0000872589 2023-01-01 2023-12-31 0000872589 2022-01-01 2022-12-31 0000872589 2021-01-01 2021-12-31 0000872589 2020-01-01 2020-12-31 0000872589 regn:ExclusionOfStockAwardsAndOptionAwardsFromSummaryCompensationTableForPEOMember ecd:PeoMember 2023-01-01 2023-12-31 0000872589 regn:InclusionOfItem402vEquityAwardValuesForPEOMember ecd:PeoMember 2023-01-01 2023-12-31 0000872589 regn:ExclusionOfStockAwardsAndOptionAwardsFromSummaryCompensationTableForNonPEONEOsMember ecd:NonPeoNeoMember 2023-01-01 2023-12-31 0000872589 regn:InclusionOfItem402vEquityAwardValuesForNonPEONEOsMember ecd:NonPeoNeoMember 2023-01-01 2023-12-31 0000872589 regn:YearEndFairValueOfEquityAwardsGrantedDuringYearThatRemainedUnvestedAsOfLastDayOfYearForPEOMember ecd:PeoMember 2023-01-01 2023-12-31 0000872589 regn:ChangeInFairValueFromLastDayOfPriorYearToLastDayOfYearOfUnvestedEquityAwardsForPEOMember ecd:PeoMember 2023-01-01 2023-12-31 0000872589 regn:VestingDateFairValueOfEquityAwardsGrantedDuringYearThatVestedDuringYearForPEOMember ecd:PeoMember 2023-01-01 2023-12-31 0000872589 regn:ChangeInFairValueFromLastDayOfPriorYearToVestingDateOfUnvestedEquityAwardsThatVestedDuringYearForPEOMember ecd:PeoMember 2023-01-01 2023-12-31 0000872589 regn:FairValueAtLastDayOfPriorYearOfEquityAwardsForfeitedDuringYearForPEOMember ecd:PeoMember 2023-01-01 2023-12-31 0000872589 regn:ValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsNotOtherwiseIncludedForPEOMember ecd:PeoMember 2023-01-01 2023-12-31 0000872589 regn:TotalInclusionOfEquityValuesForPEOMember ecd:PeoMember 2023-01-01 2023-12-31 0000872589 regn:AverageYearEndFairValueOfEquityAwardsGrantedDuringYearThatRemainedUnvestedAsOfLastDayOfYearForNonPEONEOsMember ecd:NonPeoNeoMember 2023-01-01 2023-12-31 0000872589 regn:AverageChangeInFairValueFromLastDayOfPriorYearToLastDayOfYearOfUnvestedEquityAwardsForNonPEONEOsMember ecd:NonPeoNeoMember 2023-01-01 2023-12-31 0000872589 regn:AverageVestingDateFairValueOfEquityAwardsGrantedDuringYearThatVestedDuringYearForNonPEONEOsMember ecd:NonPeoNeoMember 2023-01-01 2023-12-31 0000872589 regn:AverageChangeInFairValueFromLastDayOfPriorYearToVestingDateOfUnvestedEquityAwardsThatVestedDuringYearForNonPEONEOsMember ecd:NonPeoNeoMember 2023-01-01 2023-12-31 0000872589 regn:AverageFairValueAtLastDayOfPriorYearOfEquityAwardsForfeitedDuringYearForNonPEONEOsMember ecd:NonPeoNeoMember 2023-01-01 2023-12-31 0000872589 regn:AverageValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsNotOtherwiseIncludedForNonPEONEOsMember ecd:PeoMember 2023-01-01 2023-12-31 0000872589 regn:TotalAverageInclusionOfEquityValuesForNonPEONEOsMember ecd:NonPeoNeoMember 2023-01-01 2023-12-31 0000872589 1 2023-01-01 2023-12-31 0000872589 5 2023-01-01 2023-12-31 0000872589 2 2023-01-01 2023-12-31 0000872589 6 2023-01-01 2023-12-31 0000872589 3 2023-01-01 2023-12-31 0000872589 7 2023-01-01 2023-12-31 0000872589 4 2023-01-01 2023-12-31 iso4217:USD shares iso4217:USD shares pure false 0000872589 DEF 14A REGENERON PHARMACEUTICALS, INC. <h4 id="xdx_80E_eecd--PvpTableTextBlock_dU_zHvIQwA4Qdwf" style="font: 14pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #D60058">Pay Versus Performance</h4> As required by Item 402(v) of Regulation S-K, the following table and accompanying footnotes and discussion provide certain information regarding executive compensation and measures of Company performance for the years presented. Except where expressly stated, the information presented below was not considered by the Compensation Committee in structuring our executive compensation program for the years presented, and the reader should instead refer to the section “Compensation Discussion and Analysis” for a description of the philosophy, objectives, and structure of our pay program. <table cellpadding="0" cellspacing="0" id="xdx_30F_zI1NhSFx0ULh" style="font: 9pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; width: 2%; padding-bottom: 1pt; text-align: center; padding-left: 3pt">A</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; width: 9%; padding-bottom: 1pt; text-align: center"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; width: 4%; padding-bottom: 1pt; text-align: center">B</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; width: 9%; text-align: center"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; width: 4%; text-align: center">C</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; width: 9%; text-align: center"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; width: 5%; text-align: center">D</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; width: 9%; text-align: center"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; width: 5%; padding-bottom: 1pt; text-align: center">E</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; width: 9%; padding-bottom: 1pt; text-align: center"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; width: 3%; padding-bottom: 1pt; text-align: center">F</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; width: 3%; padding-bottom: 1pt; text-align: center"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; width: 3%; padding-bottom: 1pt; text-align: center">G</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; width: 9%; padding-bottom: 1pt; text-align: center"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; width: 4%; padding-bottom: 1pt; text-align: center">H</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; width: 9%; padding-bottom: 1pt; text-align: center"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; width: 4%; padding-bottom: 1pt; text-align: center; padding-right: 3pt">I</td></tr> <tr> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; padding-left: 3pt"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: center"> </td> <td colspan="3" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: center">Value of Initial Fixed $100 Investment Based On:</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; padding-right: 3pt"> </td></tr> <tr> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; text-align: left; padding-left: 3pt">Year</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; text-align: right">Summary Compensation Table Total for PEO ($)1</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; text-align: right">Compensation “Actually Paid” to PEO ($)1,2,3</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; text-align: right">Average Summary Compensation Table Total for Non-PEO NEOs ($)1</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; text-align: right">Average Compensation “Actually Paid” to Non-PEO NEOs ($)1,2,3</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; text-align: right">TSR ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; text-align: right">Peer Group TSR ($)4</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; text-align: right">Net Income ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; text-align: right; padding-right: 3pt">Stock Price ($)5</td></tr> <tr> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; padding-left: 3pt">2023</td> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_983_eecd--PeoTotalCompAmt_pp0p0_c20230101__20231231_fMQ_____zz4cwiA8QPfa" style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; text-align: right" title="PEO Total Compensation Amount">8,184,338</td> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_981_eecd--PeoActuallyPaidCompAmt_pp0p0_c20230101__20231231_fMSAyIDM___zzh0pzp4R48i" style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; text-align: right" title="PEO Total Compensation Amount">141,071,193</td> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_988_eecd--NonPeoNeoAvgTotalCompAmt_pp0p0_c20230101__20231231_fMQ_____zXVjvczwdIbl" style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; text-align: right" title="Non-PEO NEO Average Total Compensation Amount">6,713,442</td> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_98D_eecd--NonPeoNeoAvgCompActuallyPaidAmt_pp0p0_c20230101__20231231_fMSAyIDM___zk4FZEP3fisg" style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; text-align: right" title="Non-PEO NEO Average Compensation Actually Paid Amount">46,896,425</td> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_98D_eecd--TotalShareholderRtnAmt_pp2p0_c20230101__20231231_zezAObxYHK93" style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; text-align: right" title="Total Shareholder Return Amount">233.91</td> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_98E_eecd--PeerGroupTotalShareholderRtnAmt_pp2p0_c20230101__20231231_fNA_____zb3Mq3PFNiW3" style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; text-align: right" title="Peer Group Total Shareholder Return Amount">159.01</td> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_988_eus-gaap--NetIncomeLoss_uUSD_c20230101__20231231_zSjSKje1e1C8" style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; text-align: right" title="Net Income (Loss)">3,953,600,000</td> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_98A_eecd--CoSelectedMeasureAmt_uUSD_c20230101__20231231_fNQ_____zrqINUS3BwG4" style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; text-align: right; padding-right: 3pt" title="Company Selected Measure Amount">878.29</td></tr> <tr style="background-color: #ECECED"> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; padding-left: 3pt">2022</td> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_98D_eecd--PeoTotalCompAmt_pp0p0_c20220101__20221231_fMQ_____zt0mROulG75a" style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; text-align: right" title="PEO Total Compensation Amount">7,004,069</td> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_980_eecd--PeoActuallyPaidCompAmt_pp0p0_c20220101__20221231_fMSAyIDM___zzuFPdZlhSHl" style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; text-align: right" title="PEO Total Compensation Amount">98,786,583</td> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_984_eecd--NonPeoNeoAvgTotalCompAmt_pp0p0_c20220101__20221231_fMQ_____zvM1juwd4PTl" style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; text-align: right" title="Non-PEO NEO Average Total Compensation Amount">8,061,639</td> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_987_eecd--NonPeoNeoAvgCompActuallyPaidAmt_pp0p0_c20220101__20221231_fMSAyIDM___z6eMfxgmg2tc" style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; text-align: right" title="Non-PEO NEO Average Compensation Actually Paid Amount">32,174,465</td> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_98D_eecd--TotalShareholderRtnAmt_pp2p0_c20220101__20221231_zGo4J0nu7Pc6" style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; text-align: right" title="Total Shareholder Return Amount">192.15</td> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_985_eecd--PeerGroupTotalShareholderRtnAmt_pp2p0_c20220101__20221231_fNA_____zrBTDrIi7cb" style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; text-align: right" title="Peer Group Total Shareholder Return Amount">153.08</td> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_982_eus-gaap--NetIncomeLoss_uUSD_c20220101__20221231_zvpLorW3IhLe" style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; text-align: right" title="Net Income (Loss)">4,338,400,000</td> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_98B_eecd--CoSelectedMeasureAmt_uUSD_c20220101__20221231_fNQ_____zbvlZHuOEEkd" style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; text-align: right; padding-right: 3pt" title="Company Selected Measure Amount">721.49</td></tr> <tr> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; padding-left: 3pt">2021</td> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_983_eecd--PeoTotalCompAmt_pp0p0_c20210101__20211231_fMQ_____zL4AkIEtbUmf" style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; text-align: right" title="PEO Total Compensation Amount">6,470,514</td> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_98B_eecd--PeoActuallyPaidCompAmt_pp0p0_c20210101__20211231_fMSAyIDM___zVsvL8BP8m58" style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; text-align: right" title="PEO Total Compensation Amount">123,744,652</td> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_986_eecd--NonPeoNeoAvgTotalCompAmt_pp0p0_c20210101__20211231_fMQ_____zJwbgHWkQbu6" style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; text-align: right" title="Non-PEO NEO Average Total Compensation Amount">7,548,928</td> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_98D_eecd--NonPeoNeoAvgCompActuallyPaidAmt_pp0p0_c20210101__20211231_fMSAyIDM___zMLWfw6zx5Lk" style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; text-align: right" title="Non-PEO NEO Average Compensation Actually Paid Amount">40,168,860</td> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_984_eecd--TotalShareholderRtnAmt_pp2p0_c20210101__20211231_zT0KgGpkrhrg" style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; text-align: right" title="Total Shareholder Return Amount">168.19</td> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_980_eecd--PeerGroupTotalShareholderRtnAmt_pp2p0_c20210101__20211231_fNA_____zTQtNPRgxs12" style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; text-align: right" title="Peer Group Total Shareholder Return Amount">137.47</td> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_98C_eus-gaap--NetIncomeLoss_uUSD_c20210101__20211231_zprJrLZQ4kEk" style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; text-align: right" title="Net Income (Loss)">8,075,300,000</td> <td style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_983_eecd--CoSelectedMeasureAmt_uUSD_c20210101__20211231_fNQ_____zqUPiM9whkoa" style="border-bottom: rgb(148,149,153) 1px solid; vertical-align: bottom; text-align: right; padding-right: 3pt" title="Company Selected Measure Amount">631.52</td></tr> <tr style="background-color: #ECECED"> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; padding-left: 3pt">2020</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_982_eecd--PeoTotalCompAmt_pp0p0_c20200101__20201231_fMQ_____ztppgGImUHA2" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right" title="PEO Total Compensation Amount">135,350,121</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_98F_eecd--PeoActuallyPaidCompAmt_pp0p0_c20200101__20201231_fMSAyIDM___z0OwaxSMvd94" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right" title="PEO Total Compensation