0000872589 2024-01-01 2024-12-31 0000872589 2023-01-01 2023-12-31 0000872589 2022-01-01 2022-12-31 0000872589 2021-01-01 2021-12-31 0000872589 2020-01-01 2020-12-31 0000872589 ecd:EqtyAwrdsInSummryCompstnTblForAplblYrMember ecd:PeoMember 2024-01-01 2024-12-31 0000872589 ecd:EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember ecd:PeoMember 2024-01-01 2024-12-31 0000872589 ecd:EqtyAwrdsInSummryCompstnTblForAplblYrMember ecd:NonPeoNeoMember 2024-01-01 2024-12-31 0000872589 ecd:EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember ecd:NonPeoNeoMember 2024-01-01 2024-12-31 0000872589 ecd:YrEndFrValOfEqtyAwrdsGrntdInCvrdYrOutsdngAndUnvstdMember ecd:PeoMember 2024-01-01 2024-12-31 0000872589 ecd:ChngInFrValOfOutsdngAndUnvstdEqtyAwrdsGrntdInPrrYrsMember ecd:PeoMember 2024-01-01 2024-12-31 0000872589 ecd:VstngDtFrValOfEqtyAwrdsGrntdAndVstdInCvrdYrMember ecd:PeoMember 2024-01-01 2024-12-31 0000872589 ecd:ChngInFrValAsOfVstngDtOfPrrYrEqtyAwrdsVstdInCvrdYrMember ecd:PeoMember 2024-01-01 2024-12-31 0000872589 ecd:FrValAsOfPrrYrEndOfEqtyAwrdsGrntdInPrrYrsFldVstngCondsDrngCvrdYrMember ecd:PeoMember 2024-01-01 2024-12-31 0000872589 ecd:DvddsOrOthrErngsPdOnEqtyAwrdsNtOthrwsRflctdInTtlCompForCvrdYrMember ecd:PeoMember 2024-01-01 2024-12-31 0000872589 ecd:YrEndFrValOfEqtyAwrdsGrntdInCvrdYrOutsdngAndUnvstdMember ecd:NonPeoNeoMember 2024-01-01 2024-12-31 0000872589 ecd:ChngInFrValOfOutsdngAndUnvstdEqtyAwrdsGrntdInPrrYrsMember ecd:NonPeoNeoMember 2024-01-01 2024-12-31 0000872589 ecd:VstngDtFrValOfEqtyAwrdsGrntdAndVstdInCvrdYrMember ecd:NonPeoNeoMember 2024-01-01 2024-12-31 0000872589 ecd:ChngInFrValAsOfVstngDtOfPrrYrEqtyAwrdsVstdInCvrdYrMember ecd:NonPeoNeoMember 2024-01-01 2024-12-31 0000872589 ecd:FrValAsOfPrrYrEndOfEqtyAwrdsGrntdInPrrYrsFldVstngCondsDrngCvrdYrMember ecd:NonPeoNeoMember 2024-01-01 2024-12-31 0000872589 ecd:DvddsOrOthrErngsPdOnEqtyAwrdsNtOthrwsRflctdInTtlCompForCvrdYrMember ecd:NonPeoNeoMember 2024-01-01 2024-12-31 0000872589 1 2024-01-01 2024-12-31 0000872589 5 2024-01-01 2024-12-31 0000872589 2 2024-01-01 2024-12-31 0000872589 6 2024-01-01 2024-12-31 0000872589 3 2024-01-01 2024-12-31 0000872589 7 2024-01-01 2024-12-31 0000872589 4 2024-01-01 2024-12-31 iso4217:USD shares iso4217:USD shares pure false 0000872589 DEF 14A REGENERON PHARMACEUTICALS, INC. true We make annual equity awards, including stock option awards, to the NEOs and other employees on a regular, predetermined schedule. The meetings at which such grants are approved are generally scheduled well in advance of the grant date, without regard to the timing of earnings or other major announcements that may constitute material, non-public information. <span id="xdx_906_eecd--AwardTmgHowMnpiCnsdrdTextBlock_c20240101__20241231_zgrq1EGb3wZg">As a result, <span id="xdx_907_eecd--AwardTmgMnpiCnsdrdFlag_dbF_c20240101__20241231_zu4KbeXkKrL3">the timing of such grants of equity awards, including stock options, occurs independent of the release of any material, non-public information,</span> and <span id="xdx_901_eecd--MnpiDiscTimedForCompValFlag_dbF_c20240101__20241231_zrfstPOzqmHa">we do not time the disclosure of material, non-public information for the purpose of affecting the value of equity-based compensation.</span> </span>We generally grant annual equity awards to eligible employees whose performance is determined to merit an annual grant, including the NEOs, <span id="xdx_907_eecd--AwardTmgPredtrmndFlag_dbT_c20240101__20241231_zlCjzYRKwnsj">at a meeting held during December.</span> With respect to newly hired employees, our practice typically is to grant equity awards <span id="xdx_903_eecd--AwardTmgPredtrmndFlag_dbT_c20240101__20241231_zqiphJ4Io6Vg">at the first regular meeting of the Compensation Committee following such employee's hire date,</span> <span id="xdx_90B_eecd--AwardTmgMnpiCnsdrdFlag_dbF_c20240101__20241231_zsu1HfLW9eyl">without regard to the timing of earnings or other major announcements that may constitute material, non-public information.</span> In 2024, we did not grant stock options or other equity awards to our NEOs during any period beginning four business days before and ending one business day after the filing of any of the Company’s periodic reports on Form 10-Q or Form 10-K or the filing or furnishing of any of the Company’s current reports on Form 8-K that disclosed any material, non-public information. We make annual equity awards, including stock option awards, to the NEOs and other employees on a regular, predetermined schedule. The meetings at which such grants are approved are generally scheduled well in advance of the grant date, without regard to the timing of earnings or other major announcements that may constitute material, non-public information. <span id="xdx_906_eecd--AwardTmgHowMnpiCnsdrdTextBlock_c20240101__20241231_zgrq1EGb3wZg">As a result, <span id="xdx_907_eecd--AwardTmgMnpiCnsdrdFlag_dbF_c20240101__20241231_zu4KbeXkKrL3">the timing of such grants of equity awards, including stock options, occurs independent of the release of any material, non-public information,</span> and <span id="xdx_901_eecd--MnpiDiscTimedForCompValFlag_dbF_c20240101__20241231_zrfstPOzqmHa">we do not time the disclosure of material, non-public information for the purpose of affecting the value of equity-based compensation.</span> </span>We generally grant annual equity awards to eligible employees whose performance is determined to merit an annual grant, including the NEOs, <span id="xdx_907_eecd--AwardTmgPredtrmndFlag_dbT_c20240101__20241231_zlCjzYRKwnsj">at a meeting held during December.</span> With respect to newly hired employees, our practice typically is to grant equity awards <span id="xdx_903_eecd--AwardTmgPredtrmndFlag_dbT_c20240101__20241231_zqiphJ4Io6Vg">at the first regular meeting of the Compensation Committee following such employee's hire date,</span> <span id="xdx_90B_eecd--AwardTmgMnpiCnsdrdFlag_dbF_c20240101__20241231_zsu1HfLW9eyl">without regard to the timing of earnings or other major announcements that may constitute material, non-public information.</span> In 2024, we did not grant stock options or other equity awards to our NEOs during any period beginning four business days before and ending one business day after the filing of any of the Company’s periodic reports on Form 10-Q or Form 10-K or the filing or furnishing of any of the Company’s current reports on Form 8-K that disclosed any material, non-public information. As a result, <span id="xdx_907_eecd--AwardTmgMnpiCnsdrdFlag_dbF_c20240101__20241231_zu4KbeXkKrL3">the timing of such grants of equity awards, including stock options, occurs independent of the release of any material, non-public information,</span> and <span id="xdx_901_eecd--MnpiDiscTimedForCompValFlag_dbF_c20240101__20241231_zrfstPOzqmHa">we do not time the disclosure of material, non-public information for the purpose of affecting the value of equity-based compensation.</span> false false true true false <h4 id="xdx_80E_eecd--PvpTableTextBlock_dU_z8oR7UNb61Me" style="font: 14pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #c60c45"><span id="lregnb038"></span><span id="regn013211-def14aa086"></span><b>Pay Versus Performance</b></h4> <p style="font: 9pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #231F20"> </p> <p style="font: 9pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #231F20">As required by Item 402(v) of Regulation S-K, the following table and accompanying footnotes and discussion provide certain information regarding executive compensation of our principal executive officer (“PEO”) and non-PEO NEOs (“Non-PEO NEOs”) and measures of Company performance for the years presented. Except where expressly stated, the information presented below was not considered by the Compensation Committee in structuring our executive compensation program for the years presented, and the reader should instead refer to the section “Compensation Discussion and Analysis” for a description of the philosophy, objectives, and structure of our pay program.</p> <p style="font: 9pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #231F20"> </p> <table cellpadding="0" cellspacing="0" id="xdx_302_z3QEzeMmcgp8" style="font: 9pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; width: 12%; text-align: center; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">A</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: top; width: 1%; text-align: center; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; width: 10%; text-align: center; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">B</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: top; width: 1%; text-align: center; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; width: 10%; text-align: center; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">C</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: top; width: 1%; text-align: center; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; width: 10%; text-align: center; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">D</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: top; width: 1%; text-align: center; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; width: 10%; text-align: center; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">E</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: top; width: 1%; text-align: center; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; width: 10%; text-align: center; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">F</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: top; width: 1%; text-align: center; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; width: 10%; text-align: center; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">G</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: top; width: 1%; text-align: center; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; width: 10%; text-align: center; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">H</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: top; width: 1%; text-align: center; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; width: 10%; text-align: center; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">I</span></td></tr> <tr> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; padding-left: 