<?xml version="1.0" encoding="US-ASCII"?>
<!--XBRL Document Created with Wdesk from Workiva-->
<!-- -->
<link:linkbase xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <link:roleRef roleURI="http://www.regeneron.com/role/AccruedExpensesAndOtherCurrentLiabilities" xlink:href="regn-20181231.xsd#AccruedExpensesAndOtherCurrentLiabilities" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/AccruedExpensesAndOtherCurrentLiabilitiesScheduleOfAccruedExpensesAndOtherCurrentLiabilitiesDetails" xlink:href="regn-20181231.xsd#AccruedExpensesAndOtherCurrentLiabilitiesScheduleOfAccruedExpensesAndOtherCurrentLiabilitiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/AccruedExpensesAndOtherCurrentLiabilitiesTables" xlink:href="regn-20181231.xsd#AccruedExpensesAndOtherCurrentLiabilitiesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/BusinessOverviewAndSummaryOfSignificantAccountingPolicies" xlink:href="regn-20181231.xsd#BusinessOverviewAndSummaryOfSignificantAccountingPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/BusinessOverviewAndSummaryOfSignificantAccountingPoliciesNarrativeDetails" xlink:href="regn-20181231.xsd#BusinessOverviewAndSummaryOfSignificantAccountingPoliciesNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/BusinessOverviewAndSummaryOfSignificantAccountingPoliciesPolicies" xlink:href="regn-20181231.xsd#BusinessOverviewAndSummaryOfSignificantAccountingPoliciesPolicies" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/BusinessOverviewAndSummaryOfSignificantAccountingPoliciesScheduleOfBalanceSheetDataDetails" xlink:href="regn-20181231.xsd#BusinessOverviewAndSummaryOfSignificantAccountingPoliciesScheduleOfBalanceSheetDataDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/BusinessOverviewAndSummaryOfSignificantAccountingPoliciesScheduleOfEstimatedUsefulLivesDetails" xlink:href="regn-20181231.xsd#BusinessOverviewAndSummaryOfSignificantAccountingPoliciesScheduleOfEstimatedUsefulLivesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/BusinessOverviewAndSummaryOfSignificantAccountingPoliciesScheduleOfStatementsOfOperationsDataDetails" xlink:href="regn-20181231.xsd#BusinessOverviewAndSummaryOfSignificantAccountingPoliciesScheduleOfStatementsOfOperationsDataDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/BusinessOverviewAndSummaryOfSignificantAccountingPoliciesTables" xlink:href="regn-20181231.xsd#BusinessOverviewAndSummaryOfSignificantAccountingPoliciesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/CollaborationAndLicenseAgreements" xlink:href="regn-20181231.xsd#CollaborationAndLicenseAgreements" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsBayerNarrativeDetails" xlink:href="regn-20181231.xsd#CollaborationAndLicenseAgreementsBayerNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsSanofiAntibodiesNarrativeDetails" xlink:href="regn-20181231.xsd#CollaborationAndLicenseAgreementsSanofiAntibodiesNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsSanofiImmunoOncologyNarrativeDetails" xlink:href="regn-20181231.xsd#CollaborationAndLicenseAgreementsSanofiImmunoOncologyNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsScheduleOfAccountsReceivableAndDeferredRevenueInformationAntibodyCollaborationDetails" xlink:href="regn-20181231.xsd#CollaborationAndLicenseAgreementsScheduleOfAccountsReceivableAndDeferredRevenueInformationAntibodyCollaborationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsScheduleOfAccountsReceivableAndDeferredRevenueInformationIoCollaborationDetails" xlink:href="regn-20181231.xsd#CollaborationAndLicenseAgreementsScheduleOfAccountsReceivableAndDeferredRevenueInformationIoCollaborationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsScheduleOfAccountsReceivableAndDeferredRevenueInformationTevaCollaborationDetails" xlink:href="regn-20181231.xsd#CollaborationAndLicenseAgreementsScheduleOfAccountsReceivableAndDeferredRevenueInformationTevaCollaborationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsScheduleOfCollaborationRevenueEarnedFromBayerDetails" xlink:href="regn-20181231.xsd#CollaborationAndLicenseAgreementsScheduleOfCollaborationRevenueEarnedFromBayerDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsScheduleOfCollaborationRevenueEarnedFromSanofiDetails" xlink:href="regn-20181231.xsd#CollaborationAndLicenseAgreementsScheduleOfCollaborationRevenueEarnedFromSanofiDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsScheduleOfSignificantChangesInDeferredRevenueBalancesAntibodyCollaborationDetails" xlink:href="regn-20181231.xsd#CollaborationAndLicenseAgreementsScheduleOfSignificantChangesInDeferredRevenueBalancesAntibodyCollaborationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsScheduleOfSignificantChangesInDeferredRevenueBalancesIoCollaborationDetails" xlink:href="regn-20181231.xsd#CollaborationAndLicenseAgreementsScheduleOfSignificantChangesInDeferredRevenueBalancesIoCollaborationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsScheduleOfSignificantChangesInDeferredRevenueBalancesTevaCollaborationDetails" xlink:href="regn-20181231.xsd#CollaborationAndLicenseAgreementsScheduleOfSignificantChangesInDeferredRevenueBalancesTevaCollaborationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsTables" xlink:href="regn-20181231.xsd#CollaborationAndLicenseAgreementsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsTevaNarrativeDetails" xlink:href="regn-20181231.xsd#CollaborationAndLicenseAgreementsTevaNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/CommitmentsAndContingencies" xlink:href="regn-20181231.xsd#CommitmentsAndContingencies" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/CommitmentsAndContingenciesLeasesNarrativeDetails" xlink:href="regn-20181231.xsd#CommitmentsAndContingenciesLeasesNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/CommitmentsAndContingenciesResearchCollaborationAndLicensingAgreementsNarrativeDetails" xlink:href="regn-20181231.xsd#CommitmentsAndContingenciesResearchCollaborationAndLicensingAgreementsNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/CommitmentsAndContingenciesScheduleOfCommitmentsUnderCapitalAndFacilityLeaseObligationsDetails" xlink:href="regn-20181231.xsd#CommitmentsAndContingenciesScheduleOfCommitmentsUnderCapitalAndFacilityLeaseObligationsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/CommitmentsAndContingenciesScheduleOfCommitmentsUnderOperatingLeasesDetails" xlink:href="regn-20181231.xsd#CommitmentsAndContingenciesScheduleOfCommitmentsUnderOperatingLeasesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/CommitmentsAndContingenciesScheduleOfRentExpenseUnderOperatingLeasesDetails" xlink:href="regn-20181231.xsd#CommitmentsAndContingenciesScheduleOfRentExpenseUnderOperatingLeasesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/CommitmentsAndContingenciesTables" xlink:href="regn-20181231.xsd#CommitmentsAndContingenciesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/ConsolidatedBalanceSheets" xlink:href="regn-20181231.xsd#ConsolidatedBalanceSheets" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:href="regn-20181231.xsd#ConsolidatedBalanceSheetsParenthetical" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/ConsolidatedStatementsOfCashFlows" xlink:href="regn-20181231.xsd#ConsolidatedStatementsOfCashFlows" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/ConsolidatedStatementsOfOperationsAndComprehensiveIncome" xlink:href="regn-20181231.xsd#ConsolidatedStatementsOfOperationsAndComprehensiveIncome" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/ConsolidatedStatementsOfStockholdersEquity" xlink:href="regn-20181231.xsd#ConsolidatedStatementsOfStockholdersEquity" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/Debt" xlink:href="regn-20181231.xsd#Debt" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/DebtNarrativeDetails" xlink:href="regn-20181231.xsd#DebtNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/DeferredRevenue" xlink:href="regn-20181231.xsd#DeferredRevenue" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/DeferredRevenueScheduleOfDeferredRevenueDetails" xlink:href="regn-20181231.xsd#DeferredRevenueScheduleOfDeferredRevenueDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/DeferredRevenueTables" xlink:href="regn-20181231.xsd#DeferredRevenueTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/DerivativeInstrumentsAndHedgingActivities" xlink:href="regn-20181231.xsd#DerivativeInstrumentsAndHedgingActivities" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/DerivativeInstrumentsAndHedgingActivitiesScheduleOfNotionalAmountsOfOutstandingDerivativePositionsDetails" xlink:href="regn-20181231.xsd#DerivativeInstrumentsAndHedgingActivitiesScheduleOfNotionalAmountsOfOutstandingDerivativePositionsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/DerivativeInstrumentsAndHedgingActivitiesTables" xlink:href="regn-20181231.xsd#DerivativeInstrumentsAndHedgingActivitiesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/DocumentAndEntityInformation" xlink:href="regn-20181231.xsd#DocumentAndEntityInformation" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/EmployeeSavingsPlan" xlink:href="regn-20181231.xsd#EmployeeSavingsPlan" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/EmployeeSavingsPlanNarrativeDetails" xlink:href="regn-20181231.xsd#EmployeeSavingsPlanNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/FairValueMeasurements" xlink:href="regn-20181231.xsd#FairValueMeasurements" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/FairValueMeasurementsNarrativeDetails" xlink:href="regn-20181231.xsd#FairValueMeasurementsNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/FairValueMeasurementsScheduleOfAssetsMeasuredAtFairValueOnRecurringBasisDetails" xlink:href="regn-20181231.xsd#FairValueMeasurementsScheduleOfAssetsMeasuredAtFairValueOnRecurringBasisDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/FairValueMeasurementsTables" xlink:href="regn-20181231.xsd#FairValueMeasurementsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/IncomeTaxes" xlink:href="regn-20181231.xsd#IncomeTaxes" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/IncomeTaxesNarrativeDetails" xlink:href="regn-20181231.xsd#IncomeTaxesNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/IncomeTaxesScheduleOfComponentsOfIncomeTaxExpenseDetails" xlink:href="regn-20181231.xsd#IncomeTaxesScheduleOfComponentsOfIncomeTaxExpenseDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/IncomeTaxesScheduleOfDeferredTaxAssetsAndLiabilitiesDetails" xlink:href="regn-20181231.xsd#IncomeTaxesScheduleOfDeferredTaxAssetsAndLiabilitiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/IncomeTaxesScheduleOfEffectiveIncomeTaxRateReconciliationDetails" xlink:href="regn-20181231.xsd#IncomeTaxesScheduleOfEffectiveIncomeTaxRateReconciliationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/IncomeTaxesScheduleOfIncomeBeforeIncomeTaxDetails" xlink:href="regn-20181231.xsd#IncomeTaxesScheduleOfIncomeBeforeIncomeTaxDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/IncomeTaxesScheduleOfUnrecognizedTaxBenefitsDetails" xlink:href="regn-20181231.xsd#IncomeTaxesScheduleOfUnrecognizedTaxBenefitsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/IncomeTaxesTables" xlink:href="regn-20181231.xsd#IncomeTaxesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/Inventories" xlink:href="regn-20181231.xsd#Inventories" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/InventoriesScheduleOfInventoriesDetails" xlink:href="regn-20181231.xsd#InventoriesScheduleOfInventoriesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/InventoriesTables" xlink:href="regn-20181231.xsd#InventoriesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/LegalMatters" xlink:href="regn-20181231.xsd#LegalMatters" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/LegalMattersNarrativeDetails" xlink:href="regn-20181231.xsd#LegalMattersNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/LongTermIncentivePlans" xlink:href="regn-20181231.xsd#LongTermIncentivePlans" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/LongTermIncentivePlansNarrativeDetails" xlink:href="regn-20181231.xsd#LongTermIncentivePlansNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/LongTermIncentivePlansSummaryOfActivityRelatedToRestrictedStockAwardsDetails" xlink:href="regn-20181231.xsd#LongTermIncentivePlansSummaryOfActivityRelatedToRestrictedStockAwardsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/LongTermIncentivePlansSummaryOfTransactionsInvolvingStockOptionAwardsDetails" xlink:href="regn-20181231.xsd#LongTermIncentivePlansSummaryOfTransactionsInvolvingStockOptionAwardsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/LongTermIncentivePlansSummaryOfWeightedAverageExercisePricesAndWeightedAverageGrantDateFairValuesOfOptionsIssuedDetails" xlink:href="regn-20181231.xsd#LongTermIncentivePlansSummaryOfWeightedAverageExercisePricesAndWeightedAverageGrantDateFairValuesOfOptionsIssuedDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/LongTermIncentivePlansSummaryOfWeightedAverageValuesOfAssumptionsUsedInComputingFairValueOfOptionGrantsDetails" xlink:href="regn-20181231.xsd#LongTermIncentivePlansSummaryOfWeightedAverageValuesOfAssumptionsUsedInComputingFairValueOfOptionGrantsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/LongTermIncentivePlansTables" xlink:href="regn-20181231.xsd#LongTermIncentivePlansTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/MarketableSecurities" xlink:href="regn-20181231.xsd#MarketableSecurities" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/MarketableSecuritiesNarrativeDetails" xlink:href="regn-20181231.xsd#MarketableSecuritiesNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/MarketableSecuritiesScheduleOfDebtSecuritiesBasedOnContractualMaturityDatesDetails" xlink:href="regn-20181231.xsd#MarketableSecuritiesScheduleOfDebtSecuritiesBasedOnContractualMaturityDatesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/MarketableSecuritiesScheduleOfFairValueAndUnrealizedLossesOfDebtSecuritiesDetails" xlink:href="regn-20181231.xsd#MarketableSecuritiesScheduleOfFairValueAndUnrealizedLossesOfDebtSecuritiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/MarketableSecuritiesScheduleOfInvestmentsInAvailableForSaleDebtSecuritiesDetails" xlink:href="regn-20181231.xsd#MarketableSecuritiesScheduleOfInvestmentsInAvailableForSaleDebtSecuritiesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/MarketableSecuritiesTables" xlink:href="regn-20181231.xsd#MarketableSecuritiesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/NetIncomePerShare" xlink:href="regn-20181231.xsd#NetIncomePerShare" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/NetIncomePerShareScheduleOfAntidilutiveSecuritiesExcludedFromComputationDetails" xlink:href="regn-20181231.xsd#NetIncomePerShareScheduleOfAntidilutiveSecuritiesExcludedFromComputationDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/NetIncomePerShareScheduleOfBasicAndDilutedNetIncomePerShareDetails" xlink:href="regn-20181231.xsd#NetIncomePerShareScheduleOfBasicAndDilutedNetIncomePerShareDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/NetIncomePerShareTables" xlink:href="regn-20181231.xsd#NetIncomePerShareTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/ProductSales" xlink:href="regn-20181231.xsd#ProductSales" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/ProductSalesScheduleOfConcentrationOfRiskByRiskFactorDetails" xlink:href="regn-20181231.xsd#ProductSalesScheduleOfConcentrationOfRiskByRiskFactorDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/ProductSalesScheduleOfNetProductSalesDetails" xlink:href="regn-20181231.xsd#ProductSalesScheduleOfNetProductSalesDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/ProductSalesScheduleOfSalesRelatedDeductionsActivityDetails" xlink:href="regn-20181231.xsd#ProductSalesScheduleOfSalesRelatedDeductionsActivityDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/ProductSalesTables" xlink:href="regn-20181231.xsd#ProductSalesTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/PropertyPlantAndEquipment" xlink:href="regn-20181231.xsd#PropertyPlantAndEquipment" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/PropertyPlantAndEquipmentNarrativeDetails" xlink:href="regn-20181231.xsd#PropertyPlantAndEquipmentNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/PropertyPlantAndEquipmentScheduleOfPropertyPlantAndEquipmentDetails" xlink:href="regn-20181231.xsd#PropertyPlantAndEquipmentScheduleOfPropertyPlantAndEquipmentDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/PropertyPlantAndEquipmentTables" xlink:href="regn-20181231.xsd#PropertyPlantAndEquipmentTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/StatementOfCashFlows" xlink:href="regn-20181231.xsd#StatementOfCashFlows" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/StatementOfCashFlowsNarrativeDetails" xlink:href="regn-20181231.xsd#StatementOfCashFlowsNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/StatementOfCashFlowsScheduleOfReconciliationOfCashCashEquivalentsAndRestrictedCashDetails" xlink:href="regn-20181231.xsd#StatementOfCashFlowsScheduleOfReconciliationOfCashCashEquivalentsAndRestrictedCashDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/StatementOfCashFlowsTables" xlink:href="regn-20181231.xsd#StatementOfCashFlowsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/StockholdersEquity" xlink:href="regn-20181231.xsd#StockholdersEquity" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/StockholdersEquityNarrativeDetails" xlink:href="regn-20181231.xsd#StockholdersEquityNarrativeDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/UnauditedQuarterlyResults" xlink:href="regn-20181231.xsd#UnauditedQuarterlyResults" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/UnauditedQuarterlyResultsScheduleOfUnauditedQuarterlyResultsDetails" xlink:href="regn-20181231.xsd#UnauditedQuarterlyResultsScheduleOfUnauditedQuarterlyResultsDetails" xlink:type="simple" />