Amount">153,035,522</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_984_eecd--NonPeoNeoAvgTotalCompAmt_pp0p0_c20200101__20201231_fMQ_____zRqh3xabpPZ4" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right" title="Non-PEO NEO Average Total Compensation Amount">40,058,597</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_98E_eecd--NonPeoNeoAvgCompActuallyPaidAmt_pp0p0_c20200101__20201231_fMSAyIDM___zJSYcUQiyGvf" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right" title="Non-PEO NEO Average Compensation Actually Paid Amount">48,557,559</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_984_eecd--TotalShareholderRtnAmt_pp2p0_c20200101__20201231_zDwYEU3gTP34" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right" title="Total Shareholder Return Amount">128.66</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_983_eecd--PeerGroupTotalShareholderRtnAmt_pp2p0_c20200101__20201231_fNA_____zGlhEBXKlED8" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right" title="Peer Group Total Shareholder Return Amount">110.52</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_985_eus-gaap--NetIncomeLoss_uUSD_c20200101__20201231_zKk1VQfDEBjb" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right" title="Net Income (Loss)">3,513,200,000</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_986_eecd--CoSelectedMeasureAmt_uUSD_c20200101__20201231_fNQ_____z5UZGmasUIx3" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right; padding-right: 3pt" title="Company Selected Measure Amount">483.11</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="padding-top: 3pt; width: 18pt">1</td> <td id="xdx_F10_zCE0BETisq09" style="display: none; padding-top: 3pt; visibility: hidden">Leonard S. Schleifer, M.D., Ph.D. was our principal executive officer (“PEO”) for each year presented. George D. Yancopoulos, M.D., Ph.D., Robert E. Landry, Daniel P. Van Plew, and Andrew J. Murphy, Ph.D. comprise the non-PEO named executive officers (“Non-PEO NEOs”) for 2020 and 2023; and each of these individuals plus Joseph J. LaRosa and Marion McCourt comprise the Non-PEO NEOs for 2021 and 2022, respectively.</td></tr> <tr style="display: none; vertical-align: top; visibility: hidden"> <td style="display: none; padding-top: 3pt; visibility: hidden">2</td> <td id="xdx_F11_zLehpKzm1BBb" style="display: none; padding-top: 3pt; visibility: hidden">The amounts shown for “Compensation “Actually Paid”” have been calculated in accordance with Item 402(v) of Regulation S K and do not reflect compensation actually earned, realized, or received by the Company’s NEOs. These amounts reflect total compensation as reported in the Summary Compensation Table with certain adjustments as described in footnote 3 below.</td></tr> <tr style="display: none; vertical-align: top; visibility: hidden"> <td id="xdx_F03_zOiPj04YxKIk" style="display: none; padding-top: 3pt; visibility: hidden">3</td> <td id="xdx_F1F_zVBHXsmmOjwl" style="display: none; padding-top: 3pt; visibility: hidden">“Compensation “Actually Paid”” reflects the exclusions and inclusions of equity awards for the PEO and the Non-PEO NEOs as set forth below and calculated in accordance with FASB ASC Topic 718 using the valuation methodologies and assumptions set forth in the calculation of the grant date fair value of these awards as disclosed in the Company’s audited financial statements for the fiscal year in which the equity awards were granted.</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; display: none; width: 100%; border-collapse: collapse; visibility: hidden"> <tr style="display: none; vertical-align: top; visibility: hidden"> <td style="display: none; padding-top: 3pt; width: 18pt; visibility: hidden"> </td> <td style="display: none; padding-top: 3pt; visibility: hidden">The “Exclusion of Stock Awards and Option Awards from Summary Compensation Table” columns in the tables below reflect the aggregate amounts reported in the Summary Compensation Table for the applicable year in the “Stock Awards” and “Option Awards” columns.</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; display: none; width: 100%; border-collapse: collapse; visibility: hidden"> <tr style="display: none; vertical-align: top; visibility: hidden"> <td style="display: none; padding-top: 3pt; width: 18pt; visibility: hidden">4</td> <td id="xdx_F1F_zPJgKGD6djKa" style="display: none; padding-top: 3pt; visibility: hidden">The Peer Group TSR shown in this table utilizes the NASDAQ US Benchmark Pharmaceuticals Total Return Index (“NQ US Pharma Index”), which we also utilized in the stock performance graph required by Item 201(e) of Regulation S-K included in our Annual Reports on Form 10-K for the years reflected in the table above. The comparison assumes $100 was invested for the period starting December 31, 2019 through December 31 of the applicable fiscal year in each of the Company’s common stock and the NQ US Pharma Index. All dollar values assume reinvestment of the pre-tax value of dividends paid by companies included in the NQ US Pharma Index. The historical stock price performance of our common stock shown is not necessarily indicative of future stock price performance.</td></tr> <tr style="display: none; vertical-align: top; visibility: hidden"> <td style="display: none; padding-top: 3pt; visibility: hidden">5</td> <td id="xdx_F19_zBOdTmRk3XVh" style="display: none; padding-top: 3pt; visibility: hidden">Pursuant to Item 402(v) of Regulation S-K, we determined our stock price to be the most important financial performance measure used to link Company performance to Compensation “Actually Paid” to our PEO and other NEOs in 2023. This performance measure may not have been the most important financial performance measure for prior years and we may determine a different financial performance measure to be the most important such measure in future years.</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; padding-top: 3pt">1</td> <td style="padding-top: 3pt">Leonard S. Schleifer, M.D., Ph.D. was our principal executive officer (“PEO”) for each year presented. George D. Yancopoulos, M.D., Ph.D., Robert E. Landry, Daniel P. Van Plew, and Andrew J. Murphy, Ph.D. comprise the non-PEO named executive officers (“Non-PEO NEOs”) for 2020 and 2023; and each of these individuals plus Joseph J. LaRosa and Marion McCourt comprise the Non-PEO NEOs for 2021 and 2022, respectively.</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="padding-top: 3pt; width: 18pt">2</td> <td style="padding-top: 3pt">The amounts shown for “Compensation “Actually Paid”” have been calculated in accordance with Item 402(v) of Regulation S K and do not reflect compensation actually earned, realized, or received by the Company’s NEOs. These amounts reflect total compensation as reported in the Summary Compensation Table with certain adjustments as described in footnote 3 below.</td></tr> <tr style="vertical-align: top"> <td style="padding-top: 3pt">3</td> <td style="padding-top: 3pt">“Compensation “Actually Paid”” reflects the exclusions and inclusions of equity awards for the PEO and the Non-PEO NEOs as set forth below and calculated in accordance with FASB ASC Topic 718 using the valuation methodologies and assumptions set forth in the calculation of the grant date fair value of these awards as disclosed in the Company’s audited financial statements for the fiscal year in which the equity awards were granted.