" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchCollaborationAndLicensingArrangementsLineItems_29E73DFB27BFA734781BB238ADD8D55F" xlink:to="loc_us-gaap_RoyaltyExpense_F6C99A694D9F019CE689B238ADD8F07F" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/CommitmentsAndContingenciesTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_082E1639A23E6BB30CA5B238AE1EE168" xlink:type="locator" />
    <loc xlink:href="regn-20151231.xsd#regn_FacilityleaseobligationTableTextBlock" xlink:label="loc_regn_FacilityleaseobligationTableTextBlock_804694781577999EA2E5B238AE1E9114" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_082E1639A23E6BB30CA5B238AE1EE168" xlink:to="loc_regn_FacilityleaseobligationTableTextBlock_804694781577999EA2E5B238AE1E9114" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfFutureMinimumRentalPaymentsForOperatingLeasesTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfFutureMinimumRentalPaymentsForOperatingLeasesTableTextBlock_CB47C15DDA1E50A311ABB238AE1E0335" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_082E1639A23E6BB30CA5B238AE1EE168" xlink:to="loc_us-gaap_ScheduleOfFutureMinimumRentalPaymentsForOperatingLeasesTableTextBlock_CB47C15DDA1E50A311ABB238AE1E0335" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfRentExpenseTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfRentExpenseTableTextBlock_73CC19BFFF7E9EDE5E90B238AE1E999F" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_082E1639A23E6BB30CA5B238AE1EE168" xlink:to="loc_us-gaap_ScheduleOfRentExpenseTableTextBlock_73CC19BFFF7E9EDE5E90B238AE1E999F" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_CommitmentsUnderFacilityLeaseObligationsTableTextBlock" xlink:label="loc_regn_CommitmentsUnderFacilityLeaseObligationsTableTextBlock_260810E4F2F7FFE7F83DB238AE1EFA03" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_082E1639A23E6BB30CA5B238AE1EE168" xlink:to="loc_regn_CommitmentsUnderFacilityLeaseObligationsTableTextBlock_260810E4F2F7FFE7F83DB238AE1EFA03" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_5ED2F0FD3D5654F47EE3B238B0BB0D36" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_27A76FA59696B377F125B238B0BB3104" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_5ED2F0FD3D5654F47EE3B238B0BB0D36" xlink:to="loc_us-gaap_StatementTable_27A76FA59696B377F125B238B0BB3104" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_20AE814D9D9699EDD30FB238B0BB0091" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_27A76FA59696B377F125B238B0BB3104" xlink:to="loc_us-gaap_StatementClassOfStockAxis_20AE814D9D9699EDD30FB238B0BB0091" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_74D948E6BF5B07AAB45CB238B0BBB4E8" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_20AE814D9D9699EDD30FB238B0BB0091" xlink:to="loc_us-gaap_ClassOfStockDomain_74D948E6BF5B07AAB45CB238B0BBB4E8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonClassAMember" xlink:label="loc_us-gaap_CommonClassAMember_EBE6468871627E1857C8B238B0BCE25D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_74D948E6BF5B07AAB45CB238B0BBB4E8" xlink:to="loc_us-gaap_CommonClassAMember_EBE6468871627E1857C8B238B0BCE25D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_54C663F53E9CA2D3E7EDB238B0BC4F79" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_74D948E6BF5B07AAB45CB238B0BBB4E8" xlink:to="loc_us-gaap_CommonStockMember_54C663F53E9CA2D3E7EDB238B0BC4F79" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_AE984127F4386DA6E732B238B0BC9DDB" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_27A76FA59696B377F125B238B0BB3104" xlink:to="loc_us-gaap_StatementLineItems_AE984127F4386DA6E732B238B0BC9DDB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AssetsAbstract" xlink:label="loc_us-gaap_AssetsAbstract_3C8405C7EF8A9C013741B238B0BCD90F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_AE984127F4386DA6E732B238B0BC9DDB" xlink:to="loc_us-gaap_AssetsAbstract_3C8405C7EF8A9C013741B238B0BCD90F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AssetsCurrentAbstract" xlink:label="loc_us-gaap_AssetsCurrentAbstract_34EABC4D278F57D105EAB238B0BCDB58" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_3C8405C7EF8A9C013741B238B0BCD90F" xlink:to="loc_us-gaap_AssetsCurrentAbstract_34EABC4D278F57D105EAB238B0BCDB58" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_1EC3F2F5A470D7F8419DB238B0BC7FDB" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_34EABC4D278F57D105EAB238B0BCDB58" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_1EC3F2F5A470D7F8419DB238B0BC7FDB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MarketableSecuritiesCurrent" xlink:label="loc_us-gaap_MarketableSecuritiesCurrent_C573E63A5D9961580182B238B0BC51CC" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_34EABC4D278F57D105EAB238B0BCDB58" xlink:to="loc_us-gaap_MarketableSecuritiesCurrent_C573E63A5D9961580182B238B0BC51CC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_0F70D68FF2990D6652B8B238B0BC1DEA" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_34EABC4D278F57D105EAB238B0BCDB58" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_0F70D68FF2990D6652B8B238B0BC1DEA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsReceivableRelatedPartiesCurrent" xlink:label="loc_us-gaap_AccountsReceivableRelatedPartiesCurrent_A59EAF29BE03D820CEF2B238B0BCEE6D" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_34EABC4D278F57D105EAB238B0BCDB58" xlink:to="loc_us-gaap_AccountsReceivableRelatedPartiesCurrent_A59EAF29BE03D820CEF2B238B0BCEE6D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsAndNotesReceivableNet" xlink:label="loc_us-gaap_AccountsAndNotesReceivableNet_B474494F6C730E8B2FB2B238B0BCDDCA" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_34EABC4D278F57D105EAB238B0BCDB58" xlink:to="loc_us-gaap_AccountsAndNotesReceivableNet_B474494F6C730E8B2FB2B238B0BCDDCA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_347A93F274BAFDA43B5AB238B0BCFAEB" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_34EABC4D278F57D105EAB238B0BCDB58" xlink:to="loc_us-gaap_InventoryNet_347A93F274BAFDA43B5AB238B0BCFAEB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_F2DD1D38634139119977B238B0BC2409" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_34EABC4D278F57D105EAB238B0BCDB58" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_F2DD1D38634139119977B238B0BC2409" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AssetsCurrent" xlink:label="loc_us-gaap_AssetsCurrent_E55C26AE82B1057F5F0AB238B0BCA37D" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_34EABC4D278F57D105EAB238B0BCDB58" xlink:to="loc_us-gaap_AssetsCurrent_E55C26AE82B1057F5F0AB238B0BCA37D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MarketableSecuritiesNoncurrent" xlink:label="loc_us-gaap_MarketableSecuritiesNoncurrent_EBA24760E97A41F5D43CB238B0BC5CA0" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_3C8405C7EF8A9C013741B238B0BCD90F" xlink:to="loc_us-gaap_MarketableSecuritiesNoncurrent_EBA24760E97A41F5D43CB238B0BC5CA0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_FA5A6B3AB4CCF7126021B238B0BCA555" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_3C8405C7EF8A9C013741B238B0BCD90F" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_FA5A6B3AB4CCF7126021B238B0BCA555" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNetNoncurrent" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNetNoncurrent_CAC1F687CDCE32DC317BB238B0BCD8D4" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_3C8405C7EF8A9C013741B238B0BCD90F" xlink:to="loc_us-gaap_DeferredTaxAssetsLiabilitiesNetNoncurrent_CAC1F687CDCE32DC317BB238B0BCD8D4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherAssetsNoncurrent" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_E550B5F20ACC611160C8B238B0BD67A8" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_3C8405C7EF8A9C013741B238B0BCD90F" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_E550B5F20ACC611160C8B238B0BD67A8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_94584A89BD7BE45B7F47B238B0BD1517" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_3C8405C7EF8A9C013741B238B0BCD90F" xlink:to="loc_us-gaap_Assets_94584A89BD7BE45B7F47B238B0BD1517" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_AFB0F6263B8795C12F08B238B0BDEC7D" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_AE984127F4386DA6E732B238B0BC9DDB" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_AFB0F6263B8795C12F08B238B0BDEC7D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_3809D93ADBDBC070E5DBB238B0BD9B45" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_AFB0F6263B8795C12F08B238B0BDEC7D" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_3809D93ADBDBC070E5DBB238B0BD9B45" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_55782F42F1F1C5705830B238B0BD4F55" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_3809D93ADBDBC070E5DBB238B0BD9B45" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_55782F42F1F1C5705830B238B0BD4F55" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_DeferredRevenueFromRelatedPartyCurrent" xlink:label="loc_regn_DeferredRevenueFromRelatedPartyCurrent_A1FBE4C3A865CDECF4BDB238B0BD9342" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_3809D93ADBDBC070E5DBB238B0BD9B45" xlink:to="loc_regn_DeferredRevenueFromRelatedPartyCurrent_A1FBE4C3A865CDECF4BDB238B0BD9342" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_DeferredRevenueExcludingAmountsFromRelatedPartyCurrent" xlink:label="loc_regn_DeferredRevenueExcludingAmountsFromRelatedPartyCurrent_A8D4030DB7AC4568AAB5B238B0BD2630" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_3809D93ADBDBC070E5DBB238B0BD9B45" xlink:to="loc_regn_DeferredRevenueExcludingAmountsFromRelatedPartyCurrent_A8D4030DB7AC4568AAB5B238B0BD2630" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherLiabilitiesCurrent" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_4CDE6EA552E156E4DA90B238B0BD29B8" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_3809D93ADBDBC070E5DBB238B0BD9B45" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_4CDE6EA552E156E4DA90B238B0BD29B8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_us-gaap_LiabilitiesCurrent_022A8E62B127AB5232B3B238B0BDC475" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_3809D93ADBDBC070E5DBB238B0BD9B45" xlink:to="loc_us-gaap_LiabilitiesCurrent_022A8E62B127AB5232B3B238B0BDC475" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_DeferredRevenueFromRelatedPartyNoncurrent" xlink:label="loc_regn_DeferredRevenueFromRelatedPartyNoncurrent_5B886656DB438C84E6A2B238B0BD1490" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_AFB0F6263B8795C12F08B238B0BDEC7D" xlink:to="loc_regn_DeferredRevenueFromRelatedPartyNoncurrent_5B886656DB438C84E6A2B238B0BD1490" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_DeferredRevenueExcludingAmountsFromRelatedPartyNonCurrent" xlink:label="loc_regn_DeferredRevenueExcludingAmountsFromRelatedPartyNonCurrent_D12080E517E91F815F33B238B0BD11EB" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_AFB0F6263B8795C12F08B238B0BDEC7D" xlink:to="loc_regn_DeferredRevenueExcludingAmountsFromRelatedPartyNonCurrent_D12080E517E91F815F33B238B0BD11EB" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_FacilityLeaseObligationsNoncurrent" xlink:label="loc_regn_FacilityLeaseObligationsNoncurrent_B001EDF4E5BDC25C2FBDB238B0BD5B67" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_AFB0F6263B8795C12F08B238B0BDEC7D" xlink:to="loc_regn_FacilityLeaseObligationsNoncurrent_B001EDF4E5BDC25C2FBDB238B0BD5B67" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConvertibleLongTermNotesPayable" xlink:label="loc_us-gaap_ConvertibleLongTermNotesPayable_F7A588C18125297DBA02B238B0BDED0C" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_AFB0F6263B8795C12F08B238B0BDEC7D" xlink:to="loc_us-gaap_ConvertibleLongTermNotesPayable_F7A588C18125297DBA02B238B0BDED0C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_2A0AC58E7D9E41858F0CB238B0BD93EC" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_AFB0F6263B8795C12F08B238B0BDEC7D" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_2A0AC58E7D9E41858F0CB238B0BD93EC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Liabilities" xlink:label="loc_us-gaap_Liabilities_F66667D6006DE0A3FF28B238B0BDC316" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_AFB0F6263B8795C12F08B238B0BDEC7D" xlink:to="loc_us-gaap_Liabilities_F66667D6006DE0A3FF28B238B0BDC316" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommitmentsAndContingencies" xlink:label="loc_us-gaap_CommitmentsAndContingencies_090E737AD52DAF6A4B91B238B0BD45DF" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_AE984127F4386DA6E732B238B0BC9DDB" xlink:to="loc_us-gaap_CommitmentsAndContingencies_090E737AD52DAF6A4B91B238B0BD45DF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockholdersEquityAbstract" xlink:label="loc_us-gaap_StockholdersEquityAbstract_9A3B33452BBCCD1A4AE9B238B0BDCF11" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_AE984127F4386DA6E732B238B0BC9DDB" xlink:to="loc_us-gaap_StockholdersEquityAbstract_9A3B33452BBCCD1A4AE9B238B0BDCF11" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PreferredStockValue" xlink:label="loc_us-gaap_PreferredStockValue_AE5692E7FC784D5561A0B238B0BE1109" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_9A3B33452BBCCD1A4AE9B238B0BDCF11" xlink:to="loc_us-gaap_PreferredStockValue_AE5692E7FC784D5561A0B238B0BE1109" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockValue" xlink:label="loc_us-gaap_CommonStockValue_9FF27D30C7C278DEADF2B238B0BE1FCE" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_9A3B33452BBCCD1A4AE9B238B0BDCF11" xlink:to="loc_us-gaap_CommonStockValue_9FF27D30C7C278DEADF2B238B0BE1FCE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="loc_us-gaap_AdditionalPaidInCapital_008558AC0F90FED6D46DB238B0BE4A8D" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_9A3B33452BBCCD1A4AE9B238B0BDCF11" xlink:to="loc_us-gaap_AdditionalPaidInCapital_008558AC0F90FED6D46DB238B0BE4A8D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_B1365627DAE368F35CABB238B0BEEDEC" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_9A3B33452BBCCD1A4AE9B238B0BDCF11" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_B1365627DAE368F35CABB238B0BEEDEC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_F55CEA7E7B90E4373A92B238B0BE0D45" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_9A3B33452BBCCD1A4AE9B238B0BDCF11" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_F55CEA7E7B90E4373A92B238B0BE0D45" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TreasuryStockValue" xlink:label="loc_us-gaap_TreasuryStockValue_427EB94749BF9B055DF9B238B0BE00CE" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_9A3B33452BBCCD1A4AE9B238B0BDCF11" xlink:to="loc_us-gaap_TreasuryStockValue_427EB94749BF9B055DF9B238B0BE00CE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_D58413AB911594717904B238B0BE0887" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_9A3B33452BBCCD1A4AE9B238B0BDCF11" xlink:to="loc_us-gaap_StockholdersEquity_D58413AB911594717904B238B0BE0887" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_10BF8FE4EF387217E496B238B0BE34F3" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_AE984127F4386DA6E732B238B0BC9DDB" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_10BF8FE4EF387217E496B238B0BE34F3" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_C33B03EB7D199D7FB411B238B0B15595" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_A63B19FCDA1D09B16CEBB238B0B14A25" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_C33B03EB7D199D7FB411B238B0B15595" xlink:to="loc_us-gaap_StatementTable_A63B19FCDA1D09B16CEBB238B0B14A25" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_DE9E0CB637D1BC55A20CB238B0B1391E" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_A63B19FCDA1D09B16CEBB238B0B14A25" xlink:to="loc_us-gaap_StatementClassOfStockAxis_DE9E0CB637D1BC55A20CB238B0B1391E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_71C6982EB72A6ADA4F4EB238B0B1CCC0" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_DE9E0CB637D1BC55A20CB238B0B1391E" xlink:to="loc_us-gaap_ClassOfStockDomain_71C6982EB72A6ADA4F4EB238B0B1CCC0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonClassAMember" xlink:label="loc_us-gaap_CommonClassAMember_F06D9FEDE6FB4C36909CB238B0B1922E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_71C6982EB72A6ADA4F4EB238B0B1CCC0" xlink:to="loc_us-gaap_CommonClassAMember_F06D9FEDE6FB4C36909CB238B0B1922E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_2DA33B2415CF3BA3275CB238B0B1096D" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_71C6982EB72A6ADA4F4EB238B0B1CCC0" xlink:to="loc_us-gaap_CommonStockMember_2DA33B2415CF3BA3275CB238B0B1096D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_2998BDFB0F90D3083630B238B0B1C06C" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_A63B19FCDA1D09B16CEBB238B0B14A25" xlink:to="loc_us-gaap_StatementLineItems_2998BDFB0F90D3083630B238B0B1C06C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_ED0A25990291E4018226B238B0B11CD6" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_2998BDFB0F90D3083630B238B0B1C06C" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_ED0A25990291E4018226B238B0B11CD6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PreferredStockParOrStatedValuePerShare" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_115F53B014FB3D261C3FB238B0B17C7C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_ED0A25990291E4018226B238B0B11CD6" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_115F53B014FB3D261C3FB238B0B17C7C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PreferredStockSharesAuthorized" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_93496613BE1CD2CFD776B238B0B1E36B" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_ED0A25990291E4018226B238B0B11CD6" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_93496613BE1CD2CFD776B238B0B1E36B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PreferredStockSharesIssued" xlink:label="loc_us-gaap_PreferredStockSharesIssued_56A0B40D155AFEBE371DB238B0B11DE6" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_ED0A25990291E4018226B238B0B11CD6" xlink:to="loc_us-gaap_PreferredStockSharesIssued_56A0B40D155AFEBE371DB238B0B11DE6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PreferredStockSharesOutstanding" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_4CE314862D4B2F50B001B238B0B1C794" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_ED0A25990291E4018226B238B0B11CD6" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_4CE314862D4B2F50B001B238B0B1C794" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TreasuryStockShares" xlink:label="loc_us-gaap_TreasuryStockShares_29BE211F668FAA75E69CB238B0B2DF63" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_ED0A25990291E4018226B238B0B11CD6" xlink:to="loc_us-gaap_TreasuryStockShares_29BE211F668FAA75E69CB238B0B2DF63" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_A40F934958E7B9881933B238B0B214B9" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_ED0A25990291E4018226B238B0B11CD6" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_A40F934958E7B9881933B238B0B214B9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockSharesAuthorized" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_14846462ACB253994AD8B238B0B247C5" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_ED0A25990291E4018226B238B0B11CD6" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_14846462ACB253994AD8B238B0B247C5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="loc_us-gaap_CommonStockSharesIssued_447F8D09FD6C23DAE445B238B0B269FC" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_ED0A25990291E4018226B238B0B11CD6" xlink:to="loc_us-gaap_CommonStockSharesIssued_447F8D09FD6C23DAE445B238B0B269FC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockSharesOutstanding" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_ED4326017093BA449FF7B238B0B2E801" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_ED0A25990291E4018226B238B0B11CD6" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_ED4326017093BA449FF7B238B0B2E801" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/ConsolidatedStatementsOfCashFlows" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementOfCashFlowsAbstract" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_BFF16A753CEBAAA17511B238B06A7B41" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_E83A0986273B8CCB2097B238B06B72D2" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_BFF16A753CEBAAA17511B238B06A7B41" xlink:to="loc_us-gaap_StatementTable_E83A0986273B8CCB2097B238B06B72D2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfWarrantOrRightAxis" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_FC4D80C3E4FB6B1C604EB238B06B5043" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_E83A0986273B8CCB2097B238B06B72D2" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_FC4D80C3E4FB6B1C604EB238B06B5043" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_E236BC1AB70541862DF1B238B06BA7E4" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_FC4D80C3E4FB6B1C604EB238B06B5043" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_E236BC1AB70541862DF1B238B06BA7E4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_WarrantMember" xlink:label="loc_us-gaap_WarrantMember_4C14E3364471B0577531B238B06BC7E7" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_E236BC1AB70541862DF1B238B06BA7E4" xlink:to="loc_us-gaap_WarrantMember_4C14E3364471B0577531B238B06BC7E7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_683FA49B58AE4363A676B238B06BF9B4" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_E83A0986273B8CCB2097B238B06B72D2" xlink:to="loc_us-gaap_StatementScenarioAxis_683FA49B58AE4363A676B238B06BF9B4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_601D52A87C461F28B9EEB238B06BC8FB" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementScenarioAxis_683FA49B58AE4363A676B238B06BF9B4" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_601D52A87C461F28B9EEB238B06BC8FB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_5CC99007E776CECABA9AB238B06B0C5E" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_E83A0986273B8CCB2097B238B06B72D2" xlink:to="loc_us-gaap_StatementLineItems_5CC99007E776CECABA9AB238B06B0C5E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_47B23705CD690596DF1BB238B06B1B3D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5CC99007E776CECABA9AB238B06B0C5E" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_47B23705CD690596DF1BB238B06B1B3D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_D3DAED394E268BFC0225B238B06B2672" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_47B23705CD690596DF1BB238B06B1B3D" xlink:to="loc_us-gaap_NetIncomeLoss_D3DAED394E268BFC0225B238B06B2672" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_B9FBBA978EBF950FB9D2B238B06BF7F2" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_47B23705CD690596DF1BB238B06B1B3D" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_B9FBBA978EBF950FB9D2B238B06BF7F2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_43D0950ED9660D0E4D3BB238B06BFC50" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_B9FBBA978EBF950FB9D2B238B06BF7F2" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_43D0950ED9660D0E4D3BB238B06BFC50" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_98AA60D389C449EF1201B238B06B1F4C" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_B9FBBA978EBF950FB9D2B238B06BF7F2" xlink:to="loc_us-gaap_ShareBasedCompensation_98AA60D389C449EF1201B238B06B1F4C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_DFA514E625E57E021D33B238B06B1A35" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_B9FBBA978EBF950FB9D2B238B06BF7F2" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_DFA514E625E57E021D33B238B06B1A35" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherNoncashIncomeExpense" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_D36CE754A939A01141D5B238B06BB140" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_B9FBBA978EBF950FB9D2B238B06BF7F2" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_D36CE754A939A01141D5B238B06BB140" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredIncomeTaxes" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_205E6C38F9B2CA07BEF0B238B06B86A2" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_B9FBBA978EBF950FB9D2B238B06BF7F2" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_205E6C38F9B2CA07BEF0B238B06B86A2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_557FE6BE1B8485A2DF91B238B06C27F6" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_B9FBBA978EBF950FB9D2B238B06BF7F2" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_557FE6BE1B8485A2DF91B238B06C27F6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_3ADA81697FDB1DBD77DBB238B06CB81A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_557FE6BE1B8485A2DF91B238B06C27F6" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_3ADA81697FDB1DBD77DBB238B06CB81A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInInventories" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_437D369E2212F86BF585B238B06C9E6F" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_557FE6BE1B8485A2DF91B238B06C27F6" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_437D369E2212F86BF585B238B06C9E6F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_375DE8FCC2CD7F52D8A3B238B06C683C" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_557FE6BE1B8485A2DF91B238B06C27F6" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_375DE8FCC2CD7F52D8A3B238B06C683C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredRevenue" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredRevenue_76D246DAFAC427BB9B19B238B06C6BEC" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_557FE6BE1B8485A2DF91B238B06C27F6" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredRevenue_76D246DAFAC427BB9B19B238B06C6BEC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_4BC0DF7F67CDB3768EE5B238B06C46E7" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_557FE6BE1B8485A2DF91B238B06C27F6" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_4BC0DF7F67CDB3768EE5B238B06C46E7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_10B47929AA9E18F497ACB238B06CA58A" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_B9FBBA978EBF950FB9D2B238B06BF7F2" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_10B47929AA9E18F497ACB238B06CA58A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2EBCE3E16D9E2890D6AFB238B06CAD0F" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_47B23705CD690596DF1BB238B06B1B3D" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2EBCE3E16D9E2890D6AFB238B06CAD0F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_D542ADBFF5E0BEFA2F82B238B06C5C6C" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5CC99007E776CECABA9AB238B06B0C5E" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_D542ADBFF5E0BEFA2F82B238B06C5C6C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsToAcquireMarketableSecurities" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_033773B066265D684D1AB238B06C93E6" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_D542ADBFF5E0BEFA2F82B238B06C5C6C" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_033773B066265D684D1AB238B06C93E6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_13A42E4C15ACC1DF17A9B238B06C4E9D" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_D542ADBFF5E0BEFA2F82B238B06C5C6C" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_13A42E4C15ACC1DF17A9B238B06C4E9D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsToAcquireProductiveAssets" xlink:label="loc_us-gaap_PaymentsToAcquireProductiveAssets_D1F342699D35D67A5CADB238B06C8775" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_D542ADBFF5E0BEFA2F82B238B06C5C6C" xlink:to="loc_us-gaap_PaymentsToAcquireProductiveAssets_D1F342699D35D67A5CADB238B06C8775" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_9AFD39203E5FEE21DB9EB238B06C1464" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_D542ADBFF5E0BEFA2F82B238B06C5C6C" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_9AFD39203E5FEE21DB9EB238B06C1464" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_A8400EB13414E93272AEB238B06C1437" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5CC99007E776CECABA9AB238B06B0C5E" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_A8400EB13414E93272AEB238B06C1437" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProceedsFromRepaymentsOfLongTermDebtAndCapitalSecurities" xlink:label="loc_us-gaap_ProceedsFromRepaymentsOfLongTermDebtAndCapitalSecurities_23512C1A6903D4ACC0B9B238B06CC043" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_A8400EB13414E93272AEB238B06C1437" xlink:to="loc_us-gaap_ProceedsFromRepaymentsOfLongTermDebtAndCapitalSecurities_23512C1A6903D4ACC0B9B238B06CC043" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RepaymentsOfConvertibleDebt" xlink:label="loc_us-gaap_RepaymentsOfConvertibleDebt_07D6CB53F697E0081843B238B06C0FA6" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_A8400EB13414E93272AEB238B06C1437" xlink:to="loc_us-gaap_RepaymentsOfConvertibleDebt_07D6CB53F697E0081843B238B06C0FA6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsForRepurchaseOfWarrants" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfWarrants_6A1D9059C7FD85094699B238B06C4410" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_A8400EB13414E93272AEB238B06C1437" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfWarrants_6A1D9059C7FD85094699B238B06C4410" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_A6A5E128C9BAD6BF6E2FB238B06C20C0" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_A8400EB13414E93272AEB238B06C1437" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_A6A5E128C9BAD6BF6E2FB238B06C20C0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_3537F0C3BF4431803E6CB238B06D0113" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