3pt; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td colspan="3" style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; text-align: center; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Value of Initial Fixed <br/> $100 Investment <br/> Based On:</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; padding-top: 1pt; padding-bottom: 1pt; padding-right: 3pt"> </td></tr> <tr> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; vertical-align: bottom; text-align: left; padding-left: 3pt; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Year</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; vertical-align: top; text-align: center; padding-top: 1pt; padding-bottom: 1pt">     </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Summary</span> <br/> <span style="color: #2864AF">Compensation</span> <br/> <span style="color: #2864AF">Table Total for</span> <br/> <span style="color: #2864AF">PEO ($)¹</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt">     </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Compensation</span> <br/> <span style="color: #2864AF">“Actually Paid”</span> <br/> <span style="color: #2864AF">to PEO ($)^1,2,3</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt">     </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Average Summary</span> <br/> <span style="color: #2864AF">Compensation</span> <br/> <span style="color: #2864AF">Table</span> <br/> <span style="color: #2864AF">Total for Non-PEO</span> <br/> <span style="color: #2864AF">NEOs ($)¹</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt">     </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Average</span> <br/> <span style="color: #2864AF">Compensation</span> <br/> <span style="color: #2864AF">“Actually Paid”</span> <br/> <span style="color: #2864AF">to</span> <br/> <span style="color: #2864AF">Non-PEO NEOs</span> <br/> <span style="color: #2864AF">($)^1,2,3</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt">     </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">TSR ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt">     </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Peer Group</span> <br/> <span style="color: #2864AF">TSR ($)⁴</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt">     </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Net Income ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt">     </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt; padding-right: 3pt"><span style="color: #2864AF">Stock</span> <br/> <span style="color: #2864AF">Price</span> <br/> <span style="color: #2864AF">($)⁵</span></td></tr> <tr> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; padding-left: 3pt; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">2024</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_981_eecd--PeoTotalCompAmt_pp0p0_c20240101__20241231_fMQ_____zEwhUwvX8Nzj" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">6,823,034</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98A_eecd--PeoActuallyPaidCompAmt_pp0p0_c20240101__20241231_fMSAyIDM___zF03YLQvqlj1" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">(37,696,190)</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98B_eecd--NonPeoNeoAvgTotalCompAmt_pp0p0_c20240101__20241231_fMQ_____zeThg1hGTEr2" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">6,073,090</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_986_eecd--NonPeoNeoAvgCompActuallyPaidAmt_pp0p0_c20240101__20241231_fMSAyIDM___zF1Sozk2yqwe" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">(9,153,791)</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98E_eecd--TotalShareholderRtnAmt_pp2p0_c20240101__20241231_zn1to47dRT67" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">189.71</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98B_eecd--PeerGroupTotalShareholderRtnAmt_pp2p0_c20240101__20241231_fNA_____z9lbk19xhv66" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">172.62</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98C_eus-gaap--NetIncomeLoss_uUSD_c20240101__20241231_zXVpty9xLTAg" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">4,412,600,000</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_989_eecd--CoSelectedMeasureAmt_uUSD_c20240101__20241231_fNQ_____z7ehoWVkGVDb" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt; padding-right: 3pt"><span style="color: #231F20">712.33</span></td></tr> <tr> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; padding-left: 3pt; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"><span style="color: #2864AF">2023</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"> </td> <td id="xdx_983_eecd--PeoTotalCompAmt_pp0p0_c20230101__20231231_fMQ_____zNt9bmiZDsB9" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"><span style="color: #231F20">8,184,338</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"> </td> <td id="xdx_981_eecd--PeoActuallyPaidCompAmt_pp0p0_c20230101__20231231_fMSAyIDM___zjTPss5XU3S7" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"><span style="color: #231F20">141,071,193</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"> </td> <td id="xdx_988_eecd--NonPeoNeoAvgTotalCompAmt_pp0p0_c20230101__20231231_fMQ_____zcW9RdBbO1Th" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"><span style="color: #231F20">6,713,442</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"> </td> <td id="xdx_98D_eecd--NonPeoNeoAvgCompActuallyPaidAmt_pp0p0_c20230101__20231231_fMSAyIDM___zlc0aXnjmx32" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"><span style="color: #231F20">46,896,425</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"> </td> <td id="xdx_98D_eecd--TotalShareholderRtnAmt_pp2p0_c20230101__20231231_z1HKNiR0juc4" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"><span style="color: #231F20">233.91</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"> </td> <td id="xdx_98E_eecd--PeerGroupTotalShareholderRtnAmt_pp2p0_c20230101__20231231_fNA_____zmhhJ4NhQu5c" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"><span style="color: #231F20">159.01</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"> </td> <td id="xdx_988_eus-gaap--NetIncomeLoss_uUSD_c20230101__20231231_zywoHaHHeP8" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"><span style="color: #231F20">3,953,600,000</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"> </td> <td id="xdx_98A_eecd--CoSelectedMeasureAmt_uUSD_c20230101__20231231_fNQ_____zqKXVtBoA4Yk" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt; padding-right: 3pt; background-color: rgb(235,235,236)"><span style="color: #231F20">878.29</span></td></tr> <tr> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; padding-left: 3pt; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">2022</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98D_eecd--PeoTotalCompAmt_pp0p0_c20220101__20221231_fMQ_____zQik0ymAX4n6" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">7,004,069</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_980_eecd--PeoActuallyPaidCompAmt_pp0p0_c20220101__20221231_fMSAyIDM___zu7y1ZCYkdB7" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">98,786,583</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_984_eecd--NonPeoNeoAvgTotalCompAmt_pp0p0_c20220101__20221231_fMQ_____z7qoxBh9ePL4" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">8,061,639</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_987_eecd--NonPeoNeoAvgCompActuallyPaidAmt_pp0p0_c20220101__20221231_fMSAyIDM___zf8Gxc5vB695" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">32,174,465</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98D_eecd--TotalShareholderRtnAmt_pp2p0_c20220101__20221231_zhJ82TdT51df" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">192.15</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_985_eecd--PeerGroupTotalShareholderRtnAmt_pp2p0_c20220101__20221231_fNA_____zM1TLsJFz3bj" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">153.08</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_982_eus-gaap--NetIncomeLoss_uUSD_c20220101__20221231_zJiQVjXsNGi5" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">4,338,400,000</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98B_eecd--CoSelectedMeasureAmt_uUSD_c20220101__20221231_fNQ_____z8EgZFBd6s97" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt; padding-right: 3pt"><span style="color: #231F20">721.49</span></td></tr> <tr> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; padding-left: 3pt; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"><span style="color: #2864AF">2021</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"> </td> <td id="xdx_983_eecd--PeoTotalCompAmt_pp0p0_c20210101__20211231_fMQ_____zvz2TSimwX5b" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"><span style="color: #231F20">6,470,514</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"> </td> <td id="xdx_98B_eecd--PeoActuallyPaidCompAmt_pp0p0_c20210101__20211231_fMSAyIDM___zLRI8zdI7q21" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"><span style="color: #231F20">123,744,652</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"> </td> <td id="xdx_986_eecd--NonPeoNeoAvgTotalCompAmt_pp0p0_c20210101__20211231_fMQ_____z3qdkFLXuSCf" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"><span style="color: #231F20">7,548,928</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"> </td> <td id="xdx_98D_eecd--NonPeoNeoAvgCompActuallyPaidAmt_pp0p0_c20210101__20211231_fMSAyIDM___z1LqrF2tSE7d" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"><span style="color: #231F20">40,168,860</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"> </td> <td id="xdx_984_eecd--TotalShareholderRtnAmt_pp2p0_c20210101__20211231_z8j2TKCBtec3" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"><span style="color: #231F20">168.19</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"> </td> <td id="xdx_980_eecd--PeerGroupTotalShareholderRtnAmt_pp2p0_c20210101__20211231_fNA_____zJ9A4KdtLxnh" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"><span style="color: #231F20">137.47</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"> </td> <td