  <link:roleRef roleURI="http://www.regeneron.com/role/UnauditedQuarterlyResultsTables" xlink:href="regn-20181231.xsd#UnauditedQuarterlyResultsTables" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedNetLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedNetLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodEndLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodStartLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTerseLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTotalLabel" xlink:type="simple" />
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/netLabel" xlink:href="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd#netLabel" xlink:type="simple" />
  <link:presentationLink xlink:role="http://www.regeneron.com/role/AccruedExpensesAndOtherCurrentLiabilities" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PayablesAndAccrualsAbstract" xlink:label="loc_us-gaap_PayablesAndAccrualsAbstract_D02BAE1C5318968E74CF57AD244E5554" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsPayableAccruedLiabilitiesAndOtherLiabilitiesDisclosureCurrentTextBlock" xlink:label="loc_us-gaap_AccountsPayableAccruedLiabilitiesAndOtherLiabilitiesDisclosureCurrentTextBlock_3CA3541BEF16AA4B8DF457AD244E2C7D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PayablesAndAccrualsAbstract_D02BAE1C5318968E74CF57AD244E5554" xlink:to="loc_us-gaap_AccountsPayableAccruedLiabilitiesAndOtherLiabilitiesDisclosureCurrentTextBlock_3CA3541BEF16AA4B8DF457AD244E2C7D" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/AccruedExpensesAndOtherCurrentLiabilitiesScheduleOfAccruedExpensesAndOtherCurrentLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PayablesAndAccrualsAbstract" xlink:label="loc_us-gaap_PayablesAndAccrualsAbstract_D093ACD8975BB648626557AD24426C6F" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_5FD50BFEED0C20233D0D57AD244361A9" xlink:type="locator" />
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PayablesAndAccrualsAbstract_D093ACD8975BB648626557AD24426C6F" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_5FD50BFEED0C20233D0D57AD244361A9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_D9B58DD54CA095B5E02D57AD244389E5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_5FD50BFEED0C20233D0D57AD244361A9" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_D9B58DD54CA095B5E02D57AD244389E5" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_AccruedClinicalTrialExpenseCurrent" xlink:label="loc_regn_AccruedClinicalTrialExpenseCurrent_59DBA062C6A660589BBC57AD24435DCF" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_5FD50BFEED0C20233D0D57AD244361A9" xlink:to="loc_regn_AccruedClinicalTrialExpenseCurrent_59DBA062C6A660589BBC57AD24435DCF" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Accruedsalesrelatedchargesdeductionsandroyalties" xlink:label="loc_regn_Accruedsalesrelatedchargesdeductionsandroyalties_CF6EE0D79B561489948157AD2444D461" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_5FD50BFEED0C20233D0D57AD244361A9" xlink:to="loc_regn_Accruedsalesrelatedchargesdeductionsandroyalties_CF6EE0D79B561489948157AD2444D461" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TaxesPayableCurrent" xlink:label="loc_us-gaap_TaxesPayableCurrent_C5130023A82B7682EFF157AD2444A791" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_5FD50BFEED0C20233D0D57AD244361A9" xlink:to="loc_us-gaap_TaxesPayableCurrent_C5130023A82B7682EFF157AD2444A791" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_712EE9B337BA02A2DDCF57AD24444323" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_5FD50BFEED0C20233D0D57AD244361A9" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_712EE9B337BA02A2DDCF57AD24444323" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_C8245BDED1835F31D20657AD2444F188" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrentAbstract_5FD50BFEED0C20233D0D57AD244361A9" xlink:to="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_C8245BDED1835F31D20657AD2444F188" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/AccruedExpensesAndOtherCurrentLiabilitiesTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PayablesAndAccrualsAbstract" xlink:label="loc_us-gaap_PayablesAndAccrualsAbstract_13D39CA3AB85592FB8EE528B93436E69" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock_66B511A3BD2ACB2E7074528B9348644B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PayablesAndAccrualsAbstract_13D39CA3AB85592FB8EE528B93436E69" xlink:to="loc_us-gaap_ScheduleOfAccountsPayableAndAccruedLiabilitiesTableTextBlock_66B511A3BD2ACB2E7074528B9348644B" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/BusinessOverviewAndSummaryOfSignificantAccountingPolicies" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_C68D1CE91FFBE58128F4BEA9C8CB6EF0" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SignificantAccountingPoliciesTextBlock" xlink:label="loc_us-gaap_SignificantAccountingPoliciesTextBlock_4E8C9AABFD95CE5451D6BEA9C8CB8475" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_C68D1CE91FFBE58128F4BEA9C8CB6EF0" xlink:to="loc_us-gaap_SignificantAccountingPoliciesTextBlock_4E8C9AABFD95CE5451D6BEA9C8CB8475" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/BusinessOverviewAndSummaryOfSignificantAccountingPoliciesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_BD74766E27CEA9CF0812BEA9C8910872" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NumberOfReportableSegments" xlink:label="loc_us-gaap_NumberOfReportableSegments_17557C8DCE6C06D94EDABEA9C8914902" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_BD74766E27CEA9CF0812BEA9C8910872" xlink:to="loc_us-gaap_NumberOfReportableSegments_17557C8DCE6C06D94EDABEA9C8914902" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_B608E3D4FB16542B07D1BEA9C892B42C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_BD74766E27CEA9CF0812BEA9C8910872" xlink:to="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_B608E3D4FB16542B07D1BEA9C892B42C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_3BEFDCBF06C28DC690DCBEA9C8929C64" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_B608E3D4FB16542B07D1BEA9C892B42C" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_3BEFDCBF06C28DC690DCBEA9C8929C64" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_75B80F16C58B9CC3EB89BEA9C8923005" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_3BEFDCBF06C28DC690DCBEA9C8929C64" xlink:to="loc_us-gaap_EquityComponentDomain_75B80F16C58B9CC3EB89BEA9C8923005" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RetainedEarningsMember" xlink:label="loc_us-gaap_RetainedEarningsMember_8C0640ACA22C11661333BEA9C893EFCD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_75B80F16C58B9CC3EB89BEA9C8923005" xlink:to="loc_us-gaap_RetainedEarningsMember_8C0640ACA22C11661333BEA9C893EFCD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis" xlink:label="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis_F68FFDF04081022BCF34BEA9C8931BCD" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_B608E3D4FB16542B07D1BEA9C892B42C" xlink:to="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis_F68FFDF04081022BCF34BEA9C8931BCD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain" xlink:label="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_C3554BCDF39ED5AA3D90BEA9C893D156" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis_F68FFDF04081022BCF34BEA9C8931BCD" xlink:to="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_C3554BCDF39ED5AA3D90BEA9C893D156" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member" xlink:label="loc_us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member_40DD2C6B36F8E72915DFBEA9C899965C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_C3554BCDF39ED5AA3D90BEA9C893D156" xlink:to="loc_us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member_40DD2C6B36F8E72915DFBEA9C899965C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MajorCustomersAxis" xlink:label="loc_srt_MajorCustomersAxis_9786BB55F32A1E2591A6BEA9C899DF67" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_B608E3D4FB16542B07D1BEA9C892B42C" xlink:to="loc_srt_MajorCustomersAxis_9786BB55F32A1E2591A6BEA9C899DF67" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_NameOfMajorCustomerDomain" xlink:label="loc_srt_NameOfMajorCustomerDomain_B4ADA02817042FD6C997BEA9C89AD032" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_MajorCustomersAxis_9786BB55F32A1E2591A6BEA9C899DF67" xlink:to="loc_srt_NameOfMajorCustomerDomain_B4ADA02817042FD6C997BEA9C89AD032" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ThreeIndividualCustomersMember" xlink:label="loc_regn_ThreeIndividualCustomersMember_BF4DE17DBD5C2EB1B273BEA9C89AD8BF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_NameOfMajorCustomerDomain_B4ADA02817042FD6C997BEA9C89AD032" xlink:to="loc_regn_ThreeIndividualCustomersMember_BF4DE17DBD5C2EB1B273BEA9C89AD8BF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementScenarioAxis" xlink:label="loc_us-gaap_StatementScenarioAxis_1A28CE54175E4A063341BEA9C89ABA00" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_B608E3D4FB16542B07D1BEA9C892B42C" xlink:to="loc_us-gaap_StatementScenarioAxis_1A28CE54175E4A063341BEA9C89ABA00" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScenarioUnspecifiedDomain" xlink:label="loc_us-gaap_ScenarioUnspecifiedDomain_B6262E2BFC4DB6F6D0A7BEA9C89BE23E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementScenarioAxis_1A28CE54175E4A063341BEA9C89ABA00" xlink:to="loc_us-gaap_ScenarioUnspecifiedDomain_B6262E2BFC4DB6F6D0A7BEA9C89BE23E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProFormaMember" xlink:label="loc_us-gaap_ProFormaMember_74CA2A945597F81B4309BEA9C89B86E5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScenarioUnspecifiedDomain_B6262E2BFC4DB6F6D0A7BEA9C89BE23E" xlink:to="loc_us-gaap_ProFormaMember_74CA2A945597F81B4309BEA9C89B86E5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskByTypeAxis" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_B4315F9900B67D77DADDBEA9C89B1949" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_B608E3D4FB16542B07D1BEA9C892B42C" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_B4315F9900B67D77DADDBEA9C89B1949" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_4BDC4CC5CD7E49560223BEA9C89C600B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_B4315F9900B67D77DADDBEA9C89B1949" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_4BDC4CC5CD7E49560223BEA9C89C600B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CustomerConcentrationRiskMember" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember_2E2A5602BD760D7C301BBEA9C89CDF99" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_4BDC4CC5CD7E49560223BEA9C89C600B" xlink:to="loc_us-gaap_CustomerConcentrationRiskMember_2E2A5602BD760D7C301BBEA9C89CDF99" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_BA67D9BF5AD31D676193BEA9C89CDBDA" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_B608E3D4FB16542B07D1BEA9C892B42C" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_BA67D9BF5AD31D676193BEA9C89CDBDA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_9C2151DCCF0AF2AD4425BEA9C89C2F34" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_BA67D9BF5AD31D676193BEA9C89CDBDA" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_9C2151DCCF0AF2AD4425BEA9C89C2F34" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsReceivableMember" xlink:label="loc_us-gaap_AccountsReceivableMember_5B37B3AA31F8B2EFE85ABEA9C89D70EC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_9C2151DCCF0AF2AD4425BEA9C89C2F34" xlink:to="loc_us-gaap_AccountsReceivableMember_5B37B3AA31F8B2EFE85ABEA9C89D70EC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_9E721FFFD700B4EDC3E5BEA9C89D2AC5" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_B608E3D4FB16542B07D1BEA9C892B42C" xlink:to="loc_us-gaap_FinancialInstrumentAxis_9E721FFFD700B4EDC3E5BEA9C89D2AC5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_12C028182F848B6ABDFFBEA9C89EA5B0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_9E721FFFD700B4EDC3E5BEA9C89D2AC5" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_12C028182F848B6ABDFFBEA9C89EA5B0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquitySecuritiesMember" xlink:label="loc_us-gaap_EquitySecuritiesMember_DDE57A2237A3E6843E43BEA9C89EB95F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_12C028182F848B6ABDFFBEA9C89EA5B0" xlink:to="loc_us-gaap_EquitySecuritiesMember_DDE57A2237A3E6843E43BEA9C89EB95F" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ClassificationOfInvestmentAxis" xlink:label="loc_regn_ClassificationOfInvestmentAxis_2F288834CE295A9A6AF5BEA9C89FB53A" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_B608E3D4FB16542B07D1BEA9C892B42C" xlink:to="loc_regn_ClassificationOfInvestmentAxis_2F288834CE295A9A6AF5BEA9C89FB53A" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ClassificationOfInvestmentDomain" xlink:label="loc_regn_ClassificationOfInvestmentDomain_8A94F1A7A7D89B1D5E61BEA9C89F1AA3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ClassificationOfInvestmentAxis_2F288834CE295A9A6AF5BEA9C89FB53A" xlink:to="loc_regn_ClassificationOfInvestmentDomain_8A94F1A7A7D89B1D5E61BEA9C89F1AA3" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_UnrestrictedMember" xlink:label="loc_regn_UnrestrictedMember_A41F7F23B48415B380CCBEA9C89F95DE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ClassificationOfInvestmentDomain_8A94F1A7A7D89B1D5E61BEA9C89F1AA3" xlink:to="loc_regn_UnrestrictedMember_A41F7F23B48415B380CCBEA9C89F95DE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsForNewAccountingPronouncementsAxis" xlink:label="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_71F2BF09EEABF5BCFE55BEA9C8A52D8F" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_B608E3D4FB16542B07D1BEA9C892B42C" xlink:to="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_71F2BF09EEABF5BCFE55BEA9C8A52D8F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TypeOfAdoptionMember" xlink:label="loc_us-gaap_TypeOfAdoptionMember_14ED720D506BBCCA847BBEA9C8A5162D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_71F2BF09EEABF5BCFE55BEA9C8A52D8F" xlink:to="loc_us-gaap_TypeOfAdoptionMember_14ED720D506BBCCA847BBEA9C8A5162D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201409Member" xlink:label="loc_us-gaap_AccountingStandardsUpdate201409Member_B4D5E01F1253BEEAA1D4BEA9C8A654F6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfAdoptionMember_14ED720D506BBCCA847BBEA9C8A5162D" xlink:to="loc_us-gaap_AccountingStandardsUpdate201409Member_B4D5E01F1253BEEAA1D4BEA9C8A654F6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201601Member" xlink:label="loc_us-gaap_AccountingStandardsUpdate201601Member_0A05828C76FBC4E1E235BEA9C8A6C5B1" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfAdoptionMember_14ED720D506BBCCA847BBEA9C8A5162D" xlink:to="loc_us-gaap_AccountingStandardsUpdate201601Member_0A05828C76FBC4E1E235BEA9C8A6C5B1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201602Member" xlink:label="loc_us-gaap_AccountingStandardsUpdate201602Member_1D3C79ABBC1066FCF4F9BEA9C8A64EF3" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfAdoptionMember_14ED720D506BBCCA847BBEA9C8A5162D" xlink:to="loc_us-gaap_AccountingStandardsUpdate201602Member_1D3C79ABBC1066FCF4F9BEA9C8A64EF3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis" xlink:label="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_D070829B40B5CD444E28BEA9C8A7723A" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_B608E3D4FB16542B07D1BEA9C892B42C" xlink:to="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_D070829B40B5CD444E28BEA9C8A7723A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ChangeInAccountingPrincipleMember" xlink:label="loc_us-gaap_ChangeInAccountingPrincipleMember_FF2789209D46659829EBBEA9C8A767D7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_D070829B40B5CD444E28BEA9C8A7723A" xlink:to="loc_us-gaap_ChangeInAccountingPrincipleMember_FF2789209D46659829EBBEA9C8A767D7" xlink:type="arc" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ChangeInAccountingPrincipleMember_FF2789209D46659829EBBEA9C8A767D7" xlink:to="loc_us-gaap_AccountingStandardsUpdate201409Member_B4D5E01F1253BEEAA1D4BEA9C8A654F6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_37BB58A0BB3424585C6ABEA9C8A892AD" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_B608E3D4FB16542B07D1BEA9C892B42C" xlink:to="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_37BB58A0BB3424585C6ABEA9C8A892AD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerLiability" xlink:label="loc_us-gaap_ContractWithCustomerLiability_EA42D715697E0EED4C92BEA9C8A8763B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_37BB58A0BB3424585C6ABEA9C8A892AD" xlink:to="loc_us-gaap_ContractWithCustomerLiability_EA42D715697E0EED4C92BEA9C8A8763B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption" xlink:label="loc_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption_D4E8D98B2EC773CE7A8EBEA9C8A8DC65" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_37BB58A0BB3424585C6ABEA9C8A892AD" xlink:to="loc_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption_D4E8D98B2EC773CE7A8EBEA9C8A8DC65" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodBeforeTax" xlink:label="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodBeforeTax_DF04624E201DA3C678C3BEA9C8A9ABD4" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_37BB58A0BB3424585C6ABEA9C8A892AD" xlink:to="loc_us-gaap_ReclassificationFromAccumulatedOtherComprehensiveIncomeCurrentPeriodBeforeTax_DF04624E201DA3C678C3BEA9C8A9ABD4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskPercentage1" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_B3C75916F5052E827CE0BEA9C8A9D577" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_37BB58A0BB3424585C6ABEA9C8A892AD" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_B3C75916F5052E827CE0BEA9C8A9D577" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent" xlink:label="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_7A7FA8672FA0CE1A2093BEA9C8A9CC87" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_37BB58A0BB3424585C6ABEA9C8A892AD" xlink:to="loc_us-gaap_AllowanceForDoubtfulAccountsReceivableCurrent_7A7FA8672FA0