_A8400EB13414E93272AEB238B06C1437" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_3537F0C3BF4431803E6CB238B06D0113" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ExcessTaxBenefitFromShareBasedCompensationFinancingActivities" xlink:label="loc_us-gaap_ExcessTaxBenefitFromShareBasedCompensationFinancingActivities_6C4B618EFA3F36581748B238B06D3CD1" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_A8400EB13414E93272AEB238B06C1437" xlink:to="loc_us-gaap_ExcessTaxBenefitFromShareBasedCompensationFinancingActivities_6C4B618EFA3F36581748B238B06D3CD1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_29D81C7F8DB80DAABD16B238B06D3612" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_A8400EB13414E93272AEB238B06C1437" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_29D81C7F8DB80DAABD16B238B06D3612" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:label="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_978E145AA9EAEBAB6C9FB238B06D8F82" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5CC99007E776CECABA9AB238B06B0C5E" xlink:to="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_978E145AA9EAEBAB6C9FB238B06D8F82" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_DD63F666288A84469FCEB238B06DB080" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5CC99007E776CECABA9AB238B06B0C5E" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_DD63F666288A84469FCEB238B06DB080" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_11328BA7D5E3FC4F3C66B238B06D118F" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5CC99007E776CECABA9AB238B06B0C5E" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_11328BA7D5E3FC4F3C66B238B06D118F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InterestPaidNet" xlink:label="loc_us-gaap_InterestPaidNet_F4261518ACB091FA793DB238B06D5BF0" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5CC99007E776CECABA9AB238B06B0C5E" xlink:to="loc_us-gaap_InterestPaidNet_F4261518ACB091FA793DB238B06D5BF0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxesPaidNet" xlink:label="loc_us-gaap_IncomeTaxesPaidNet_171AA47C6F1B765E69FDB238B0729B72" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_5CC99007E776CECABA9AB238B06B0C5E" xlink:to="loc_us-gaap_IncomeTaxesPaidNet_171AA47C6F1B765E69FDB238B0729B72" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/ConsolidatedStatementsOfOperationsAndComprehensiveIncome" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract" xlink:label="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_F1487A3F9E239CA4656FB238B0ABFEFA" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_38AFD63F0C9D1A95EF70B238B0ABE86D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_F1487A3F9E239CA4656FB238B0ABFEFA" xlink:to="loc_us-gaap_StatementTable_38AFD63F0C9D1A95EF70B238B0ABE86D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_8581DBD6BBE99C18A3B7B238B0AB6766" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_38AFD63F0C9D1A95EF70B238B0ABE86D" xlink:to="loc_us-gaap_StatementScenarioAxis_8581DBD6BBE99C18A3B7B238B0AB6766" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_BF055C5475C4AB2914F7B238B0AB946C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementScenarioAxis_8581DBD6BBE99C18A3B7B238B0AB6766" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_BF055C5475C4AB2914F7B238B0AB946C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_98C3DBF9FFB43A3542C9B238B0AB2466" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_38AFD63F0C9D1A95EF70B238B0ABE86D" xlink:to="loc_us-gaap_StatementLineItems_98C3DBF9FFB43A3542C9B238B0AB2466" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeStatementAbstract" xlink:label="loc_us-gaap_IncomeStatementAbstract_0BAFC100D01A72716A96B238B0ABE2E3" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_98C3DBF9FFB43A3542C9B238B0AB2466" xlink:to="loc_us-gaap_IncomeStatementAbstract_0BAFC100D01A72716A96B238B0ABE2E3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RevenuesAbstract" xlink:label="loc_us-gaap_RevenuesAbstract_072DC51D8CA085DBC8ADB238B0ABE377" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_0BAFC100D01A72716A96B238B0ABE2E3" xlink:to="loc_us-gaap_RevenuesAbstract_072DC51D8CA085DBC8ADB238B0ABE377" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SalesRevenueGoodsNet" xlink:label="loc_us-gaap_SalesRevenueGoodsNet_84690E51A08D7478CBFCB238B0AB8639" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesAbstract_072DC51D8CA085DBC8ADB238B0ABE377" xlink:to="loc_us-gaap_SalesRevenueGoodsNet_84690E51A08D7478CBFCB238B0AB8639" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RevenueFromRelatedParties" xlink:label="loc_us-gaap_RevenueFromRelatedParties_A459A76F773A7B19D3C9B238B0AB17D2" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesAbstract_072DC51D8CA085DBC8ADB238B0ABE377" xlink:to="loc_us-gaap_RevenueFromRelatedParties_A459A76F773A7B19D3C9B238B0AB17D2" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_OtherCollaborationRevenue" xlink:label="loc_regn_OtherCollaborationRevenue_D383BD97113767731C41B238B0ABEB8B" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesAbstract_072DC51D8CA085DBC8ADB238B0ABE377" xlink:to="loc_regn_OtherCollaborationRevenue_D383BD97113767731C41B238B0ABEB8B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LicensesRevenue" xlink:label="loc_us-gaap_LicensesRevenue_6AE2333B26DF6594B01FB238B0ABB314" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesAbstract_072DC51D8CA085DBC8ADB238B0ABE377" xlink:to="loc_us-gaap_LicensesRevenue_6AE2333B26DF6594B01FB238B0ABB314" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_B79099BA939CAA5A95DBB238B0AB7188" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesAbstract_072DC51D8CA085DBC8ADB238B0ABE377" xlink:to="loc_us-gaap_Revenues_B79099BA939CAA5A95DBB238B0AB7188" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CostsAndExpensesAbstract" xlink:label="loc_us-gaap_CostsAndExpensesAbstract_ADF4AE3E671C12035D3AB238B0AB4831" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_0BAFC100D01A72716A96B238B0ABE2E3" xlink:to="loc_us-gaap_CostsAndExpensesAbstract_ADF4AE3E671C12035D3AB238B0AB4831" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_2C5F06D0FDF836CAB8A6B238B0AB55EC" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_ADF4AE3E671C12035D3AB238B0AB4831" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_2C5F06D0FDF836CAB8A6B238B0AB55EC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_CC5462001BC914AF0ABAB238B0AC1375" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_ADF4AE3E671C12035D3AB238B0AB4831" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_CC5462001BC914AF0ABAB238B0AC1375" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CostOfGoodsSold" xlink:label="loc_us-gaap_CostOfGoodsSold_A9A4AF17912E9B8BFFC9B238B0AC297E" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_ADF4AE3E671C12035D3AB238B0AB4831" xlink:to="loc_us-gaap_CostOfGoodsSold_A9A4AF17912E9B8BFFC9B238B0AC297E" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Costofmanufacturing" xlink:label="loc_regn_Costofmanufacturing_44A0226FE647B0166895B238B0AC126D" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_ADF4AE3E671C12035D3AB238B0AB4831" xlink:to="loc_regn_Costofmanufacturing_44A0226FE647B0166895B238B0AC126D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CostsAndExpenses" xlink:label="loc_us-gaap_CostsAndExpenses_91D7E80474E900DF0DA0B238B0ACBEDB" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_ADF4AE3E671C12035D3AB238B0AB4831" xlink:to="loc_us-gaap_CostsAndExpenses_91D7E80474E900DF0DA0B238B0ACBEDB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaap_OperatingIncomeLoss_7D3D4F301FDCDC235B39B238B0ACFDBE" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_0BAFC100D01A72716A96B238B0ABE2E3" xlink:to="loc_us-gaap_OperatingIncomeLoss_7D3D4F301FDCDC235B39B238B0ACFDBE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NonoperatingIncomeExpenseAbstract" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseAbstract_5E66DA46797C62FB7969B238B0ACE8D5" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_0BAFC100D01A72716A96B238B0ABE2E3" xlink:to="loc_us-gaap_NonoperatingIncomeExpenseAbstract_5E66DA46797C62FB7969B238B0ACE8D5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_4FC0C4ADC6CE36652CD7B238B0ACB415" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_5E66DA46797C62FB7969B238B0ACE8D5" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_4FC0C4ADC6CE36652CD7B238B0ACB415" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaap_InterestExpense_423DE9107C212AE86752B238B0AC8A72" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_5E66DA46797C62FB7969B238B0ACE8D5" xlink:to="loc_us-gaap_InterestExpense_423DE9107C212AE86752B238B0AC8A72" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_D4519E790F53790A9409B238B0AC7115" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_5E66DA46797C62FB7969B238B0ACE8D5" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_D4519E790F53790A9409B238B0AC7115" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_2FB5B46137263648B59BB238B0AC9DB4" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_5E66DA46797C62FB7969B238B0ACE8D5" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_2FB5B46137263648B59BB238B0AC9DB4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_6F517FD8EDF297AEA8C7B238B0AC59BC" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_0BAFC100D01A72716A96B238B0ABE2E3" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_6F517FD8EDF297AEA8C7B238B0AC59BC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_50BCDB8396873188E30CB238B0AC8982" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_0BAFC100D01A72716A96B238B0ABE2E3" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_50BCDB8396873188E30CB238B0AC8982" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_C83CCE9C46463D3672DDB238B0ACA9A7" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_0BAFC100D01A72716A96B238B0ABE2E3" xlink:to="loc_us-gaap_NetIncomeLoss_C83CCE9C46463D3672DDB238B0ACA9A7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareBasic" xlink:label="loc_us-gaap_EarningsPerShareBasic_492AB60CF4662F01B0E4B238B0ACD2A5" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_0BAFC100D01A72716A96B238B0ABE2E3" xlink:to="loc_us-gaap_EarningsPerShareBasic_492AB60CF4662F01B0E4B238B0ACD2A5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareDiluted" xlink:label="loc_us-gaap_EarningsPerShareDiluted_855D62B2D9EC9994A0D4B238B0AC901E" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_0BAFC100D01A72716A96B238B0ABE2E3" xlink:to="loc_us-gaap_EarningsPerShareDiluted_855D62B2D9EC9994A0D4B238B0AC901E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_4293D7B7E077E6AF897AB238B0AC51C2" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_0BAFC100D01A72716A96B238B0ABE2E3" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_4293D7B7E077E6AF897AB238B0AC51C2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_5AEF82E64CAB95C6C7BCB238B0ACAB30" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_0BAFC100D01A72716A96B238B0ABE2E3" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_5AEF82E64CAB95C6C7BCB238B0ACAB30" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTaxAbstract" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxAbstract_F73FDD897294B99437E7B238B0AC90B5" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_98C3DBF9FFB43A3542C9B238B0AB2466" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTaxAbstract_F73FDD897294B99437E7B238B0AC90B5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_2BE767134EAD1BC83728B238B0AC3140" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxAbstract_F73FDD897294B99437E7B238B0AC90B5" xlink:to="loc_us-gaap_NetIncomeLoss_2BE767134EAD1BC83728B238B0AC3140" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_E7B042271FFF3F648EE0B238B0AC512C" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxAbstract_F73FDD897294B99437E7B238B0AC90B5" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_E7B042271FFF3F648EE0B238B0AC512C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_7E27B4FB727CAD12F531B238B0ACCA3B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_E7B042271FFF3F648EE0B238B0AC512C" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_7E27B4FB727CAD12F531B238B0ACCA3B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_F4ABD95324AB63C80C14B238B0AD25E0" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxAbstract_F73FDD897294B99437E7B238B0AC90B5" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_F4ABD95324AB63C80C14B238B0AD25E0" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/ConsolidatedStatementsOfStockholdersEquity" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementOfStockholdersEquityAbstract" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_E77B811D4EDC6D2FC68AB238B08A0B7B" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_D5CDE9A250C61D22EBE5B238B08A3B80" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_E77B811D4EDC6D2FC68AB238B08A0B7B" xlink:to="loc_us-gaap_StatementTable_D5CDE9A250C61D22EBE5B238B08A3B80" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_57CD96CDF7341570E056B238B08BD39B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_D5CDE9A250C61D22EBE5B238B08A3B80" xlink:to="loc_us-gaap_StatementClassOfStockAxis_57CD96CDF7341570E056B238B08BD39B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_0664200BADBF9F62D818B238B08B6F92" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_57CD96CDF7341570E056B238B08BD39B" xlink:to="loc_us-gaap_ClassOfStockDomain_0664200BADBF9F62D818B238B08B6F92" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonClassAMember" xlink:label="loc_us-gaap_CommonClassAMember_22A6F2526759B62D9A95B238B08BBBD0" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_0664200BADBF9F62D818B238B08B6F92" xlink:to="loc_us-gaap_CommonClassAMember_22A6F2526759B62D9A95B238B08BBBD0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_200CC749F75EC85B744DB238B08BA9D1" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_0664200BADBF9F62D818B238B08B6F92" xlink:to="loc_us-gaap_CommonStockMember_200CC749F75EC85B744DB238B08BA9D1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_C6C1E8AAFB93EFD8BC78B238B08BC97D" xlink:type="locator" />
    <presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_D5CDE9A250C61D22EBE5B238B08A3B80" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_C6C1E8AAFB93EFD8BC78B238B08BC97D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_23B6644607EF22B6050FB238B08B4674" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_C6C1E8AAFB93EFD8BC78B238B08BC97D" xlink:to="loc_us-gaap_EquityComponentDomain_23B6644607EF22B6050FB238B08B4674" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_393C95B33DBDC8AED5C4B238B08B872B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_23B6644607EF22B6050FB238B08B4674" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_393C95B33DBDC8AED5C4B238B08B872B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RetainedEarningsMember" xlink:label="loc_us-gaap_RetainedEarningsMember_A22F37753583C0C00F3FB238B08B51ED" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_23B6644607EF22B6050FB238B08B4674" xlink:to="loc_us-gaap_RetainedEarningsMember_A22F37753583C0C00F3FB238B08B51ED" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TreasuryStockMember" xlink:label="loc_us-gaap_TreasuryStockMember_691F7ED212CDD33652D6B238B08B609B" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_23B6644607EF22B6050FB238B08B4674" xlink:to="loc_us-gaap_TreasuryStockMember_691F7ED212CDD33652D6B238B08B609B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_4067E34780AF68D98620B238B08B22A1" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_23B6644607EF22B6050FB238B08B4674" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_4067E34780AF68D98620B238B08B22A1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_6F44678F0E64833DEAAFB238B08BB2F4" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_D5CDE9A250C61D22EBE5B238B08A3B80" xlink:to="loc_us-gaap_StatementLineItems_6F44678F0E64833DEAAFB238B08BB2F4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_6F44678F0E64833DEAAFB238B08BB2F4" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_0D48C5BFA8B94831E6FBB238B08B6560" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:to="loc_us-gaap_StockholdersEquity_0D48C5BFA8B94831E6FBB238B08B6560" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SharesOutstanding" xlink:label="loc_us-gaap_SharesOutstanding_1DA9F63386C7F59460E6B238B08B43F0" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:to="loc_us-gaap_SharesOutstanding_1DA9F63386C7F59460E6B238B08B43F0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_FA44E933B23625C850A2B238B08B11A5" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_FA44E933B23625C850A2B238B08B11A5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_BC2E2372932F6E67D280B238B08BE07C" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_BC2E2372932F6E67D280B238B08BE07C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation" xlink:label="loc_us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_C0ADFC123ABE9A2CA9CFB238B08B1989" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:to="loc_us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_C0ADFC123ABE9A2CA9CFB238B08B1989" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation" xlink:label="loc_us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation_ECF9CBC392BD43C70802B238B08C06E1" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:to="loc_us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation_ECF9CBC392BD43C70802B238B08C06E1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_27CC22486946C1D9EE64B238B08CCD10" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_27CC22486946C1D9EE64B238B08CCD10" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtConversionConvertedInstrumentSharesIssued1" xlink:label="loc_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_DC091FE80A7A59C20C94B238B08C757F" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:to="loc_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_DC091FE80A7A59C20C94B238B08C757F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueEmployeeBenefitPlan" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeBenefitPlan_29E0D06110BB9A5B6927B238B0912E1F" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeBenefitPlan_29E0D06110BB9A5B6927B238B0912E1F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeBenefitPlan" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeBenefitPlan_7AA26E28C8376D69EA10B238B0911250" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeBenefitPlan_7AA26E28C8376D69EA10B238B0911250" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardGross" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardGross_7A6235AFBA3F07285AFCB238B091EDD0" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardGross_7A6235AFBA3F07285AFCB238B091EDD0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_539383417E4BEE6670D3B238B091E63D" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_539383417E4BEE6670D3B238B091E63D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_AAFCDAE56F6D4F690730B238B091A5EC" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesConversionOfConvertibleSecurities_AAFCDAE56F6D4F690730B238B091A5EC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_B3CC67BEC305CE6CC3DDB238B0912F80" xlink:type="locator" />
    <presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_B3CC67BEC305CE6CC3DDB238B0912F80" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AdjustmentToAdditionalPaidInCapitalIncomeTaxEffectFromShareBasedCompensationNet" xlink:label="loc_us-gaap_AdjustmentToAdditionalPaidInCapitalIncomeTaxEffectFromShareBasedCompensationNet_C1F5163D7458850A0D69B238B0918D09" xlink:type="locator" />
    <presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:to="loc_us-gaap_AdjustmentToAdditionalPaidInCapitalIncomeTaxEffectFromShareBasedCompensationNet_C1F5163D7458850A0D69B238B0918D09" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_C7373D4307A60043816FB238B091C246" xlink:type="locator" />
    <presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_C7373D4307A60043816FB238B091C246" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TreasuryStockSharesAcquired" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_3CF8E117D699A24E3C1EB238B0914FF6" xlink:type="locator" />
    <presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_3CF8E117D699A24E3C1EB238B0914FF6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalOther" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalOther_CAAD4A002AECF2424342B238B0910EE9" xlink:type="locator" />
    <presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalOther_CAAD4A002AECF2424342B238B0910EE9" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Maximumamountofwarrantpayable" xlink:label="loc_regn_Maximumamountofwarrantpayable_E9EB71E0D7F96D55CB99B238B09244BE" xlink:type="locator" />
    <presentationArc order="19" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:to="loc_regn_Maximumamountofwarrantpayable_E9EB71E0D7F96D55CB99B238B09244BE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebtSubsequentAdjustments" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebtSubsequentAdjustments_523EB7CE8986ED97A710B238B09227AF" xlink:type="locator" />
    <presentationArc order="20" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebtSubsequentAdjustments_523EB7CE8986ED97A710B238B09227AF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_B727C6CC06AC5E977FACB238B0929A88" xlink:type="locator" />
    <presentationArc order="21" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:to="loc_us-gaap_NetIncomeLoss_B727C6CC06AC5E977FACB238B0929A88" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_8D9FEA9E9D3545B82BEBB238B09272EA" xlink:type="locator" />
    <presentationArc order="22" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_8D9FEA9E9D3545B82BEBB238B09272EA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_FCD94A52869D92675242B238B0921E0E" xlink:type="locator" />
    <presentationArc order="23" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:to="loc_us-gaap_StockholdersEquity_FCD94A52869D92675242B238B0921E0E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SharesOutstanding" xlink:label="loc_us-gaap_SharesOutstanding_35D44CAEA4854439B8C9B238B092CB62" xlink:type="locator" />
    <presentationArc order="24" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_459B1A3A042FCB7182DBB238B08B370F" xlink:to="loc_us-gaap_SharesOutstanding_35D44CAEA4854439B8C9B238B092CB62" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/Debt" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtDisclosureAbstract" xlink:label="loc_us-gaap_DebtDisclosureAbstract_BD901DE346CF352EC2E2B238AE70A3A5" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtDisclosureTextBlock" xlink:label="loc_us-gaap_DebtDisclosureTextBlock_9FBEF2A369EDEB3D74CAB238AE706898" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_BD901DE346CF352EC2E2B238AE70A3A5" xlink:to="loc_us-gaap_DebtDisclosureTextBlock_9FBEF2A369EDEB3D74CAB238AE706898" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/DebtDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtDisclosureAbstract" xlink:label="loc_us-gaap_DebtDisclosureAbstract_ECEF5977C85C70B20528C19AB43FBC8E" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="loc_us-gaap_DebtInstrumentTable_E1C1953296C04F8AAD9EC19AB4404973" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_ECEF5977C85C70B20528C19AB43FBC8E" xlink:to="loc_us-gaap_DebtInstrumentTable_E1C1953296C04F8AAD9EC19AB4404973" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_2DD5DD0F5B9F58D6B863C19AB440EA87" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_E1C1953296C04F8AAD9EC19AB4404973" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_2DD5DD0F5B9F58D6B863C19AB440EA87" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_5D38FA1CD5A3C7475D0FC19AB440B945" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_2DD5DD0F5B9F58D6B863C19AB440EA87" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_5D38FA1CD5A3C7475D0FC19AB440B945" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SubsequentEventMember" xlink:label="loc_us-gaap_SubsequentEventMember_04B55F9C9D202CE3C6F8C19AB4406299" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_5D38FA1CD5A3C7475D0FC19AB440B945" xlink:to="loc_us-gaap_SubsequentEventMember_04B55F9C9D202CE3C6F8C19AB4406299" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_6D9199BEFCAE71128E27C19AB4402F56" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_E1C1953296C04F8AAD9EC19AB4404973" xlink:to="loc_us-gaap_StatementScenarioAxis_6D9199BEFCAE71128E27C19AB4402F56" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_012CA842B58C458F2AB3C19AB440696E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementScenarioAxis_6D9199BEFCAE71128E27C19AB4402F56" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_012CA842B58C458F2AB3C19AB440696E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScenarioForecastMember" xlink:label="loc_us-gaap_ScenarioForecastMember_473C024BA0D848A1F2B1C19AB440EB3F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScenarioUnspecifiedDomain_012CA842B58C458F2AB3C19AB440696E" xlink:to="loc_us-gaap_ScenarioForecastMember_473C024BA0D848A1F2B1C19AB440EB3F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_5D181D1E3379E2F909B8C19AB4409619" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_E1C1953296C04F8AAD9EC19AB4404973" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_5D181D1E3379E2F909B8C19AB4409619" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_9938901FC0A51A99B638C19AB440FF9E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_5D181D1E3379E2F909B8C19AB4409619" xlink:to="loc_us-gaap_EquityComponentDomain_9938901FC0A51A99B638C19AB440FF9E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_271B6F77A44FE1FFA1A8C19AB4409450" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_9938901FC0A51A99B638C19AB440FF9E" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_271B6F77A44FE1FFA1A8C19AB4409450" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_78E546D5DB7FDC857FCEC19AB4409ACC" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_E1C1953296C04F8AAD9EC19AB4404973" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_78E546D5DB7FDC857FCEC19AB4409ACC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_0CACD6D9B2ACE27F9024C19AB440EC7B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_78E546D5DB7FDC857FCEC19AB4409ACC" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_0CACD6D9B2ACE27F9024C19AB440EC7B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConvertibleDebtMember" xlink:label="loc_us-gaap_ConvertibleDebtMember_65E43D2E1B05843FB7E1C19AB440953B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_0CACD6D9B2ACE27F9024C19AB440EC7B" xlink:to="loc_us-gaap_ConvertibleDebtMember_65E43D2E1B05843FB7E1C19AB440953B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CreditFacilityDomain" xlink:label="loc_us-gaap_CreditFacilityDomain_C084B7439C887D877E4EC19AB4405464" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_0CACD6D9B2ACE27F9024C19AB440EC7B" xlink:to="loc_us-gaap_CreditFacilityDomain_C084B7439C887D877E4EC19AB4405464" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OptionIndexedToIssuersEquityTypeAxis" xlink:label="loc_us-gaap_OptionIndexedToIssuersEquityTypeAxis_D6572CA0DFB91A75A61DC19AB44166C2" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_E1C1953296C04F8AAD9EC19AB4404973" xlink:to="loc_us-gaap_OptionIndexedToIssuersEquityTypeAxis_D6572CA0DFB91A75A61DC19AB44166C2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OptionIndexedToIssuersEquityTypeDomain" xlink:label="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_A8B1AC4ABDDB7591ED4AC19AB441FE12" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OptionIndexedToIssuersEquityTypeAxis_D6572CA0DFB91A75A61DC19AB44166C2" xlink:to="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_A8B1AC4ABDDB7591ED4AC19AB441FE12" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CallOptionMember" xlink:label="loc_us-gaap_CallOptionMember_DB186E3A5E7F464A9518C19AB4418A5C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_A8B1AC4ABDDB7591ED4AC19AB441FE12" xlink:to="loc_us-gaap_CallOptionMember_DB186E3A5E7F464A9518C19AB4418A5C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfWarrantOrRightAxis" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_AD2C74F6902EF64C07C7C19AB4411516" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_E1C1953296C04F8AAD9EC19AB4404973" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_AD2C74F6902EF64C07C7C19AB4411516" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_29B5F8D221A29AA7A567C19AB441ED9A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_AD2C74F6902EF64C07C7C19AB4411516" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_29B5F8D221A29AA7A567C19AB441ED9A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_WarrantMember" xlink:label="loc_us-gaap_WarrantMember_8C05BD457FF4D480D926C19AB4414105" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_29B5F8D221A29AA7A567C19AB441ED9A" xlink:to="loc_us-gaap_WarrantMember_8C05BD457FF4D480D926C19AB4414105" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_E1C1953296C04F8AAD9EC19AB4404973" xlink:to="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TreasuryStockValue" xlink:label="loc_us-gaap_TreasuryStockValue_28FC263ABD5A4ED03062C19AB4418922" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:to="loc_us-gaap_TreasuryStockValue_28FC263ABD5A4ED03062C19AB4418922" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_6FBF6441654D2D95154FC19AB441FF0D" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_6FBF6441654D2D95154FC19AB441FF0D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_947BF43464D495361803C19AB4416071" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