id="xdx_98C_eus-gaap--NetIncomeLoss_uUSD_c20210101__20211231_zhSINSWhWZL9" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"><span style="color: #231F20">8,075,300,000</span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt; background-color: rgb(235,235,236)"> </td> <td id="xdx_983_eecd--CoSelectedMeasureAmt_uUSD_c20210101__20211231_fNQ_____zM9QaLGcGk0b" style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt; padding-right: 3pt; background-color: rgb(235,235,236)"><span style="color: #231F20">631.52</span></td></tr> <tr> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; padding-left: 3pt; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">2020</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_982_eecd--PeoTotalCompAmt_pp0p0_c20200101__20201231_fMQ_____zAPvzgnoZWYa" style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">135,350,121</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98F_eecd--PeoActuallyPaidCompAmt_pp0p0_c20200101__20201231_fMSAyIDM___zq5BXIiehrgk" style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">153,035,522</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_984_eecd--NonPeoNeoAvgTotalCompAmt_pp0p0_c20200101__20201231_fMQ_____zPlUTSiCgmhc" style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">40,058,597</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98E_eecd--NonPeoNeoAvgCompActuallyPaidAmt_pp0p0_c20200101__20201231_fMSAyIDM___z4GlgwNky203" style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">48,557,559</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_984_eecd--TotalShareholderRtnAmt_pp2p0_c20200101__20201231_zBut34iH1tNc" style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">128.66</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_983_eecd--PeerGroupTotalShareholderRtnAmt_pp2p0_c20200101__20201231_fNA_____zb1jZrKKrCd6" style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">110.52</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_985_eus-gaap--NetIncomeLoss_uUSD_c20200101__20201231_zHP9GJra694g" style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">3,513,200,000</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: top; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_986_eecd--CoSelectedMeasureAmt_uUSD_c20200101__20201231_fNQ_____zAT1mL9ONjC9" style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; text-align: right; padding-top: 1pt; padding-bottom: 1pt; padding-right: 3pt"><span style="color: #231F20">483.11</span></td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="display: none; visibility: hidden"> <td style="display: none; vertical-align: top; padding-bottom: 3pt; padding-top: 3pt; width: 18pt; visibility: hidden"><span style="display: none; color: #010101; visibility: hidden"><sup id="xdx_F06_zzQRQJ6VijSj" style="display: none; visibility: hidden">1</sup></span></td> <td style="display: none; vertical-align: bottom; padding-bottom: 3pt; padding-top: 3pt; visibility: hidden"><span id="xdx_F19_zEeXdtXUw4ea" style="display: none; color: #231F20; visibility: hidden">Leonard S. Schleifer, M.D., Ph.D. was our PEO for each year presented. George D. Yancopoulos, M.D., Ph.D., Robert E. Landry, Daniel P. Van Plew, and Andrew J. Murphy, Ph.D. comprise the Non-PEO NEOs for 2020 and 2023; and each of these individuals plus Joseph J. LaRosa, Marion McCourt, and Christopher Fenimore comprise the Non-PEO NEOs for 2021, 2022, and 2024, respectively.</span></td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="display: none; visibility: hidden"> <td style="display: none; vertical-align: top; padding-bottom: 3pt; width: 18pt; visibility: hidden"><span style="display: none; color: #010101; visibility: hidden"><sup id="xdx_F0B_zF0ELM7gmGb9" style="display: none; visibility: hidden">2</sup></span></td> <td style="display: none; vertical-align: bottom; padding-bottom: 3pt; visibility: hidden"><span id="xdx_F1E_z8c3LcSCSTuh" style="display: none; color: #231F20; visibility: hidden">The amounts shown for “Compensation “Actually Paid”” have been calculated in accordance with Item 402(v) of Regulation S-K and do not reflect compensation actually earned, realized, or received by the Company’s NEOs. These amounts reflect total compensation as reported in the Summary Compensation Table with certain adjustments as described in footnote 3 below.</span></td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="display: none; visibility: hidden"> <td style="display: none; vertical-align: top; padding-bottom: 3pt; width: 18pt; visibility: hidden"><span style="display: none; color: #010101; visibility: hidden"><sup id="xdx_F04_z5nGAQkyGavg" style="display: none; visibility: hidden">3</sup></span></td> <td style="display: none; vertical-align: bottom; padding-bottom: 3pt; visibility: hidden"><span id="xdx_F1E_zeXDyvSCnTMh" style="display: none; color: #231F20; visibility: hidden">“Compensation “Actually Paid”” reflects the exclusions and inclusions of equity awards for the PEO and the Non-PEO NEOs as set forth below and calculated in accordance with FASB ASC Topic 718 using the valuation methodologies and assumptions set forth in the calculation of the grant date fair value of these awards as disclosed in the Company’s audited financial statements for the fiscal year in which the equity awards were granted.</span></td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="display: none; visibility: hidden"> <td style="display: none; vertical-align: top; width: 18pt; visibility: hidden"> </td> <td style="display: none; vertical-align: bottom; visibility: hidden"><span style="display: none; color: #231F20; visibility: hidden">The “Exclusion of Stock Awards and Option Awards from Summary Compensation Table” columns in the tables below reflect the aggregate amounts reported in the Summary Compensation Table for the applicable year in the “Stock Awards” and “Option Awards” columns.  </span></td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="display: none; vertical-align: top; visibility: hidden"> <td style="display: none; padding-top: 3pt; padding-bottom: 3pt; width: 18pt; visibility: hidden"><span style="display: none; color: #010101; visibility: hidden"><sup id="xdx_F0A_zLYqrpHVxW5k" style="display: none; visibility: hidden">4</sup></span></td> <td style="display: none; padding-top: 3pt; padding-bottom: 3pt; visibility: hidden"><span id="xdx_F17_zCaHUNwbFMTc" style="display: none; color: #231F20; visibility: hidden">The Peer Group TSR shown in this table utilizes the NASDAQ US Benchmark Pharmaceuticals Total Return Index (“NQ US Pharma Index”), which we also utilized in the stock performance graph required by Item 201(e) of Regulation S-K included in our Annual Reports on Form 10-K for the years reflected in the table above. The comparison assumes $100 was invested for the period starting December 31, 2019 through December 31 of the applicable fiscal year in each of the Company’s common stock and the NQ US Pharma Index. All dollar values assume reinvestment of the pre-tax value of dividends paid by companies included in the NQ US Pharma Index. The historical stock price performance of our common stock shown is not necessarily indicative of future stock price performance.</span></td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="display: none; vertical-align: top; visibility: hidden"> <td style="display: none; width: 18pt; visibility: hidden"><span style="display: none; color: #010101; visibility: hidden"><sup id="xdx_F08_zfCbB7fLgAK7" style="display: none; visibility: hidden">5</sup></span></td> <td style="display: none; visibility: hidden"><span id="xdx_F1E_zgBbyDL0awjh" style="display: none; color: #231F20; visibility: hidden">Pursuant to Item 402(v) of Regulation S-K, we determined our stock price to be the most important financial performance measure used to link Company performance to Compensation “Actually Paid” to our NEOs in 2024. This performance measure may not have been the most important financial performance measure for prior years and we may determine a different financial performance measure to be the most important such measure in future years.</span></td></tr> </table> <p id="xdx_84D_eecd--NamedExecutiveOfficersFnTextBlock_dU_znPfQgQ1Din5" style="margin: 0"> </p> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr> <td style="vertical-align: top; width: 18pt; padding-bottom: 3pt; padding-top: 3pt"><span style="color: #010101">¹</span></td> <td style="vertical-align: bottom; padding-bottom: 3pt; padding-top: 3pt"><span style="color: #231F20"><span id="xdx_908_eecd--PeoName_c20240101__20241231_zdbR1Qey3FVa"><span id="xdx_90C_eecd--PeoName_c20230101__20231231_zW9Z8oCEgA7g"><span id="xdx_909_eecd--PeoName_c20220101__20221231_zakwbSr4Dhag"><span id="xdx_904_eecd--PeoName_c20210101__20211231_zlmbo7YmRFh"><span id="xdx_90E_eecd--PeoName_c20200101__20201231_z9fGb2sjNTa8">Leonard S. Schleifer</span></span></span></span></span>, M.D., Ph.D. was our PEO for each year presented. George D. Yancopoulos, M.D., Ph.D., Robert E. Landry, Daniel P. Van Plew, and Andrew J. Murphy, Ph.D. comprise the Non-PEO NEOs for 2020 and 2023; and each of these individuals plus Joseph J. LaRosa, Marion McCourt, and Christopher Fenimore comprise the Non-PEO NEOs for 2021, 2022, and 2024, respectively.</span></td></tr> </table> <p id="xdx_856_zo0gsBjsBlPi" style="margin: 0"></p> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr> <td style="vertical-align: top; padding-bottom: 3pt; width: 18pt"><span style="color: #010101">²</span></td> <td style="vertical-align: bottom; padding-bottom: 3pt"><span style="color: #231F20">The amounts shown for “Compensation “Actually Paid”” have been calculated in accordance with Item 402(v) of Regulation S-K and do not reflect compensation actually earned, realized, or received by the Company’s NEOs. These amounts reflect total compensation as reported in the Summary Compensation Table with certain adjustments as described in footnote 3 below.</span></td></tr> <tr> <td style="vertical-align: top; padding-bottom: 3pt"><span style="color: #010101">³</span></td> <td style="vertical-align: bottom; padding-bottom: 3pt"><span style="color: #231F20">“Compensation “Actually Paid”” reflects the exclusions and inclusions of equity awards for the PEO and the Non-PEO NEOs as set forth below and calculated in accordance with FASB ASC Topic 718 using the valuation methodologies and assumptions set forth in the calculation of the grant date fair value of these awards as disclosed in the Company’s audited financial statements for the fiscal year in which the equity awards were granted.