CE1A2093BEA9C8A9CC87" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProvisionForDoubtfulAccounts" xlink:label="loc_us-gaap_ProvisionForDoubtfulAccounts_143C3C4B3B66ED1A4F2CBEA9C8A9CF64" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_37BB58A0BB3424585C6ABEA9C8A892AD" xlink:to="loc_us-gaap_ProvisionForDoubtfulAccounts_143C3C4B3B66ED1A4F2CBEA9C8A9CF64" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_51A4F8DEE424A5436082BEA9C8A9791A" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_37BB58A0BB3424585C6ABEA9C8A892AD" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_51A4F8DEE424A5436082BEA9C8A9791A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeaseLiability" xlink:label="loc_us-gaap_OperatingLeaseLiability_181ED3A415FFD87A3DDDBEA9C8AA326A" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_37BB58A0BB3424585C6ABEA9C8A892AD" xlink:to="loc_us-gaap_OperatingLeaseLiability_181ED3A415FFD87A3DDDBEA9C8AA326A" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/BusinessOverviewAndSummaryOfSignificantAccountingPoliciesPolicies" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_E39A7165BC8F032EF070BEA344B8D142" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BasisOfAccountingPolicyPolicyTextBlock" xlink:label="loc_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_CD47E999B457E6AD35F4BEA344BE9384" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_E39A7165BC8F032EF070BEA344B8D142" xlink:to="loc_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_CD47E999B457E6AD35F4BEA344BE9384" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UseOfEstimates" xlink:label="loc_us-gaap_UseOfEstimates_4CAAC9D816EC399006CFBEA344BF12C4" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_E39A7165BC8F032EF070BEA344B8D142" xlink:to="loc_us-gaap_UseOfEstimates_4CAAC9D816EC399006CFBEA344BF12C4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashAndCashEquivalentsPolicyTextBlock" xlink:label="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_82E6DFECEE2D0E5F1848BEA344C04DFA" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_E39A7165BC8F032EF070BEA344B8D142" xlink:to="loc_us-gaap_CashAndCashEquivalentsPolicyTextBlock_82E6DFECEE2D0E5F1848BEA344C04DFA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MarketableSecuritiesPolicy" xlink:label="loc_us-gaap_MarketableSecuritiesPolicy_69EF78C6F6DD7E779699BEA344C07E23" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_E39A7165BC8F032EF070BEA344B8D142" xlink:to="loc_us-gaap_MarketableSecuritiesPolicy_69EF78C6F6DD7E779699BEA344C07E23" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TradeAndOtherAccountsReceivablePolicy" xlink:label="loc_us-gaap_TradeAndOtherAccountsReceivablePolicy_9D1B38F2A0EE3CB78DE5BEA344C1A376" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_E39A7165BC8F032EF070BEA344B8D142" xlink:to="loc_us-gaap_TradeAndOtherAccountsReceivablePolicy_9D1B38F2A0EE3CB78DE5BEA344C1A376" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryPolicyTextBlock" xlink:label="loc_us-gaap_InventoryPolicyTextBlock_EFFD0BFA019C2A884AA0BEA344C1EDC6" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_E39A7165BC8F032EF070BEA344B8D142" xlink:to="loc_us-gaap_InventoryPolicyTextBlock_EFFD0BFA019C2A884AA0BEA344C1EDC6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentPolicyTextBlock" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_4A73701D78DF89879F82BEA344C14A03" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_E39A7165BC8F032EF070BEA344B8D142" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_4A73701D78DF89879F82BEA344C14A03" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerPolicyTextBlock" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerPolicyTextBlock_55B5201FE947E111C18FBEA344C2CE97" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_E39A7165BC8F032EF070BEA344B8D142" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerPolicyTextBlock_55B5201FE947E111C18FBEA344C2CE97" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ResearchAndDevelopmentExpensePolicy" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_C9C3BBB53023D6EBF9ECBEA344C2F2D8" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_E39A7165BC8F032EF070BEA344B8D142" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_C9C3BBB53023D6EBF9ECBEA344C2F2D8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy" xlink:label="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_A1CA729A8F4EBC766866BEA344C27E13" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_E39A7165BC8F032EF070BEA344B8D142" xlink:to="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_A1CA729A8F4EBC766866BEA344C27E13" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxPolicyTextBlock" xlink:label="loc_us-gaap_IncomeTaxPolicyTextBlock_587B884C133142875664BEA344C3A486" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_E39A7165BC8F032EF070BEA344B8D142" xlink:to="loc_us-gaap_IncomeTaxPolicyTextBlock_587B884C133142875664BEA344C3A486" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerSharePolicyTextBlock" xlink:label="loc_us-gaap_EarningsPerSharePolicyTextBlock_B076C659FB6250178920BEA344C36E89" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_E39A7165BC8F032EF070BEA344B8D142" xlink:to="loc_us-gaap_EarningsPerSharePolicyTextBlock_B076C659FB6250178920BEA344C36E89" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskCreditRisk" xlink:label="loc_us-gaap_ConcentrationRiskCreditRisk_4A72E01F711029658A6ABEA344C3B92A" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_E39A7165BC8F032EF070BEA344B8D142" xlink:to="loc_us-gaap_ConcentrationRiskCreditRisk_4A72E01F711029658A6ABEA344C3B92A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:label="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_DF23DF887C0186B43597BEA344C4B63E" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_E39A7165BC8F032EF070BEA344B8D142" xlink:to="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_DF23DF887C0186B43597BEA344C4B63E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LegalCostsPolicyTextBlock" xlink:label="loc_us-gaap_LegalCostsPolicyTextBlock_FA63FBDE50064A2A11CABEA344C47411" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_E39A7165BC8F032EF070BEA344B8D142" xlink:to="loc_us-gaap_LegalCostsPolicyTextBlock_FA63FBDE50064A2A11CABEA344C47411" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/BusinessOverviewAndSummaryOfSignificantAccountingPoliciesScheduleOfBalanceSheetDataDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_38FFA3CDE6C9FFA6CA2DC3CD9B149239" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_D4A75E1702BFC2FBA7C3C3CD9B14EB78" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_38FFA3CDE6C9FFA6CA2DC3CD9B149239" xlink:to="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_D4A75E1702BFC2FBA7C3C3CD9B14EB78" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis" xlink:label="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_84EAD7486EF9BF78D4BAC3CD9B140DDB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_D4A75E1702BFC2FBA7C3C3CD9B14EB78" xlink:to="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_84EAD7486EF9BF78D4BAC3CD9B140DDB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProjectMember" xlink:label="loc_us-gaap_ProjectMember_26CE94AC34E518BB620FC3CD9B14DC2A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_84EAD7486EF9BF78D4BAC3CD9B140DDB" xlink:to="loc_us-gaap_ProjectMember_26CE94AC34E518BB620FC3CD9B14DC2A" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_SanofiCollaborationAgreementMember" xlink:label="loc_regn_SanofiCollaborationAgreementMember_4DC5FF9F1D509F5B3E72C3CD9B158761" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_26CE94AC34E518BB620FC3CD9B14DC2A" xlink:to="loc_regn_SanofiCollaborationAgreementMember_4DC5FF9F1D509F5B3E72C3CD9B158761" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_BayerTevaPharmaceuticalsAndOtherAgreementsMember" xlink:label="loc_regn_BayerTevaPharmaceuticalsAndOtherAgreementsMember_3054982FF4538B2F5D2DC3CD9B15BB4C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_26CE94AC34E518BB620FC3CD9B14DC2A" xlink:to="loc_regn_BayerTevaPharmaceuticalsAndOtherAgreementsMember_3054982FF4538B2F5D2DC3CD9B15BB4C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis" xlink:label="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis_9FB9AE5749923670CBF3C3CD9B15BB76" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_D4A75E1702BFC2FBA7C3C3CD9B14EB78" xlink:to="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis_9FB9AE5749923670CBF3C3CD9B15BB76" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain" xlink:label="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_9F2EA70D9F995D96B01DC3CD9B16DFE9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis_9FB9AE5749923670CBF3C3CD9B15BB76" xlink:to="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_9F2EA70D9F995D96B01DC3CD9B16DFE9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member" xlink:label="loc_us-gaap_CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member_D96F60668C43F91C2E13C3CD9B167B5F