_947BF43464D495361803C19AB4416071" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_DebtInstrumentPercentageOfPrincipalValueThatHoldersCanRequireCompanyToRepurchase" xlink:label="loc_regn_DebtInstrumentPercentageOfPrincipalValueThatHoldersCanRequireCompanyToRepurchase_FB3A8781ABC8D671BB65C19AB441CC86" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:to="loc_regn_DebtInstrumentPercentageOfPrincipalValueThatHoldersCanRequireCompanyToRepurchase_FB3A8781ABC8D671BB65C19AB441CC86" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_DebtInstrumentConvertibleFairValueOfLiabilityComponent" xlink:label="loc_regn_DebtInstrumentConvertibleFairValueOfLiabilityComponent_65178721842DAB04BA0FC19AB441273C" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:to="loc_regn_DebtInstrumentConvertibleFairValueOfLiabilityComponent_65178721842DAB04BA0FC19AB441273C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent" xlink:label="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_5772F2C69C3CEB56EDD4C19AB4412F2F" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:to="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_5772F2C69C3CEB56EDD4C19AB4412F2F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_2E603B3DDE9B470C5634C19AB4415631" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_2E603B3DDE9B470C5634C19AB4415631" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_319F8A1CC1EBDCC88840C19AB4421F18" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:to="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_319F8A1CC1EBDCC88840C19AB4421F18" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_NetCarryingAmountOfLiabilityComponentAbstract" xlink:label="loc_regn_NetCarryingAmountOfLiabilityComponentAbstract_232C28273124A9FFC549C19AB44243B4" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:to="loc_regn_NetCarryingAmountOfLiabilityComponentAbstract_232C28273124A9FFC549C19AB44243B4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConvertibleDebt" xlink:label="loc_us-gaap_ConvertibleDebt_009A981AF3C1C8E63E8EC19E9300397A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_NetCarryingAmountOfLiabilityComponentAbstract_232C28273124A9FFC549C19AB44243B4" xlink:to="loc_us-gaap_ConvertibleDebt_009A981AF3C1C8E63E8EC19E9300397A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_573AB4BB360776A778EEC19AB44292EC" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_NetCarryingAmountOfLiabilityComponentAbstract_232C28273124A9FFC549C19AB44243B4" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_573AB4BB360776A778EEC19AB44292EC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConvertibleNotesPayable" xlink:label="loc_us-gaap_ConvertibleNotesPayable_F34BB5FB51ADAB7A0F31C1AB8FBB4CBD" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_NetCarryingAmountOfLiabilityComponentAbstract_232C28273124A9FFC549C19AB44243B4" xlink:to="loc_us-gaap_ConvertibleNotesPayable_F34BB5FB51ADAB7A0F31C1AB8FBB4CBD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TreasuryStockShares" xlink:label="loc_us-gaap_TreasuryStockShares_0C3B54EE6CDC07DA7EFDC19AB44850CF" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:to="loc_us-gaap_TreasuryStockShares_0C3B54EE6CDC07DA7EFDC19AB44850CF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InterestExpenseDebtAbstract" xlink:label="loc_us-gaap_InterestExpenseDebtAbstract_6850D2AD0D0D35548B8CC19AB4487543" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:to="loc_us-gaap_InterestExpenseDebtAbstract_6850D2AD0D0D35548B8CC19AB4487543" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InterestExpenseDebtExcludingAmortization" xlink:label="loc_us-gaap_InterestExpenseDebtExcludingAmortization_E4F2CD021166131A1FBEC19AB448D781" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestExpenseDebtAbstract_6850D2AD0D0D35548B8CC19AB4487543" xlink:to="loc_us-gaap_InterestExpenseDebtExcludingAmortization_E4F2CD021166131A1FBEC19AB448D781" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AmortizationOfFinancingCostsAndDiscounts" xlink:label="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_E7BBD3140C0517E2F80EC19AB448C64E" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestExpenseDebtAbstract_6850D2AD0D0D35548B8CC19AB4487543" xlink:to="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_E7BBD3140C0517E2F80EC19AB448C64E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InterestExpenseDebt" xlink:label="loc_us-gaap_InterestExpenseDebt_9B40056DD4F5CAA5F7ECC19AB448C618" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InterestExpenseDebtAbstract_6850D2AD0D0D35548B8CC19AB4487543" xlink:to="loc_us-gaap_InterestExpenseDebt_9B40056DD4F5CAA5F7ECC19AB448C618" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_WarrantsAndRightsNoteDisclosureAbstract" xlink:label="loc_us-gaap_WarrantsAndRightsNoteDisclosureAbstract_0C2B1A101EB8095E6C1BC19AB44806C6" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:to="loc_us-gaap_WarrantsAndRightsNoteDisclosureAbstract_0C2B1A101EB8095E6C1BC19AB44806C6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_AF7479AA00D63E66EE96C19AB4488B83" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WarrantsAndRightsNoteDisclosureAbstract_0C2B1A101EB8095E6C1BC19AB44806C6" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_AF7479AA00D63E66EE96C19AB4488B83" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProceedsFromIssuanceOfWarrants" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfWarrants_6D53CE8FC02CC564FD80C19AB448A0AD" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WarrantsAndRightsNoteDisclosureAbstract_0C2B1A101EB8095E6C1BC19AB44806C6" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfWarrants_6D53CE8FC02CC564FD80C19AB448A0AD" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Reductionofnumberofwarrants" xlink:label="loc_regn_Reductionofnumberofwarrants_1D0A7238E6D242700A4CC19AB44A6BEA" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WarrantsAndRightsNoteDisclosureAbstract_0C2B1A101EB8095E6C1BC19AB44806C6" xlink:to="loc_regn_Reductionofnumberofwarrants_1D0A7238E6D242700A4CC19AB44A6BEA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalOther" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalOther_BF16EAF5318220152FB0C19AB44ABEDA" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WarrantsAndRightsNoteDisclosureAbstract_0C2B1A101EB8095E6C1BC19AB44806C6" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalOther_BF16EAF5318220152FB0C19AB44ABEDA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtConversionConvertedInstrumentSharesIssued1" xlink:label="loc_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_AA01F5DD36CF32C68F5DC19AB448CB79" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:to="loc_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_AA01F5DD36CF32C68F5DC19AB448CB79" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TreasuryStockSharesAcquired" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_48F4648BC1410B3B6C16C19AB449284A" xlink:type="locator" />
    <presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_48F4648BC1410B3B6C16C19AB449284A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsForRepurchaseOfWarrants" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfWarrants_1D444BBE165FD06AE2D8C19AB4491F21" xlink:type="locator" />
    <presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfWarrants_1D444BBE165FD06AE2D8C19AB4491F21" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Warrantsoutstanding" xlink:label="loc_regn_Warrantsoutstanding_42F239200A7EE673B7B0C19AB4497C80" xlink:type="locator" />
    <presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:to="loc_regn_Warrantsoutstanding_42F239200A7EE673B7B0C19AB4497C80" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Maximumreductionofwarrantsheldbywarrantholder" xlink:label="loc_regn_Maximumreductionofwarrantsheldbywarrantholder_F91A10C947CC8FB7A454C19AB449C469" xlink:type="locator" />
    <presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:to="loc_regn_Maximumreductionofwarrantsheldbywarrantholder_F91A10C947CC8FB7A454C19AB449C469" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueAdjustmentOfWarrants" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_B515026C68E8B56EB0ADC19AB449A577" xlink:type="locator" />
    <presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_B515026C68E8B56EB0ADC19AB449A577" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Maximumamountofwarrantpayable" xlink:label="loc_regn_Maximumamountofwarrantpayable_9FB09519C1BDCCB4D74BC19AB449531F" xlink:type="locator" />
    <presentationArc order="19" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:to="loc_regn_Maximumamountofwarrantpayable_9FB09519C1BDCCB4D74BC19AB449531F" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Limitpricepershareforwarrantholderstocloseouthedgeposition" xlink:label="loc_regn_Limitpricepershareforwarrantholderstocloseouthedgeposition_5223686BDC5944151C1BC19AB44985C7" xlink:type="locator" />
    <presentationArc order="20" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:to="loc_regn_Limitpricepershareforwarrantholderstocloseouthedgeposition_5223686BDC5944151C1BC19AB44985C7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsPayableOtherCurrentAndNoncurrent" xlink:label="loc_us-gaap_AccountsPayableOtherCurrentAndNoncurrent_3B4C3CBCD363B6517AF0C19AB4494F9A" xlink:type="locator" />
    <presentationArc order="21" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:to="loc_us-gaap_AccountsPayableOtherCurrentAndNoncurrent_3B4C3CBCD363B6517AF0C19AB4494F9A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherLiabilitiesFairValueDisclosure" xlink:label="loc_us-gaap_OtherLiabilitiesFairValueDisclosure_2DE18B1A2BDB4DE05E79C19AB449B472" xlink:type="locator" />
    <presentationArc order="22" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:to="loc_us-gaap_OtherLiabilitiesFairValueDisclosure_2DE18B1A2BDB4DE05E79C19AB449B472" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongtermConvertibleDebtCurrentAndNoncurrentAbstract" xlink:label="loc_us-gaap_LongtermConvertibleDebtCurrentAndNoncurrentAbstract_0AB50172D0F2156C33E6C19AB449560C" xlink:type="locator" />
    <presentationArc order="23" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:to="loc_us-gaap_LongtermConvertibleDebtCurrentAndNoncurrentAbstract_0AB50172D0F2156C33E6C19AB449560C" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_DebtConversion" xlink:label="loc_regn_DebtConversion_6FFA8C661B30B5D8F359C19AB449130C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermConvertibleDebtCurrentAndNoncurrentAbstract_0AB50172D0F2156C33E6C19AB449560C" xlink:to="loc_regn_DebtConversion_6FFA8C661B30B5D8F359C19AB449130C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal" xlink:label="loc_us-gaap_DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal_2D1DF868DF7CC44C0653C19AB4495FA2" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermConvertibleDebtCurrentAndNoncurrentAbstract_0AB50172D0F2156C33E6C19AB449560C" xlink:to="loc_us-gaap_DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal_2D1DF868DF7CC44C0653C19AB4495FA2" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_PurchaseOfConvertibleNoteHedges" xlink:label="loc_regn_PurchaseOfConvertibleNoteHedges_375C8DE27D72A1AA2344C19AB449C725" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermConvertibleDebtCurrentAndNoncurrentAbstract_0AB50172D0F2156C33E6C19AB449560C" xlink:to="loc_regn_PurchaseOfConvertibleNoteHedges_375C8DE27D72A1AA2344C19AB449C725" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RepaymentsOfConvertibleDebt" xlink:label="loc_us-gaap_RepaymentsOfConvertibleDebt_389FB468D221AFF4BE7BC19AB4481B57" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermConvertibleDebtCurrentAndNoncurrentAbstract_0AB50172D0F2156C33E6C19AB449560C" xlink:to="loc_us-gaap_RepaymentsOfConvertibleDebt_389FB468D221AFF4BE7BC19AB4481B57" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_B4EEE0EE10F9041C229BC19AB448FCF3" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermConvertibleDebtCurrentAndNoncurrentAbstract_0AB50172D0F2156C33E6C19AB449560C" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_B4EEE0EE10F9041C229BC19AB448FCF3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_A6C12AE35806D358E45DC19AB449480D" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermConvertibleDebtCurrentAndNoncurrentAbstract_0AB50172D0F2156C33E6C19AB449560C" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_A6C12AE35806D358E45DC19AB449480D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebtSubsequentAdjustments" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebtSubsequentAdjustments_FEC6461405C8196E699BC19AB449F680" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermConvertibleDebtCurrentAndNoncurrentAbstract_0AB50172D0F2156C33E6C19AB449560C" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebtSubsequentAdjustments_FEC6461405C8196E699BC19AB449F680" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LineOfCreditFacilityAbstract" xlink:label="loc_us-gaap_LineOfCreditFacilityAbstract_8896C355C19BFB5BFAA5C1C3234EB7A3" xlink:type="locator" />
    <presentationArc order="24" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_0AAE067EDD39DDCA6CB3C19AB44161FA" xlink:to="loc_us-gaap_LineOfCreditFacilityAbstract_8896C355C19BFB5BFAA5C1C3234EB7A3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_BC9FBE83D58E7C651765C19AB44A5EF7" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityAbstract_8896C355C19BFB5BFAA5C1C3234EB7A3" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_BC9FBE83D58E7C651765C19AB44A5EF7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LineOfCreditFacilityExpirationPeriod" xlink:label="loc_us-gaap_LineOfCreditFacilityExpirationPeriod_14E6610868562F8F4D5FC19AB44A0E4D" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityAbstract_8896C355C19BFB5BFAA5C1C3234EB7A3" xlink:to="loc_us-gaap_LineOfCreditFacilityExpirationPeriod_14E6610868562F8F4D5FC19AB44A0E4D" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Availableincreasetothecreditfacility" xlink:label="loc_regn_Availableincreasetothecreditfacility_06AB907126670AA4FD23C19AB44A040C" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityAbstract_8896C355C19BFB5BFAA5C1C3234EB7A3" xlink:to="loc_regn_Availableincreasetothecreditfacility_06AB907126670AA4FD23C19AB44A040C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LineOfCreditFacilityCurrentBorrowingCapacity" xlink:label="loc_us-gaap_LineOfCreditFacilityCurrentBorrowingCapacity_49A10CD69178AB7C9900C19AB44AE440" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityAbstract_8896C355C19BFB5BFAA5C1C3234EB7A3" xlink:to="loc_us-gaap_LineOfCreditFacilityCurrentBorrowingCapacity_49A10CD69178AB7C9900C19AB44AE440" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/DebtTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtDisclosureAbstract" xlink:label="loc_us-gaap_DebtDisclosureAbstract_CE3E7D0BCDA965E65E1BB238AE68547E" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="loc_us-gaap_DebtInstrumentTable_23716250024F83390EEFB238AE6834B9" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_CE3E7D0BCDA965E65E1BB238AE68547E" xlink:to="loc_us-gaap_DebtInstrumentTable_23716250024F83390EEFB238AE6834B9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_759535DBA10A6E28D267B238AE689343" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_23716250024F83390EEFB238AE6834B9" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_759535DBA10A6E28D267B238AE689343" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_5E7FDE133889B6398652B238AE68620D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_759535DBA10A6E28D267B238AE689343" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_5E7FDE133889B6398652B238AE68620D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentAxis" xlink:label="loc_us-gaap_DebtInstrumentAxis_C14541E70D0C61294D7DB238AE687C48" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_23716250024F83390EEFB238AE6834B9" xlink:to="loc_us-gaap_DebtInstrumentAxis_C14541E70D0C61294D7DB238AE687C48" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentNameDomain" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_762B68FD4EECA92858E9B238AE68A86F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_C14541E70D0C61294D7DB238AE687C48" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_762B68FD4EECA92858E9B238AE68A86F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_VariableRateAxis" xlink:label="loc_us-gaap_VariableRateAxis_C80497E33E1D150D0827B238AE68C01E" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_23716250024F83390EEFB238AE6834B9" xlink:to="loc_us-gaap_VariableRateAxis_C80497E33E1D150D0827B238AE68C01E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_VariableRateDomain" xlink:label="loc_us-gaap_VariableRateDomain_87D2E4641AC326EE5A57B238AE68DD3A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateAxis_C80497E33E1D150D0827B238AE68C01E" xlink:to="loc_us-gaap_VariableRateDomain_87D2E4641AC326EE5A57B238AE68DD3A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodAxis" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_798C992442F3744123BDB238AE69AA72" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_23716250024F83390EEFB238AE6834B9" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_798C992442F3744123BDB238AE69AA72" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_4A63CEB3BD8D308E3446B238AE695938" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_798C992442F3744123BDB238AE69AA72" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_4A63CEB3BD8D308E3446B238AE695938" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_53B361DC31FB28E216D5B238AE691191" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_23716250024F83390EEFB238AE6834B9" xlink:to="loc_us-gaap_DebtInstrumentLineItems_53B361DC31FB28E216D5B238AE691191" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfDebtInstrumentsTextBlock" xlink:label="loc_us-gaap_ScheduleOfDebtInstrumentsTextBlock_40EAE105B92C9E53FD72B238AE692CE8" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_CE3E7D0BCDA965E65E1BB238AE68547E" xlink:to="loc_us-gaap_ScheduleOfDebtInstrumentsTextBlock_40EAE105B92C9E53FD72B238AE692CE8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConvertibleDebtTableTextBlock" xlink:label="loc_us-gaap_ConvertibleDebtTableTextBlock_9B90DA874343B410FCB0B238AE6953DA" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_CE3E7D0BCDA965E65E1BB238AE68547E" xlink:to="loc_us-gaap_ConvertibleDebtTableTextBlock_9B90DA874343B410FCB0B238AE6953DA" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/DeferredRevenue" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueDisclosureAbstract" xlink:label="loc_us-gaap_DeferredRevenueDisclosureAbstract_BF19FEF777ADE9E028BDB238AE8878C7" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueDisclosureTextBlock" xlink:label="loc_us-gaap_DeferredRevenueDisclosureTextBlock_1A1C07432C719C1D0CD3B238AE88F81A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueDisclosureAbstract_BF19FEF777ADE9E028BDB238AE8878C7" xlink:to="loc_us-gaap_DeferredRevenueDisclosureTextBlock_1A1C07432C719C1D0CD3B238AE88F81A" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/DeferredRevenueDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueDisclosureAbstract" xlink:label="loc_us-gaap_DeferredRevenueDisclosureAbstract_A3A98152E8A908786A24B238AE799BC1" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueArrangementByTypeTable" xlink:label="loc_us-gaap_DeferredRevenueArrangementByTypeTable_2D6A4CE401EC475AD699B238AE7922E1" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueDisclosureAbstract_A3A98152E8A908786A24B238AE799BC1" xlink:to="loc_us-gaap_DeferredRevenueArrangementByTypeTable_2D6A4CE401EC475AD699B238AE7922E1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueArrangementTypeAxis" xlink:label="loc_us-gaap_DeferredRevenueArrangementTypeAxis_D2F833F0D6DCBB253968B238AE796FD9" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueArrangementByTypeTable_2D6A4CE401EC475AD699B238AE7922E1" xlink:to="loc_us-gaap_DeferredRevenueArrangementTypeAxis_D2F833F0D6DCBB253968B238AE796FD9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueArrangementTypeDomain" xlink:label="loc_us-gaap_DeferredRevenueArrangementTypeDomain_FAFD030A4AB20C316B81B238AE795237" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueArrangementTypeAxis_D2F833F0D6DCBB253968B238AE796FD9" xlink:to="loc_us-gaap_DeferredRevenueArrangementTypeDomain_FAFD030A4AB20C316B81B238AE795237" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_CollaborationAgreementWithSanofiMember" xlink:label="loc_regn_CollaborationAgreementWithSanofiMember_1160EBE148E757069F86B238AE7910FB" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueArrangementTypeDomain_FAFD030A4AB20C316B81B238AE795237" xlink:to="loc_regn_CollaborationAgreementWithSanofiMember_1160EBE148E757069F86B238AE7910FB" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_CollaborationAgreementWithBayerHealthcareLlcMember" xlink:label="loc_regn_CollaborationAgreementWithBayerHealthcareLlcMember_0208C89612AE03B585EEB238AE797E60" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueArrangementTypeDomain_FAFD030A4AB20C316B81B238AE795237" xlink:to="loc_regn_CollaborationAgreementWithBayerHealthcareLlcMember_0208C89612AE03B585EEB238AE797E60" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NonsoftwareLicenseArrangementMember" xlink:label="loc_us-gaap_NonsoftwareLicenseArrangementMember_662623F2477BEC8E123AB238AE794C93" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueArrangementTypeDomain_FAFD030A4AB20C316B81B238AE795237" xlink:to="loc_us-gaap_NonsoftwareLicenseArrangementMember_662623F2477BEC8E123AB238AE794C93" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_OtherDeferredRevenueAgreementsMember" xlink:label="loc_regn_OtherDeferredRevenueAgreementsMember_EEEE3F6708B5618FC6AFB238AE79D2E4" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueArrangementTypeDomain_FAFD030A4AB20C316B81B238AE795237" xlink:to="loc_regn_OtherDeferredRevenueAgreementsMember_EEEE3F6708B5618FC6AFB238AE79D2E4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueArrangementLineItems" xlink:label="loc_us-gaap_DeferredRevenueArrangementLineItems_2A2052C468B73555DA41B238AE7969CA" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueArrangementByTypeTable_2D6A4CE401EC475AD699B238AE7922E1" xlink:to="loc_us-gaap_DeferredRevenueArrangementLineItems_2A2052C468B73555DA41B238AE7969CA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueAndCreditsCurrentAbstract" xlink:label="loc_us-gaap_DeferredRevenueAndCreditsCurrentAbstract_E1094F1F5FEBF4F5735FB238AE79AED6" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueArrangementLineItems_2A2052C468B73555DA41B238AE7969CA" xlink:to="loc_us-gaap_DeferredRevenueAndCreditsCurrentAbstract_E1094F1F5FEBF4F5735FB238AE79AED6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueCurrent" xlink:label="loc_us-gaap_DeferredRevenueCurrent_8173B9BA0063B95F1824B238AE7941A0" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueAndCreditsCurrentAbstract_E1094F1F5FEBF4F5735FB238AE79AED6" xlink:to="loc_us-gaap_DeferredRevenueCurrent_8173B9BA0063B95F1824B238AE7941A0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueAndCreditsNoncurrentAbstract" xlink:label="loc_us-gaap_DeferredRevenueAndCreditsNoncurrentAbstract_609CC9CF13D102C70080B238AE79F1AF" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueArrangementLineItems_2A2052C468B73555DA41B238AE7969CA" xlink:to="loc_us-gaap_DeferredRevenueAndCreditsNoncurrentAbstract_609CC9CF13D102C70080B238AE79F1AF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueNoncurrent" xlink:label="loc_us-gaap_DeferredRevenueNoncurrent_563695AB0B7709CD2FBBB238AE7FB770" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueAndCreditsNoncurrentAbstract_609CC9CF13D102C70080B238AE79F1AF" xlink:to="loc_us-gaap_DeferredRevenueNoncurrent_563695AB0B7709CD2FBBB238AE7FB770" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/DeferredRevenueTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueDisclosureAbstract" xlink:label="loc_us-gaap_DeferredRevenueDisclosureAbstract_9BA46F358A20137A091DB238AE819C0D" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueByArrangementDisclosureTextBlock" xlink:label="loc_us-gaap_DeferredRevenueByArrangementDisclosureTextBlock_874C9174A9AA3A8D965FB238AE81C56D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueDisclosureAbstract_9BA46F358A20137A091DB238AE819C0D" xlink:to="loc_us-gaap_DeferredRevenueByArrangementDisclosureTextBlock_874C9174A9AA3A8D965FB238AE81C56D" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/DocumentAndEntityInformation" xlink:type="extended">
    <loc xlink:href="regn-20151231.xsd#regn_DocumentAndEntityInformationAbstract" xlink:label="loc_regn_DocumentAndEntityInformationAbstract_E0436C6F8B3520FEDC90B238B0C3C810" xlink:type="locator" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntitiesTable" xlink:label="loc_dei_EntitiesTable_801E69619F27B783737FB238B0C45305" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_DocumentAndEntityInformationAbstract_E0436C6F8B3520FEDC90B238B0C3C810" xlink:to="loc_dei_EntitiesTable_801E69619F27B783737FB238B0C45305" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_65DA9598C461999DDAB6B238B0C40A85" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntitiesTable_801E69619F27B783737FB238B0C45305" xlink:to="loc_us-gaap_StatementClassOfStockAxis_65DA9598C461999DDAB6B238B0C40A85" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_31CE557D832DF0FB577FB238B0C44B16" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_65DA9598C461999DDAB6B238B0C40A85" xlink:to="loc_us-gaap_ClassOfStockDomain_31CE557D832DF0FB577FB238B0C44B16" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_849A5AAC66E8D08F42C7B238B0C47FF6" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_31CE557D832DF0FB577FB238B0C44B16" xlink:to="loc_us-gaap_CommonStockMember_849A5AAC66E8D08F42C7B238B0C47FF6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonClassAMember" xlink:label="loc_us-gaap_CommonClassAMember_086A7A90A479B5E6EE1DB238B0C4D072" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_31CE557D832DF0FB577FB238B0C44B16" xlink:to="loc_us-gaap_CommonClassAMember_086A7A90A479B5E6EE1DB238B0C4D072" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityInformationLineItems" xlink:label="loc_dei_EntityInformationLineItems_E00C8A2CD657F88D7BB3B238B0C4EB28" xlink:type="locator" />
    <presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntitiesTable_801E69619F27B783737FB238B0C45305" xlink:to="loc_dei_EntityInformationLineItems_E00C8A2CD657F88D7BB3B238B0C4EB28" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityRegistrantName" xlink:label="loc_dei_EntityRegistrantName_9C1B62AF19A29AD0A416B238B0C4C27C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_E00C8A2CD657F88D7BB3B238B0C4EB28" xlink:to="loc_dei_EntityRegistrantName_9C1B62AF19A29AD0A416B238B0C4C27C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityCentralIndexKey" xlink:label="loc_dei_EntityCentralIndexKey_BFEDB1C826D53DA869ECB238B0C441E5" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_E00C8A2CD657F88D7BB3B238B0C4EB28" xlink:to="loc_dei_EntityCentralIndexKey_BFEDB1C826D53DA869ECB238B0C441E5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_CurrentFiscalYearEndDate" xlink:label="loc_dei_CurrentFiscalYearEndDate_398FB5ADDB5440F9D4C7B238B0C4F546" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_E00C8A2CD657F88D7BB3B238B0C4EB28" xlink:to="loc_dei_CurrentFiscalYearEndDate_398FB5ADDB5440F9D4C7B238B0C4F546" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityFilerCategory" xlink:label="loc_dei_EntityFilerCategory_0B0FB5A355E199CC85A5B238B0C4370C" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_E00C8A2CD657F88D7BB3B238B0C4EB28" xlink:to="loc_dei_EntityFilerCategory_0B0FB5A355E199CC85A5B238B0C4370C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentType" xlink:label="loc_dei_DocumentType_9A37E5352D82D7599111B238B0C52FA8" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_E00C8A2CD657F88D7BB3B238B0C4EB28" xlink:to="loc_dei_DocumentType_9A37E5352D82D7599111B238B0C52FA8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentPeriodEndDate" xlink:label="loc_dei_DocumentPeriodEndDate_3C43CC21A0FC9AFDA841B238B0C568BA" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_E00C8A2CD657F88D7BB3B238B0C4EB28" xlink:to="loc_dei_DocumentPeriodEndDate_3C43CC21A0FC9AFDA841B238B0C568BA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentFiscalYearFocus" xlink:label="loc_dei_DocumentFiscalYearFocus_4960CC55D80BC38073E5B238B0C50084" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_E00C8A2CD657F88D7BB3B238B0C4EB28" xlink:to="loc_dei_DocumentFiscalYearFocus_4960CC55D80BC38073E5B238B0C50084" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_DocumentFiscalPeriodFocus" xlink:label="loc_dei_DocumentFiscalPeriodFocus_5D02E6DD2D064EF38A97B238B0C5E717" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_E00C8A2CD657F88D7BB3B238B0C4EB28" xlink:to="loc_dei_DocumentFiscalPeriodFocus_5D02E6DD2D064EF38A97B238B0C5E717" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_AmendmentFlag" xlink:label="loc_dei_AmendmentFlag_CC69D78B322EC69B72FDB238B0C5E64F" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_E00C8A2CD657F88D7BB3B238B0C4EB28" xlink:to="loc_dei_AmendmentFlag_CC69D78B322EC69B72FDB238B0C5E64F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityCommonStockSharesOutstanding" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_CEAC1E48FE20D2F60C6FB238B0C5A8F7" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_E00C8A2CD657F88D7BB3B238B0C4EB28" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_CEAC1E48FE20D2F60C6FB238B0C5A8F7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityWellKnownSeasonedIssuer" xlink:label="loc_dei_EntityWellKnownSeasonedIssuer_61940347ED6BAF879722B238B0C5F83E" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_E00C8A2CD657F88D7BB3B238B0C4EB28" xlink:to="loc_dei_EntityWellKnownSeasonedIssuer_61940347ED6BAF879722B238B0C5F83E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityVoluntaryFilers" xlink:label="loc_dei_EntityVoluntaryFilers_771E0EEF1FB90ECF24D7B238B0C54C87" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_E00C8A2CD657F88D7BB3B238B0C4EB28" xlink:to="loc_dei_EntityVoluntaryFilers_771E0EEF1FB90ECF24D7B238B0C54C87" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityCurrentReportingStatus" xlink:label="loc_dei_EntityCurrentReportingStatus_2D72AC00DA542D561086B238B0C5E162" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_E00C8A2CD657F88D7BB3B238B0C4EB28" xlink:to="loc_dei_EntityCurrentReportingStatus_2D72AC00DA542D561086B238B0C5E162" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityPublicFloat" xlink:label="loc_dei_EntityPublicFloat_25C929AAA5CC3D882977B238B0C51C66" xlink:type="locator" />