</span></td></tr> <tr> <td style="vertical-align: top"> </td> <td style="vertical-align: bottom"><span style="color: #231F20">The “Exclusion of Stock Awards and Option Awards from Summary Compensation Table” columns in the tables below reflect the aggregate amounts reported in the Summary Compensation Table for the applicable year in the “Stock Awards” and “Option Awards” columns.  </span></td></tr> </table> <p id="xdx_843_eecd--AdjToPeoCompFnTextBlock_dU_gL2ATPCFTB-BIGJND_zBbz6Uql1S3k" style="font: 9pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #231F20"> </p> <p style="font: 9pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #231F20"></p> <table cellpadding="0" cellspacing="0" id="xdx_302_zfH8aIZovAIa" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 97%; border-collapse: collapse; margin-left: 18pt" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 28%; text-align: left; padding-top: 1pt; padding-bottom: 1pt; padding-left: 3pt"><span style="color: #2864AF">Year</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 3%; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 15%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Summary Compensation</span><br/> <span style="color: #2864AF">Table Total for PEO ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 3%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 15%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Exclusion of Stock Awards</span> <br/> <span style="color: #2864AF">and Option Awards from</span> <br/> <span style="color: #2864AF">Summary Compensation</span> <br/> <span style="color: #2864AF">Table for PEO ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 3%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 15%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Inclusion of Item 402(v)</span><br/> <span style="color: #2864AF">Equity Award Values for</span><br/> <span style="color: #2864AF">PEO ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 3%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 15%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Compensation “Actually</span><br/> <span style="color: #2864AF">Paid” to PEO ($)</span></td></tr> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt; padding-left: 3pt"><span style="color: #2864AF">2024</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_989_eecd--PeoTotalCompAmt_c20240101__20241231_zlVyfIhmi6x2" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">6,823,034</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_987_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__ecd--EqtyAwrdsInSummryCompstnTblForAplblYrMember_fKGEp_zEIHyO16TPwj" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">0</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_980_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__ecd--EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember_fKGEp_zDdchw9wLik2" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">(44,519,224)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98B_eecd--PeoActuallyPaidCompAmt_c20240101__20241231_zpyuYhl7TMVd" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">(37,696,190)</span></td></tr> </table> <p style="font: 9pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #231F20"></p> <p id="xdx_84A_eecd--AdjToNonPeoNeoCompFnTextBlock_dU_gL2ATNPNCFTB-QA_zgr0EzCQINX4" style="font: 9pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #231F20"> </p> <table cellpadding="0" cellspacing="0" id="xdx_302_zTwpU1Wq5P0i" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 97%; border-collapse: collapse; margin-left: 18pt" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 28%; padding-top: 1pt; padding-bottom: 1pt; padding-left: 3pt"><span style="color: #2864AF">Year</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 3%; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 15%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Average Summary</span> <br/> <span style="color: #2864AF">Compensation Table Total for</span> <br/> <span style="color: #2864AF">Non-PEO NEOs ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 3%; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 15%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Exclusion of Stock Awards</span> <br/> <span style="color: #2864AF">and Option Awards from</span> <br/> <span style="color: #2864AF">Summary Compensation</span> <br/> <span style="color: #2864AF">Table for Non-PEO NEOs ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 3%; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 15%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Inclusion of Item 402(v)</span><br/> <span style="color: #2864AF">Equity Award Values for</span><br/> <span style="color: #2864AF">Non-PEO NEOs ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 3%; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 15%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Average Compensation</span> <br/> <span style="color: #2864AF">“Actually Paid” to</span> <br/> <span style="color: #2864AF">Non-PEO NEOs ($)</span></td></tr> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt; padding-left: 3pt"><span style="color: #2864AF">2024</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98E_eecd--NonPeoNeoAvgTotalCompAmt_c20240101__20241231_zu7wlsEE0Tkc" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">6,073,090</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_985_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__ecd--EqtyAwrdsInSummryCompstnTblForAplblYrMember_fKGEp_zalqu1EpQkGe" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">(3,699,679)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_982_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__ecd--EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember_fKGEp_zNzzVCS8Wwl2" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">(11,527,202)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98B_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20240101__20241231_zoEf1qM1Ndwd" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">(9,153,791)</span></td></tr> </table> <p id="xdx_85C_zeFgbuDuPXz2" style="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0"> </p> <div style="border-bottom: Silver 4px solid; margin-bottom: 6pt"><table cellpadding="0" cellspacing="0" style="font: 12pt Arial, Helvetica, Sans-Serif; width: 100%"><tr><td style="text-align: center; width: 100%"> </td></tr></table></div> <div style="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"></div> <p style="font: 20pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: rgb(40,100,175)"><b> </b></p> <div id="xdx_C01_gL2ATPCFTB-BIGJND_zUjhmqYjvR04"><p style="font: 8pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #231F20"> </p> <table cellpadding="0" cellspacing="0" id="xdx_307_zEwt4gLIgGcf" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 97%; border-collapse: collapse; margin-left: 18pt" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 23%; text-align: left; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF"><b>Year</b></span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 1%; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 10%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Year-End Fair</span> <br/> <span style="color: #2864AF">Value of Equity</span> <br/> <span style="color: #2864AF">Awards Granted</span> <br/> <span style="color: #2864AF">During Year</span> <br/> <span style="color: #2864AF">That Remained</span> <br/> <span style="color: #2864AF">Unvested as of</span> <br/> <span style="color: #2864AF">Last Day of Year</span> <br/> <span style="color: #2864AF">for PEO ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 1%; text-align: right; padding-top: 1pt; padding-bottom: 1pt">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 10%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Change in Fair</span> <br/> <span style="color: #2864AF">Value from Last</span> <br/> <span style="color: #2864AF">Day of Prior Year</span> <br/> <span style="color: #2864AF">to Last Day of Year</span> <br/> <span style="color: #2864AF">of Unvested Equity</span> <br/> <span style="color: #2864AF">Awards for</span> <br/> <span style="color: #2864AF">PEO ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 1%; text-align: right; padding-top: 1pt; padding-bottom: 1pt">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 10%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Vesting-Date Fair</span> <br/> <span style="color: #2864AF">Value of Equity</span> <br/> <span style="color: #2864AF">Awards Granted</span> <br/> <span style="color: #2864AF">During Year that</span> <br/> <span style="color: #2864AF">Vested During</span> <br/> <span style="color: #2864AF">Year for PEO ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 1%; text-align: right; padding-top: 1pt; padding-bottom: 1pt">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 10%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Change in Fair</span> <br/> <span style="color: #2864AF">Value from Last</span> <br/> <span style="color: #2864AF">Day of Prior Year</span> <br/> <span style="color: #2864AF">to Vesting Date of</span> <br/> <span style="color: #2864AF">Unvested Equity</span> <br/> <span style="color: #2864AF">Awards that</span> <br/> <span style="color: #2864AF">Vested During</span> <br/> <span style="color: #2864AF">Year for PEO ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 1%; text-align: right; padding-top: 1pt; padding-bottom: 1pt">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 10%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Fair Value at Last</span> <br/> <span style="color: #2864AF">Day of Prior Year</span> <br/> <span style="color: #2864AF">of Equity Awards</span> <br/> <span style="color: #2864AF">Forfeited During</span> <br/> <span style="color: #2864AF">Year for PEO ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 1%; text-align: right; padding-top: 