</td></tr> <tr style="vertical-align: top"> <td style="padding-top: 3pt"> </td> <td style="padding-top: 3pt">The “Exclusion of Stock Awards and Option Awards from Summary Compensation Table” columns in the tables below reflect the aggregate amounts reported in the Summary Compensation Table for the applicable year in the “Stock Awards” and “Option Awards” columns.</td></tr> </table> <table cellpadding="0" cellspacing="0" id="xdx_308_zettrqKs8ERl" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr> <td style="width: 18pt"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; padding-left: 3pt">Year</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; width: 2%; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; width: 18%; text-align: right">Summary Compensation Table Total for PEO ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; width: 2%; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; width: 18%; text-align: right">Exclusion of Stock Awards and Option Awards from Summary Compensation Table for PEO ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; width: 2%; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; width: 14%; text-align: right">Inclusion of Item 402(v) Equity Award Values for PEO ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; width: 2%; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; width: 14%; text-align: right; padding-right: 3pt">Compensation “Actually Paid” to PEO ($)</td></tr> <tr> <td> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; padding-left: 3pt">2023</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_989_eecd--PeoTotalCompAmt_c20230101__20231231_zBYK6oHgOabd" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">8,184,338</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_98D_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--ExclusionOfStockAwardsAndOptionAwardsFromSummaryCompensationTableForPEOMember_fKGEp_zK9X3Hk8Y4j5" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">0</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_989_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--InclusionOfItem402vEquityAwardValuesForPEOMember_fKGEp_zf9Utyuub5Bh" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">132,886,855</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_984_eecd--PeoActuallyPaidCompAmt_c20230101__20231231_z8aTYBOxXBj9" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right; padding-right: 3pt">141,071,193</td></tr> </table> <table cellpadding="0" cellspacing="0" id="xdx_30811_zettrqKs8ERl" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr> <td style="width: 18pt"> </td> <td style="vertical-align: bottom; padding-left: 3pt"> </td> <td style="vertical-align: top; text-align: right; width: 2%"> </td> <td style="vertical-align: bottom; text-align: right; width: 18%"> </td> <td style="vertical-align: top; text-align: right; width: 2%"> </td> <td style="vertical-align: bottom; text-align: right; width: 18%"> </td> <td style="vertical-align: top; text-align: right; width: 2%"> </td> <td style="vertical-align: bottom; text-align: right; width: 14%"> </td> <td style="vertical-align: top; text-align: right; width: 2%"> </td> <td style="vertical-align: bottom; text-align: right; padding-right: 3pt; width: 14%"> </td></tr> <tr> <td> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; padding-left: 3pt">Year</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">Average Summary Compensation Table Total for Non-PEO NEOs ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">Exclusion of Stock Awards and Option Awards from Summary Compensation Table for Non-PEO NEOs ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">Inclusion of Item 402(v) Equity Award Values for Non-PEO NEOs ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right; padding-right: 3pt">Average Compensation “Actually Paid” to Non-PEO NEOs ($)</td></tr> <tr> <td> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; padding-left: 3pt">2023</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_986_eecd--NonPeoNeoAvgTotalCompAmt_c20230101__20231231_zH7Dx6gimRni" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">6,713,442</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_98D_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--ExclusionOfStockAwardsAndOptionAwardsFromSummaryCompensationTableForNonPEONEOsMember_fKGEp_zEkI5CQ2sSJh" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">(3,374,461)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_982_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--InclusionOfItem402vEquityAwardValuesForNonPEONEOsMember_fKGEp_zogS42O9yBb4" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">43,557,444</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_98D_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20230101__20231231_zjOKRGf5qAI2" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right; padding-right: 3pt">46,896,425</td></tr> </table> <div style="border-bottom: Silver 4px solid; margin-bottom: 6pt"><table cellpadding="0" cellspacing="0" style="font: 12pt Arial, Helvetica, Sans-Serif; width: 100%"><tr><td style="text-align: center; width: 100%"> </td></tr></table></div> <div style="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"></div> The “Inclusion of Item 402(v) Equity Award Values” columns in the tables above are derived from the dollar values set forth in the following tables: <div id="xdx_C0D_gL2ATPCFTB-ZNHISU_zWTM9XeHQKaa"> <table cellpadding="0" cellspacing="0" id="xdx_308_zdYcRYtY8rz1" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr> <td style="white-space: nowrap; width: 18pt"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; padding-left: 3pt">Year</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; width: 1%; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; width: 15%; text-align: right">Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for PEO ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; width: 1%; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; width: 10%; text-align: right">Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for PEO ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; width: 1%; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; width: 10%; text-align: right">Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for PEO ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; width: 1%; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; width: 10%; text-align: right">Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for PEO ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; width: 1%; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; width: 10%; text-align: right">Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for PEO ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; width: 1%; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; width: 10%; text-align: right">Value of Dividends or Other Earnings Paid on Stock or Option Awards Not Otherwise Included for PEO ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; width: 