    <presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_E00C8A2CD657F88D7BB3B238B0C4EB28" xlink:to="loc_dei_EntityPublicFloat_25C929AAA5CC3D882977B238B0C51C66" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/EmployeeSavingsPlan" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CompensationAndRetirementDisclosureAbstract" xlink:label="loc_us-gaap_CompensationAndRetirementDisclosureAbstract_79F77E2D14BA79867EF4B238AD301A5D" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PensionAndOtherPostretirementBenefitsDisclosureTextBlock" xlink:label="loc_us-gaap_PensionAndOtherPostretirementBenefitsDisclosureTextBlock_CBF601E4B3A2EA207AB2B238AD30A41B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CompensationAndRetirementDisclosureAbstract_79F77E2D14BA79867EF4B238AD301A5D" xlink:to="loc_us-gaap_PensionAndOtherPostretirementBenefitsDisclosureTextBlock_CBF601E4B3A2EA207AB2B238AD30A41B" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/EmployeeSavingsPlanDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CompensationAndRetirementDisclosureAbstract" xlink:label="loc_us-gaap_CompensationAndRetirementDisclosureAbstract_1CA637C7AC311060F022B238AD285087" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_8110638EC61BF3466AEEB238AD2856F6" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CompensationAndRetirementDisclosureAbstract_1CA637C7AC311060F022B238AD285087" xlink:to="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_8110638EC61BF3466AEEB238AD2856F6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SubsequentEventTypeAxis" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_0AE11A82DA143B08ACB3B238AD28CCFA" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_8110638EC61BF3466AEEB238AD2856F6" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_0AE11A82DA143B08ACB3B238AD28CCFA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SubsequentEventTypeDomain" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_29D1529117250BE680F1B238AD284E90" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_0AE11A82DA143B08ACB3B238AD28CCFA" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_29D1529117250BE680F1B238AD284E90" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems" xlink:label="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_24E57CDD814B8B32358FB238AD28C416" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansDisclosuresTable_8110638EC61BF3466AEEB238AD2856F6" xlink:to="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_24E57CDD814B8B32358FB238AD28C416" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DefinedContributionPlanCostRecognized" xlink:label="loc_us-gaap_DefinedContributionPlanCostRecognized_F7E8103F567F5309648FB238AD29EEED" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_24E57CDD814B8B32358FB238AD28C416" xlink:to="loc_us-gaap_DefinedContributionPlanCostRecognized_F7E8103F567F5309648FB238AD29EEED" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeBenefitPlan" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeBenefitPlan_2DC1E226D5D9782FF272B238AD29CAE1" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DefinedBenefitPlansAndOtherPostretirementBenefitPlansTableTextBlockLineItems_24E57CDD814B8B32358FB238AD28C416" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeBenefitPlan_2DC1E226D5D9782FF272B238AD29CAE1" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/ExecutiveStockPurchasePlanDetails" xlink:type="extended">
    <loc xlink:href="regn-20151231.xsd#regn_ExecutiveStockPurchasePlanAbstract" xlink:label="loc_regn_ExecutiveStockPurchasePlanAbstract_4D2690BCE92765752032B238AD32EFEE" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfEmployeeStockOwnershipPlanESOPDisclosuresTable" xlink:label="loc_us-gaap_ScheduleOfEmployeeStockOwnershipPlanESOPDisclosuresTable_0B25EFEFEBD5A13518B9B238AD32A903" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ExecutiveStockPurchasePlanAbstract_4D2690BCE92765752032B238AD32EFEE" xlink:to="loc_us-gaap_ScheduleOfEmployeeStockOwnershipPlanESOPDisclosuresTable_0B25EFEFEBD5A13518B9B238AD32A903" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EmployeeStockOwnershipPlanESOPDisclosuresByPlanAxis" xlink:label="loc_us-gaap_EmployeeStockOwnershipPlanESOPDisclosuresByPlanAxis_34118593BE13F1DD19D3B238AD37E4A0" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEmployeeStockOwnershipPlanESOPDisclosuresTable_0B25EFEFEBD5A13518B9B238AD32A903" xlink:to="loc_us-gaap_EmployeeStockOwnershipPlanESOPDisclosuresByPlanAxis_34118593BE13F1DD19D3B238AD37E4A0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EmployeeStockOwnershipPlanESOPPlanDomain" xlink:label="loc_us-gaap_EmployeeStockOwnershipPlanESOPPlanDomain_3A7E5B7B309CED7BA663B238AD389A40" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeStockOwnershipPlanESOPDisclosuresByPlanAxis_34118593BE13F1DD19D3B238AD37E4A0" xlink:to="loc_us-gaap_EmployeeStockOwnershipPlanESOPPlanDomain_3A7E5B7B309CED7BA663B238AD389A40" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EmployeeStockOwnershipPlanESOPDisclosuresLineItems" xlink:label="loc_us-gaap_EmployeeStockOwnershipPlanESOPDisclosuresLineItems_99F0FF9F6B43075E4EF3B238AD383F5B" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEmployeeStockOwnershipPlanESOPDisclosuresTable_0B25EFEFEBD5A13518B9B238AD32A903" xlink:to="loc_us-gaap_EmployeeStockOwnershipPlanESOPDisclosuresLineItems_99F0FF9F6B43075E4EF3B238AD383F5B" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/FairValueMeasurements" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_31E6B4FE778A91B0006DB238AF0AF1F2" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueDisclosuresTextBlock" xlink:label="loc_us-gaap_FairValueDisclosuresTextBlock_0A35DC8595355ADE81B6B238AF0ADD7C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_31E6B4FE778A91B0006DB238AF0AF1F2" xlink:to="loc_us-gaap_FairValueDisclosuresTextBlock_0A35DC8595355ADE81B6B238AF0ADD7C" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/FairValueMeasurementsDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_7BA11807D40B600F7ED0B238AEF3D58D" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_89B62E9901EF7C4DB852B238AEF3989E" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_7BA11807D40B600F7ED0B238AEF3D58D" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_89B62E9901EF7C4DB852B238AEF3989E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfWarrantOrRightAxis" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_A72108D66CD97365C6ADB238AEF341A5" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_89B62E9901EF7C4DB852B238AEF3989E" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_A72108D66CD97365C6ADB238AEF341A5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_FEB406D0DDEA6E6E5D2FB238AEF3F64C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_A72108D66CD97365C6ADB238AEF341A5" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_FEB406D0DDEA6E6E5D2FB238AEF3F64C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_WarrantMember" xlink:label="loc_us-gaap_WarrantMember_73791356123531DEC95FB238AEF3E8BA" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_FEB406D0DDEA6E6E5D2FB238AEF3F64C" xlink:to="loc_us-gaap_WarrantMember_73791356123531DEC95FB238AEF3E8BA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueByMeasurementBasisAxis" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_99B8366FE8B37830F6A6B238AEF3B443" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_89B62E9901EF7C4DB852B238AEF3989E" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_99B8366FE8B37830F6A6B238AEF3B443" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueDisclosureItemAmountsDomain" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_F9AAB7834394968761D1B238AEF3D852" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_99B8366FE8B37830F6A6B238AEF3B443" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_F9AAB7834394968761D1B238AEF3D852" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_FB0347D036E2541A571CB238AEF32A53" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_F9AAB7834394968761D1B238AEF3D852" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_FB0347D036E2541A571CB238AEF32A53" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_4FF7478D26E826C44DFCB238AEF3B1E8" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_F9AAB7834394968761D1B238AEF3D852" xlink:to="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_4FF7478D26E826C44DFCB238AEF3B1E8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_60ED39B94CB6FF4000A2B238AEF4E127" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_89B62E9901EF7C4DB852B238AEF3989E" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_60ED39B94CB6FF4000A2B238AEF4E127" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_93EC53483E2167380180B238AEF9899D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_60ED39B94CB6FF4000A2B238AEF4E127" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_93EC53483E2167380180B238AEF9899D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_F2AD390C77331CA549AEB238AEF973F9" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_93EC53483E2167380180B238AEF9899D" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_F2AD390C77331CA549AEB238AEF973F9" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ClassificationOfInvestmentAxis" xlink:label="loc_regn_ClassificationOfInvestmentAxis_8775E332A724392C98F1B238AEF9DEC0" xlink:type="locator" />
    <presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_89B62E9901EF7C4DB852B238AEF3989E" xlink:to="loc_regn_ClassificationOfInvestmentAxis_8775E332A724392C98F1B238AEF9DEC0" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ClassificationOfInvestmentDomain" xlink:label="loc_regn_ClassificationOfInvestmentDomain_D6B45F1D8DD9DCDA8AC0B238AEF99DDB" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ClassificationOfInvestmentAxis_8775E332A724392C98F1B238AEF9DEC0" xlink:to="loc_regn_ClassificationOfInvestmentDomain_D6B45F1D8DD9DCDA8AC0B238AEF99DDB" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_UnrestrictedMember" xlink:label="loc_regn_UnrestrictedMember_96AF1B6619B60689EABAB238AEF9186A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ClassificationOfInvestmentDomain_D6B45F1D8DD9DCDA8AC0B238AEF99DDB" xlink:to="loc_regn_UnrestrictedMember_96AF1B6619B60689EABAB238AEF9186A" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_RestrictedMember" xlink:label="loc_regn_RestrictedMember_FC90FB63921E4255C3DAB238AEF96A5B" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ClassificationOfInvestmentDomain_D6B45F1D8DD9DCDA8AC0B238AEF99DDB" xlink:to="loc_regn_RestrictedMember_FC90FB63921E4255C3DAB238AEF96A5B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_52FF8130D4B7E03CC059B238AEF99243" xlink:type="locator" />
    <presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_89B62E9901EF7C4DB852B238AEF3989E" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_52FF8130D4B7E03CC059B238AEF99243" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_89017DE16F86EBC04B61B238AEF90E65" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_52FF8130D4B7E03CC059B238AEF99243" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_89017DE16F86EBC04B61B238AEF90E65" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_6E4335F006E741D05BAAB238AEF9C0CD" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_89017DE16F86EBC04B61B238AEF90E65" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_6E4335F006E741D05BAAB238AEF9C0CD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_D29455BF30A60772B7D6B238AEF9DEAB" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_89017DE16F86EBC04B61B238AEF90E65" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_D29455BF30A60772B7D6B238AEF9DEAB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueInputsLevel3Member" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_20131DD1A805201C3C6DB238AEFA3763" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_89017DE16F86EBC04B61B238AEF90E65" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_20131DD1A805201C3C6DB238AEFA3763" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_AC90F0BA7FF7BD603782B238AEFA788A" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_89B62E9901EF7C4DB852B238AEF3989E" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_AC90F0BA7FF7BD603782B238AEFA788A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_70DF4C1B1B68EB7C53DAB238AEFAC8F0" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_AC90F0BA7FF7BD603782B238AEFA788A" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_70DF4C1B1B68EB7C53DAB238AEFAC8F0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConvertibleDebtMember" xlink:label="loc_us-gaap_ConvertibleDebtMember_4284B2B53EB529C2DE7BB238AEFAC793" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_70DF4C1B1B68EB7C53DAB238AEFAC8F0" xlink:to="loc_us-gaap_ConvertibleDebtMember_4284B2B53EB529C2DE7BB238AEFAC793" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_C412C376D4A05F922376B238AEFACBE2" xlink:type="locator" />
    <presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_89B62E9901EF7C4DB852B238AEF3989E" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_C412C376D4A05F922376B238AEFACBE2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ImpairmentOfInvestments" xlink:label="loc_us-gaap_ImpairmentOfInvestments_98641362C95622F29272B238AEFAC658" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_C412C376D4A05F922376B238AEFACBE2" xlink:to="loc_us-gaap_ImpairmentOfInvestments_98641362C95622F29272B238AEFAC658" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAbstract" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAbstract_EEADC2EB7F20CDBED842B238AEFAC610" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_C412C376D4A05F922376B238AEFACBE2" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAbstract_EEADC2EB7F20CDBED842B238AEFAC610" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FinancialInstrumentsOwnedCorporateDebtAtFairValue" xlink:label="loc_us-gaap_FinancialInstrumentsOwnedCorporateDebtAtFairValue_2F43BE6241F4070DEE9DB238AEFA674E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_EEADC2EB7F20CDBED842B238AEFAC610" xlink:to="loc_us-gaap_FinancialInstrumentsOwnedCorporateDebtAtFairValue_2F43BE6241F4070DEE9DB238AEFA674E" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_USGovernmentObligationsFairValueDisclosure" xlink:label="loc_regn_USGovernmentObligationsFairValueDisclosure_D2A621C4AF66DE0B1489B238AEFAA8F2" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_EEADC2EB7F20CDBED842B238AEFAC610" xlink:to="loc_regn_USGovernmentObligationsFairValueDisclosure_D2A621C4AF66DE0B1489B238AEFAA8F2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MunicipalDebtSecuritiesAtCarryingValue" xlink:label="loc_us-gaap_MunicipalDebtSecuritiesAtCarryingValue_2B6CB4475D9DC1BCCD11B238AEFAA531" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_EEADC2EB7F20CDBED842B238AEFAC610" xlink:to="loc_us-gaap_MunicipalDebtSecuritiesAtCarryingValue_2B6CB4475D9DC1BCCD11B238AEFAA531" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesEquitySecurities" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesEquitySecurities_F9A62EB35B5D03E14C9FB238AEFA0380" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_EEADC2EB7F20CDBED842B238AEFAC610" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesEquitySecurities_F9A62EB35B5D03E14C9FB238AEFA0380" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecurities_6BE1D1B94AA2DC33B28FB238AEFA748E" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_EEADC2EB7F20CDBED842B238AEFAC610" xlink:to="loc_us-gaap_AvailableForSaleSecurities_6BE1D1B94AA2DC33B28FB238AEFA748E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MarketableSecuritiesUnrealizedGainLoss" xlink:label="loc_us-gaap_MarketableSecuritiesUnrealizedGainLoss_111AC1B3641C671611C8B238AEFA34F2" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_C412C376D4A05F922376B238AEFACBE2" xlink:to="loc_us-gaap_MarketableSecuritiesUnrealizedGainLoss_111AC1B3641C671611C8B238AEFA34F2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueAssetsLevel2ToLevel1TransfersAmount" xlink:label="loc_us-gaap_FairValueAssetsLevel2ToLevel1TransfersAmount_4460BBD42D7AA388AA03B238AEFA7870" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_C412C376D4A05F922376B238AEFACBE2" xlink:to="loc_us-gaap_FairValueAssetsLevel2ToLevel1TransfersAmount_4460BBD42D7AA388AA03B238AEFA7870" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongtermConvertibleDebtCurrentAndNoncurrentAbstract" xlink:label="loc_us-gaap_LongtermConvertibleDebtCurrentAndNoncurrentAbstract_64889587FDA70F15BDBAB238AEFA58AF" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_C412C376D4A05F922376B238AEFACBE2" xlink:to="loc_us-gaap_LongtermConvertibleDebtCurrentAndNoncurrentAbstract_64889587FDA70F15BDBAB238AEFA58AF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConvertibleDebtNoncurrent" xlink:label="loc_us-gaap_ConvertibleDebtNoncurrent_78E27ABFC2D6192D1D54B238AEFA0418" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermConvertibleDebtCurrentAndNoncurrentAbstract_64889587FDA70F15BDBAB238AEFA58AF" xlink:to="loc_us-gaap_ConvertibleDebtNoncurrent_78E27ABFC2D6192D1D54B238AEFA0418" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_4E346666BF34F4F9778CB238AEFA4135" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermConvertibleDebtCurrentAndNoncurrentAbstract_64889587FDA70F15BDBAB238AEFA58AF" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_4E346666BF34F4F9778CB238AEFA4135" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConvertibleDebtFairValueDisclosures" xlink:label="loc_us-gaap_ConvertibleDebtFairValueDisclosures_1669CAF7450752F23CEAB238AEFAF666" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermConvertibleDebtCurrentAndNoncurrentAbstract_64889587FDA70F15BDBAB238AEFA58AF" xlink:to="loc_us-gaap_ConvertibleDebtFairValueDisclosures_1669CAF7450752F23CEAB238AEFAF666" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_us-gaap_LiabilitiesCurrent_CDB2E4E47CBDFDF15F43B238AEFB26DC" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_C412C376D4A05F922376B238AEFACBE2" xlink:to="loc_us-gaap_LiabilitiesCurrent_CDB2E4E47CBDFDF15F43B238AEFB26DC" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/FairValueMeasurementsTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_1AD0F841F265E9607ADEB238AF0231E6" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringAndNonrecurringBasisTableTextBlock" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringAndNonrecurringBasisTableTextBlock_58145D28B211AE3D0091B238AF02AAC9" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_1AD0F841F265E9607ADEB238AF0231E6" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringAndNonrecurringBasisTableTextBlock_58145D28B211AE3D0091B238AF02AAC9" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/IncomeTaxes" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_4F44CB41AB9A1BBD25F0B238AD1BBDF8" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxDisclosureTextBlock" xlink:label="loc_us-gaap_IncomeTaxDisclosureTextBlock_996B4B25A869ED1021B2B238AD1BC42C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_4F44CB41AB9A1BBD25F0B238AD1BBDF8" xlink:to="loc_us-gaap_IncomeTaxDisclosureTextBlock_996B4B25A869ED1021B2B238AD1BC42C" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/IncomeTaxesDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_72D70E0D0C54322992FCC6D05CAFB85A" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingLossCarryforwardsTable" xlink:label="loc_us-gaap_OperatingLossCarryforwardsTable_17177DB4AD93D25D39B1C6D05CAFDCC1" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_72D70E0D0C54322992FCC6D05CAFB85A" xlink:to="loc_us-gaap_OperatingLossCarryforwardsTable_17177DB4AD93D25D39B1C6D05CAFDCC1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityByLocationAxis" xlink:label="loc_dei_EntityByLocationAxis_BCF682ACF0374CB79697C6D05CAF7487" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_17177DB4AD93D25D39B1C6D05CAFDCC1" xlink:to="loc_dei_EntityByLocationAxis_BCF682ACF0374CB79697C6D05CAF7487" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_LocationDomain" xlink:label="loc_dei_LocationDomain_EDE099A2ED296BE565BEC6D05CAF6E03" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityByLocationAxis_BCF682ACF0374CB79697C6D05CAF7487" xlink:to="loc_dei_LocationDomain_EDE099A2ED296BE565BEC6D05CAF6E03" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd#country_US" xlink:label="loc_country_US_C7B7A95A219BAE0B7F4EC6D05CAFE2DA" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LocationDomain_EDE099A2ED296BE565BEC6D05CAF6E03" xlink:to="loc_country_US_C7B7A95A219BAE0B7F4EC6D05CAFE2DA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GeographicDistributionForeignMember" xlink:label="loc_us-gaap_GeographicDistributionForeignMember_AE7E52ACC43BDF4AD9CBC6D05CAF0567" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LocationDomain_EDE099A2ED296BE565BEC6D05CAF6E03" xlink:to="loc_us-gaap_GeographicDistributionForeignMember_AE7E52ACC43BDF4AD9CBC6D05CAF0567" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingLossCarryforwardsLineItems" xlink:label="loc_us-gaap_OperatingLossCarryforwardsLineItems_BEFED242F0DC4C8B7420C6D05CAF6704" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_17177DB4AD93D25D39B1C6D05CAFDCC1" xlink:to="loc_us-gaap_OperatingLossCarryforwardsLineItems_BEFED242F0DC4C8B7420C6D05CAF6704" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_0E82AEDDD819852486B3C6D05CAF1B71" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_BEFED242F0DC4C8B7420C6D05CAF6704" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_0E82AEDDD819852486B3C6D05CAF1B71" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ComponentsOfIncomeTaxExpenseBenefitContinuingOperationsAbstract" xlink:label="loc_us-gaap_ComponentsOfIncomeTaxExpenseBenefitContinuingOperationsAbstract_CF56AB6862E9F36D18A1C6D05CAFE0C3" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_BEFED242F0DC4C8B7420C6D05CAF6704" xlink:to="loc_us-gaap_ComponentsOfIncomeTaxExpenseBenefitContinuingOperationsAbstract_CF56AB6862E9F36D18A1C6D05CAFE0C3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_A442C12F19A587F29BE7C6D05CAFB03D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfIncomeTaxExpenseBenefitContinuingOperationsAbstract_CF56AB6862E9F36D18A1C6D05CAFE0C3" xlink:to="loc_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_A442C12F19A587F29BE7C6D05CAFB03D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CurrentFederalTaxExpenseBenefit" xlink:label="loc_us-gaap_CurrentFederalTaxExpenseBenefit_D6E8D7F01142710048DCC6D05CB02595" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_A442C12F19A587F29BE7C6D05CAFB03D" xlink:to="loc_us-gaap_CurrentFederalTaxExpenseBenefit_D6E8D7F01142710048DCC6D05CB02595" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CurrentStateAndLocalTaxExpenseBenefit" xlink:label="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_323FA5EB1E71CFD39E16C6D05CB0860C" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_A442C12F19A587F29BE7C6D05CAFB03D" xlink:to="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_323FA5EB1E71CFD39E16C6D05CB0860C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CurrentForeignTaxExpenseBenefit" xlink:label="loc_us-gaap_CurrentForeignTaxExpenseBenefit_315094E822D5D9AE0FA4C6D05CB0E71C" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_A442C12F19A587F29BE7C6D05CAFB03D" xlink:to="loc_us-gaap_CurrentForeignTaxExpenseBenefit_315094E822D5D9AE0FA4C6D05CB0E71C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_77E0E1DADC161907AEB0C6D05CB0D584" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_A442C12F19A587F29BE7C6D05CAFB03D" xlink:to="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_77E0E1DADC161907AEB0C6D05CB0D584" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract_A6B1856A3C28B8386C7BC6D05CB093B5" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfIncomeTaxExpenseBenefitContinuingOperationsAbstract_CF56AB6862E9F36D18A1C6D05CAFE0C3" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract_A6B1856A3C28B8386C7BC6D05CB093B5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredFederalIncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_9B693F351212D51AFA2FC6D05CB022AA" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract_A6B1856A3C28B8386C7BC6D05CB093B5" xlink:to="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_9B693F351212D51AFA2FC6D05CB022AA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_C24FBB9FF4983FBA3D4BC6D05CB0A9AC" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract_A6B1856A3C28B8386C7BC6D05CB093B5" xlink:to="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_C24FBB9FF4983FBA3D4BC6D05CB0A9AC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredForeignIncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_1EAE1920A93EBF163AC8C6D05CB135BE" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract_A6B1856A3C28B8386C7BC6D05CB093B5" xlink:to="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_1EAE1920A93EBF163AC8C6D05CB135BE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_4361739AF66C725767DAC6D05CB138BA" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract_A6B1856A3C28B8386C7BC6D05CB093B5" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_4361739AF66C725767DAC6D05CB138BA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_3D37EAF77BAAC7549497C6D05CB13A82" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfIncomeTaxExpenseBenefitContinuingOperationsAbstract_CF56AB6862E9F36D18A1C6D05CAFE0C3" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_3D37EAF77BAAC7549497C6D05CB13A82" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_8387440E937080507BACC6D05CB17240" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_BEFED242F0DC4C8B7420C6D05CAF6704" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_8387440E937080507BACC6D05CB17240" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_88DB95601B2D65D04BA8C6D05CB15F34" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_8387440E937080507BACC6D05CB17240" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_88DB95601B2D65D04BA8C6D05CB15F34" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_E18644916DE1BB16467CC6D05CB1EEC2" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_8387440E937080507BACC6D05CB17240" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_E18644916DE1BB16467CC6D05CB1EEC2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationChangeInEnactedTaxRate" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInEnactedTaxRate_21A489E4B8C781CAE35FC6D05CB1C4E6" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_8387440E937080507BACC6D05CB17240" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInEnactedTaxRate_21A489E4B8C781CAE35FC6D05CB1C4E6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_28B3DF8C22B3D7799FB7C6D05CB10A0F" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_8387440E937080507BACC6D05CB17240" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_28B3DF8C22B3D7799FB7C6D05CB10A0F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationTaxCredits" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCredits_453964CE9072DACDCAFFC6D05CB1A3D7" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_8387440E937080507BACC6D05CB17240" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCredits_453964CE9072DACDCAFFC6D05CB1A3D7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationDeductionsMedicarePrescriptionDrugBenefit" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationDeductionsMedicarePrescriptionDrugBenefit_B6D7C4D0F7A2F2E5473FC6D05CB18670" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_8387440E937080507BACC6D05CB17240" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationDeductionsMedicarePrescriptionDrugBenefit_B6D7C4D0F7A2F2E5473FC6D05CB18670" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationDeductionsQualifiedProductionActivities" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationDeductionsQualifiedProductionActivities_AC3FFDEF4E47CD895037C6D05CB106EC" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_8387440E937080507BACC6D05CB17240" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationDeductionsQualifiedProductionActivities_AC3FFDEF4E47CD895037C6D05CB106EC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther_01853FE2108CD860BA22C6D05CB1CAD0" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_8387440E937080507BACC6D05CB17240" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther_01853FE2108CD860BA22C6D05CB1CAD0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_6FEE4936D43018E36386C6D05CB18780" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperationsTaxRateReconciliationAbstract_8387440E937080507BACC6D05CB17240" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_6FEE4936D43018E36386C6D05CB18780" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ComponentsOfDeferredTaxAssetsAndLiabilitiesAbstract" xlink:label="loc_us-gaap_ComponentsOfDeferredTaxAssetsAndLiabilitiesAbstract_BB1B9B610445E239F27BC6D05CB1201E" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_BEFED242F0DC4C8B7420C6D05CAF6704" xlink:to="loc_us-gaap_ComponentsOfDeferredTaxAssetsAndLiabilitiesAbstract_BB1B9B610445E239F27BC6D05CB1201E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ComponentsOfDeferredTaxAssetsAbstract" xlink:label="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_423001A083E8FBD75537C6D05CB1516C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAndLiabilitiesAbstract_BB1B9B610445E239F27BC6D05CB1201E" xlink:to="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_423001A083E8FBD75537C6D05CB1516C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwards" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_C5809ABD612CFEE342C7C6D05CB171DD" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_423001A083E8FBD75537C6D05CB1516C" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_C5809ABD612CFEE342C7C6D05CB171DD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsPropertyPlantAndEquipment" xlink:label="loc_us-gaap_DeferredTaxAssetsPropertyPlantAndEquipment_F4B7D0F3E48AB62C18B4C6D05CB17027" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_423001A083E8FBD75537C6D05CB1516C" xlink:to="loc_us-gaap_DeferredTaxAssetsPropertyPlantAndEquipment_F4B7D0F3E48AB62C18B4C6D05CB17027" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsDeferredIncome" xlink:label="loc_us-gaap_DeferredTaxAssetsDeferredIncome_6DC12DFF6C0D420F8AD4C6D05CB15B92" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_423001A083E8FBD75537C6D05CB1516C" xlink:to="loc_us-gaap_DeferredTaxAssetsDeferredIncome_6DC12DFF6C0D420F8AD4C6D05CB15B92" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefits" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefits_3694B75B37AE01B218E8C6D05CB29254" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_423001A083E8FBD75537C6D05CB1516C" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefits_3694B75B37AE01B218E8C6D05CB29254" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsTaxCreditCarryforwards" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards_E0468260B44D761A09E1C6D05CB2D600" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_423001A083E8FBD75537C6D05CB1516C" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards_E0468260B44D761A09E1C6D05CB2D600" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_DeferredTaxAssetsDeferredExpenseCapitalizedResearchAndDevelopmentCosts" xlink:label="loc_regn_DeferredTaxAssetsDeferredExpenseCapitalizedResearchAndDevelopmentCosts_0572D0B39FE9458A59BEC6D05CB2FB94" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_423001A083E8FBD75537C6D05CB1516C" xlink:to="loc_regn_DeferredTaxAssetsDeferredExpenseCapitalizedResearchAndDevelopmentCosts_0572D0B39FE9458A59BEC6D05CB2FB94" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities_24B5F71551871B325273C6D05CB209C6" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_423001A083E8FBD75537C6D05CB1516C" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities_24B5F71551871B325273C6D05CB209C6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsOther" xlink:label="loc_us-gaap_DeferredTaxAssetsOther_4DF039C8475A9504BF83C6D05CB2A994" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_423001A083E8FBD75537C6D05CB1516C" xlink:to="loc_us-gaap_DeferredTaxAssetsOther_4DF039C8475A9504BF83C6D05CB2A994" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsGross" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_A4C459FE41EC90027A56C6D05CB2EF48" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_423001A083E8FBD75537C6D05CB1516C" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_A4C459FE41EC90027A56C6D05CB2EF48" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsValuationAllowance" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_811BA2662B7A51795C02C6D05CB221DB" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAndLiabilitiesAbstract_BB1B9B610445E239F27BC6D05CB1201E" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_811BA2662B7A51795C02C6D05CB221DB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsNet" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_2140CC40A914307F217AC6D05CB215CF" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAndLiabilitiesAbstract_BB1B9B610445E239F27BC6D05CB1201E" xlink:to="loc_us-gaap_DeferredTaxAssetsNet_2140CC40A914307F217AC6D05CB215CF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ComponentsOfDeferredTaxLiabilitiesAbstract" xlink:label="loc_us-gaap_ComponentsOfDeferredTaxLiabilitiesAbstract_29AD4E71E3911A5DC126C6D05CB2F2E9" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAndLiabilitiesAbstract_BB1B9B610445E239F27BC6D05CB1201E" xlink:to="loc_us-gaap_ComponentsOfDeferredTaxLiabilitiesAbstract_29AD4E71E3911A5DC126C6D05CB2F2E9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxLiabilitiesDeferredExpenseReservesAndAccruals" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesDeferredExpenseReservesAndAccruals_26F97B72857A96B46156C6D05CB20BF5" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxLiabilitiesAbstract_29AD4E71E3911A5DC126C6D05CB2F2E9" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesDeferredExpenseReservesAndAccruals_26F97B72857A96B46156C6D05CB20BF5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_95B49E2CD1951369E952C6D05CB2EF6C" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxLiabilitiesAbstract_29AD4E71E3911A5DC126C6D05CB2F2E9" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_95B49E2CD1951369E952C6D05CB2EF6C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxLiabilitiesFinancingArrangements" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesFinancingArrangements_AFEA107D25BA17F253D3C6D05CB28B9A" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxLiabilitiesAbstract_29AD4E71E3911A5DC126C6D05CB2F2E9" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesFinancingArrangements_AFEA107D25BA17F253D3C6D05CB28B9A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxLiabilitiesOther" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesOther_B873873B4E2EABDB396AC6D05CB2C92F" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxLiabilitiesAbstract_29AD4E71E3911A5DC126C6D05CB2F2E9" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesOther_B873873B4E2EABDB396AC6D05CB2C92F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_2B5BF44CD242B593B735C6D05CB25ECA" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxLiabilitiesAbstract_29AD4E71E3911A5DC126C6D05CB2F2E9" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilities_2B5BF44CD242B593B735C6D05CB25ECA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNet" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_CB4A6371725A55BBBFC7C6D05CB2FC78" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAndLiabilitiesAbstract_BB1B9B610445E239F27BC6D05CB1201E" xlink:to="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_CB4A6371725A55BBBFC7C6D05CB2FC78" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AdjustmentToAdditionalPaidInCapitalIncomeTaxEffectFromShareBasedCompensationNet" xlink:label="loc_us-gaap_AdjustmentToAdditionalPaidInCapitalIncomeTaxEffectFromShareBasedCompensationNet_B6AB5147B4C2E19C0A6CC6D05CB2F2D0" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_BEFED242F0DC4C8B7420C6D05CAF6704" xlink:to="loc_us-gaap_AdjustmentToAdditionalPaidInCapitalIncomeTaxEffectFromShareBasedCompensationNet_B6AB5147B4C2E19C0A6CC6D05CB2F2D0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxReconciliationTaxCreditsResearch" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxCreditsResearch_E5A7745117E5BFCA1D13C6D05CB25169" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_BEFED242F0DC4C8B7420C6D05CAF6704" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxCreditsResearch_E5A7745117E5BFCA1D13C6D05CB25169" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate_97BA51D7B9A337B54C5DC6D05CB27498" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_BEFED242F0DC4C8B7420C6D05CAF6704" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate_97BA51D7B9A337B54C5DC6D05CB27498" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossTax_16172E80CA7B67A68A7AC6D05CB22658" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_BEFED242F0DC4C8B7420C6D05CAF6704" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossTax_16172E80CA7B67A68A7AC6D05CB22658" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward" xlink:label="loc_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward_3F3FC40E6E9ADE87ADE5C6D05CB2C4E0" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_BEFED242F0DC4C8B7420C6D05CAF6704" xlink:to="loc_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward_3F3FC40E6E9ADE87ADE5C6D05CB2C4E0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnrecognizedTaxBenefits" xlink:label="loc_us-gaap_UnrecognizedTaxBenefits_7BFF8320146E7B7D5F77C6D05CB3F079" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward_3F3FC40E6E9ADE87ADE5C6D05CB2C4E0" xlink:to="loc_us-gaap_UnrecognizedTaxBenefits_7BFF8320146E7B7D5F77C6D05CB3F079" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions_252FBC027CB5588EA1A9C6D05CB32C7A" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward_3F3FC40E6E9ADE87ADE5C6D05CB2C4E0" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions_252FBC027CB5588EA1A9C6D05CB32C7A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsPeriodIncreaseDecrease" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsPeriodIncreaseDecrease_6336EE20B61AF78C061AC6D05CB3F47F" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward_3F3FC40E6E9ADE87ADE5C6D05CB2C4E0" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsPeriodIncreaseDecrease_6336EE20B61AF78C061AC6D05CB3F47F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromSettlementsWithTaxingAuthorities" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromSettlementsWithTaxingAuthorities_25156C210E62AC5AC764C6D05CB33239" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward_3F3FC40E6E9ADE87ADE5C6D05CB2C4E0" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromSettlementsWithTaxingAuthorities_25156C210E62AC5AC764C6D05CB33239" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnrecognizedTaxBenefits" xlink:label="loc_us-gaap_UnrecognizedTaxBenefits_4CECD16A0118A838CA31C6D05CB3883D" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward_3F3FC40E6E9ADE87ADE5C6D05CB2C4E0" xlink:to="loc_us-gaap_UnrecognizedTaxBenefits_4CECD16A0118A838CA31C6D05CB3883D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsInterestOnIncomeTaxesAccrued" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsInterestOnIncomeTaxesAccrued_78EB4965F06D56725BD4C6D05CB32692" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_BEFED242F0DC4C8B7420C6D05CAF6704" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsInterestOnIncomeTaxesAccrued_78EB4965F06D56725BD4C6D05CB32692" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/IncomeTaxesTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_E43E794621DAC53E65D4B238AD184CAC" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfIncomeBeforeIncomeTaxDomesticAndForeignTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfIncomeBeforeIncomeTaxDomesticAndForeignTableTextBlock_A03238AF9F5922BD55C9B238AD18F4B6" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_E43E794621DAC53E65D4B238AD184CAC" xlink:to="loc_us-gaap_ScheduleOfIncomeBeforeIncomeTaxDomesticAndForeignTableTextBlock_A03238AF9F5922BD55C9B238AD18F4B6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock_A31E86BC3F8C4D2437CBB238AD182411" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_E43E794621DAC53E65D4B238AD184CAC" xlink:to="loc_us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock_A31E86BC3F8C4D2437CBB238AD182411" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock_990C19E1FCDBDABC8277B238AD1881A9" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_E43E794621DAC53E65D4B238AD184CAC" xlink:to="loc_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock_990C19E1FCDBDABC8277B238AD1881A9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock_0B966E5BC5216AD2E095B238AD18C479" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_E43E794621DAC53E65D4B238AD184CAC" xlink:to="loc_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock_0B966E5BC5216AD2E095B238AD18C479" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfUnrecognizedTaxBenefitsRollForwardTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfUnrecognizedTaxBenefitsRollForwardTableTextBlock_EE12D9885F915DFC9360B238AD18537A" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_E43E794621DAC53E65D4B238AD184CAC" xlink:to="loc_us-gaap_ScheduleOfUnrecognizedTaxBenefitsRollForwardTableTextBlock_EE12D9885F915DFC9360B238AD18537A" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/Inventory" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryDisclosureAbstract" xlink:label="loc_us-gaap_InventoryDisclosureAbstract_0CAB3428BD1A7FB6A223B238AEDC1EC1" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryDisclosureTextBlock" xlink:label="loc_us-gaap_InventoryDisclosureTextBlock_7D105A459F97E5A505CDB238AEDC3B38" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_0CAB3428BD1A7FB6A223B238AEDC1EC1" xlink:to="loc_us-gaap_InventoryDisclosureTextBlock_7D105A459F97E5A505CDB238AEDC3B38" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/InventoryDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryDisclosureAbstract" xlink:label="loc_us-gaap_InventoryDisclosureAbstract_EBC098831540FEBB3C97B238AECD1A5B" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryRawMaterialsNetOfReserves" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_1F6C5507AB391544639FB238AECD0C75" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_EBC098831540FEBB3C97B238AECD1A5B" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_1F6C5507AB391544639FB238AECD0C75" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryWorkInProcessNetOfReserves" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_96C9EB1FFF4F18AD0FFFB238AECD8D3C" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_EBC098831540FEBB3C97B238AECD1A5B" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_96C9EB1FFF4F18AD0FFFB238AECD8D3C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_23F8A6ACB39A8B8B7931B238AECDE30F" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_EBC098831540FEBB3C97B238AECD1A5B" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_23F8A6ACB39A8B8B7931B238AECDE30F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherInventoryNetOfReserves" xlink:label="loc_us-gaap_OtherInventoryNetOfReserves_CEA28B4CFBF72C6F8309B238AECD4DAF" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_EBC098831540FEBB3C97B238AECD1A5B" xlink:to="loc_us-gaap_OtherInventoryNetOfReserves_CEA28B4CFBF72C6F8309B238AECD4DAF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_8B37FC01C8BFB76240B3B238AECDA320" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_EBC098831540FEBB3C97B238AECD1A5B" xlink:to="loc_us-gaap_InventoryNet_8B37FC01C8BFB76240B3B238AECDA320" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryWriteDown" xlink:label="loc_us-gaap_InventoryWriteDown_329E1778768AA2B5444BB238AECD981B" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_EBC098831540FEBB3C97B238AECD1A5B" xlink:to="loc_us-gaap_InventoryWriteDown_329E1778768AA2B5444BB238AECD981B" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/InventoryTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InventoryDisclosureAbstract" xlink:label="loc_us-gaap_InventoryDisclosureAbstract_EEFFD9BF0FF7D1C3D9FEB238AED5168D" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfInventoryCurrentTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfInventoryCurrentTableTextBlock_752D664216E4DD9E59C9B238AED550F0" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_EEFFD9BF0FF7D1C3D9FEB238AED5168D" xlink:to="loc_us-gaap_ScheduleOfInventoryCurrentTableTextBlock_752D664216E4DD9E59C9B238AED550F0" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/LegalMatters" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_00FFBE2D288D0096647CB238ACD56701" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LegalMattersAndContingenciesTextBlock" xlink:label="loc_us-gaap_LegalMattersAndContingenciesTextBlock_EFB59255794956DBD76FB238ACD59C8F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_00FFBE2D288D0096647CB238ACD56701" xlink:to="loc_us-gaap_LegalMattersAndContingenciesTextBlock_EFB59255794956DBD76FB238ACD59C8F" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/LongTermIncentivePlans" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_1B0578EC90EA303570D0B238AD9B3242" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_7D2996ACB6DFC164BBE0B238AD9B6C66" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_1B0578EC90EA303570D0B238AD9B3242" xlink:to="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_7D2996ACB6DFC164BBE0B238AD9B6C66" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/LongTermIncentivePlansDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_1810DB8688D2054BEEC7C1B571F18872" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_663742B9075529CA0CE6C1B571F1D8B5" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_1810DB8688D2054BEEC7C1B571F18872" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_663742B9075529CA0CE6C1B571F1D8B5" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductAxis" xlink:label="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductAxis_21EB5931518F4ECB5EE3C1B571F2041E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_663742B9075529CA0CE6C1B571F1D8B5" xlink:to="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductAxis_21EB5931518F4ECB5EE3C1B571F2041E" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain" xlink:label="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_535FC34FB1F81AFD7354C1B571F25997" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductAxis_21EB5931518F4ECB5EE3C1B571F2041E" xlink:to="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_535FC34FB1F81AFD7354C1B571F25997" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_AntibodyCollaborationMember" xlink:label="loc_regn_AntibodyCollaborationMember_9ADEBE83A7EFEBA03C59C1B571F266A9" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_535FC34FB1F81AFD7354C1B571F25997" xlink:to="loc_regn_AntibodyCollaborationMember_9ADEBE83A7EFEBA03C59C1B571F266A9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_5EBD89CE62B83C2598A6C1B571F219A1" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_663742B9075529CA0CE6C1B571F1D8B5" xlink:to="loc_us-gaap_StatementScenarioAxis_5EBD89CE62B83C2598A6C1B571F219A1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_DD32C81B0F0CC9E0C2A9C1B571F2C170" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementScenarioAxis_5EBD89CE62B83C2598A6C1B571F219A1" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_DD32C81B0F0CC9E0C2A9C1B571F2C170" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScenarioPreviouslyReportedMember" xlink:label="loc_us-gaap_ScenarioPreviouslyReportedMember_77A0908E1D49A048AC66C1B571F2AA3F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScenarioUnspecifiedDomain_DD32C81B0F0CC9E0C2A9C1B571F2C170" xlink:to="loc_us-gaap_ScenarioPreviouslyReportedMember_77A0908E1D49A048AC66C1B571F2AA3F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScenarioForecastMember" xlink:label="loc_us-gaap_ScenarioForecastMember_8C19765629172FE68681C1B571F272E3" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScenarioUnspecifiedDomain_DD32C81B0F0CC9E0C2A9C1B571F2C170" xlink:to="loc_us-gaap_ScenarioForecastMember_8C19765629172FE68681C1B571F272E3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RestatementAdjustmentMember" xlink:label="loc_us-gaap_RestatementAdjustmentMember_E2315891F5B7A5D97112C1B571F20D99" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScenarioUnspecifiedDomain_DD32C81B0F0CC9E0C2A9C1B571F2C170" xlink:to="loc_us-gaap_RestatementAdjustmentMember_E2315891F5B7A5D97112C1B571F20D99" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScenarioActualMember" xlink:label="loc_us-gaap_ScenarioActualMember_9DB77E84DEDCA1BDF38DC1B571F28835" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScenarioUnspecifiedDomain_DD32C81B0F0CC9E0C2A9C1B571F2C170" xlink:to="loc_us-gaap_ScenarioActualMember_9DB77E84DEDCA1BDF38DC1B571F28835" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_3CB289CC7426FE285DCAC1B571F39F77" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_663742B9075529CA0CE6C1B571F1D8B5" xlink:to="loc_us-gaap_StatementClassOfStockAxis_3CB289CC7426FE285DCAC1B571F39F77" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_E7560E2D58420B269BF1C1B571F3DFE0" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_3CB289CC7426FE285DCAC1B571F39F77" xlink:to="loc_us-gaap_ClassOfStockDomain_E7560E2D58420B269BF1C1B571F3DFE0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_F71942E44D8892BB76E0C1B571F3DE16" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_E7560E2D58420B269BF1C1B571F3DFE0" xlink:to="loc_us-gaap_CommonStockMember_F71942E44D8892BB76E0C1B571F3DE16" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PlanNameAxis" xlink:label="loc_us-gaap_PlanNameAxis_A0C2794E2665A46F72A4C1B571F3C318" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_663742B9075529CA0CE6C1B571F1D8B5" xlink:to="loc_us-gaap_PlanNameAxis_A0C2794E2665A46F72A4C1B571F3C318" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PlanNameDomain" xlink:label="loc_us-gaap_PlanNameDomain_B71E1F3F9EBAFFF1CBD3C1B571F397CE" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameAxis_A0C2794E2665A46F72A4C1B571F3C318" xlink:to="loc_us-gaap_PlanNameDomain_B71E1F3F9EBAFFF1CBD3C1B571F397CE" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_LongTermIncentivePlan2014Member" xlink:label="loc_regn_LongTermIncentivePlan2014Member_D2839ED510097C1AE6D9C1B571F3BD8D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_B71E1F3F9EBAFFF1CBD3C1B571F397CE" xlink:to="loc_regn_LongTermIncentivePlan2014Member_D2839ED510097C1AE6D9C1B571F3BD8D" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_LongTermIncentivePlan2000Member" xlink:label="loc_regn_LongTermIncentivePlan2000Member_BDC9434149510A832828C1B571F3E198" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_B71E1F3F9EBAFFF1CBD3C1B571F397CE" xlink:to="loc_regn_LongTermIncentivePlan2000Member_BDC9434149510A832828C1B571F3E198" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_DC3433CEA3074846FEA8C1B571F364D6" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_663742B9075529CA0CE6C1B571F1D8B5" xlink:to="loc_us-gaap_AwardTypeAxis_DC3433CEA3074846FEA8C1B571F364D6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_294FE3AF6ABDCAF5ACEEC1B571F31DCB" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_DC3433CEA3074846FEA8C1B571F364D6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_294FE3AF6ABDCAF5ACEEC1B571F31DCB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EmployeeStockOptionMember" xlink:label="loc_us-gaap_EmployeeStockOptionMember_636C4A73CC609B152394C1B571F36E7C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_294FE3AF6ABDCAF5ACEEC1B571F31DCB" xlink:to="loc_us-gaap_EmployeeStockOptionMember_636C4A73CC609B152394C1B571F36E7C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PhantomShareUnitsPSUsMember" xlink:label="loc_us-gaap_PhantomShareUnitsPSUsMember_BF51EFE9345A54A37312C1B571F37855" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_294FE3AF6ABDCAF5ACEEC1B571F31DCB" xlink:to="loc_us-gaap_PhantomShareUnitsPSUsMember_BF51EFE9345A54A37312C1B571F37855" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_NonPerformanceBasedStockOptionsMember" xlink:label="loc_regn_NonPerformanceBasedStockOptionsMember_03C807E32C3F9399C5A0C1B571F4DE2C" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_294FE3AF6ABDCAF5ACEEC1B571F31DCB" xlink:to="loc_regn_NonPerformanceBasedStockOptionsMember_03C807E32C3F9399C5A0C1B571F4DE2C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PerformanceSharesMember" xlink:label="loc_us-gaap_PerformanceSharesMember_1C525431A330403EAE9FC1B571F41A15" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_294FE3AF6ABDCAF5ACEEC1B571F31DCB" xlink:to="loc_us-gaap_PerformanceSharesMember_1C525431A330403EAE9FC1B571F41A15" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RestrictedStockMember" xlink:label="loc_us-gaap_RestrictedStockMember_19910B458A987B3708D0C1B571F4F50B" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_294FE3AF6ABDCAF5ACEEC1B571F31DCB" xlink:to="loc_us-gaap_RestrictedStockMember_19910B458A987B3708D0C1B571F4F50B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeAxis" xlink:label="loc_us-gaap_RangeAxis_2DA7F577B15BBD214918C1B571F411D7" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_663742B9075529CA0CE6C1B571F1D8B5" xlink:to="loc_us-gaap_RangeAxis_2DA7F577B15BBD214918C1B571F411D7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RangeMember" xlink:label="loc_us-gaap_RangeMember_6EB7F095DD66BA70D984C1B571F487EC" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeAxis_2DA7F577B15BBD214918C1B571F411D7" xlink:to="loc_us-gaap_RangeMember_6EB7F095DD66BA70D984C1B571F487EC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MinimumMember" xlink:label="loc_us-gaap_MinimumMember_FF76BE82ED044BE2FA41C1B571F42A17" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_6EB7F095DD66BA70D984C1B571F487EC" xlink:to="loc_us-gaap_MinimumMember_FF76BE82ED044BE2FA41C1B571F42A17" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MaximumMember" xlink:label="loc_us-gaap_MaximumMember_449AF1098B4B239B69D0C1B571F4A9E7" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RangeMember_6EB7F095DD66BA70D984C1B571F487EC" xlink:to="loc_us-gaap_MaximumMember_449AF1098B4B239B69D0C1B571F4A9E7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_663742B9075529CA0CE6C1B571F1D8B5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_CDC9A6025B834C81A12FC1B571F480C8" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_us-gaap_ShareBasedCompensation_CDC9A6025B834C81A12FC1B571F480C8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_07F6790040D5513441BDC1B571F4B175" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_07F6790040D5513441BDC1B571F4B175" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNetNoncurrent" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNetNoncurrent_FCF6A911B1731AFD5961C1B571F43332" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_us-gaap_DeferredTaxAssetsLiabilitiesNetNoncurrent_FCF6A911B1731AFD5961C1B571F43332" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_22903EAC6559BC326479C1B571F4AF11" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_22903EAC6559BC326479C1B571F4AF11" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_D6D1A68EAEAE28AC3980C1B571F5DB7F" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_D6D1A68EAEAE28AC3980C1B571F5DB7F" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ShareBasedCompensationArrangementByShareBasedPaymentAwardExpiration" xlink:label="loc_regn_ShareBasedCompensationArrangementByShareBasedPaymentAwardExpiration_6F0B31F8E462CFDA9075C1B571F506E2" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_regn_ShareBasedCompensationArrangementByShareBasedPaymentAwardExpiration_6F0B31F8E462CFDA9075C1B571F506E2" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ShareBasedCompensationArrangementByShareBasedPaymentAwardPeriodFromVestingDateAwardsMayBeReceived" xlink:label="loc_regn_ShareBasedCompensationArrangementByShareBasedPaymentAwardPeriodFromVestingDateAwardsMayBeReceived_3120C658612024CC88B3C1B571F53147" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_regn_ShareBasedCompensationArrangementByShareBasedPaymentAwardPeriodFromVestingDateAwardsMayBeReceived_3120C658612024CC88B3C1B571F53147" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_9CD5382437CE1F713707C1B571F5DEDE" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_9CD5382437CE1F713707C1B571F5DEDE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_DED3B764929EFD32A45DC1B571F55FC5" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_DED3B764929EFD32A45DC1B571F55FC5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_543D7785D2059FEF0A40C1B571F5B91A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_DED3B764929EFD32A45DC1B571F55FC5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_543D7785D2059FEF0A40C1B571F5B91A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod_F4596CFF0ED63A21B51DC1B571F5A693" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_DED3B764929EFD32A45DC1B571F55FC5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod_F4596CFF0ED63A21B51DC1B571F5A693" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_CC5946AF96555FC6CF83C1B571F5C0F7" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_DED3B764929EFD32A45DC1B571F55FC5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_CC5946AF96555FC6CF83C1B571F5C0F7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod_3E8E47439138EE581605C1B571F57838" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_DED3B764929EFD32A45DC1B571F55FC5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod_3E8E47439138EE581605C1B571F57838" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_3F68E3C42C56FA4DFC21C1B571F590FF" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_DED3B764929EFD32A45DC1B571F55FC5" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_3F68E3C42C56FA4DFC21C1B571F590FF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_B780CC748E40A469E1E5C1B571F5A643" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_DED3B764929EFD32A45DC1B571F55FC5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_B780CC748E40A469E1E5C1B571F5A643" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_E2BCDD23FD4AFFCE4720C1B571F5BAC7" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_E2BCDD23FD4AFFCE4720C1B571F5BAC7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_9753F9FE9DA2497CAAC2C1B571F5B527" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_E2BCDD23FD4AFFCE4720C1B571F5BAC7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_9753F9FE9DA2497CAAC2C1B571F5B527" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_4E412C5C0440FB1605CBC1B571F5368D" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_E2BCDD23FD4AFFCE4720C1B571F5BAC7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_4E412C5C0440FB1605CBC1B571F5368D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_BD0284338FCDDA3471EDC1B571F6DDA9" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_E2BCDD23FD4AFFCE4720C1B571F5BAC7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_BD0284338FCDDA3471EDC1B571F6DDA9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice_0AD47870EA8859A915AFC1B571F6CC08" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_E2BCDD23FD4AFFCE4720C1B571F5BAC7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice_0AD47870EA8859A915AFC1B571F6CC08" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_1C3D0B21D5DAB08E0E46C1B571F6AF8D" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_E2BCDD23FD4AFFCE4720C1B571F5BAC7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_1C3D0B21D5DAB08E0E46C1B571F6AF8D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_F7AE9346C3BC1EBB247CC1B571F653C9" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_E2BCDD23FD4AFFCE4720C1B571F5BAC7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_F7AE9346C3BC1EBB247CC1B571F653C9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_3E502321AE6384AF2E12C1B571F6B61F" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_E2BCDD23FD4AFFCE4720C1B571F5BAC7" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_3E502321AE6384AF2E12C1B571F6B61F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_4205A5D455F755E772D6C1B571F64477" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_E2BCDD23FD4AFFCE4720C1B571F5BAC7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_4205A5D455F755E772D6C1B571F64477" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber_F264A347C43CE54E6427C1B571F6A4F8" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_E2BCDD23FD4AFFCE4720C1B571F5BAC7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber_F264A347C43CE54E6427C1B571F6A4F8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice_D787FDBAD3473C57A52BC1B571F6D2EC" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_E2BCDD23FD4AFFCE4720C1B571F5BAC7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice_D787FDBAD3473C57A52BC1B571F6D2EC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1_671750A00503DD6E2914C1B571F68237" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_E2BCDD23FD4AFFCE4720C1B571F5BAC7" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1_671750A00503DD6E2914C1B571F68237" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue_13E9BBEB8A42976FB26BC1B571F60B12" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_E2BCDD23FD4AFFCE4720C1B571F5BAC7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue_13E9BBEB8A42976FB26BC1B571F60B12" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_2A371690EF9991AFEBD8C1B571F6BCD6" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_E2BCDD23FD4AFFCE4720C1B571F5BAC7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_2A371690EF9991AFEBD8C1B571F6BCD6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_3CFDD881A21ABAB9BF60C1B571F6AD10" xlink:type="locator" />