1pt; padding-bottom: 1pt">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 10%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Value of Dividends</span> <br/> <span style="color: #2864AF">or Other Earnings</span> <br/> <span style="color: #2864AF">Paid on Stock or</span> <br/> <span style="color: #2864AF">Option Awards Not</span> <br/> <span style="color: #2864AF">Otherwise Included</span> <br/> <span style="color: #2864AF">for PEO ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 1%; text-align: right; padding-top: 1pt; padding-bottom: 1pt">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 10%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Total-Inclusion</span> <br/> <span style="color: #2864AF">of Equity Values</span> <br/> <span style="color: #2864AF">for PEO ($)</span></td></tr> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">2024</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_983_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__ecd--YrEndFrValOfEqtyAwrdsGrntdInCvrdYrOutsdngAndUnvstdMember_fKGEp_z3yl4g2SfSZb" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">0</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_984_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__ecd--ChngInFrValOfOutsdngAndUnvstdEqtyAwrdsGrntdInPrrYrsMember_fKGEp_zPO4wfYYBTVl" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">(44,519,224)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_987_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__ecd--VstngDtFrValOfEqtyAwrdsGrntdAndVstdInCvrdYrMember_fKGEp_zIzQaiXNLR3k" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">0</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_987_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__ecd--ChngInFrValAsOfVstngDtOfPrrYrEqtyAwrdsVstdInCvrdYrMember_fKGEp_z2VWzbmjbqe9" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">0</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98E_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__ecd--FrValAsOfPrrYrEndOfEqtyAwrdsGrntdInPrrYrsFldVstngCondsDrngCvrdYrMember_fKGEp_z6ruR8x33Kzi" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">0</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98C_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__ecd--DvddsOrOthrErngsPdOnEqtyAwrdsNtOthrwsRflctdInTtlCompForCvrdYrMember_fKGEp_zmyJyrINxj7h" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">0</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98A_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__ecd--EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember_fKGEp_z6fKbJl9qicd" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">(44,519,224)</span></td></tr> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; text-align: left; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td></tr> </table> </div> <div id="xdx_C07_gL2ATNPNCFTB-QA_zgm1TuDB2dSc"> <table cellpadding="0" cellspacing="0" id="xdx_30E_zmaJWXRWo7nk" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 97%; border-collapse: collapse; margin-left: 18pt" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; text-align: left; padding-top: 1pt; padding-bottom: 1pt; width: 23%"><span style="color: #2864AF">Year</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt; width: 1%">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt; width: 10%"><span style="color: #2864AF">Average Year-End</span> <br/> <span style="color: #2864AF">Fair Value of Equity</span> <br/> <span style="color: #2864AF">Awards Granted</span> <br/> <span style="color: #2864AF">During Year</span> <br/> <span style="color: #2864AF">That Remained </span><br/> <span style="color: #2864AF">Unvested as of</span> <br/> <span style="color: #2864AF">Last Day of Year for</span> <br/> <span style="color: #2864AF">Non-PEO NEOs ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt; width: 1%">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt; width: 10%"><span style="color: #2864AF">Average Change</span> <br/> <span style="color: #2864AF">in Fair Value from</span> <br/> <span style="color: #2864AF">Last Day of Prior</span> <br/> <span style="color: #2864AF">Year to Last Day of </span><br/> <span style="color: #2864AF">Year of Unvested</span> <br/> <span style="color: #2864AF">Equity Awards for</span> <br/> <span style="color: #2864AF">Non-PEO NEOs ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt; width: 1%">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt; width: 10%"><span style="color: #2864AF">Average Vesting-</span> <br/> <span style="color: #2864AF">Date Fair Value</span> <br/> <span style="color: #2864AF">of Equity Awards</span> <br/> <span style="color: #2864AF">Granted During</span> <br/> <span style="color: #2864AF">Year that Vested</span> <br/> <span style="color: #2864AF">During Year for</span> <br/> <span style="color: #2864AF">Non-PEO NEOs ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt; width: 1%">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt; width: 10%"><span style="color: #2864AF">Average Change</span> <br/> <span style="color: #2864AF">in Fair Value from</span> <br/> <span style="color: #2864AF">Last Day of Prior</span> <br/> <span style="color: #2864AF">Year to Vesting</span> <br/> <span style="color: #2864AF">Date of Unvested</span> <br/> <span style="color: #2864AF">Equity Awards</span> <br/> <span style="color: #2864AF">that Vested During</span> <br/> <span style="color: #2864AF">Year for Non-PEO</span> <br/> <span style="color: #2864AF">NEOs ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt; width: 1%">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt; width: 10%"><span style="color: #2864AF">Average Fair</span> <br/> <span style="color: #2864AF">Value at Last Day</span> <br/> <span style="color: #2864AF">of Prior Year of</span> <br/> <span style="color: #2864AF">Equity Awards</span> <br/> <span style="color: #2864AF">Forfeited During</span> <br/> <span style="color: #2864AF">Year for Non-PEO</span> <br/> <span style="color: #2864AF">NEOs ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt; width: 1%">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt; width: 10%"><span style="color: #2864AF">Average Value</span> <br/> <span style="color: #2864AF">of Dividends or</span> <br/> <span style="color: #2864AF">Other Earnings</span> <br/> <span style="color: #2864AF">Paid on Stock or</span> <br/> <span style="color: #2864AF">Option Awards</span> <br/> <span style="color: #2864AF">Not  Otherwise</span> <br/> <span style="color: #2864AF">Included for</span> <br/> <span style="color: #2864AF">Non- PEO NEOs ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt; width: 1%">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt; width: 10%"><span style="color: #2864AF">Total—Average</span> <br/> <span style="color: #2864AF">Inclusion of</span> <br/> <span style="color: #2864AF">Equity Values</span> <br/> <span style="color: #2864AF">for Non-PEO</span> <br/> <span style="color: #2864AF">NEOs ($)</span></td></tr> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">2024</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_984_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__ecd--YrEndFrValOfEqtyAwrdsGrntdInCvrdYrOutsdngAndUnvstdMember_fKGEp_zO2lrCZbQ5i6" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">3,264,990</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_987_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__ecd--ChngInFrValOfOutsdngAndUnvstdEqtyAwrdsGrntdInPrrYrsMember_fKGEp_zygDWPCSXHc5" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">(11,592,995)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98B_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__ecd--VstngDtFrValOfEqtyAwrdsGrntdAndVstdInCvrdYrMember_fKGEp_zGN3aVfmvkD9" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">0</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98C_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__ecd--ChngInFrValAsOfVstngDtOfPrrYrEqtyAwrdsVstdInCvrdYrMember_fKGEp_zgpCMBnrnrwe" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">(1,537,430)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_985_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__ecd--FrValAsOfPrrYrEndOfEqtyAwrdsGrntdInPrrYrsFldVstngCondsDrngCvrdYrMember_fKGEp_znWx4gQNLsEe" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">(1,661,767)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_982_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__ecd--DvddsOrOthrErngsPdOnEqtyAwrdsNtOthrwsRflctdInTtlCompForCvrdYrMember_fKGEp_z0HoeqhzxVne" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">0</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98B_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__ecd--EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember_fKGEp_zg9K4Ywk2LK5" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">(11,527,202)</span></td></tr> </table> </div> <p style="margin-top: 0; margin-bottom: 0"></p> <p style="margin-top: 0; margin-bottom: 0"></p> <p id="xdx_843_eecd--PeerGroupIssuersFnTextBlock_zKz7mDlMKCV" style="margin: 0"></p> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; padding-top: 3pt; padding-bottom: 3pt"><span style="color: #010101">⁴</span></td> <td style="padding-top: 3pt; padding-bottom: 3pt"><span style="color: #231F20">The Peer Group TSR shown in this table utilizes the NASDAQ US Benchmark Pharmaceuticals Total Return Index (“NQ US Pharma Index”), which we also utilized in the stock performance graph required by Item 201(e) of Regulation S-K included in our Annual Reports on Form 10-K for the years reflected in the table above. The comparison assumes $100 was invested for the period starting December 31, 2019 through December 31 of the applicable fiscal year in each of the Company’s common stock and the NQ US Pharma Index. All dollar values assume reinvestment of the pre-tax value of dividends paid by companies included in the NQ US Pharma Index. The historical stock price performance of our common stock shown is not necessarily indicative of future stock price performance.