1%; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; width: 10%; text-align: right; padding-right: 3pt">Total - Inclusion of Equity Values for PEO ($)</td></tr> <tr> <td> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; padding-left: 3pt">2023</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_981_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--YearEndFairValueOfEquityAwardsGrantedDuringYearThatRemainedUnvestedAsOfLastDayOfYearForPEOMember_fKGEp_zMqiHevLwNBg" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">0</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_987_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--ChangeInFairValueFromLastDayOfPriorYearToLastDayOfYearOfUnvestedEquityAwardsForPEOMember_fKGEp_zBs0wBwfn3Uk" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">126,245,090</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_984_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--VestingDateFairValueOfEquityAwardsGrantedDuringYearThatVestedDuringYearForPEOMember_fKGEp_zHHY0C6XRVY7" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">0</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_981_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--ChangeInFairValueFromLastDayOfPriorYearToVestingDateOfUnvestedEquityAwardsThatVestedDuringYearForPEOMember_fKGEp_zcz3H72u4bo9" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">6,641,765</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_98C_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--FairValueAtLastDayOfPriorYearOfEquityAwardsForfeitedDuringYearForPEOMember_fKGEp_zqwxdDioyYmj" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">0</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_98A_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--ValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsNotOtherwiseIncludedForPEOMember_fKGEp_zqHNXaIOoa5a" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">0</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_985_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--TotalInclusionOfEquityValuesForPEOMember_fKGEp_z8a1Zvl3X1s9" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right; padding-right: 3pt">132,886,855</td></tr> </table> </div> <div id="xdx_C01_gL2ATNPNCFTB-EUEKM_zj0uLuoBvthg"> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr style="font-size: 12pt"> <td style="font-size: 12pt; width: 18pt"> </td> <td style="vertical-align: bottom; padding-left: 3pt; font-size: 12pt"> </td> <td style="vertical-align: top; text-align: right; font-size: 12pt; width: 1%"> </td> <td style="vertical-align: bottom; text-align: right; font-size: 12pt; width: 15%"> </td> <td style="vertical-align: top; text-align: right; font-size: 12pt; width: 1%"> </td> <td style="vertical-align: bottom; text-align: right; font-size: 12pt; width: 10%"> </td> <td style="vertical-align: top; text-align: right; font-size: 12pt; width: 1%"> </td> <td style="vertical-align: bottom; text-align: right; font-size: 12pt; width: 10%"> </td> <td style="vertical-align: top; text-align: right; font-size: 12pt; width: 1%"> </td> <td style="vertical-align: bottom; text-align: right; font-size: 12pt; width: 10%"> </td> <td style="vertical-align: top; text-align: right; font-size: 12pt; width: 1%"> </td> <td style="vertical-align: bottom; text-align: right; font-size: 12pt; width: 10%"> </td> <td style="vertical-align: top; text-align: right; font-size: 12pt; width: 1%"> </td> <td style="vertical-align: bottom; text-align: right; font-size: 12pt; width: 10%"> </td> <td style="vertical-align: top; text-align: right; font-size: 12pt; width: 1%"> </td> <td style="vertical-align: bottom; text-align: right; padding-right: 3pt; font-size: 12pt; width: 10%"> </td></tr> <tr> <td style="white-space: nowrap"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; padding-left: 3pt">Year</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; text-align: right">Average Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for Non-PEO NEOs ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; text-align: right">Average Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for Non-PEO NEOs ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; text-align: right">Average Vesting- Date Fair Value of Equity Awards Granted During Year that Vested During Year for Non-PEO NEOs ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; text-align: right">Average Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for Non-PEO NEOs ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; text-align: right">Average Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for Non-PEO NEOs ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; text-align: right">Average Value of Dividends or Other Earnings Paid on Stock or Option Awards Not Otherwise Included for Non- PEO NEOs ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; text-align: right; padding-right: 3pt">Total—Average Inclusion of Equity Values for Non-PEO NEOs ($)</td></tr> <tr> <td> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; padding-left: 3pt">2023</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_984_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AverageYearEndFairValueOfEquityAwardsGrantedDuringYearThatRemainedUnvestedAsOfLastDayOfYearForNonPEONEOsMember_fKGEp_zIz3TebNYMqg" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">3,521,007</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_988_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AverageChangeInFairValueFromLastDayOfPriorYearToLastDayOfYearOfUnvestedEquityAwardsForNonPEONEOsMember_fKGEp_z3Xexy894ne2" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">34,981,296</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_982_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AverageVestingDateFairValueOfEquityAwardsGrantedDuringYearThatVestedDuringYearForNonPEONEOsMember_fKGEp_zqHmRYfNiC1d" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">0</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_981_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AverageChangeInFairValueFromLastDayOfPriorYearToVestingDateOfUnvestedEquityAwardsThatVestedDuringYearForNonPEONEOsMember_fKGEp_zxgBctHV3ndh" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">5,055,141</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_987_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AverageFairValueAtLastDayOfPriorYearOfEquityAwardsForfeitedDuringYearForNonPEONEOsMember_fKGEp_zTs5BkNzDt56" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">0</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_98D_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--AverageValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsNotOtherwiseIncludedForNonPEONEOsMember_fKGEp_zRZGUddfe2K8" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">0</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_984_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--TotalAverageInclusionOfEquityValuesForNonPEONEOsMember_fKGEp_zPisA0Svrtt4" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right; padding-right: 3pt">43,557,444</td></tr> </table> </div> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; padding-top: 3pt">4</td> <td style="padding-top: 3pt">The Peer Group TSR shown in this table utilizes the NASDAQ US Benchmark Pharmaceuticals Total Return Index (“NQ US Pharma Index”), which we also utilized in the stock performance graph required by Item 201(e) of Regulation S-K included in our Annual Reports on Form 10-K for the years reflected in the table above. The comparison assumes $100 was invested for the period starting December 31, 2019 through December 31 of the applicable fiscal year in each of the Company’s common stock and the NQ US Pharma Index. All dollar values assume reinvestment of the pre-tax value of dividends paid by companies included in the NQ US Pharma Index. The historical stock price performance of our common stock shown is not necessarily indicative of future stock price performance.