    <presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_E2BCDD23FD4AFFCE4720C1B571F5BAC7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_3CFDD881A21ABAB9BF60C1B571F6AD10" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_F41127FAFA7D297B1E99C1B571F75866" xlink:type="locator" />
    <presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_E2BCDD23FD4AFFCE4720C1B571F5BAC7" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_F41127FAFA7D297B1E99C1B571F75866" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_7E7F11B9D7280B2ED221C1B571F7210A" xlink:type="locator" />
    <presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_E2BCDD23FD4AFFCE4720C1B571F5BAC7" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_7E7F11B9D7280B2ED221C1B571F7210A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_7016660DC6C3602195D3C1B571F72665" xlink:type="locator" />
    <presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_E2BCDD23FD4AFFCE4720C1B571F5BAC7" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_7016660DC6C3602195D3C1B571F72665" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ExercisePriceEqualToMarketPriceAbstract" xlink:label="loc_regn_ExercisePriceEqualToMarketPriceAbstract_B6BFED05321527ACA5E2C1B571F74C8D" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_regn_ExercisePriceEqualToMarketPriceAbstract_B6BFED05321527ACA5E2C1B571F74C8D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod_BE77456E34351D663741C1B571F76AFE" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ExercisePriceEqualToMarketPriceAbstract_B6BFED05321527ACA5E2C1B571F74C8D" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod_BE77456E34351D663741C1B571F76AFE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_F1B5544486B6D7089652C1B571F7284E" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ExercisePriceEqualToMarketPriceAbstract_B6BFED05321527ACA5E2C1B571F74C8D" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_F1B5544486B6D7089652C1B571F7284E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_099540C198BB495AF24DC1B571F7DFCE" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ExercisePriceEqualToMarketPriceAbstract_B6BFED05321527ACA5E2C1B571F74C8D" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_099540C198BB495AF24DC1B571F7DFCE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationAggregateDisclosuresAbstract" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAggregateDisclosuresAbstract_6CE668AF7EA6F4E90C85C1B571F7729C" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationAggregateDisclosuresAbstract_6CE668AF7EA6F4E90C85C1B571F7729C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_E71BB5DB2B0F9549CCBAC1B571F786E4" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAggregateDisclosuresAbstract_6CE668AF7EA6F4E90C85C1B571F7729C" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_E71BB5DB2B0F9549CCBAC1B571F786E4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_BDC7FFAC981DC6A23987C1B571F715A9" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAggregateDisclosuresAbstract_6CE668AF7EA6F4E90C85C1B571F7729C" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_BDC7FFAC981DC6A23987C1B571F715A9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_F6C58B6F684A3418D0F7C1B571F78B89" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAggregateDisclosuresAbstract_6CE668AF7EA6F4E90C85C1B571F7729C" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_F6C58B6F684A3418D0F7C1B571F78B89" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_1903843F6B4D5F3A17C4C1B571F8463A" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_1903843F6B4D5F3A17C4C1B571F8463A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_DD5CBFB7EE7582834A4CC1B571F826AF" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_1903843F6B4D5F3A17C4C1B571F8463A" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_DD5CBFB7EE7582834A4CC1B571F826AF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_61850E89AF9F6599E411C1B571F85325" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_1903843F6B4D5F3A17C4C1B571F8463A" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_61850E89AF9F6599E411C1B571F85325" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_BBF20EC464AE5CACDB1EC1B571F8DE3F" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_1903843F6B4D5F3A17C4C1B571F8463A" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_BBF20EC464AE5CACDB1EC1B571F8DE3F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_74F3DD723C4346782B67C1B571F84079" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_1903843F6B4D5F3A17C4C1B571F8463A" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_74F3DD723C4346782B67C1B571F84079" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_F8968891BFFFDF2F3787C1B571F8E766" xlink:type="locator" />
    <presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_F8968891BFFFDF2F3787C1B571F8E766" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_59E0AA9B4026DA175834C1B571F84565" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_F8968891BFFFDF2F3787C1B571F8E766" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_59E0AA9B4026DA175834C1B571F84565" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_CD9759696DD6822AC7ADC1B571F85047" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_F8968891BFFFDF2F3787C1B571F8E766" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_CD9759696DD6822AC7ADC1B571F85047" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_9774DDB42DEAA2B18FD5C1B571F83683" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_F8968891BFFFDF2F3787C1B571F8E766" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_9774DDB42DEAA2B18FD5C1B571F83683" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_D94B054C3A60252DBBDBC1B571F8D9F7" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_F8968891BFFFDF2F3787C1B571F8E766" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_D94B054C3A60252DBBDBC1B571F8D9F7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAdditionalDisclosuresAbstract" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAdditionalDisclosuresAbstract_1EB951994BAFB585E957C1B571F81867" xlink:type="locator" />
    <presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAdditionalDisclosuresAbstract_1EB951994BAFB585E957C1B571F81867" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_0DF8435DBE01BA6DFA4DC1B571F80588" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAdditionalDisclosuresAbstract_1EB951994BAFB585E957C1B571F81867" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_0DF8435DBE01BA6DFA4DC1B571F80588" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_7704D17C66C553BF6220C1B571F8D787" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAdditionalDisclosuresAbstract_1EB951994BAFB585E957C1B571F81867" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_7704D17C66C553BF6220C1B571F8D787" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_C701B44A58F893A79BCEC1B571F9AB1A" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAdditionalDisclosuresAbstract_1EB951994BAFB585E957C1B571F81867" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_C701B44A58F893A79BCEC1B571F9AB1A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_0102A914A596347BF513C1B571F922D3" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsAdditionalDisclosuresAbstract_1EB951994BAFB585E957C1B571F81867" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_0102A914A596347BF513C1B571F922D3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_399B08007386C9CAE750C1B571F99B95" xlink:type="locator" />
    <presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_us-gaap_Assets_399B08007386C9CAE750C1B571F99B95" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="loc_us-gaap_AdditionalPaidInCapital_67CA326EFA57D23137E4C1B571F931EF" xlink:type="locator" />
    <presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_us-gaap_AdditionalPaidInCapital_67CA326EFA57D23137E4C1B571F931EF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_8538C30FCA01FDA4AF14C1B571F96BA1" xlink:type="locator" />
    <presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_8538C30FCA01FDA4AF14C1B571F96BA1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_C288757ED90B2C573FD2C1B571F9C046" xlink:type="locator" />
    <presentationArc order="19" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_us-gaap_StockholdersEquity_C288757ED90B2C573FD2C1B571F9C046" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_A3E935B891219AAAB43CC1B571F94871" xlink:type="locator" />
    <presentationArc order="20" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_A3E935B891219AAAB43CC1B571F94871" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CostsAndExpenses" xlink:label="loc_us-gaap_CostsAndExpenses_7E6614EC6CC2EFCD244EC1B571F9C3B5" xlink:type="locator" />
    <presentationArc order="21" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_us-gaap_CostsAndExpenses_7E6614EC6CC2EFCD244EC1B571F9C3B5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaap_OperatingIncomeLoss_A9737762CC8D28EEBB9BC1B571F9A4AD" xlink:type="locator" />
    <presentationArc order="22" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_us-gaap_OperatingIncomeLoss_A9737762CC8D28EEBB9BC1B571F9A4AD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_305356124EAD5F253DFBC1B571F92B9D" xlink:type="locator" />
    <presentationArc order="23" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_305356124EAD5F253DFBC1B571F92B9D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_ECCD3805D2B595B3B2D3C1B571F9150B" xlink:type="locator" />
    <presentationArc order="24" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_ECCD3805D2B595B3B2D3C1B571F9150B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_590411623AD42AFBFB0DC1B571F96E44" xlink:type="locator" />
    <presentationArc order="25" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_us-gaap_NetIncomeLoss_590411623AD42AFBFB0DC1B571F96E44" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareBasic" xlink:label="loc_us-gaap_EarningsPerShareBasic_BD43ED211F8B6A4F66BCC1B571F940F8" xlink:type="locator" />
    <presentationArc order="26" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_us-gaap_EarningsPerShareBasic_BD43ED211F8B6A4F66BCC1B571F940F8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareDiluted" xlink:label="loc_us-gaap_EarningsPerShareDiluted_C61317AB90149E87B8CAC1B571FAFE1D" xlink:type="locator" />
    <presentationArc order="27" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_us-gaap_EarningsPerShareDiluted_C61317AB90149E87B8CAC1B571FAFE1D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredIncomeTaxes" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_66C1C87DDAC0F5B5C29BC1B571FA6DA0" xlink:type="locator" />
    <presentationArc order="28" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_66C1C87DDAC0F5B5C29BC1B571FA6DA0" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsNonvestedNumber" xlink:label="loc_regn_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsNonvestedNumber_159677001BB4283A1822C1B571FA9E98" xlink:type="locator" />
    <presentationArc order="29" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_CFE8E74141780C1AC755C1B571F41B34" xlink:to="loc_regn_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsNonvestedNumber_159677001BB4283A1822C1B571FA9E98" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/LongTermIncentivePlansTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_ACE5D3E6F38C86FCA10DB238AD93B3BD" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock_EEEADB53236D2CB8133EB238AD934469" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_ACE5D3E6F38C86FCA10DB238AD93B3BD" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock_EEEADB53236D2CB8133EB238AD934469" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValueTableTextBlock" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValueTableTextBlock_121700686483D13B309FB238AD934F35" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_ACE5D3E6F38C86FCA10DB238AD93B3BD" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValueTableTextBlock_121700686483D13B309FB238AD934F35" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock_45F14522DB2574BE41ECB238AD93D33A" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_ACE5D3E6F38C86FCA10DB238AD93B3BD" xlink:to="loc_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock_45F14522DB2574BE41ECB238AD93D33A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfSharebasedCompensationRestrictedStockAndRestrictedStockUnitsActivityTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfSharebasedCompensationRestrictedStockAndRestrictedStockUnitsActivityTableTextBlock_88BB7A87CC1DB6321AA7B238AD94525C" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_ACE5D3E6F38C86FCA10DB238AD93B3BD" xlink:to="loc_us-gaap_ScheduleOfSharebasedCompensationRestrictedStockAndRestrictedStockUnitsActivityTableTextBlock_88BB7A87CC1DB6321AA7B238AD94525C" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/MarketableSecurities" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_C8DDAA4C5E37F695D737B238AF37284E" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MarketableSecuritiesTextBlock" xlink:label="loc_us-gaap_MarketableSecuritiesTextBlock_EDC15A4B431417705B15B238AF377101" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_C8DDAA4C5E37F695D737B238AF37284E" xlink:to="loc_us-gaap_MarketableSecuritiesTextBlock_EDC15A4B431417705B15B238AF377101" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/MarketableSecuritiesDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_512B6E3ACD7C59C5CF37B238AF210D7B" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesTable" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_5BB36D194543CAD3AFC0B238AF211279" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_512B6E3ACD7C59C5CF37B238AF210D7B" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_5BB36D194543CAD3AFC0B238AF211279" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_F172AE130F46B6B99665B238AF2136D5" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_5BB36D194543CAD3AFC0B238AF211279" xlink:to="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_F172AE130F46B6B99665B238AF2136D5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain" xlink:label="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_DBCC2F5CE2FA3D684FE4B238AF210ABC" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesAxis_F172AE130F46B6B99665B238AF2136D5" xlink:to="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_DBCC2F5CE2FA3D684FE4B238AF210ABC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_USTreasuryAndGovernmentMember" xlink:label="loc_us-gaap_USTreasuryAndGovernmentMember_1638E2046F6D6D510E03B238AF21D0ED" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_DBCC2F5CE2FA3D684FE4B238AF210ABC" xlink:to="loc_us-gaap_USTreasuryAndGovernmentMember_1638E2046F6D6D510E03B238AF21D0ED" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CorporateBondSecuritiesMember" xlink:label="loc_us-gaap_CorporateBondSecuritiesMember_14ECD23D9B4169BC6BBEB238AF21B55C" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_DBCC2F5CE2FA3D684FE4B238AF210ABC" xlink:to="loc_us-gaap_CorporateBondSecuritiesMember_14ECD23D9B4169BC6BBEB238AF21B55C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MunicipalBondsMember" xlink:label="loc_us-gaap_MunicipalBondsMember_44861C8C9D12C79473F2B238AF21310B" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_DBCC2F5CE2FA3D684FE4B238AF210ABC" xlink:to="loc_us-gaap_MunicipalBondsMember_44861C8C9D12C79473F2B238AF21310B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquitySecuritiesMember" xlink:label="loc_us-gaap_EquitySecuritiesMember_D01FE161B9CB7D0CA97CB238AF21352F" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MajorTypesOfDebtAndEquitySecuritiesDomain_DBCC2F5CE2FA3D684FE4B238AF210ABC" xlink:to="loc_us-gaap_EquitySecuritiesMember_D01FE161B9CB7D0CA97CB238AF21352F" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ClassificationOfInvestmentAxis" xlink:label="loc_regn_ClassificationOfInvestmentAxis_D9F5A05FD25AE2E22B3FB238AF2273E0" xlink:type="locator" />
    <presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_5BB36D194543CAD3AFC0B238AF211279" xlink:to="loc_regn_ClassificationOfInvestmentAxis_D9F5A05FD25AE2E22B3FB238AF2273E0" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ClassificationOfInvestmentDomain" xlink:label="loc_regn_ClassificationOfInvestmentDomain_DEA05D904D5E1496FE01B238AF22B2F3" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ClassificationOfInvestmentAxis_D9F5A05FD25AE2E22B3FB238AF2273E0" xlink:to="loc_regn_ClassificationOfInvestmentDomain_DEA05D904D5E1496FE01B238AF22B2F3" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_UnrestrictedMember" xlink:label="loc_regn_UnrestrictedMember_449F8E284AD9BF7532B4B238AF2212F3" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ClassificationOfInvestmentDomain_DEA05D904D5E1496FE01B238AF22B2F3" xlink:to="loc_regn_UnrestrictedMember_449F8E284AD9BF7532B4B238AF2212F3" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_RestrictedMember" xlink:label="loc_regn_RestrictedMember_BB97546B484E4E5B3010B238AF220E3E" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ClassificationOfInvestmentDomain_DEA05D904D5E1496FE01B238AF22B2F3" xlink:to="loc_regn_RestrictedMember_BB97546B484E4E5B3010B238AF220E3E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_7A712D4CAE259D643E31B238AF27B194" xlink:type="locator" />
    <presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesTable_5BB36D194543CAD3AFC0B238AF211279" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_7A712D4CAE259D643E31B238AF27B194" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ImpairmentOfInvestments" xlink:label="loc_us-gaap_ImpairmentOfInvestments_4FD5318A9E9F2A348C36B238AF278E38" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_7A712D4CAE259D643E31B238AF27B194" xlink:to="loc_us-gaap_ImpairmentOfInvestments_4FD5318A9E9F2A348C36B238AF278E38" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesGrossRealizedGains" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesGrossRealizedGains_FAAABF7EACEF9C921510B238AF2748EE" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_7A712D4CAE259D643E31B238AF27B194" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesGrossRealizedGains_FAAABF7EACEF9C921510B238AF2748EE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAmortizedCost" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_B38ECB652A57C65AA2FDB238AF274B06" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_7A712D4CAE259D643E31B238AF27B194" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAmortizedCost_B38ECB652A57C65AA2FDB238AF274B06" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_AB9B6924CA99BBC18C8CB238AF27514B" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_7A712D4CAE259D643E31B238AF27B194" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_AB9B6924CA99BBC18C8CB238AF27514B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_8A26892574262D49E4E6B238AF27481A" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_7A712D4CAE259D643E31B238AF27B194" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_8A26892574262D49E4E6B238AF27481A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecurities_BB9E354D36DC63B10D11B238AF27D86C" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_7A712D4CAE259D643E31B238AF27B194" xlink:to="loc_us-gaap_AvailableForSaleSecurities_BB9E354D36DC63B10D11B238AF27D86C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract_CEB8A8BFBACCA46E5873B238AF27EC32" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_7A712D4CAE259D643E31B238AF27B194" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract_CEB8A8BFBACCA46E5873B238AF27EC32" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_6563417E3CAD77766CA1B238AF271443" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract_CEB8A8BFBACCA46E5873B238AF27EC32" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_6563417E3CAD77766CA1B238AF271443" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_6F2C4FBCCFBD659AC3D4B238AF287292" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract_CEB8A8BFBACCA46E5873B238AF27EC32" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_6F2C4FBCCFBD659AC3D4B238AF287292" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_2C51C32A3DD9A5CC6E8FB238AF28264E" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract_CEB8A8BFBACCA46E5873B238AF27EC32" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterFiveThroughTenYearsFairValue_2C51C32A3DD9A5CC6E8FB238AF28264E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_FAB6BAEC44759E290F75B238AF2813D9" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesFairValueAbstract_CEB8A8BFBACCA46E5873B238AF27EC32" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_FAB6BAEC44759E290F75B238AF2813D9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValueAbstract" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValueAbstract_C82A50AB6F8F6EEFF500B238AF286BCE" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_7A712D4CAE259D643E31B238AF27B194" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValueAbstract_C82A50AB6F8F6EEFF500B238AF286BCE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_BC89AF1EC0BEBF724E5DB238AF282C53" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValueAbstract_C82A50AB6F8F6EEFF500B238AF286BCE" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue_BC89AF1EC0BEBF724E5DB238AF282C53" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_03F1F74D39F6FAF1F177B238AF289179" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValueAbstract_C82A50AB6F8F6EEFF500B238AF286BCE" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue_03F1F74D39F6FAF1F177B238AF289179" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_05F72CD4F472DE913F18B238AF284502" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValueAbstract_C82A50AB6F8F6EEFF500B238AF286BCE" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue_05F72CD4F472DE913F18B238AF284502" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAggregateLossesAbstract" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAggregateLossesAbstract_7DDAF56A41C208EA63BEB238AF28DF90" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_7A712D4CAE259D643E31B238AF27B194" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAggregateLossesAbstract_7DDAF56A41C208EA63BEB238AF28DF90" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_853E53DCB926A14947C8B238AF2828D4" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAggregateLossesAbstract_7DDAF56A41C208EA63BEB238AF28DF90" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_853E53DCB926A14947C8B238AF2828D4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_A1A7C919C574BA93E8DFB238AF28C300" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAggregateLossesAbstract_7DDAF56A41C208EA63BEB238AF28DF90" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_A1A7C919C574BA93E8DFB238AF28C300" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAccumulatedLoss" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAccumulatedLoss_69B7C5CF626A05909428B238AF283024" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAggregateLossesAbstract_7DDAF56A41C208EA63BEB238AF28DF90" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAccumulatedLoss_69B7C5CF626A05909428B238AF283024" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_A1475264F755102436A3B238AF28156B" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_7A712D4CAE259D643E31B238AF27B194" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesGrossRealizedLosses_A1475264F755102436A3B238AF28156B" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/MarketableSecuritiesTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_5DE1114976ED12D36139B238AF305CD2" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AvailableForSaleSecuritiesTextBlock" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesTextBlock_B2E605BB89F2269077D6B238AF30AD11" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_5DE1114976ED12D36139B238AF305CD2" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesTextBlock_B2E605BB89F2269077D6B238AF30AD11" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_InvestmentsClassifiedByContractualMaturityDateTableTextBlock" xlink:label="loc_us-gaap_InvestmentsClassifiedByContractualMaturityDateTableTextBlock_EA9EA01C03BF1DF701FBB238AF307404" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_5DE1114976ED12D36139B238AF305CD2" xlink:to="loc_us-gaap_InvestmentsClassifiedByContractualMaturityDateTableTextBlock_EA9EA01C03BF1DF701FBB238AF307404" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfUnrealizedLossOnInvestmentsTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfUnrealizedLossOnInvestmentsTableTextBlock_620DCF23AD2D36A5B5AEB238AF301596" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_5DE1114976ED12D36139B238AF305CD2" xlink:to="loc_us-gaap_ScheduleOfUnrealizedLossOnInvestmentsTableTextBlock_620DCF23AD2D36A5B5AEB238AF301596" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/NetIncomeLossPerShare" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_EA305A2D1C4DD005CDDFB238ACCE3F3A" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareTextBlock" xlink:label="loc_us-gaap_EarningsPerShareTextBlock_4E408E493289DFE40C8AB238ACCED793" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_EA305A2D1C4DD005CDDFB238ACCE3F3A" xlink:to="loc_us-gaap_EarningsPerShareTextBlock_4E408E493289DFE40C8AB238ACCED793" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/NetIncomeLossPerShareDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_2BB756B32C03BBB37BD8B238ACBDB36B" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_3A7375A3943296953E23B238ACBEDF62" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_2BB756B32C03BBB37BD8B238ACBDB36B" xlink:to="loc_us-gaap_NetIncomeLoss_3A7375A3943296953E23B238ACBEDF62" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DilutiveSecuritiesAbstract" xlink:label="loc_us-gaap_DilutiveSecuritiesAbstract_042E6EB4E23B41D41EE9B238ACBE57A9" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_2BB756B32C03BBB37BD8B238ACBDB36B" xlink:to="loc_us-gaap_DilutiveSecuritiesAbstract_042E6EB4E23B41D41EE9B238ACBE57A9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract_8C2AD3FE33D1F3B163E8B238ACBE7D61" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_2BB756B32C03BBB37BD8B238ACBDB36B" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract_8C2AD3FE33D1F3B163E8B238ACBE7D61" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_B8ADE7785E8D270BBC46B238ACBE1F79" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract_8C2AD3FE33D1F3B163E8B238ACBE7D61" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_B8ADE7785E8D270BBC46B238ACBE1F79" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustmentAbstract" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustmentAbstract_BD5523EA7A84E752F584B238ACBECF0F" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract_8C2AD3FE33D1F3B163E8B238ACBE7D61" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustmentAbstract_BD5523EA7A84E752F584B238ACBECF0F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_B7285D4FDB8CEC18A174B238ACBE0E93" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustmentAbstract_BD5523EA7A84E752F584B238ACBECF0F" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_B7285D4FDB8CEC18A174B238ACBE0E93" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_IncrementalCommonSharesAttributableToNonvestedRestrictedShares" xlink:label="loc_regn_IncrementalCommonSharesAttributableToNonvestedRestrictedShares_1FA200375754EAB8EEFCB238ACBEE40E" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustmentAbstract_BD5523EA7A84E752F584B238ACBECF0F" xlink:to="loc_regn_IncrementalCommonSharesAttributableToNonvestedRestrictedShares_1FA200375754EAB8EEFCB238ACBEE40E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants_B35EDBF90F5422F5F656B238ACBEF6E5" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustmentAbstract_BD5523EA7A84E752F584B238ACBECF0F" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants_B35EDBF90F5422F5F656B238ACBEF6E5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_E48B8BF5CC2FB6D7D3AFB238ACBE428F" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustmentAbstract_BD5523EA7A84E752F584B238ACBECF0F" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_E48B8BF5CC2FB6D7D3AFB238ACBE428F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_CA89BF31EA3048753424B238ACBE3784" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract_8C2AD3FE33D1F3B163E8B238ACBE7D61" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_CA89BF31EA3048753424B238ACBE3784" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareBasicAndDilutedAbstract" xlink:label="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_8585AF2709D15631EA3DB238ACBEB82C" xlink:type="locator" />