</span></td></tr> </table> <p id="xdx_85F_zc2nMggROFp8" style="margin: 0"> </p> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt"><span style="color: #010101">⁵</span></td> <td><span style="color: #231F20">Pursuant to Item 402(v) of Regulation S-K, we determined our <span id="xdx_90A_eecd--CoSelectedMeasureName_c20240101__20241231_zQniQEE48kLc">stock price</span> to be the most important financial performance measure used to link Company performance to Compensation “Actually Paid” to our NEOs in 2024. This performance measure may not have been the most important financial performance measure for prior years and we may determine a different financial performance measure to be the most important such measure in future years.</span></td></tr> </table> 6823034 -37696190 6073090 -9153791 189.71 172.62 4412600000 712.33 8184338 141071193 6713442 46896425 233.91 159.01 3953600000 878.29 7004069 98786583 8061639 32174465 192.15 153.08 4338400000 721.49 6470514 123744652 7548928 40168860 168.19 137.47 8075300000 631.52 135350121 153035522 40058597 48557559 128.66 110.52 3513200000 483.11 <p id="xdx_84D_eecd--NamedExecutiveOfficersFnTextBlock_dU_znPfQgQ1Din5" style="margin: 0"> </p> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr> <td style="vertical-align: top; width: 18pt; padding-bottom: 3pt; padding-top: 3pt"><span style="color: #010101">¹</span></td> <td style="vertical-align: bottom; padding-bottom: 3pt; padding-top: 3pt"><span style="color: #231F20"><span id="xdx_908_eecd--PeoName_c20240101__20241231_zdbR1Qey3FVa"><span id="xdx_90C_eecd--PeoName_c20230101__20231231_zW9Z8oCEgA7g"><span id="xdx_909_eecd--PeoName_c20220101__20221231_zakwbSr4Dhag"><span id="xdx_904_eecd--PeoName_c20210101__20211231_zlmbo7YmRFh"><span id="xdx_90E_eecd--PeoName_c20200101__20201231_z9fGb2sjNTa8">Leonard S. Schleifer</span></span></span></span></span>, M.D., Ph.D. was our PEO for each year presented. George D. Yancopoulos, M.D., Ph.D., Robert E. Landry, Daniel P. Van Plew, and Andrew J. Murphy, Ph.D. comprise the Non-PEO NEOs for 2020 and 2023; and each of these individuals plus Joseph J. LaRosa, Marion McCourt, and Christopher Fenimore comprise the Non-PEO NEOs for 2021, 2022, and 2024, respectively.</span></td></tr> </table> Leonard S. Schleifer Leonard S. Schleifer Leonard S. Schleifer Leonard S. Schleifer Leonard S. Schleifer <p id="xdx_843_eecd--AdjToPeoCompFnTextBlock_dU_gL2ATPCFTB-BIGJND_zBbz6Uql1S3k" style="font: 9pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #231F20"> </p> <p style="font: 9pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #231F20"></p> <table cellpadding="0" cellspacing="0" id="xdx_302_zfH8aIZovAIa" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 97%; border-collapse: collapse; margin-left: 18pt" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 28%; text-align: left; padding-top: 1pt; padding-bottom: 1pt; padding-left: 3pt"><span style="color: #2864AF">Year</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 3%; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 15%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Summary Compensation</span><br/> <span style="color: #2864AF">Table Total for PEO ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 3%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 15%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Exclusion of Stock Awards</span> <br/> <span style="color: #2864AF">and Option Awards from</span> <br/> <span style="color: #2864AF">Summary Compensation</span> <br/> <span style="color: #2864AF">Table for PEO ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 3%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 15%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Inclusion of Item 402(v)</span><br/> <span style="color: #2864AF">Equity Award Values for</span><br/> <span style="color: #2864AF">PEO ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 3%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 15%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Compensation “Actually</span><br/> <span style="color: #2864AF">Paid” to PEO ($)</span></td></tr> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt; padding-left: 3pt"><span style="color: #2864AF">2024</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_989_eecd--PeoTotalCompAmt_c20240101__20241231_zlVyfIhmi6x2" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">6,823,034</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_987_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__ecd--EqtyAwrdsInSummryCompstnTblForAplblYrMember_fKGEp_zEIHyO16TPwj" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">0</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_980_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__ecd--EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember_fKGEp_zDdchw9wLik2" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">(44,519,224)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98B_eecd--PeoActuallyPaidCompAmt_c20240101__20241231_zpyuYhl7TMVd" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">(37,696,190)</span></td></tr> </table> <p style="font: 9pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #231F20"></p> <p style="font: 8pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #231F20"> </p> <table cellpadding="0" cellspacing="0" id="xdx_307_zEwt4gLIgGcf" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 97%; border-collapse: collapse; margin-left: 18pt" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 23%; text-align: left; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF"><b>Year</b></span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 1%; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 10%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Year-End Fair</span> <br/> <span style="color: #2864AF">Value of Equity</span> <br/> <span style="color: #2864AF">Awards Granted</span> <br/> <span style="color: #2864AF">During Year</span> <br/> <span style="color: #2864AF">That Remained</span> <br/> <span style="color: #2864AF">Unvested as of</span> <br/> <span style="color: #2864AF">Last Day of Year</span> <br/> <span style="color: #2864AF">for PEO ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 1%; text-align: right; padding-top: 1pt; padding-bottom: 1pt">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 10%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Change in Fair</span> <br/> <span style="color: #2864AF">Value from Last</span> <br/> <span style="color: #2864AF">Day of Prior Year</span> <br/> <span style="color: #2864AF">to Last Day of Year</span> <br/> <span style="color: #2864AF">of Unvested Equity</span> <br/> <span style="color: #2864AF">Awards for</span> <br/> <span style="color: #2864AF">PEO ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 1%; text-align: right; padding-top: 1pt; padding-bottom: 1pt">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 10%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Vesting-Date Fair</span> <br/> <span style="color: #2864AF">Value of Equity</span> <br/> <span style="color: #2864AF">Awards Granted</span> <br/> <span style="color: #2864AF">During Year that</span> <br/> <span style="color: #2864AF">Vested During</span> <br/> <span style="color: #2864AF">Year for PEO ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 1%; text-align: right; padding-top: 1pt; padding-bottom: 1pt">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 10%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Change in Fair</span> <br/> <span style="color: #2864AF">Value from Last</span> <br/> <span style="color: #2864AF">Day of Prior Year</span> <br/> <span style="color: #2864AF">to Vesting Date of</span> <br/> <span style="color: #2864AF">Unvested Equity</span> <br/> <span style="color: #2864AF">Awards that</span> <br/> <span style="color: #2864AF">Vested During</span> <br/> <span style="color: #2864AF">Year for PEO ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 1%; text-align: right; padding-top: 1pt; padding-bottom: 1pt">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 10%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Fair Value at Last</span> <br/> <span style="color: #2864AF">Day of Prior Year</span> <br/> <span style="color: #2864AF">of Equity Awards</span> <br/> <span style="color: #2864AF">Forfeited During</span> <br/> <span style="color: #2864AF">Year for PEO ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 1%; text-align: right; padding-top: 1pt; padding-bottom: 1pt">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 10%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Value of Dividends</span> <br/> <span style="color: #2864AF">or Other Earnings</span> <br/> <span style="color: #2864AF">Paid on Stock or</span> <br/> <span style="color: #2864AF">Option Awards Not</span> <br/> <span style="color: #2864AF">Otherwise Included</span> <br/> <span style="color: #2864AF">for PEO ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 1%; text-align: right; padding-top: 1pt; padding-bottom: 1pt">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 10%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Total-Inclusion</span> <br/> <span style="color: #2864AF">of Equity Values</span> <br/> <span style="color: #2864AF">for PEO ($)</span></td></tr> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">2024</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_983_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__ecd--YrEndFrValOfEqtyAwrdsGrntdInCvrdYrOutsdngAndUnvstdMember_fKGEp_z3yl4g2SfSZb" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">0</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_984_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__ecd--ChngInFrValOfOutsdngAndUnvstdEqtyAwrdsGrntdInPrrYrsMember_fKGEp_zPO4wfYYBTVl" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">(44,519,224)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_987_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__ecd--VstngDtFrValOfEqtyAwrdsGrntdAndVstdInCvrdYrMember_fKGEp_zIzQaiXNLR3k" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">0</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_987_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__ecd--ChngInFrValAsOfVstngDtOfPrrYrEqtyAwrdsVstdInCvrdYrMember_fKGEp_z2VWzbmjbqe9" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">0</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98E_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__ecd--FrValAsOfPrrYrEndOfEqtyAwrdsGrntdInPrrYrsFldVstngCondsDrngCvrdYrMember_fKGEp_z6ruR8x33Kzi" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">0</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98C_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__ecd--DvddsOrOthrErngsPdOnEqtyAwrdsNtOthrwsRflctdInTtlCompForCvrdYrMember_fKGEp_zmyJyrINxj7h" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">0</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98A_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__ecd--EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember_fKGEp_z6fKbJl9qicd" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">(44,519,224)</span></td></tr> <tr