</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="padding-top: 3pt; width: 18pt">5</td> <td style="padding-top: 3pt">Pursuant to Item 402(v) of Regulation S-K, we determined our stock price to be the most important financial performance measure used to link Company performance to Compensation “Actually Paid” to our PEO and other NEOs in 2023. This performance measure may not have been the most important financial performance measure for prior years and we may determine a different financial performance measure to be the most important such measure in future years.</td></tr> </table> 8184338 141071193 6713442 46896425 233.91 159.01

3953600000

878.29 7004069 98786583 8061639 32174465 192.15 153.08

4338400000

721.49 6470514 123744652 7548928 40168860 168.19 137.47

8075300000

631.52 135350121 153035522 40058597 48557559 128.66 110.52

3513200000

483.11 <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; padding-top: 3pt">1</td> <td style="padding-top: 3pt">Leonard S. Schleifer, M.D., Ph.D. was our principal executive officer (“PEO”) for each year presented. George D. Yancopoulos, M.D., Ph.D., Robert E. Landry, Daniel P. Van Plew, and Andrew J. Murphy, Ph.D. comprise the non-PEO named executive officers (“Non-PEO NEOs”) for 2020 and 2023; and each of these individuals plus Joseph J. LaRosa and Marion McCourt comprise the Non-PEO NEOs for 2021 and 2022, respectively.</td></tr> </table> Leonard S. Schleifer Leonard S. Schleifer Leonard S. Schleifer Leonard S. Schleifer <table cellpadding="0" cellspacing="0" id="xdx_308_zettrqKs8ERl" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr> <td style="width: 18pt"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; padding-left: 3pt">Year</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; width: 2%; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; width: 18%; text-align: right">Summary Compensation Table Total for PEO ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; width: 2%; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; width: 18%; text-align: right">Exclusion of Stock Awards and Option Awards from Summary Compensation Table for PEO ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; width: 2%; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; width: 14%; text-align: right">Inclusion of Item 402(v) Equity Award Values for PEO ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; width: 2%; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; width: 14%; text-align: right; padding-right: 3pt">Compensation “Actually Paid” to PEO ($)</td></tr> <tr> <td> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; padding-left: 3pt">2023</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_989_eecd--PeoTotalCompAmt_c20230101__20231231_zBYK6oHgOabd" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">8,184,338</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_98D_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--ExclusionOfStockAwardsAndOptionAwardsFromSummaryCompensationTableForPEOMember_fKGEp_zK9X3Hk8Y4j5" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">0</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_989_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--InclusionOfItem402vEquityAwardValuesForPEOMember_fKGEp_zf9Utyuub5Bh" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">132,886,855</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_984_eecd--PeoActuallyPaidCompAmt_c20230101__20231231_z8aTYBOxXBj9" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right; padding-right: 3pt">141,071,193</td></tr> </table> <table cellpadding="0" cellspacing="0" id="xdx_308_zdYcRYtY8rz1" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr> <td style="white-space: nowrap; width: 18pt"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; padding-left: 3pt">Year</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; width: 1%; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; width: 15%; text-align: right">Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for PEO ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; width: 1%; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; width: 10%; text-align: right">Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for PEO ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; width: 1%; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; width: 10%; text-align: right">Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for PEO ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; width: 1%; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; width: 10%; text-align: right">Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for PEO ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; width: 1%; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; width: 10%; text-align: right">Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for PEO ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; width: 1%; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; width: 10%; text-align: right">Value of Dividends or Other Earnings Paid on Stock or Option Awards Not Otherwise Included for PEO ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; width: 1%; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; width: 10%; text-align: right; padding-right: 3pt">Total - Inclusion of Equity Values for PEO ($)</td></tr> <tr> <td> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; padding-left: 