    <presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_2BB756B32C03BBB37BD8B238ACBDB36B" xlink:to="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_8585AF2709D15631EA3DB238ACBEB82C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareBasic" xlink:label="loc_us-gaap_EarningsPerShareBasic_0FCF54B6DDA949449D9BB238ACBEB8A2" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_8585AF2709D15631EA3DB238ACBEB82C" xlink:to="loc_us-gaap_EarningsPerShareBasic_0FCF54B6DDA949449D9BB238ACBEB8A2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareDiluted" xlink:label="loc_us-gaap_EarningsPerShareDiluted_1F5F992FB289B97B4606B238ACBEF902" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_8585AF2709D15631EA3DB238ACBEB82C" xlink:to="loc_us-gaap_EarningsPerShareDiluted_1F5F992FB289B97B4606B238ACBEF902" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_6D9031F6EB77D56DBECFB238ACBEE55A" xlink:type="locator" />
    <presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_2BB756B32C03BBB37BD8B238ACBDB36B" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_6D9031F6EB77D56DBECFB238ACBEE55A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_7EF25D95AE00B92DFD67B238ACBE91C2" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_6D9031F6EB77D56DBECFB238ACBEE55A" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_7EF25D95AE00B92DFD67B238ACBE91C2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AntidilutiveSecuritiesNameDomain" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_6BEFFB64F6DD46BF02C1B238ACBFC158" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_7EF25D95AE00B92DFD67B238ACBE91C2" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_6BEFFB64F6DD46BF02C1B238ACBFC158" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EmployeeStockOptionMember" xlink:label="loc_us-gaap_EmployeeStockOptionMember_E2D1C38364CFF759AA4DB238ACBFC1B1" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_6BEFFB64F6DD46BF02C1B238ACBFC158" xlink:to="loc_us-gaap_EmployeeStockOptionMember_E2D1C38364CFF759AA4DB238ACBFC1B1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RestrictedStockMember" xlink:label="loc_us-gaap_RestrictedStockMember_79CA7756D93BF8A79C52B238ACBF86E0" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_6BEFFB64F6DD46BF02C1B238ACBFC158" xlink:to="loc_us-gaap_RestrictedStockMember_79CA7756D93BF8A79C52B238ACBF86E0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConvertibleDebtSecuritiesMember" xlink:label="loc_us-gaap_ConvertibleDebtSecuritiesMember_C1AD1075032DC66A3421B238ACBF2C06" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_6BEFFB64F6DD46BF02C1B238ACBFC158" xlink:to="loc_us-gaap_ConvertibleDebtSecuritiesMember_C1AD1075032DC66A3421B238ACBF2C06" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_237FA7938A13E64F9991B238ACBF9719" xlink:type="locator" />
    <presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_6D9031F6EB77D56DBECFB238ACBEE55A" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_237FA7938A13E64F9991B238ACBF9719" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_F28412C9072F25D09DA2B238ACBF1059" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_237FA7938A13E64F9991B238ACBF9719" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_F28412C9072F25D09DA2B238ACBF1059" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/NetIncomeLossPerShareTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_17CB4FD59C32E0F6C496B238ACC68361" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_E2499B6AB377CEE88D0AB238ACC6AEC5" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_17CB4FD59C32E0F6C496B238ACC68361" xlink:to="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_E2499B6AB377CEE88D0AB238ACC6AEC5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_6AAF88FD3BA8FBA538E7B238ACC65453" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_17CB4FD59C32E0F6C496B238ACC68361" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_6AAF88FD3BA8FBA538E7B238ACC65453" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/NetProductSales" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RevenuesAbstract" xlink:label="loc_us-gaap_RevenuesAbstract_B086F55434CEB037A86AB238B0145250" xlink:type="locator" />
    <loc xlink:href="regn-20151231.xsd#regn_ProductSalesandConcentrationRiskTextBlock" xlink:label="loc_regn_ProductSalesandConcentrationRiskTextBlock_6DB16089E4997B53A1BAB238B0144798" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesAbstract_B086F55434CEB037A86AB238B0145250" xlink:to="loc_regn_ProductSalesandConcentrationRiskTextBlock_6DB16089E4997B53A1BAB238B0144798" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/NetProductSalesDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RevenuesAbstract" xlink:label="loc_us-gaap_RevenuesAbstract_8416ABDA2B8C21A5A739B238B0044411" xlink:type="locator" />
    <loc xlink:href="regn-20151231.xsd#regn_RevenueDisclosureTable" xlink:label="loc_regn_RevenueDisclosureTable_2D825491236FB0385F52B238B004C0C9" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesAbstract_8416ABDA2B8C21A5A739B238B0044411" xlink:to="loc_regn_RevenueDisclosureTable_2D825491236FB0385F52B238B004C0C9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProductOrServiceAxis" xlink:label="loc_us-gaap_ProductOrServiceAxis_0BED28AF54C772E38398B238B004E1DB" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_RevenueDisclosureTable_2D825491236FB0385F52B238B004C0C9" xlink:to="loc_us-gaap_ProductOrServiceAxis_0BED28AF54C772E38398B238B004E1DB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProductsAndServicesDomain" xlink:label="loc_us-gaap_ProductsAndServicesDomain_771F3AF83A8F425AF55EB238B004E5B8" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductOrServiceAxis_0BED28AF54C772E38398B238B004E1DB" xlink:to="loc_us-gaap_ProductsAndServicesDomain_771F3AF83A8F425AF55EB238B004E5B8" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_EyleaNetProductSalesMember" xlink:label="loc_regn_EyleaNetProductSalesMember_3980AD11273F06E81297B238B004A215" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_771F3AF83A8F425AF55EB238B004E5B8" xlink:to="loc_regn_EyleaNetProductSalesMember_3980AD11273F06E81297B238B004A215" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ArcalystNetProductSalesMember" xlink:label="loc_regn_ArcalystNetProductSalesMember_AE517250792D3F35F6DEB238B004F185" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductsAndServicesDomain_771F3AF83A8F425AF55EB238B004E5B8" xlink:to="loc_regn_ArcalystNetProductSalesMember_AE517250792D3F35F6DEB238B004F185" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConcentrationRiskByTypeAxis" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_45F4F8F3875264346788B238B0040AFE" xlink:type="locator" />
    <presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_RevenueDisclosureTable_2D825491236FB0385F52B238B004C0C9" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_45F4F8F3875264346788B238B0040AFE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_D475F5E37D6C3DF41E05B238B004CEC0" xlink:type="locator" />
    <presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_45F4F8F3875264346788B238B0040AFE" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_D475F5E37D6C3DF41E05B238B004CEC0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CustomerConcentrationRiskMember" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember_BF1ED15D2A7A9DBBB32BB238B0044E60" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_D475F5E37D6C3DF41E05B238B004CEC0" xlink:to="loc_us-gaap_CustomerConcentrationRiskMember_BF1ED15D2A7A9DBBB32BB238B0044E60" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_860391C75CF70E3AB12AB238B00419FD" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_RevenueDisclosureTable_2D825491236FB0385F52B238B004C0C9" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_860391C75CF70E3AB12AB238B00419FD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_302E0B02880DD17D45F5B238B004E197" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_860391C75CF70E3AB12AB238B00419FD" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_302E0B02880DD17D45F5B238B004E197" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_GrosssalesrevenueMember" xlink:label="loc_regn_GrosssalesrevenueMember_F33266DF6EDD15D4BA5EB238B0046418" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_302E0B02880DD17D45F5B238B004E197" xlink:to="loc_regn_GrosssalesrevenueMember_F33266DF6EDD15D4BA5EB238B0046418" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ValuationAllowancesAndReservesTypeAxis" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_947E7076646AD99A517EB238B00451E7" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_RevenueDisclosureTable_2D825491236FB0385F52B238B004C0C9" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_947E7076646AD99A517EB238B00451E7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ValuationAllowancesAndReservesDomain" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDomain_E9566FBB22DA69B7B3DCB238B0046E3D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_947E7076646AD99A517EB238B00451E7" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDomain_E9566FBB22DA69B7B3DCB238B0046E3D" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_RebatesAndChargebacksMember" xlink:label="loc_regn_RebatesAndChargebacksMember_63E20FE899C0836CCED0B238B00418EF" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesDomain_E9566FBB22DA69B7B3DCB238B0046E3D" xlink:to="loc_regn_RebatesAndChargebacksMember_63E20FE899C0836CCED0B238B00418EF" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_DistributionRelatedFeesMember" xlink:label="loc_regn_DistributionRelatedFeesMember_7C6EE5FC2E6753EE32CEB238B00521E8" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesDomain_E9566FBB22DA69B7B3DCB238B0046E3D" xlink:to="loc_regn_DistributionRelatedFeesMember_7C6EE5FC2E6753EE32CEB238B00521E8" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_OtherSalesRelatedDeductionsMember" xlink:label="loc_regn_OtherSalesRelatedDeductionsMember_945B7DC28917786BB311B238B0057D1F" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesDomain_E9566FBB22DA69B7B3DCB238B0046E3D" xlink:to="loc_regn_OtherSalesRelatedDeductionsMember_945B7DC28917786BB311B238B0057D1F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems" xlink:label="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_1B4723B83E0D086C087AB238B005432A" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_RevenueDisclosureTable_2D825491236FB0385F52B238B004C0C9" xlink:to="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_1B4723B83E0D086C087AB238B005432A" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_BrandedPrescriptionDrugFee" xlink:label="loc_regn_BrandedPrescriptionDrugFee_7BDBE3C20D6F17E5C6B3B238B0053E01" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_1B4723B83E0D086C087AB238B005432A" xlink:to="loc_regn_BrandedPrescriptionDrugFee_7BDBE3C20D6F17E5C6B3B238B0053E01" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_SalesRevenueGoodsNet" xlink:label="loc_us-gaap_SalesRevenueGoodsNet_97F2B42CFCDC1E17D913B238B005B5EF" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_1B4723B83E0D086C087AB238B005432A" xlink:to="loc_us-gaap_SalesRevenueGoodsNet_97F2B42CFCDC1E17D913B238B005B5EF" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RisksAndUncertaintiesAbstract" xlink:label="loc_us-gaap_RisksAndUncertaintiesAbstract_7EE2B6508E79FF214C4AB238B005EC90" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_1B4723B83E0D086C087AB238B005432A" xlink:to="loc_us-gaap_RisksAndUncertaintiesAbstract_7EE2B6508E79FF214C4AB238B005EC90" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConcentrationRiskPercentage1" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_77DF0AC95370608D3951B238B00A66AE" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RisksAndUncertaintiesAbstract_7EE2B6508E79FF214C4AB238B005EC90" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_77DF0AC95370608D3951B238B00A66AE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_MovementInValuationAllowancesAndReservesRollForward" xlink:label="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_AF48C946CB61371EBB4FB238B00AB3F5" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_1B4723B83E0D086C087AB238B005432A" xlink:to="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_AF48C946CB61371EBB4FB238B00AB3F5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ValuationAllowancesAndReservesBalance" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesBalance_40D1F9B765B04D810670B238B00AD3C4" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_AF48C946CB61371EBB4FB238B00AB3F5" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesBalance_40D1F9B765B04D810670B238B00AD3C4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ValuationAllowancesAndReservesChargedToOtherAccounts" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesChargedToOtherAccounts_131E0F6E069E0451BFF4B238B00A9CD2" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_AF48C946CB61371EBB4FB238B00AB3F5" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesChargedToOtherAccounts_131E0F6E069E0451BFF4B238B00A9CD2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ValuationAllowancesAndReservesDeductions" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDeductions_DAD5F01B7EAA90148820B238B00A4B7F" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_AF48C946CB61371EBB4FB238B00AB3F5" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDeductions_DAD5F01B7EAA90148820B238B00A4B7F" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/NetProductSalesTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RevenuesAbstract" xlink:label="loc_us-gaap_RevenuesAbstract_C2C2E294DE09328B3F73B238B00D78AA" xlink:type="locator" />
    <loc xlink:href="regn-20151231.xsd#regn_ScheduleOfSalesRelatedDeductionsActivityTableTextBlock" xlink:label="loc_regn_ScheduleOfSalesRelatedDeductionsActivityTableTextBlock_EFB41C1354CF781CA899B238B00D2173" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesAbstract_C2C2E294DE09328B3F73B238B00D78AA" xlink:to="loc_regn_ScheduleOfSalesRelatedDeductionsActivityTableTextBlock_EFB41C1354CF781CA899B238B00D2173" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/PropertyPlantAndEquipment" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAbstract" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_1843A34854386C00C02AB238AEC5C46E" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock_39A6F3AAEFDB47085A3BB238AEC56B76" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_1843A34854386C00C02AB238AEC5C46E" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock_39A6F3AAEFDB47085A3BB238AEC56B76" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/PropertyPlantAndEquipmentDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAbstract" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_3CF46F953AD5140F046DB238AEB573C5" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_CED9446765E7E4515E36B238AEB5807C" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_3CF46F953AD5140F046DB238AEB573C5" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_CED9446765E7E4515E36B238AEB5807C" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityByLocationAxis" xlink:label="loc_dei_EntityByLocationAxis_B0CDFEFE55C75C67EDD6B238AEB587A8" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_CED9446765E7E4515E36B238AEB5807C" xlink:to="loc_dei_EntityByLocationAxis_B0CDFEFE55C75C67EDD6B238AEB587A8" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_LocationDomain" xlink:label="loc_dei_LocationDomain_D08CD43310262D91DD86B238AEB5D06E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityByLocationAxis_B0CDFEFE55C75C67EDD6B238AEB587A8" xlink:to="loc_dei_LocationDomain_D08CD43310262D91DD86B238AEB5D06E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd#country_US" xlink:label="loc_country_US_6AA4B784521AFF1FC7E3B238AEB562EE" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LocationDomain_D08CD43310262D91DD86B238AEB5D06E" xlink:to="loc_country_US_6AA4B784521AFF1FC7E3B238AEB562EE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GeographicDistributionForeignMember" xlink:label="loc_us-gaap_GeographicDistributionForeignMember_C8981F469AE92E4F1703B238AEB582D3" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LocationDomain_D08CD43310262D91DD86B238AEB5D06E" xlink:to="loc_us-gaap_GeographicDistributionForeignMember_C8981F469AE92E4F1703B238AEB582D3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_D61CCE953D84F0324A21B238AEB50AE0" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_CED9446765E7E4515E36B238AEB5807C" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_D61CCE953D84F0324A21B238AEB50AE0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_E3960582D2697B6C2582B238AEB5EB92" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_D61CCE953D84F0324A21B238AEB50AE0" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_E3960582D2697B6C2582B238AEB5EB92" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/sic/2011/sic-2011-01-31.xsd#sic_Z3821" xlink:label="loc_sic_Z3821_7271C340C5C155BF7E62B238AEB5947E" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_E3960582D2697B6C2582B238AEB5EB92" xlink:to="loc_sic_Z3821_7271C340C5C155BF7E62B238AEB5947E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BuildingAndBuildingImprovementsMember" xlink:label="loc_us-gaap_BuildingAndBuildingImprovementsMember_7A1D23C388DDD7CD4ED1B238AEB54740" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_E3960582D2697B6C2582B238AEB5EB92" xlink:to="loc_us-gaap_BuildingAndBuildingImprovementsMember_7A1D23C388DDD7CD4ED1B238AEB54740" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquipmentMember" xlink:label="loc_us-gaap_EquipmentMember_8BA78F57B39175CA10A0B238AEB69266" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_E3960582D2697B6C2582B238AEB5EB92" xlink:to="loc_us-gaap_EquipmentMember_8BA78F57B39175CA10A0B238AEB69266" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_TarrytownNewYorkMember" xlink:label="loc_regn_TarrytownNewYorkMember_6F5118B6709A4BB0342EB238AEB6B5C6" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_E3960582D2697B6C2582B238AEB5EB92" xlink:to="loc_regn_TarrytownNewYorkMember_6F5118B6709A4BB0342EB238AEB6B5C6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_E02F68833CC258FF9EEDB238AEB6C640" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_CED9446765E7E4515E36B238AEB5807C" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentLineItems_E02F68833CC258FF9EEDB238AEB6C640" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Land" xlink:label="loc_us-gaap_Land_4EA1A9AFCED342179B82B238AEB616A1" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_E02F68833CC258FF9EEDB238AEB6C640" xlink:to="loc_us-gaap_Land_4EA1A9AFCED342179B82B238AEB616A1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_BuildingsAndImprovementsGross" xlink:label="loc_us-gaap_BuildingsAndImprovementsGross_94D2C7E64AB2B5926A53B238AEB6C7A9" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_E02F68833CC258FF9EEDB238AEB6C640" xlink:to="loc_us-gaap_BuildingsAndImprovementsGross_94D2C7E64AB2B5926A53B238AEB6C7A9" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LeaseholdImprovementsGross" xlink:label="loc_us-gaap_LeaseholdImprovementsGross_8EC92A61D7A9E93B42DFB238AEB6C955" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_E02F68833CC258FF9EEDB238AEB6C640" xlink:to="loc_us-gaap_LeaseholdImprovementsGross_8EC92A61D7A9E93B42DFB238AEB6C955" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConstructionInProgressGross" xlink:label="loc_us-gaap_ConstructionInProgressGross_9D2CBBECDAE5B4796584B238AEB64D3B" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_E02F68833CC258FF9EEDB238AEB6C640" xlink:to="loc_us-gaap_ConstructionInProgressGross_9D2CBBECDAE5B4796584B238AEB64D3B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_20FB051EF4989147B868B238AEB60688" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_E02F68833CC258FF9EEDB238AEB6C640" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_20FB051EF4989147B868B238AEB60688" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_FurnitureAndFixturesGross" xlink:label="loc_us-gaap_FurnitureAndFixturesGross_1950040EFA84F2704418B238AEB6CA43" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_E02F68833CC258FF9EEDB238AEB6C640" xlink:to="loc_us-gaap_FurnitureAndFixturesGross_1950040EFA84F2704418B238AEB6CA43" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_09A466ADB9F338702B7EB238AEB600D7" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_E02F68833CC258FF9EEDB238AEB6C640" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_09A466ADB9F338702B7EB238AEB600D7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_1A4EE4E46A2B695E23DEB238AEB611CA" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_E02F68833CC258FF9EEDB238AEB6C640" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_1A4EE4E46A2B695E23DEB238AEB611CA" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_0400B2BC5FB0D11B0965B238AEB61610" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_E02F68833CC258FF9EEDB238AEB6C640" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_0400B2BC5FB0D11B0965B238AEB61610" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_CostsIncurredByLandlordToConstructNewLaboratoryAndOfficeFacilities" xlink:label="loc_regn_CostsIncurredByLandlordToConstructNewLaboratoryAndOfficeFacilities_EF4CFE959D7C3F1AE65AB238AEB676F6" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_E02F68833CC258FF9EEDB238AEB6C640" xlink:to="loc_regn_CostsIncurredByLandlordToConstructNewLaboratoryAndOfficeFacilities_EF4CFE959D7C3F1AE65AB238AEB676F6" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/PropertyPlantAndEquipmentTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAbstract" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_B80A375B493498BD1F76B238AEBE661C" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTextBlock" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_B4F300CA861141ECCB36B238AEBED38B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_B80A375B493498BD1F76B238AEBE661C" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_B4F300CA861141ECCB36B238AEBED38B" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/StatementOfCashFlows" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_8F548D5822E804BBC9FBB238ACAE1142" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CashFlowSupplementalDisclosuresTextBlock" xlink:label="loc_us-gaap_CashFlowSupplementalDisclosuresTextBlock_227B69257CF304195FA2B238ACAEEA99" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_8F548D5822E804BBC9FBB238ACAE1142" xlink:to="loc_us-gaap_CashFlowSupplementalDisclosuresTextBlock_227B69257CF304195FA2B238ACAEEA99" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/StatementOfCashFlowsDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_F05FCBDA48E3B0B3D173B238ACA158E2" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_A80DFBB3B5A277F0B8FEB238ACA1DCFC" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_F05FCBDA48E3B0B3D173B238ACA158E2" xlink:to="loc_us-gaap_StatementTable_A80DFBB3B5A277F0B8FEB238ACA1DCFC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfWarrantOrRightAxis" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_40E87298B128F44C3D0CB238ACA1520F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_A80DFBB3B5A277F0B8FEB238ACA1DCFC" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_40E87298B128F44C3D0CB238ACA1520F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_9A88706B2DC4FA099584B238ACA67592" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_40E87298B128F44C3D0CB238ACA1520F" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_9A88706B2DC4FA099584B238ACA67592" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_WarrantMember" xlink:label="loc_us-gaap_WarrantMember_DE5290E14543ECC39F86B238ACA6BC34" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_9A88706B2DC4FA099584B238ACA67592" xlink:to="loc_us-gaap_WarrantMember_DE5290E14543ECC39F86B238ACA6BC34" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConvertibleNotesPayableMember" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember_CE87112807345C982030B238ACA6866F" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_9A88706B2DC4FA099584B238ACA67592" xlink:to="loc_us-gaap_ConvertibleNotesPayableMember_CE87112807345C982030B238ACA6866F" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_FacilityLeaseObligationsAxis" xlink:label="loc_regn_FacilityLeaseObligationsAxis_97E8E190C0BF4DDFA30FB238ACA60CB1" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_A80DFBB3B5A277F0B8FEB238ACA1DCFC" xlink:to="loc_regn_FacilityLeaseObligationsAxis_97E8E190C0BF4DDFA30FB238ACA60CB1" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_FacilityLeaseObligationsNameDomain" xlink:label="loc_regn_FacilityLeaseObligationsNameDomain_5D557AF04BF6F8C6CFFAB238ACA675CA" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_FacilityLeaseObligationsAxis_97E8E190C0BF4DDFA30FB238ACA60CB1" xlink:to="loc_regn_FacilityLeaseObligationsNameDomain_5D557AF04BF6F8C6CFFAB238ACA675CA" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_FacilitiesBuildingDandEMember" xlink:label="loc_regn_FacilitiesBuildingDandEMember_BCA63638336C4C26F810B238ACA69917" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_FacilityLeaseObligationsNameDomain_5D557AF04BF6F8C6CFFAB238ACA675CA" xlink:to="loc_regn_FacilitiesBuildingDandEMember_BCA63638336C4C26F810B238ACA69917" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_57ADBF2F419F1F4715B6B238ACA74E3F" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_A80DFBB3B5A277F0B8FEB238ACA1DCFC" xlink:to="loc_us-gaap_StatementLineItems_57ADBF2F419F1F4715B6B238ACA74E3F" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_AccruedCapitalExpenditures" xlink:label="loc_regn_AccruedCapitalExpenditures_4A95E25C11CDC5786ECBB238ACA70915" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_57ADBF2F419F1F4715B6B238ACA74E3F" xlink:to="loc_regn_AccruedCapitalExpenditures_4A95E25C11CDC5786ECBB238ACA70915" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NotesPayable" xlink:label="loc_us-gaap_NotesPayable_F6A01D10FE393C504E6DB238ACA78C13" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_57ADBF2F419F1F4715B6B238ACA74E3F" xlink:to="loc_us-gaap_NotesPayable_F6A01D10FE393C504E6DB238ACA78C13" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AccountsPayableOtherCurrentAndNoncurrent" xlink:label="loc_us-gaap_AccountsPayableOtherCurrentAndNoncurrent_A5A2C7759A9163CEBAB0B238ACA79570" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_57ADBF2F419F1F4715B6B238ACA74E3F" xlink:to="loc_us-gaap_AccountsPayableOtherCurrentAndNoncurrent_A5A2C7759A9163CEBAB0B238ACA79570" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OtherLiabilitiesFairValueDisclosure" xlink:label="loc_us-gaap_OtherLiabilitiesFairValueDisclosure_FC0054FF008CA58D0F1BB238ACA7F6EC" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_57ADBF2F419F1F4715B6B238ACA74E3F" xlink:to="loc_us-gaap_OtherLiabilitiesFairValueDisclosure_FC0054FF008CA58D0F1BB238ACA7F6EC" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Facilityleaseobligationsrecognized" xlink:label="loc_regn_Facilityleaseobligationsrecognized_1EDE81879B94C5B0B54EB238ACA774E0" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_57ADBF2F419F1F4715B6B238ACA74E3F" xlink:to="loc_regn_Facilityleaseobligationsrecognized_1EDE81879B94C5B0B54EB238ACA774E0" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