style="vertical-align: bottom"> <td style="white-space: nowrap; text-align: left; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt"> </td></tr> </table> 6823034 0 -44519224 -37696190 <p id="xdx_84A_eecd--AdjToNonPeoNeoCompFnTextBlock_dU_gL2ATNPNCFTB-QA_zgr0EzCQINX4" style="font: 9pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #231F20"> </p> <table cellpadding="0" cellspacing="0" id="xdx_302_zTwpU1Wq5P0i" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 97%; border-collapse: collapse; margin-left: 18pt" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 28%; padding-top: 1pt; padding-bottom: 1pt; padding-left: 3pt"><span style="color: #2864AF">Year</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 3%; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 15%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Average Summary</span> <br/> <span style="color: #2864AF">Compensation Table Total for</span> <br/> <span style="color: #2864AF">Non-PEO NEOs ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 3%; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 15%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Exclusion of Stock Awards</span> <br/> <span style="color: #2864AF">and Option Awards from</span> <br/> <span style="color: #2864AF">Summary Compensation</span> <br/> <span style="color: #2864AF">Table for Non-PEO NEOs ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 3%; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 15%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Inclusion of Item 402(v)</span><br/> <span style="color: #2864AF">Equity Award Values for</span><br/> <span style="color: #2864AF">Non-PEO NEOs ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 3%; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; width: 15%; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">Average Compensation</span> <br/> <span style="color: #2864AF">“Actually Paid” to</span> <br/> <span style="color: #2864AF">Non-PEO NEOs ($)</span></td></tr> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt; padding-left: 3pt"><span style="color: #2864AF">2024</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98E_eecd--NonPeoNeoAvgTotalCompAmt_c20240101__20241231_zu7wlsEE0Tkc" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">6,073,090</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_985_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__ecd--EqtyAwrdsInSummryCompstnTblForAplblYrMember_fKGEp_zalqu1EpQkGe" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">(3,699,679)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_982_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__ecd--EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember_fKGEp_zNzzVCS8Wwl2" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">(11,527,202)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98B_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20240101__20241231_zoEf1qM1Ndwd" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">(9,153,791)</span></td></tr> </table> <table cellpadding="0" cellspacing="0" id="xdx_30E_zmaJWXRWo7nk" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 97%; border-collapse: collapse; margin-left: 18pt" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; text-align: left; padding-top: 1pt; padding-bottom: 1pt; width: 23%"><span style="color: #2864AF">Year</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt; width: 1%">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt; width: 10%"><span style="color: #2864AF">Average Year-End</span> <br/> <span style="color: #2864AF">Fair Value of Equity</span> <br/> <span style="color: #2864AF">Awards Granted</span> <br/> <span style="color: #2864AF">During Year</span> <br/> <span style="color: #2864AF">That Remained </span><br/> <span style="color: #2864AF">Unvested as of</span> <br/> <span style="color: #2864AF">Last Day of Year for</span> <br/> <span style="color: #2864AF">Non-PEO NEOs ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt; width: 1%">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt; width: 10%"><span style="color: #2864AF">Average Change</span> <br/> <span style="color: #2864AF">in Fair Value from</span> <br/> <span style="color: #2864AF">Last Day of Prior</span> <br/> <span style="color: #2864AF">Year to Last Day of </span><br/> <span style="color: #2864AF">Year of Unvested</span> <br/> <span style="color: #2864AF">Equity Awards for</span> <br/> <span style="color: #2864AF">Non-PEO NEOs ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt; width: 1%">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt; width: 10%"><span style="color: #2864AF">Average Vesting-</span> <br/> <span style="color: #2864AF">Date Fair Value</span> <br/> <span style="color: #2864AF">of Equity Awards</span> <br/> <span style="color: #2864AF">Granted During</span> <br/> <span style="color: #2864AF">Year that Vested</span> <br/> <span style="color: #2864AF">During Year for</span> <br/> <span style="color: #2864AF">Non-PEO NEOs ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt; width: 1%">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt; width: 10%"><span style="color: #2864AF">Average Change</span> <br/> <span style="color: #2864AF">in Fair Value from</span> <br/> <span style="color: #2864AF">Last Day of Prior</span> <br/> <span style="color: #2864AF">Year to Vesting</span> <br/> <span style="color: #2864AF">Date of Unvested</span> <br/> <span style="color: #2864AF">Equity Awards</span> <br/> <span style="color: #2864AF">that Vested During</span> <br/> <span style="color: #2864AF">Year for Non-PEO</span> <br/> <span style="color: #2864AF">NEOs ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt; width: 1%">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt; width: 10%"><span style="color: #2864AF">Average Fair</span> <br/> <span style="color: #2864AF">Value at Last Day</span> <br/> <span style="color: #2864AF">of Prior Year of</span> <br/> <span style="color: #2864AF">Equity Awards</span> <br/> <span style="color: #2864AF">Forfeited During</span> <br/> <span style="color: #2864AF">Year for Non-PEO</span> <br/> <span style="color: #2864AF">NEOs ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt; width: 1%">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt; width: 10%"><span style="color: #2864AF">Average Value</span> <br/> <span style="color: #2864AF">of Dividends or</span> <br/> <span style="color: #2864AF">Other Earnings</span> <br/> <span style="color: #2864AF">Paid on Stock or</span> <br/> <span style="color: #2864AF">Option Awards</span> <br/> <span style="color: #2864AF">Not  Otherwise</span> <br/> <span style="color: #2864AF">Included for</span> <br/> <span style="color: #2864AF">Non- PEO NEOs ($)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; padding-top: 1pt; padding-bottom: 1pt; width: 1%">   </td> <td style="border-bottom: rgb(59,88,164) 1px solid; white-space: nowrap; text-align: right; padding-top: 1pt; padding-bottom: 1pt; width: 10%"><span style="color: #2864AF">Total—Average</span> <br/> <span style="color: #2864AF">Inclusion of</span> <br/> <span style="color: #2864AF">Equity Values</span> <br/> <span style="color: #2864AF">for Non-PEO</span> <br/> <span style="color: #2864AF">NEOs ($)</span></td></tr> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #2864AF">2024</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_984_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__ecd--YrEndFrValOfEqtyAwrdsGrntdInCvrdYrOutsdngAndUnvstdMember_fKGEp_zO2lrCZbQ5i6" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">3,264,990</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_987_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__ecd--ChngInFrValOfOutsdngAndUnvstdEqtyAwrdsGrntdInPrrYrsMember_fKGEp_zygDWPCSXHc5" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">(11,592,995)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98B_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__ecd--VstngDtFrValOfEqtyAwrdsGrntdAndVstdInCvrdYrMember_fKGEp_zGN3aVfmvkD9" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">0</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98C_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__ecd--ChngInFrValAsOfVstngDtOfPrrYrEqtyAwrdsVstdInCvrdYrMember_fKGEp_zgpCMBnrnrwe" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">(1,537,430)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_985_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__ecd--FrValAsOfPrrYrEndOfEqtyAwrdsGrntdInPrrYrsFldVstngCondsDrngCvrdYrMember_fKGEp_znWx4gQNLsEe" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">(1,661,767)</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_982_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__ecd--DvddsOrOthrErngsPdOnEqtyAwrdsNtOthrwsRflctdInTtlCompForCvrdYrMember_fKGEp_z0HoeqhzxVne" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">0</span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; padding-top: 1pt; padding-bottom: 1pt"> </td> <td id="xdx_98B_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__ecd--EqtyAwrdsAdjsExclgValRprtdInSummryCompstnTblMember_fKGEp_zg9K4Ywk2LK5" style="border-bottom: rgb(59,88,164) 1px solid; text-align: right; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20">(11,527,202)</span></td></tr> </table> 6073090 -3699679 -11527202 -9153791 0 -44519224 0 0 0 0 -44519224 3264990 -11592995 0 -1537430 -1661767 0 -11527202 <p id="xdx_843_eecd--PeerGroupIssuersFnTextBlock_zKz7mDlMKCV" style="margin: 0"></p> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; padding-top: 3pt; padding-bottom: 3pt"><span style="color: #010101">⁴</span></td> <td style="padding-top: 3pt; padding-bottom: 3pt"><span style="color: #231F20">The Peer Group TSR shown in this table utilizes the NASDAQ US Benchmark Pharmaceuticals Total Return Index (“NQ US Pharma Index”), which we also utilized in the stock performance graph required by Item 201(e) of Regulation S-K included in our Annual Reports on Form 10-K for the years reflected in the table above. The comparison assumes $100 was invested for the period starting December 31, 2019 through December 31 of the applicable fiscal year in each of the Company’s common stock and the NQ US Pharma Index. All dollar values assume reinvestment of the pre-tax value of dividends paid by companies included in the NQ US Pharma Index. The historical stock price performance of our common stock shown is not necessarily indicative of future stock price performance.