3pt">2023</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_981_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--YearEndFairValueOfEquityAwardsGrantedDuringYearThatRemainedUnvestedAsOfLastDayOfYearForPEOMember_fKGEp_zMqiHevLwNBg" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">0</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_987_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--ChangeInFairValueFromLastDayOfPriorYearToLastDayOfYearOfUnvestedEquityAwardsForPEOMember_fKGEp_zBs0wBwfn3Uk" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">126,245,090</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_984_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--VestingDateFairValueOfEquityAwardsGrantedDuringYearThatVestedDuringYearForPEOMember_fKGEp_zHHY0C6XRVY7" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">0</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_981_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--ChangeInFairValueFromLastDayOfPriorYearToVestingDateOfUnvestedEquityAwardsThatVestedDuringYearForPEOMember_fKGEp_zcz3H72u4bo9" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">6,641,765</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_98C_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--FairValueAtLastDayOfPriorYearOfEquityAwardsForfeitedDuringYearForPEOMember_fKGEp_zqwxdDioyYmj" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">0</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_98A_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--ValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsNotOtherwiseIncludedForPEOMember_fKGEp_zqHNXaIOoa5a" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">0</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_985_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--TotalInclusionOfEquityValuesForPEOMember_fKGEp_z8a1Zvl3X1s9" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right; padding-right: 3pt">132,886,855</td></tr> </table> 8184338 0 132886855 141071193 <table cellpadding="0" cellspacing="0" id="xdx_30811_zettrqKs8ERl" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr> <td style="width: 18pt"> </td> <td style="vertical-align: bottom; padding-left: 3pt"> </td> <td style="vertical-align: top; text-align: right; width: 2%"> </td> <td style="vertical-align: bottom; text-align: right; width: 18%"> </td> <td style="vertical-align: top; text-align: right; width: 2%"> </td> <td style="vertical-align: bottom; text-align: right; width: 18%"> </td> <td style="vertical-align: top; text-align: right; width: 2%"> </td> <td style="vertical-align: bottom; text-align: right; width: 14%"> </td> <td style="vertical-align: top; text-align: right; width: 2%"> </td> <td style="vertical-align: bottom; text-align: right; padding-right: 3pt; width: 14%"> </td></tr> <tr> <td> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; padding-left: 3pt">Year</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">Average Summary Compensation Table Total for Non-PEO NEOs ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">Exclusion of Stock Awards and Option Awards from Summary Compensation Table for Non-PEO NEOs ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">Inclusion of Item 402(v) Equity Award Values for Non-PEO NEOs ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right; padding-right: 3pt">Average Compensation “Actually Paid” to Non-PEO NEOs ($)</td></tr> <tr> <td> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; padding-left: 3pt">2023</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_986_eecd--NonPeoNeoAvgTotalCompAmt_c20230101__20231231_zH7Dx6gimRni" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">6,713,442</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_98D_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--ExclusionOfStockAwardsAndOptionAwardsFromSummaryCompensationTableForNonPEONEOsMember_fKGEp_zEkI5CQ2sSJh" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">(3,374,461)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_982_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--InclusionOfItem402vEquityAwardValuesForNonPEONEOsMember_fKGEp_zogS42O9yBb4" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">43,557,444</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_98D_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20230101__20231231_zjOKRGf5qAI2" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right; padding-right: 3pt">46,896,425</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr style="font-size: 12pt"> <td style="font-size: 12pt; width: 18pt"> </td> <td style="vertical-align: bottom; padding-left: 3pt; font-size: 12pt"> </td> <td style="vertical-align: top; text-align: right; font-size: 12pt; width: 1%"> </td> <td style="vertical-align: bottom; text-align: right; font-size: 12pt; width: 15%"> </td> <td style="vertical-align: top; text-align: right; font-size: 12pt; width: 1%"> </td> <td style="vertical-align: bottom; text-align: right; font-size: 12pt; width: 10%"> </td> <td style="vertical-align: top; text-align: right; font-size: 12pt; width: 1%"> </td> <td style="vertical-align: bottom; text-align: right; font-size: 12pt; width: 10%"> </td> <td style="vertical-align: top; text-align: right; font-size: 12pt; width: 1%"> </td> <td style="vertical-align: bottom; text-align: right; font-size: 12pt; width: 10%"> </td> <td style="vertical-align: top; text-align: right; font-size: 12pt; width: 1%"> </td> <td style="vertical-align: bottom; text-align: right; font-size: 12pt; width: 10%"> </td> <td style="vertical-align: top; text-align: right; font-size: 12pt; width: 1%"> </td> <td style="vertical-align: bottom; text-align: right; font-size: 12pt; width: 10%"> </td> <td style="vertical-align: top; text-align: right; font-size: 12pt; width: 1%"> </td> <td style="vertical-align: bottom; text-align: right; padding-right: 3pt; font-size: 12pt; width: 10%"> </td></tr> <tr> <td style="white-space: nowrap"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; padding-left: 3pt">Year</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; text-align: right">Average Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for Non-PEO NEOs ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; text-align: right">Average Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for Non-PEO NEOs ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; text-align: right">Average Vesting- Date Fair Value of Equity Awards Granted During Year that Vested During Year for Non-PEO NEOs ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; text-align: right">Average Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for Non-PEO NEOs ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; text-align: right">Average Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for Non-PEO NEOs ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; text-align: right">Average Value of Dividends or Other Earnings Paid on Stock or Option Awards Not Otherwise Included for Non- PEO NEOs ($)</td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: top; text-align: right"> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; white-space: nowrap; vertical-align: bottom; text-align: right; padding-right: 3pt">Total—Average Inclusion of Equity Values for Non-PEO NEOs ($)</td></tr> <tr> <td> </td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; padding-left: 