/StockholdersEquity" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_B5F845D552EB6C3715D2B238ADC8F699" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StockholdersEquityNoteDisclosureTextBlock" xlink:label="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_AE7173409A2D2F6C1E6EB238ADC89FB3" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_B5F845D552EB6C3715D2B238ADC8F699" xlink:to="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_AE7173409A2D2F6C1E6EB238ADC89FB3" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/StockholdersEquityDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_2FE8AEA8200A0378E4CBB238ADB827FB" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfStockByClassTable" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_8ADF4A6F2FA7D38CD679B238ADB8F271" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_2FE8AEA8200A0378E4CBB238ADB827FB" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_8ADF4A6F2FA7D38CD679B238ADB8F271" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_55BD496A8DE60639C4A5B238ADB8BB3D" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_8ADF4A6F2FA7D38CD679B238ADB8F271" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_55BD496A8DE60639C4A5B238ADB8BB3D" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_87BFAE75E4C4727F916EB238ADB8CC7A" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_55BD496A8DE60639C4A5B238ADB8BB3D" xlink:to="loc_us-gaap_EquityComponentDomain_87BFAE75E4C4727F916EB238ADB8CC7A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_BB3BAE8E2688968FB458B238ADB92FF4" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_87BFAE75E4C4727F916EB238ADB8CC7A" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_BB3BAE8E2688968FB458B238ADB92FF4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_D6D61431017181362714B238ADB9F1FD" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_8ADF4A6F2FA7D38CD679B238ADB8F271" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_D6D61431017181362714B238ADB9F1FD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_C6CA5405FDCB73EA4C57B238ADB9E913" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_D6D61431017181362714B238ADB9F1FD" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_C6CA5405FDCB73EA4C57B238ADB9E913" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_PDGFRbetaoutsidetheUSMember" xlink:label="loc_regn_PDGFRbetaoutsidetheUSMember_7F2F191F94A6270C41C1B238ADB9EB70" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_C6CA5405FDCB73EA4C57B238ADB9E913" xlink:to="loc_regn_PDGFRbetaoutsidetheUSMember_7F2F191F94A6270C41C1B238ADB9EB70" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_DEFF2B45945BAAA89C01B238ADB9C4E5" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_8ADF4A6F2FA7D38CD679B238ADB8F271" xlink:to="loc_us-gaap_StatementClassOfStockAxis_DEFF2B45945BAAA89C01B238ADB9C4E5" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_97DB3DE13AB5705B95A0B238ADB98A40" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_DEFF2B45945BAAA89C01B238ADB9C4E5" xlink:to="loc_us-gaap_ClassOfStockDomain_97DB3DE13AB5705B95A0B238ADB98A40" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonClassAMember" xlink:label="loc_us-gaap_CommonClassAMember_EF908261A954AE973574B238ADB9A1DB" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_97DB3DE13AB5705B95A0B238ADB98A40" xlink:to="loc_us-gaap_CommonClassAMember_EF908261A954AE973574B238ADB9A1DB" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_7B7932F3C04016D344CCB238ADB92F26" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_97DB3DE13AB5705B95A0B238ADB98A40" xlink:to="loc_us-gaap_CommonStockMember_7B7932F3C04016D344CCB238ADB92F26" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_LegalEntityAxis" xlink:label="loc_dei_LegalEntityAxis_AE7DF9473F3607F39BBCB238ADB913D7" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_8ADF4A6F2FA7D38CD679B238ADB8F271" xlink:to="loc_dei_LegalEntityAxis_AE7DF9473F3607F39BBCB238ADB913D7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd#dei_EntityDomain" xlink:label="loc_dei_EntityDomain_18E2040A3B15674B1C1AB238ADB9CA1B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_AE7DF9473F3607F39BBCB238ADB913D7" xlink:to="loc_dei_EntityDomain_18E2040A3B15674B1C1AB238ADB9CA1B" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_SanofiMember" xlink:label="loc_regn_SanofiMember_91BBC00EAD66CE7BC57AB238ADB957F3" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_18E2040A3B15674B1C1AB238ADB9CA1B" xlink:to="loc_regn_SanofiMember_91BBC00EAD66CE7BC57AB238ADB957F3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_AF7C86B1BDBEB4989746B238ADB92598" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_8ADF4A6F2FA7D38CD679B238ADB8F271" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_AF7C86B1BDBEB4989746B238ADB92598" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_7A7431EFBF0BCD0E61D4B238ADB97EDC" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_AF7C86B1BDBEB4989746B238ADB92598" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_7A7431EFBF0BCD0E61D4B238ADB97EDC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ConvertibleDebtMember" xlink:label="loc_us-gaap_ConvertibleDebtMember_503CA64DC017F3B1B5C1B238ADBED978" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_7A7431EFBF0BCD0E61D4B238ADB97EDC" xlink:to="loc_us-gaap_ConvertibleDebtMember_503CA64DC017F3B1B5C1B238ADBED978" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfWarrantOrRightAxis" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_0729DA4054269EFD71FAB238ADBF0438" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_8ADF4A6F2FA7D38CD679B238ADB8F271" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_0729DA4054269EFD71FAB238ADBF0438" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_9DD687B1E894E136B1E8B238ADBF042F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_0729DA4054269EFD71FAB238ADBF0438" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_9DD687B1E894E136B1E8B238ADBF042F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OptionIndexedToIssuersEquityTypeAxis" xlink:label="loc_us-gaap_OptionIndexedToIssuersEquityTypeAxis_52ED3FA4B47A5E7C8DF0B238ADBF5EC3" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_8ADF4A6F2FA7D38CD679B238ADB8F271" xlink:to="loc_us-gaap_OptionIndexedToIssuersEquityTypeAxis_52ED3FA4B47A5E7C8DF0B238ADBF5EC3" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_OptionIndexedToIssuersEquityTypeDomain" xlink:label="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_889469A85E23D23C6F17B238ADBF9E1B" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OptionIndexedToIssuersEquityTypeAxis_52ED3FA4B47A5E7C8DF0B238ADBF5EC3" xlink:to="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_889469A85E23D23C6F17B238ADBF9E1B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CallOptionMember" xlink:label="loc_us-gaap_CallOptionMember_28BA3597B1DCC40B6A63B238ADBF0F4F" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_889469A85E23D23C6F17B238ADBF9E1B" xlink:to="loc_us-gaap_CallOptionMember_28BA3597B1DCC40B6A63B238ADBF0F4F" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfStockLineItems" xlink:label="loc_us-gaap_ClassOfStockLineItems_6401D5B2D7E2A4272104B238ADBF8773" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_8ADF4A6F2FA7D38CD679B238ADB8F271" xlink:to="loc_us-gaap_ClassOfStockLineItems_6401D5B2D7E2A4272104B238ADBF8773" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockSharesAuthorized" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_034E2369D420C20AA0FFB238ADBF7793" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_6401D5B2D7E2A4272104B238ADBF8773" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_034E2369D420C20AA0FFB238ADBF7793" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_FF98837A869D2BB9ACABB238ADBFA9A2" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_6401D5B2D7E2A4272104B238ADBF8773" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_FF98837A869D2BB9ACABB238ADBFA9A2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_CommonStockVotingRights" xlink:label="loc_us-gaap_CommonStockVotingRights_E4FDB0E480D8CDAC2147B238ADBF6AA6" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_6401D5B2D7E2A4272104B238ADBF8773" xlink:to="loc_us-gaap_CommonStockVotingRights_E4FDB0E480D8CDAC2147B238ADBF6AA6" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PreferredStockSharesAuthorized" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_E62DFC9408CEB9968A52B238ADBF8975" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_6401D5B2D7E2A4272104B238ADBF8773" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_E62DFC9408CEB9968A52B238ADBF8975" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_NumberofsharesofCommonStockpurchased" xlink:label="loc_regn_NumberofsharesofCommonStockpurchased_2A47B4A7B6EA4CBEBA9DB238ADBF4D62" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_6401D5B2D7E2A4272104B238ADBF8773" xlink:to="loc_regn_NumberofsharesofCommonStockpurchased_2A47B4A7B6EA4CBEBA9DB238ADBF4D62" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_NumberofdemandrightstorequiretheCompanytoconductregisteredunderwrittenpublicoffering" xlink:label="loc_regn_NumberofdemandrightstorequiretheCompanytoconductregisteredunderwrittenpublicoffering_18029ACB8035F7C06103B238ADBF0CE1" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_6401D5B2D7E2A4272104B238ADBF8773" xlink:to="loc_regn_NumberofdemandrightstorequiretheCompanytoconductregisteredunderwrittenpublicoffering_18029ACB8035F7C06103B238ADBF0CE1" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_MaximumPercentageOfOutstandingSharesThatMayBeAcquiredUnderStandstillProvisions" xlink:label="loc_regn_MaximumPercentageOfOutstandingSharesThatMayBeAcquiredUnderStandstillProvisions_D81FFBAFFADF8A9BC540B238ADBF14E9" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_6401D5B2D7E2A4272104B238ADBF8773" xlink:to="loc_regn_MaximumPercentageOfOutstandingSharesThatMayBeAcquiredUnderStandstillProvisions_D81FFBAFFADF8A9BC540B238ADBF14E9" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_DebtConversion" xlink:label="loc_regn_DebtConversion_7BD77EB8B61EB8B6F50AB238ADC0CE25" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_6401D5B2D7E2A4272104B238ADBF8773" xlink:to="loc_regn_DebtConversion_7BD77EB8B61EB8B6F50AB238ADC0CE25" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_PercentageOfOutstandingSharesOrVotingRightsUnderAmendedInvestorAgreement" xlink:label="loc_regn_PercentageOfOutstandingSharesOrVotingRightsUnderAmendedInvestorAgreement_211D2CB49D8011D8298EB238ADC0D5FD" xlink:type="locator" />
    <presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_6401D5B2D7E2A4272104B238ADBF8773" xlink:to="loc_regn_PercentageOfOutstandingSharesOrVotingRightsUnderAmendedInvestorAgreement_211D2CB49D8011D8298EB238ADC0D5FD" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_PercentageOfOutstandingSharesthattheCompanyisrequiredtoappointanindividualagreeduponbytheCompanyandtheCollaboratortotheCompanysboardofdirectors" xlink:label="loc_regn_PercentageOfOutstandingSharesthattheCompanyisrequiredtoappointanindividualagreeduponbytheCompanyandtheCollaboratortotheCompanysboardofdirectors_8A380D691100E467CA8EB238ADC004F2" xlink:type="locator" />
    <presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_6401D5B2D7E2A4272104B238ADBF8773" xlink:to="loc_regn_PercentageOfOutstandingSharesthattheCompanyisrequiredtoappointanindividualagreeduponbytheCompanyandtheCollaboratortotheCompanysboardofdirectors_8A380D691100E467CA8EB238ADC004F2" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_7EE58922E87EEA0D7B6BB238ADC0B117" xlink:type="locator" />
    <presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_6401D5B2D7E2A4272104B238ADBF8773" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_7EE58922E87EEA0D7B6BB238ADC0B117" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_PurchaseOfConvertibleNoteHedges" xlink:label="loc_regn_PurchaseOfConvertibleNoteHedges_33A6A192133B62A51350B238ADC01599" xlink:type="locator" />
    <presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_6401D5B2D7E2A4272104B238ADBF8773" xlink:to="loc_regn_PurchaseOfConvertibleNoteHedges_33A6A192133B62A51350B238ADC01599" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_D180FAA83AE2F0C1A50BB238ADC091C7" xlink:type="locator" />
    <presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_6401D5B2D7E2A4272104B238ADBF8773" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_D180FAA83AE2F0C1A50BB238ADC091C7" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProceedsFromIssuanceOfWarrants" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfWarrants_F487C3403F239FA255DFB238ADC07564" xlink:type="locator" />
    <presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_6401D5B2D7E2A4272104B238ADBF8773" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfWarrants_F487C3403F239FA255DFB238ADC07564" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RepaymentsOfConvertibleDebt" xlink:label="loc_us-gaap_RepaymentsOfConvertibleDebt_A0F31B8E6E618CA444C2B238ADC030F4" xlink:type="locator" />
    <presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_6401D5B2D7E2A4272104B238ADBF8773" xlink:to="loc_us-gaap_RepaymentsOfConvertibleDebt_A0F31B8E6E618CA444C2B238ADC030F4" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DebtConversionConvertedInstrumentSharesIssued1" xlink:label="loc_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_F7B66E7AC60BC6B51D34B238ADC04FA1" xlink:type="locator" />
    <presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_6401D5B2D7E2A4272104B238ADBF8773" xlink:to="loc_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_F7B66E7AC60BC6B51D34B238ADC04FA1" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_6179DBA6875CE909281EB238ADC0B8DD" xlink:type="locator" />
    <presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_6401D5B2D7E2A4272104B238ADBF8773" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_6179DBA6875CE909281EB238ADC0B8DD" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebtSubsequentAdjustments" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebtSubsequentAdjustments_83AEB5E38EBA81A44010B238ADC0F15E" xlink:type="locator" />
    <presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_6401D5B2D7E2A4272104B238ADBF8773" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebtSubsequentAdjustments_83AEB5E38EBA81A44010B238ADC0F15E" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_TreasuryStockSharesAcquired" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_85A3DE5E082AF0A550F3B238ADC0AD23" xlink:type="locator" />
    <presentationArc order="19" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_6401D5B2D7E2A4272104B238ADBF8773" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_85A3DE5E082AF0A550F3B238ADC0AD23" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_PaymentsForRepurchaseOfWarrants" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfWarrants_A5C74E06D0ECABFDAC23B238ADC028CD" xlink:type="locator" />
    <presentationArc order="20" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_6401D5B2D7E2A4272104B238ADBF8773" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfWarrants_A5C74E06D0ECABFDAC23B238ADC028CD" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Maximumreductionofwarrantsheldbywarrantholder" xlink:label="loc_regn_Maximumreductionofwarrantsheldbywarrantholder_8D2B85CF6F94302582ADB238ADC05C05" xlink:type="locator" />
    <presentationArc order="21" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_6401D5B2D7E2A4272104B238ADBF8773" xlink:to="loc_regn_Maximumreductionofwarrantsheldbywarrantholder_8D2B85CF6F94302582ADB238ADC05C05" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Maximumamountofwarrantpayable" xlink:label="loc_regn_Maximumamountofwarrantpayable_4101247FD228BB76DAA3B238ADC08A0C" xlink:type="locator" />
    <presentationArc order="22" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_6401D5B2D7E2A4272104B238ADBF8773" xlink:to="loc_regn_Maximumamountofwarrantpayable_4101247FD228BB76DAA3B238ADC08A0C" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/TechnologyLicensingAgreements" xlink:type="extended">
    <loc xlink:href="regn-20151231.xsd#regn_TechnologyLicensingAgreementsAbstract" xlink:label="loc_regn_TechnologyLicensingAgreementsAbstract_9984C6DB351B3E250683B238AF4E94A1" xlink:type="locator" />
    <loc xlink:href="regn-20151231.xsd#regn_TechnologyLicensingAgreementsTextBlock" xlink:label="loc_regn_TechnologyLicensingAgreementsTextBlock_50AE9A8166B879B6A183B238AF4E08BE" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_TechnologyLicensingAgreementsAbstract_9984C6DB351B3E250683B238AF4E94A1" xlink:to="loc_regn_TechnologyLicensingAgreementsTextBlock_50AE9A8166B879B6A183B238AF4E08BE" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/TechnologyLicensingAgreementsDetails" xlink:type="extended">
    <loc xlink:href="regn-20151231.xsd#regn_TechnologyLicensingAgreementsAbstract" xlink:label="loc_regn_TechnologyLicensingAgreementsAbstract_627EA2E33ED9E03A244BB238AF406AC5" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueArrangementByTypeTable" xlink:label="loc_us-gaap_DeferredRevenueArrangementByTypeTable_02315536582BB6275FECB238AF408C62" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_TechnologyLicensingAgreementsAbstract_627EA2E33ED9E03A244BB238AF406AC5" xlink:to="loc_us-gaap_DeferredRevenueArrangementByTypeTable_02315536582BB6275FECB238AF408C62" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueArrangementTypeAxis" xlink:label="loc_us-gaap_DeferredRevenueArrangementTypeAxis_5A6695C4E1F5A06B630EB238AF409696" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueArrangementByTypeTable_02315536582BB6275FECB238AF408C62" xlink:to="loc_us-gaap_DeferredRevenueArrangementTypeAxis_5A6695C4E1F5A06B630EB238AF409696" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueArrangementTypeDomain" xlink:label="loc_us-gaap_DeferredRevenueArrangementTypeDomain_46C226D2C666C7089772B238AF46DD96" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueArrangementTypeAxis_5A6695C4E1F5A06B630EB238AF409696" xlink:to="loc_us-gaap_DeferredRevenueArrangementTypeDomain_46C226D2C666C7089772B238AF46DD96" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NonsoftwareLicenseArrangementMember" xlink:label="loc_us-gaap_NonsoftwareLicenseArrangementMember_E82BD83D12F08E46EA51B238AF4669E7" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueArrangementTypeDomain_46C226D2C666C7089772B238AF46DD96" xlink:to="loc_us-gaap_NonsoftwareLicenseArrangementMember_E82BD83D12F08E46EA51B238AF4669E7" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_LicenseAgreementWithAstellasPharmaIncMember" xlink:label="loc_regn_LicenseAgreementWithAstellasPharmaIncMember_653D26A72DC245351392B238AF46B010" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonsoftwareLicenseArrangementMember_E82BD83D12F08E46EA51B238AF4669E7" xlink:to="loc_regn_LicenseAgreementWithAstellasPharmaIncMember_653D26A72DC245351392B238AF46B010" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenueArrangementLineItems" xlink:label="loc_us-gaap_DeferredRevenueArrangementLineItems_6BBAE64E9DA7673B8437B238AF4647EE" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueArrangementByTypeTable_02315536582BB6275FECB238AF408C62" xlink:to="loc_us-gaap_DeferredRevenueArrangementLineItems_6BBAE64E9DA7673B8437B238AF4647EE" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Licenseagreementterm" xlink:label="loc_regn_Licenseagreementterm_5A60FF03A86143FCDADBB238AF46A893" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueArrangementLineItems_6BBAE64E9DA7673B8437B238AF4647EE" xlink:to="loc_regn_Licenseagreementterm_5A60FF03A86143FCDADBB238AF46A893" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ProceedsFromLicenseFeesReceived" xlink:label="loc_us-gaap_ProceedsFromLicenseFeesReceived_D432348F4B45ED4C984BB238AF463045" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueArrangementLineItems_6BBAE64E9DA7673B8437B238AF4647EE" xlink:to="loc_us-gaap_ProceedsFromLicenseFeesReceived_D432348F4B45ED4C984BB238AF463045" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_RecognitionPeriodForAdvancePayment" xlink:label="loc_regn_RecognitionPeriodForAdvancePayment_4667737C770C5DBE1C56B238AF46E1C2" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueArrangementLineItems_6BBAE64E9DA7673B8437B238AF4647EE" xlink:to="loc_regn_RecognitionPeriodForAdvancePayment_4667737C770C5DBE1C56B238AF46E1C2" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Futurepaymenttobemadeundertermsofamendedlicensingagreement" xlink:label="loc_regn_Futurepaymenttobemadeundertermsofamendedlicensingagreement_8450D16BB0EC1DF0A8EAB238AF46D356" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueArrangementLineItems_6BBAE64E9DA7673B8437B238AF4647EE" xlink:to="loc_regn_Futurepaymenttobemadeundertermsofamendedlicensingagreement_8450D16BB0EC1DF0A8EAB238AF46D356" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_NumberOfDaysOfAdvanceWrittenNoticeToTerminateAgreement" xlink:label="loc_regn_NumberOfDaysOfAdvanceWrittenNoticeToTerminateAgreement_8DB10D126DFEB806A759B238AF46A323" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueArrangementLineItems_6BBAE64E9DA7673B8437B238AF4647EE" xlink:to="loc_regn_NumberOfDaysOfAdvanceWrittenNoticeToTerminateAgreement_8DB10D126DFEB806A759B238AF46A323" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_LicensesRevenue" xlink:label="loc_us-gaap_LicensesRevenue_EFA6E249B45BA033D579B238AF46E7B0" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueArrangementLineItems_6BBAE64E9DA7673B8437B238AF4647EE" xlink:to="loc_us-gaap_LicensesRevenue_EFA6E249B45BA033D579B238AF46E7B0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_DeferredRevenue" xlink:label="loc_us-gaap_DeferredRevenue_F816F7F89C26C3493F9DB238AF466DFB" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredRevenueArrangementLineItems_6BBAE64E9DA7673B8437B238AF4647EE" xlink:to="loc_us-gaap_DeferredRevenue_F816F7F89C26C3493F9DB238AF466DFB" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/UnauditedQuarterlyResults" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_QuarterlyFinancialInformationDisclosureAbstract" xlink:label="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_FD56AF97CDC5BBCD4CD9B238AC98E367" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_QuarterlyFinancialInformationTextBlock" xlink:label="loc_us-gaap_QuarterlyFinancialInformationTextBlock_F2D41E942E5B7E198F01B238AC98DDA1" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_FD56AF97CDC5BBCD4CD9B238AC98E367" xlink:to="loc_us-gaap_QuarterlyFinancialInformationTextBlock_F2D41E942E5B7E198F01B238AC98DDA1" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/UnauditedQuarterlyResultsDetails" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_QuarterlyFinancialInformationDisclosureAbstract" xlink:label="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_C01A7A74B047AEB31DB9B238AC83FD79" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfEffectOfFourthQuarterEventsTable" xlink:label="loc_us-gaap_ScheduleOfEffectOfFourthQuarterEventsTable_91E7B7642CF7738CF8AAB238AC88D940" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_C01A7A74B047AEB31DB9B238AC83FD79" xlink:to="loc_us-gaap_ScheduleOfEffectOfFourthQuarterEventsTable_91E7B7642CF7738CF8AAB238AC88D940" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_30CF57CF24FFD6CA251AB238AC8841EC" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEffectOfFourthQuarterEventsTable_91E7B7642CF7738CF8AAB238AC88D940" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_30CF57CF24FFD6CA251AB238AC8841EC" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_358CA3C7E4B2363868FDB238AC88D0B9" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_30CF57CF24FFD6CA251AB238AC8841EC" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_358CA3C7E4B2363868FDB238AC88D0B9" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Ang2Member" xlink:label="loc_regn_Ang2Member_F71AE650E0D388B938F0B238AC889930" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_358CA3C7E4B2363868FDB238AC88D0B9" xlink:to="loc_regn_Ang2Member_F71AE650E0D388B938F0B238AC889930" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_PDGFMember" xlink:label="loc_regn_PDGFMember_283EC649DC0F47B7283CB238AC8865F5" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_358CA3C7E4B2363868FDB238AC88D0B9" xlink:to="loc_regn_PDGFMember_283EC649DC0F47B7283CB238AC8865F5" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductAxis" xlink:label="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductAxis_FEF58EEC61EB99C378D6B238AC88199C" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEffectOfFourthQuarterEventsTable_91E7B7642CF7738CF8AAB238AC88D940" xlink:to="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductAxis_FEF58EEC61EB99C378D6B238AC88199C" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain" xlink:label="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_0ED8B1260A2B4222BB7BB238AC881DFE" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductAxis_FEF58EEC61EB99C378D6B238AC88199C" xlink:to="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_0ED8B1260A2B4222BB7BB238AC881DFE" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_AntibodyCollaborationMember" xlink:label="loc_regn_AntibodyCollaborationMember_D72D36FD0E47D15CC474B238AC886767" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_0ED8B1260A2B4222BB7BB238AC881DFE" xlink:to="loc_regn_AntibodyCollaborationMember_D72D36FD0E47D15CC474B238AC886767" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EffectOfFourthQuarterEventsLineItems" xlink:label="loc_us-gaap_EffectOfFourthQuarterEventsLineItems_A0CD27144F5600CC5DC7B238AC8994E0" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEffectOfFourthQuarterEventsTable_91E7B7642CF7738CF8AAB238AC88D940" xlink:to="loc_us-gaap_EffectOfFourthQuarterEventsLineItems_A0CD27144F5600CC5DC7B238AC8994E0" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_Revenues" xlink:label="loc_us-gaap_Revenues_C583788DE96468F486E5B238AC89A521" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EffectOfFourthQuarterEventsLineItems_A0CD27144F5600CC5DC7B238AC8994E0" xlink:to="loc_us-gaap_Revenues_C583788DE96468F486E5B238AC89A521" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_71BBA632A0CBB2DF57B4B238AC89224B" xlink:type="locator" />
    <presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EffectOfFourthQuarterEventsLineItems_A0CD27144F5600CC5DC7B238AC8994E0" xlink:to="loc_us-gaap_NetIncomeLoss_71BBA632A0CBB2DF57B4B238AC89224B" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareBasic" xlink:label="loc_us-gaap_EarningsPerShareBasic_EE23CDB1A59BAA39588EB238AC8900FE" xlink:type="locator" />
    <presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EffectOfFourthQuarterEventsLineItems_A0CD27144F5600CC5DC7B238AC8994E0" xlink:to="loc_us-gaap_EarningsPerShareBasic_EE23CDB1A59BAA39588EB238AC8900FE" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_EarningsPerShareDiluted" xlink:label="loc_us-gaap_EarningsPerShareDiluted_76151268888F478FF832B238AC898D6A" xlink:type="locator" />
    <presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EffectOfFourthQuarterEventsLineItems_A0CD27144F5600CC5DC7B238AC8994E0" xlink:to="loc_us-gaap_EarningsPerShareDiluted_76151268888F478FF832B238AC898D6A" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized" xlink:label="loc_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_46ED2C495A3360EFB6C7B238AC8909FA" xlink:type="locator" />
    <presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EffectOfFourthQuarterEventsLineItems_A0CD27144F5600CC5DC7B238AC8994E0" xlink:to="loc_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_46ED2C495A3360EFB6C7B238AC8909FA" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_BrandedPrescriptionDrugFee" xlink:label="loc_regn_BrandedPrescriptionDrugFee_209C4CBD27AFCDD2CC86B238AC89A547" xlink:type="locator" />
    <presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EffectOfFourthQuarterEventsLineItems_A0CD27144F5600CC5DC7B238AC8994E0" xlink:to="loc_regn_BrandedPrescriptionDrugFee_209C4CBD27AFCDD2CC86B238AC89A547" xlink:type="arc" />
    <loc xlink:href="regn-20151231.xsd#regn_Numberoffamiliesofnovelantibodies" xlink:label="loc_regn_Numberoffamiliesofnovelantibodies_A4AF412B0CB41E8FC798B238AC89A911" xlink:type="locator" />
    <presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EffectOfFourthQuarterEventsLineItems_A0CD27144F5600CC5DC7B238AC8994E0" xlink:to="loc_regn_Numberoffamiliesofnovelantibodies_A4AF412B0CB41E8FC798B238AC89A911" xlink:type="arc" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff" xlink:label="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_C1C23E7EA8E54FD301F6B238AC8945F9" xlink:type="locator" />
    <presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EffectOfFourthQuarterEventsLineItems_A0CD27144F5600CC5DC7B238AC8994E0" xlink:to="loc_us-gaap_ResearchAndDevelopmentAssetAcquiredOtherThanThroughBusinessCombinationWrittenOff_C1C23E7EA8E54FD301F6B238AC8945F9" xlink:type="arc" />
  </presentationLink>
  <presentationLink xlink:role="http://www.regeneron.com/role/UnauditedQuarterlyResultsTables" xlink:type="extended">
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_QuarterlyFinancialInformationDisclosureAbstract" xlink:label="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_F3C3FBAB7E310A530FFBB238AC90D18C" xlink:type="locator" />
    <loc xlink:href="http://xbrl.fasb.org/us-gaap/2015/elts/us-gaap-2015-01-31.xsd#us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock_0CCC02311F4C100AC89EB238AC90E3F5" xlink:type="locator" />
    <presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_F3C3FBAB7E310A530FFBB238AC90D18C" xlink:to="loc_us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock_0CCC02311F4C100AC89EB238AC90E3F5" xlink:type="arc" />
  </presentationLink>
</linkbase>