</span></td></tr> </table> stock price <div id="xdx_800_eecd--CompActuallyPaidVsTotalShareholderRtnTextBlock_dU_zWbboaFR4cV9"></div> <div id="xdx_846_eecd--TotalShareholderRtnVsPeerGroupTextBlock_dU_zjO6viaKdUlh"></div> <p style="font: 9pt Arial, Helvetica, Sans-Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt; color: #2864AF"><b>PEO and Average Non-PEO NEO Compensation “Actually Paid” Versus Regeneron TSR and Peer Group TSR, 2020-2024</b></p> <p style="font: 9pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #2864AF"> </p> <p style="font: 9pt Arial, Helvetica, Sans-Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt; color: #2864AF"><img alt="" src="regn013211-def14ax106x1.jpg" style="width: 535px"/></p> <div id="xdx_850_zGYR4651tUzl"></div> <div id="xdx_846_eecd--TotalShareholderRtnVsPeerGroupTextBlock_dU_zjO6viaKdUlh"></div> <p style="font: 9pt Arial, Helvetica, Sans-Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt; color: #2864AF"><b>PEO and Average Non-PEO NEO Compensation “Actually Paid” Versus Regeneron TSR and Peer Group TSR, 2020-2024</b></p> <p style="font: 9pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #2864AF"> </p> <p style="font: 9pt Arial, Helvetica, Sans-Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt; color: #2864AF"><img alt="" src="regn013211-def14ax106x1.jpg" style="width: 535px"/></p> <p id="xdx_80B_eecd--CompActuallyPaidVsNetIncomeTextBlock_dU_zfIdzJUawbt6" style="font: 9pt Arial, Helvetica, Sans-Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt; color: #2864AF"><b>PEO and Average NEO Compensation “Actually Paid” Versus Regeneron Net Income, 2020-2024</b></p> <p style="font: 9pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #2864AF"> </p> <p style="font: 9pt Arial, Helvetica, Sans-Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt; color: #2864AF"><img alt="" src="regn013211-def14ax107x1.jpg" style="width: 566px"/></p> <p id="xdx_805_eecd--CompActuallyPaidVsCoSelectedMeasureTextBlock_dU_zdGcdWdaJnqb" style="font: 9pt Arial, Helvetica, Sans-Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt; color: #2864AF"><b>PEO and Average Non-PEO NEO Compensation “Actually Paid” Versus Regeneron Stock Price, 2020-2024</b></p> <p style="font: 9pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #2864AF"> </p> <p style="font: 9pt Arial, Helvetica, Sans-Serif; margin-top: 0pt; text-align: center; margin-bottom: 0pt; color: #2864AF"><img alt="" src="regn013211-def14ax107x2.jpg" style="width: 565px"/></p> <p style="font: 9pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #2864AF"> </p> <h5 id="xdx_80C_eecd--TabularListTableTextBlock_dU_zHERKVRyMe94" style="font: 12pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #2864AF"><b>2024 Tabular List of Most Important Financial and Non-Financial Performance Measures</b></h5> <p style="font: 9pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #231F20"> </p> <p style="font: 9pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #231F20">The following table presents the financial and non-financial performance measures that the Company considers to have been the most important in linking Compensation “Actually Paid” to our PEO and our Non-PEO NEOs in 2024 to Company performance. The measures in this table are not ranked.</p> <p style="font: 9pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #231F20"> </p> <table cellpadding="0" cellspacing="0" style="font: 9pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr> <td style="border-top: rgb(59,90,164) 2px solid; border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; width: 49%; padding-top: 1pt; padding-bottom: 1pt; padding-left: 3pt"><span style="color: #231F20"><span class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_905_eecd--MeasureName_c20240101__20241231__ecd--MeasureAxis__1_z99JXG5QLpW4">Stock Price</span></span></td> <td style="border-top: rgb(59,90,164) 2px solid; border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; width: 2%; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-top: rgb(59,90,164) 2px solid; border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; width: 49%; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20"><span class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_905_eecd--MeasureName_c20240101__20241231__ecd--MeasureAxis__5_zgWMzX6oK6s5">Regulatory submissions for new products or indications</span></span></td></tr> <tr> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; background-color: rgb(235,235,236); padding-top: 1pt; padding-bottom: 1pt; padding-left: 3pt"><span style="color: #231F20"><span class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_90A_eecd--MeasureName_c20240101__20241231__ecd--MeasureAxis__2_z6oyBx4YAY8d">TSR</span></span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; background-color: rgb(235,235,236); padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; background-color: rgb(235,235,236); padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20"><span class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_909_eecd--MeasureName_c20240101__20241231__ecd--MeasureAxis__6_zwiRLRSgHh5i">Positive data readouts</span></span></td></tr> <tr> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; padding-top: 1pt; padding-bottom: 1pt; padding-left: 3pt"><span style="color: #231F20"><span class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_902_eecd--MeasureName_c20240101__20241231__ecd--MeasureAxis__3_ziLOm3S87t03">Non-GAAP diluted EPS</span></span></td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: top; padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(204,204,204) 1px solid; vertical-align: bottom; padding-top: 1pt; padding-bottom: 1pt"><span style="color: #231F20"><span class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_909_eecd--MeasureName_c20240101__20241231__ecd--MeasureAxis__7_zOCEyLSsIMYh">New Investigational New Drug Applications</span></span></td></tr> <tr> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; background-color: rgb(235,235,236); padding-top: 1pt; padding-bottom: 1pt; padding-left: 3pt"><span style="color: #231F20"><span class="xdx_phnt_RGlzY2xvc3VyZSAtIFBheSB2cyBQZXJmb3JtYW5jZSBEaXNjbG9zdXJlAA__" id="xdx_909_eecd--MeasureName_c20240101__20241231__ecd--MeasureAxis__4_zo9mSdbnUOFe">Approvals of new products or indications</span></span></td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: top; background-color: rgb(235,235,236); padding-top: 1pt; padding-bottom: 1pt"> </td> <td style="border-bottom: rgb(59,88,164) 1px solid; vertical-align: bottom; background-color: rgb(235,235,236); padding-top: 1pt; padding-bottom: 1pt"> </td></tr> </table> Stock Price Regulatory submissions for new products or indications TSR Positive data readouts Non-GAAP diluted EPS New Investigational New Drug Applications Approvals of new products or indications Leonard S. Schleifer, M.D., Ph.D. was our PEO for each year presented. George D. Yancopoulos, M.D., Ph.D., Robert E. Landry, Daniel P. Van Plew, and Andrew J. Murphy, Ph.D. comprise the Non-PEO NEOs for 2020 and 2023; and each of these individuals plus Joseph J. LaRosa, Marion McCourt, and Christopher Fenimore comprise the Non-PEO NEOs for 2021, 2022, and 2024, respectively. The amounts shown for “Compensation “Actually Paid”” have been calculated in accordance with Item 402(v) of Regulation S-K and do not reflect compensation actually earned, realized, or received by the Company’s NEOs. These amounts reflect total compensation as reported in the Summary Compensation Table with certain adjustments as described in footnote 3 below. “Compensation “Actually Paid”” reflects the exclusions and inclusions of equity awards for the PEO and the Non-PEO NEOs as set forth below and calculated in accordance with FASB ASC Topic 718 using the valuation methodologies and assumptions set forth in the calculation of the grant date fair value of these awards as disclosed in the Company’s audited financial statements for the fiscal year in which the equity awards were granted. The Peer Group TSR shown in this table utilizes the NASDAQ US Benchmark Pharmaceuticals Total Return Index (“NQ US Pharma Index”), which we also utilized in the stock performance graph required by Item 201(e) of Regulation S-K included in our Annual Reports on Form 10-K for the years reflected in the table above. The comparison assumes $100 was invested for the period starting December 31, 2019 through December 31 of the applicable fiscal year in each of the Company’s common stock and the NQ US Pharma Index. All dollar values assume reinvestment of the pre-tax value of dividends paid by companies included in the NQ US Pharma Index. The historical stock price performance of our common stock shown is not necessarily indicative of future stock price performance. Pursuant to Item 402(v) of Regulation S-K, we determined our stock price to be the most important financial performance measure used to link Company performance to Compensation “Actually Paid” to our NEOs in 2024. This performance measure may not have been the most important financial performance measure for prior years and we may determine a different financial performance measure to be the most important such measure in future years.