3pt">2023</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_984_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AverageYearEndFairValueOfEquityAwardsGrantedDuringYearThatRemainedUnvestedAsOfLastDayOfYearForNonPEONEOsMember_fKGEp_zIz3TebNYMqg" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">3,521,007</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_988_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AverageChangeInFairValueFromLastDayOfPriorYearToLastDayOfYearOfUnvestedEquityAwardsForNonPEONEOsMember_fKGEp_z3Xexy894ne2" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">34,981,296</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_982_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AverageVestingDateFairValueOfEquityAwardsGrantedDuringYearThatVestedDuringYearForNonPEONEOsMember_fKGEp_zqHmRYfNiC1d" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">0</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_981_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AverageChangeInFairValueFromLastDayOfPriorYearToVestingDateOfUnvestedEquityAwardsThatVestedDuringYearForNonPEONEOsMember_fKGEp_zxgBctHV3ndh" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">5,055,141</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_987_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--AverageFairValueAtLastDayOfPriorYearOfEquityAwardsForfeitedDuringYearForNonPEONEOsMember_fKGEp_zTs5BkNzDt56" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">0</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_98D_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--AverageValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsNotOtherwiseIncludedForNonPEONEOsMember_fKGEp_zRZGUddfe2K8" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right">0</td> <td style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: top; text-align: right"> </td> <td id="xdx_984_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--TotalAverageInclusionOfEquityValuesForNonPEONEOsMember_fKGEp_zPisA0Svrtt4" style="border-bottom: rgb(33,90,168) 2px solid; vertical-align: bottom; text-align: right; padding-right: 3pt">43,557,444</td></tr> </table> 6713442 -3374461 43557444 46896425 0 126245090 0 6641765 0 0 132886855 3521007 34981296 0 5055141 0 0 43557444 <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; padding-top: 3pt">4</td> <td style="padding-top: 3pt">The Peer Group TSR shown in this table utilizes the NASDAQ US Benchmark Pharmaceuticals Total Return Index (“NQ US Pharma Index”), which we also utilized in the stock performance graph required by Item 201(e) of Regulation S-K included in our Annual Reports on Form 10-K for the years reflected in the table above. The comparison assumes $100 was invested for the period starting December 31, 2019 through December 31 of the applicable fiscal year in each of the Company’s common stock and the NQ US Pharma Index. All dollar values assume reinvestment of the pre-tax value of dividends paid by companies included in the NQ US Pharma Index. The historical stock price performance of our common stock shown is not necessarily indicative of future stock price performance.</td></tr> </table> stock price PEO and Average Non-PEO NEO Compensation “Actually Paid” Versus Regeneron TSR, 2020-2023 <img alt="" src="lregnx107x1.jpg"/> PEO and Average NEO Compensation “Actually Paid” Versus Regeneron Net Income, 2020-2023 <img alt="" src="lregnx108x1.jpg"/> PEO and Average Non-PEO NEO Compensation “Actually Paid” Versus Regeneron Stock Price, 2020-2023 <img alt="" src="lregnx108x2.jpg"/> Comparison of Regeneron Cumulative TSR to the NQ US Pharma Total Return Index, 2020-2023 <img alt="" src="lregnx109x1.jpg"/> <h5 id="xdx_80C_eecd--TabularListTableTextBlock_dU_zaKFkA2MTKFk" style="font: 12pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #215AA8">2023 Tabular List of Most Important Financial and Non-Financial Performance Measures</h5> The following table presents the financial and non-financial performance measures that the Company considers to have been the most important in linking Compensation “Actually Paid” to our PEO and our Non-PEO NEOs in 2023 to Company performance. The measures in this table are not ranked. <table cellpadding="0" cellspacing="0" style="font: 12pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: bottom"> <td style="border-top: rgb(33,90,168) 2px solid; width: 55%; border-bottom: rgb(148,149,153) 1px solid; padding-left: 3pt">Stock Price</td> <td style="border-top: rgb(33,90,168) 2px solid; width: 45%; border-bottom: rgb(148,149,153) 1px solid">Regulatory submissions for new products or indications</td></tr> <tr style="vertical-align: bottom; background-color: #ECECED"> <td style="border-bottom: rgb(148,149,153) 1px solid; padding-left: 3pt">TSR</td> <td style="border-bottom: rgb(148,149,153) 1px solid">Positive data readouts</td></tr> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(148,149,153) 1px solid; padding-left: 3pt">Non-GAAP diluted EPS</td> <td style="border-bottom: rgb(148,149,153) 1px solid">New Investigational New Drug Applications</td></tr> <tr style="vertical-align: bottom; background-color: #ECECED"> <td style="border-bottom: rgb(33,90,168) 2px solid; padding-left: 3pt">Approvals of new products or indications</td> <td style="border-bottom: rgb(33,90,168) 2px solid"> </td></tr> </table> Stock Price Regulatory submissions for new products or indications TSR Positive data readouts Non-GAAP diluted EPS New Investigational New Drug Applications Approvals of new products or indications Leonard S. Schleifer, M.D., Ph.D. was our principal executive officer (“PEO”) for each year presented. George D. Yancopoulos, M.D., Ph.D., Robert E. Landry, Daniel P. Van Plew, and Andrew J. Murphy, Ph.D. comprise the non-PEO named executive officers (“Non-PEO NEOs”) for 2020 and 2023; and each of these individuals plus Joseph J. LaRosa and Marion McCourt comprise the Non-PEO NEOs for 2021 and 2022, respectively. The amounts shown for “Compensation “Actually Paid”” have been calculated in accordance with Item 402(v) of Regulation S K and do not reflect compensation actually earned, realized, or received by the Company’s NEOs. These amounts reflect total compensation as reported in the Summary Compensation Table with certain adjustments as described in footnote 3 below. “Compensation “Actually Paid”” reflects the exclusions and inclusions of equity awards for the PEO and the Non-PEO NEOs as set forth below and calculated in accordance with FASB ASC Topic 718 using the valuation methodologies and assumptions set forth in the calculation of the grant date fair value of these awards as disclosed in the Company’s audited financial statements for the fiscal year in which the equity awards were granted. The Peer Group TSR shown in this table utilizes the NASDAQ US Benchmark Pharmaceuticals Total Return Index (“NQ US Pharma Index”), which we also utilized in the stock performance graph required by Item 201(e) of Regulation S-K included in our Annual Reports on Form 10-K for the years reflected in the table above. The comparison assumes $100 was invested for the period starting December 31, 2019 through December 31 of the applicable fiscal year in each of the Company’s common stock and the NQ US Pharma Index. All dollar values assume reinvestment of the pre-tax value of dividends paid by companies included in the NQ US Pharma Index. The historical stock price performance of our common stock shown is not necessarily indicative of future stock price performance. Pursuant to Item 402(v) of Regulation S-K, we determined our stock price to be the most important financial performance measure used to link Company performance to Compensation “Actually Paid” to our PEO and other NEOs in 2023. This performance measure may not have been the most important financial performance measure for prior years and we may determine a different financial performance measure to be the most important such measure in future years.