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_9F2EA70D9F995D96B01DC3CD9B16DFE9" xlink:to="loc_us-gaap_CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member_D96F60668C43F91C2E13C3CD9B167B5F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member" xlink:label="loc_us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member_43CB7B13B1B3A0E5BD30C3CD9B16FEF3" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_9F2EA70D9F995D96B01DC3CD9B16DFE9" xlink:to="loc_us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member_43CB7B13B1B3A0E5BD30C3CD9B16FEF3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsForNewAccountingPronouncementsAxis" xlink:label="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_12A766C5F6A10BBD1801C3CD9B1659EB" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_D4A75E1702BFC2FBA7C3C3CD9B14EB78" xlink:to="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_12A766C5F6A10BBD1801C3CD9B1659EB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TypeOfAdoptionMember" xlink:label="loc_us-gaap_TypeOfAdoptionMember_6DA78E997E9030A83094C3CD9B160F12" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_12A766C5F6A10BBD1801C3CD9B1659EB" xlink:to="loc_us-gaap_TypeOfAdoptionMember_6DA78E997E9030A83094C3CD9B160F12" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201409Member" xlink:label="loc_us-gaap_AccountingStandardsUpdate201409Member_B6F6957F671EA5BA2CC0C3CD9B1759AB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfAdoptionMember_6DA78E997E9030A83094C3CD9B160F12" xlink:to="loc_us-gaap_AccountingStandardsUpdate201409Member_B6F6957F671EA5BA2CC0C3CD9B1759AB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_7A0369126A516D1D8229C3CD9B17930E" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_D4A75E1702BFC2FBA7C3C3CD9B14EB78" xlink:to="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_7A0369126A516D1D8229C3CD9B17930E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_1A1A3905028E20576ED9C3CD9B17ACB6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_7A0369126A516D1D8229C3CD9B17930E" xlink:to="loc_us-gaap_InventoryNet_1A1A3905028E20576ED9C3CD9B17ACB6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredIncomeTaxAssetsNet" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_D5DC19E5559A391AFBC2C3CD9B178412" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_7A0369126A516D1D8229C3CD9B17930E" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_D5DC19E5559A391AFBC2C3CD9B178412" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_E6E4B4418C1A6ED42D40C3CD9B1867C6" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_7A0369126A516D1D8229C3CD9B17930E" xlink:to="loc_us-gaap_Assets_E6E4B4418C1A6ED42D40C3CD9B1867C6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccruedLiabilitiesAndOtherLiabilities" xlink:label="loc_us-gaap_AccruedLiabilitiesAndOtherLiabilities_71E9131503851B06E532C3CD9B185206" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_7A0369126A516D1D8229C3CD9B17930E" xlink:to="loc_us-gaap_AccruedLiabilitiesAndOtherLiabilities_71E9131503851B06E532C3CD9B185206" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerLiabilityCurrent" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_C1D45124C14AAC3CABC0C3CD9B1880A1" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_7A0369126A516D1D8229C3CD9B17930E" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_C1D45124C14AAC3CABC0C3CD9B1880A1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_us-gaap_LiabilitiesCurrent_6D1758F95B385413AAC8C3CD9B187ABA" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_7A0369126A516D1D8229C3CD9B17930E" xlink:to="loc_us-gaap_LiabilitiesCurrent_6D1758F95B385413AAC8C3CD9B187ABA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_3C48BAE278473F7BC552C3CD9B1893E1" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_7A0369126A516D1D8229C3CD9B17930E" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_3C48BAE278473F7BC552C3CD9B1893E1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Liabilities" xlink:label="loc_us-gaap_Liabilities_B8C930307ECC0416CAD8C3CD9B1963F5" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_7A0369126A516D1D8229C3CD9B17930E" xlink:to="loc_us-gaap_Liabilities_B8C930307ECC0416CAD8C3CD9B1963F5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_9E267BE57F2DB2D39F19C3CD9B195204" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_7A0369126A516D1D8229C3CD9B17930E" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_9E267BE57F2DB2D39F19C3CD9B195204" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_1FDBA9F6CF0D86B3EF25C3CD9B19D2D8" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_7A0369126A516D1D8229C3CD9B17930E" xlink:to="loc_us-gaap_StockholdersEquity_1FDBA9F6CF0D86B3EF25C3CD9B19D2D8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_41A03E24DD9BCF41D0EEC3CD9B19D1BA" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_7A0369126A516D1D8229C3CD9B17930E" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_41A03E24DD9BCF41D0EEC3CD9B19D1BA" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/BusinessOverviewAndSummaryOfSignificantAccountingPoliciesScheduleOfEstimatedUsefulLivesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_A999DEEF5A5F38514736BEA9C81551FA" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_918CEBF37BFF5AB1E1F0BEA9C815F9A9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_A999DEEF5A5F38514736BEA9C81551FA" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_918CEBF37BFF5AB1E1F0BEA9C815F9A9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_464B751A452D33EF7830BEA9C8159ED5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_918CEBF37BFF5AB1E1F0BEA9C815F9A9" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_464B751A452D33EF7830BEA9C8159ED5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_D22122CFDDF19E3EAF8BBEA9C81668C6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_464B751A452D33EF7830BEA9C8159ED5" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_D22122CFDDF19E3EAF8BBEA9C81668C6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BuildingAndBuildingImprovementsMember" xlink:label="loc_us-gaap_BuildingAndBuildingImprovementsMember_CA9F2286BF26E240A16BBEA9C816C979" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_D22122CFDDF19E3EAF8BBEA9C81668C6" xlink:to="loc_us-gaap_BuildingAndBuildingImprovementsMember_CA9F2286BF26E240A16BBEA9C816C979" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquipmentMember" xlink:label="loc_us-gaap_EquipmentMember_E9B75F60D6F3DBB26A8BBEA9C8178C00" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_D22122CFDDF19E3EAF8BBEA9C81668C6" xlink:to="loc_us-gaap_EquipmentMember_E9B75F60D6F3DBB26A8BBEA9C8178C00" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FurnitureAndFixturesMember" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_A5BA5DA39B8A13B32401BEA9C8187068" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_D22122CFDDF19E3EAF8BBEA9C81668C6" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_A5BA5DA39B8A13B32401BEA9C8187068" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_CCC6CC82C66CF1190254BEA9C818AD75" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_918CEBF37BFF5AB1E1F0BEA9C815F9A9" xlink:to="loc_srt_RangeAxis_CCC6CC82C66CF1190254BEA9C818AD75" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_7AA560D2F87DF666126FBEA9C818B88A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_CCC6CC82C66CF1190254BEA9C818AD75" xlink:to="loc_srt_RangeMember_7AA560D2F87DF666126FBEA9C818B88A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MinimumMember" xlink:label="loc_srt_MinimumMember_7448EF5079BE5562DB22BEA9C819DC69" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_7AA560D2F87DF666126FBEA9C818B88A" xlink:to="loc_srt_MinimumMember_7448EF5079BE5562DB22BEA9C819DC69" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_9D6B960047188E630506BEA9C81943DA" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_7AA560D2F87DF666126FBEA9C818B88A" xlink:to="loc_srt_MaximumMember_9D6B960047188E630506BEA9C81943DA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_8BBB6FA38FD1B6E1352CBEA9C819A6B9" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_918CEBF37BFF5AB1E1F0BEA9C815F9A9" xlink:to="loc_us-gaap_StatementLineItems_8BBB6FA38FD1B6E1352CBEA9C819A6B9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_B292B4155148B0B87880BEA9C819F2EC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8BBB6FA38FD1B6E1352CBEA9C819A6B9" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_B292B4155148B0B87880BEA9C819F2EC" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/BusinessOverviewAndSummaryOfSignificantAccountingPoliciesScheduleOfStatementsOfOperationsDataDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_C5FAA47B7A0B347282C6BEA9C82329B9" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_CF8BDF365EAD4B920988BEA9C8239708" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_C5FAA47B7A0B347282C6BEA9C82329B9" xlink:to="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_CF8BDF365EAD4B920988BEA9C8239708" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis" xlink:label="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_E44B4843C921F47EA020BEA9C824C0AC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_CF8BDF365EAD4B920988BEA9C8239708" xlink:to="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_E44B4843C921F47EA020BEA9C824C0AC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProjectMember" xlink:label="loc_us-gaap_ProjectMember_3F3CAAB7D16C4AB1877DBEA9C825D2C6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_E44B4843C921F47EA020BEA9C824C0AC" xlink:to="loc_us-gaap_ProjectMember_3F3CAAB7D16C4AB1877DBEA9C825D2C6" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_SanofiCollaborationAgreementMember" xlink:label="loc_regn_SanofiCollaborationAgreementMember_56ABAD4873ABA8F85414BEA9C825F57E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_3F3CAAB7D16C4AB1877DBEA9C825D2C6" xlink:to="loc_regn_SanofiCollaborationAgreementMember_56ABAD4873ABA8F85414BEA9C825F57E" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_OtherCollaborationAgreementsMember" xlink:label="loc_regn_OtherCollaborationAgreementsMember_5049479631E6505CDE26BEA9C825036D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_3F3CAAB7D16C4AB1877DBEA9C825D2C6" xlink:to="loc_regn_OtherCollaborationAgreementsMember_5049479631E6505CDE26BEA9C825036D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsForNewAccountingPronouncementsAxis" xlink:label="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_7150D9438413343E2051BEA9C82622BB" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_CF8BDF365EAD4B920988BEA9C8239708" xlink:to="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_7150D9438413343E2051BEA9C82622BB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TypeOfAdoptionMember" xlink:label="loc_us-gaap_TypeOfAdoptionMember_F3F0987F10E168D756D5BEA9C8267255" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_7150D9438413343E2051BEA9C82622BB" xlink:to="loc_us-gaap_TypeOfAdoptionMember_F3F0987F10E168D756D5BEA9C8267255" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201409Member" xlink:label="loc_us-gaap_AccountingStandardsUpdate201409Member_4E23D910DA67538887EEBEA9C8264D21" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfAdoptionMember_F3F0987F10E168D756D5BEA9C8267255" xlink:to="loc_us-gaap_AccountingStandardsUpdate201409Member_4E23D910DA67538887EEBEA9C8264D21" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis" xlink:label="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis_AEEE2ED45DF355E48932BEA9C827E012" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_CF8BDF365EAD4B920988BEA9C8239708" xlink:to="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis_AEEE2ED45DF355E48932BEA9C827E012" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain" xlink:label="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_C9CAEABC657D708E3CF4BEA9C827C3C1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis_AEEE2ED45DF355E48932BEA9C827E012" xlink:to="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_C9CAEABC657D708E3CF4BEA9C827C3C1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member" xlink:label="loc_us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member_C00BABEBC6C0C30D1C2EBEA9C82870F6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_C9CAEABC657D708E3CF4BEA9C827C3C1" xlink:to="loc_us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member_C00BABEBC6C0C30D1C2EBEA9C82870F6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member" xlink:label="loc_us-gaap_CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member_617A4BDC49779DDD928FBEA9C8281958" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_C9CAEABC657D708E3CF4BEA9C827C3C1" xlink:to="loc_us-gaap_CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member_617A4BDC49779DDD928FBEA9C8281958" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductOrServiceAxis" xlink:label="loc_srt_ProductOrServiceAxis_ADBE17A38EBBE2A9C65CBEA9C8285B4C" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_CF8BDF365EAD4B920988BEA9C8239708" xlink:to="loc_srt_ProductOrServiceAxis_ADBE17A38EBBE2A9C65CBEA9C8285B4C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_6D3D7AF8DB4E590EA6CBBEA9C829E501" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_ADBE17A38EBBE2A9C65CBEA9C8285B4C" xlink:to="loc_srt_ProductsAndServicesDomain_6D3D7AF8DB4E590EA6CBBEA9C829E501" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProductAndServiceOtherMember" xlink:label="loc_us-gaap_ProductAndServiceOtherMember_6684EDBFEDE1D82CBB69BEA9C829F9CA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_6D3D7AF8DB4E590EA6CBBEA9C829E501" xlink:to="loc_us-gaap_ProductAndServiceOtherMember_6684EDBFEDE1D82CBB69BEA9C829F9CA" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_CollaborationandContractManufacturingMember" xlink:label="loc_regn_CollaborationandContractManufacturingMember_C8BD7DA8A9EF22772D6EBEA9C8297E3F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_6D3D7AF8DB4E590EA6CBBEA9C829E501" xlink:to="loc_regn_CollaborationandContractManufacturingMember_C8BD7DA8A9EF22772D6EBEA9C8297E3F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems" xlink:label="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_E3ED5197B4D8143DABA2BEA9C82AA12D" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleTable_CF8BDF365EAD4B920988BEA9C8239708" xlink:to="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_E3ED5197B4D8143DABA2BEA9C82AA12D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_4C04B850227C37613961BEA9C82A4BDB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_E3ED5197B4D8143DABA2BEA9C82AA12D" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_4C04B850227C37613961BEA9C82A4BDB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_1181A46317A5986E3DA7BEA9C82ABF0B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_E3ED5197B4D8143DABA2BEA9C82AA12D" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_1181A46317A5986E3DA7BEA9C82ABF0B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaap_OperatingIncomeLoss_72676634023F615DA6D3BEA9C82BF883" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_E3ED5197B4D8143DABA2BEA9C82AA12D" xlink:to="loc_us-gaap_OperatingIncomeLoss_72676634023F615DA6D3BEA9C82BF883" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_8704B63884693C68A18ABEA9C82B89B6" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_E3ED5197B4D8143DABA2BEA9C82AA12D" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_8704B63884693C68A18ABEA9C82B89B6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_2E2C8800626A70722F98BEA9C82B3975" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_E3ED5197B4D8143DABA2BEA9C82AA12D" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_2E2C8800626A70722F98BEA9C82B3975" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_CC189E25287EA9E08FE5BEA9C82B44B9" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NewAccountingPronouncementsOrChangeInAccountingPrincipleLineItems_E3ED5197B4D8143DABA2BEA9C82AA12D" xlink:to="loc_us-gaap_NetIncomeLoss_CC189E25287EA9E08FE5BEA9C82B44B9" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/BusinessOverviewAndSummaryOfSignificantAccountingPoliciesTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingPoliciesAbstract" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_8492F8749A4029083041BEA9C8BB7BD5" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfNewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock" xlink:label="loc_us-gaap_ScheduleOfNewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock_DC77CF5433A4C6361E9DBEA9C8BC0164" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_8492F8749A4029083041BEA9C8BB7BD5" xlink:to="loc_us-gaap_ScheduleOfNewAccountingPronouncementsAndChangesInAccountingPrinciplesTextBlock_DC77CF5433A4C6361E9DBEA9C8BC0164" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_EstimatedUsefulLivesOfPropertyPlantAndEquipmentTableTextBlock" xlink:label="loc_regn_EstimatedUsefulLivesOfPropertyPlantAndEquipmentTableTextBlock_857B1B8A8EBAA0136BE5BEA9C8BC53F3" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_8492F8749A4029083041BEA9C8BB7BD5" xlink:to="loc_regn_EstimatedUsefulLivesOfPropertyPlantAndEquipmentTableTextBlock_857B1B8A8EBAA0136BE5BEA9C8BC53F3" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/CollaborationAndLicenseAgreements" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_C7CCC1CB027809DAA85D57AD257857BF" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CollaborativeArrangementDisclosureTextBlock" xlink:label="loc_us-gaap_CollaborativeArrangementDisclosureTextBlock_29DD377609B40B71791557AD25784414" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_C7CCC1CB027809DAA85D57AD257857BF" xlink:to="loc_us-gaap_CollaborativeArrangementDisclosureTextBlock_29DD377609B40B71791557AD25784414" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsBayerNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_FD585C65CE547BFEB539C3CD9A6D8519" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTable" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_1FF9AF76BEF2B1809D6CC3CD9A6D5792" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_FD585C65CE547BFEB539C3CD9A6D8519" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_1FF9AF76BEF2B1809D6CC3CD9A6D5792" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_3C865AE150D8CFC015DFC3CD9A6ECDB1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_1FF9AF76BEF2B1809D6CC3CD9A6D5792" xlink:to="loc_srt_RangeAxis_3C865AE150D8CFC015DFC3CD9A6ECDB1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_28614D766A68DEC4D082C3CD9A6EE422" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_3C865AE150D8CFC015DFC3CD9A6ECDB1" xlink:to="loc_srt_RangeMember_28614D766A68DEC4D082C3CD9A6EE422" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MinimumMember" xlink:label="loc_srt_MinimumMember_3881EC922A933120A1E4C3CD9A6E5744" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_28614D766A68DEC4D082C3CD9A6EE422" xlink:to="loc_srt_MinimumMember_3881EC922A933120A1E4C3CD9A6E5744" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_3D5F3C860F04688B8899C3CD9A6EECB3" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_28614D766A68DEC4D082C3CD9A6EE422" xlink:to="loc_srt_MaximumMember_3D5F3C860F04688B8899C3CD9A6EECB3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_05FEB609F62DA453732DC3CD9A6FCB02" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_1FF9AF76BEF2B1809D6CC3CD9A6D5792" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_05FEB609F62DA453732DC3CD9A6FCB02" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_B9BE8602D0AD1A665A22C3CD9A6FF166" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_05FEB609F62DA453732DC3CD9A6FCB02" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_B9BE8602D0AD1A665A22C3CD9A6FF166" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Ang2AntibodyMember" xlink:label="loc_regn_Ang2AntibodyMember_BFDEDBE75AA4ED4CE483C3CD9A709662" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_B9BE8602D0AD1A665A22C3CD9A6FF166" xlink:to="loc_regn_Ang2AntibodyMember_BFDEDBE75AA4ED4CE483C3CD9A709662" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Ang2AntibodyAndPDGFRbetaAntibodyMember" xlink:label="loc_regn_Ang2AntibodyAndPDGFRbetaAntibodyMember_E9EFFA153E5F75220650C3CD9A708619" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_B9BE8602D0AD1A665A22C3CD9A6FF166" xlink:to="loc_regn_Ang2AntibodyAndPDGFRbetaAntibodyMember_E9EFFA153E5F75220650C3CD9A708619" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis" xlink:label="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_A81C9DBFC345A3BBB52CC3CD9A70C778" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_1FF9AF76BEF2B1809D6CC3CD9A6D5792" xlink:to="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_A81C9DBFC345A3BBB52CC3CD9A70C778" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProjectMember" xlink:label="loc_us-gaap_ProjectMember_6605753F97905B557866C3CD9A70EB15" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_A81C9DBFC345A3BBB52CC3CD9A70C778" xlink:to="loc_us-gaap_ProjectMember_6605753F97905B557866C3CD9A70EB15" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_BayerCollaborationAgreementMember" xlink:label="loc_regn_BayerCollaborationAgreementMember_799D45F627B5894A4F0BC3CD9A714452" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_6605753F97905B557866C3CD9A70EB15" xlink:to="loc_regn_BayerCollaborationAgreementMember_799D45F627B5894A4F0BC3CD9A714452" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_983B258BDCE245BC8B5DC3CD9A718CA5" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_1FF9AF76BEF2B1809D6CC3CD9A6D5792" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_983B258BDCE245BC8B5DC3CD9A718CA5" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Upfrontpaymentreceived" xlink:label="loc_regn_Upfrontpaymentreceived_47B0645D0BB451C5A26CC3CD9A719E24" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_983B258BDCE245BC8B5DC3CD9A718CA5" xlink:to="loc_regn_Upfrontpaymentreceived_47B0645D0BB451C5A26CC3CD9A719E24" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_MaximumAmountOfSalesMilestonePaymentsIfTotalSalesAchieveSpecificLevels" xlink:label="loc_regn_MaximumAmountOfSalesMilestonePaymentsIfTotalSalesAchieveSpecificLevels_B6994F55CC1D1850FA9FC3CD9A72B501" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_983B258BDCE245BC8B5DC3CD9A718CA5" xlink:to="loc_regn_MaximumAmountOfSalesMilestonePaymentsIfTotalSalesAchieveSpecificLevels_B6994F55CC1D1850FA9FC3CD9A72B501" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromCollaborators" xlink:label="loc_us-gaap_ProceedsFromCollaborators_E5FD3AE3630F09A5C602C3CD9A72EDF1" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_983B258BDCE245BC8B5DC3CD9A718CA5" xlink:to="loc_us-gaap_ProceedsFromCollaborators_E5FD3AE3630F09A5C602C3CD9A72EDF1" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Minimumadvancenoticerequiredtoterminatecollaborationagreement" xlink:label="loc_regn_Minimumadvancenoticerequiredtoterminatecollaborationagreement_8CC60B1B8DC5B63F0CDBC3CD9A724CF4" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_983B258BDCE245BC8B5DC3CD9A718CA5" xlink:to="loc_regn_Minimumadvancenoticerequiredtoterminatecollaborationagreement_8CC60B1B8DC5B63F0CDBC3CD9A724CF4" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Maximumadvancenoticerequiredtoterminatecollaborationagreement" xlink:label="loc_regn_Maximumadvancenoticerequiredtoterminatecollaborationagreement_690A3C459ACEF82C5089C3CD9A727592" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_983B258BDCE245BC8B5DC3CD9A718CA5" xlink:to="loc_regn_Maximumadvancenoticerequiredtoterminatecollaborationagreement_690A3C459ACEF82C5089C3CD9A727592" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_RevenuebasedonpercentageofannualsalesinJapan" xlink:label="loc_regn_RevenuebasedonpercentageofannualsalesinJapan_EDE710ED02499425875AC3CD9A72CE28" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_983B258BDCE245BC8B5DC3CD9A718CA5" xlink:to="loc_regn_RevenuebasedonpercentageofannualsalesinJapan_EDE710ED02499425875AC3CD9A72CE28" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Percentageofrepaymentofdevelopmentbalanceoutofprofits" xlink:label="loc_regn_Percentageofrepaymentofdevelopmentbalanceoutofprofits_A42C6B304CD7A4A7FA21C3CD9A7212C7" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_983B258BDCE245BC8B5DC3CD9A718CA5" xlink:to="loc_regn_Percentageofrepaymentofdevelopmentbalanceoutofprofits_A42C6B304CD7A4A7FA21C3CD9A7212C7" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Contingentreimbursementobligation" xlink:label="loc_regn_Contingentreimbursementobligation_22A59A9CB00AAE59A41FC3CD9A73D9C9" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_983B258BDCE245BC8B5DC3CD9A718CA5" xlink:to="loc_regn_Contingentreimbursementobligation_22A59A9CB00AAE59A41FC3CD9A73D9C9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_1C0148834C86B7D98110C3CD9A739562" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_983B258BDCE245BC8B5DC3CD9A718CA5" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_1C0148834C86B7D98110C3CD9A739562" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsSanofiAntibodiesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_2E7AE7A88070734B835D5882EDB186BB" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTable" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_1A2CC20E9014739742B65882EDB10403" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_2E7AE7A88070734B835D5882EDB186BB" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_1A2CC20E9014739742B65882EDB10403" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_31AC327B79CF669592C75882EDB183DE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_1A2CC20E9014739742B65882EDB10403" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_31AC327B79CF669592C75882EDB183DE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain" xlink:label="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_C8EB9CD338AEA8C6372C5882EDB2C1DA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersByTypeAxis_31AC327B79CF669592C75882EDB183DE" xlink:to="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_C8EB9CD338AEA8C6372C5882EDB2C1DA" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_PraluentKevzaraandDupixentMemberMember" xlink:label="loc_regn_PraluentKevzaraandDupixentMemberMember_EE3AD2D12BAD9A3081035882EDB275C6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ResearchAndDevelopmentArrangementContractToPerformForOthersTypeDomain_C8EB9CD338AEA8C6372C5882EDB2C1DA" xlink:to="loc_regn_PraluentKevzaraandDupixentMemberMember_EE3AD2D12BAD9A3081035882EDB275C6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis" xlink:label="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_5F78611DADF136D055DA5882EDB31177" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_1A2CC20E9014739742B65882EDB10403" xlink:to="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_5F78611DADF136D055DA5882EDB31177" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProjectMember" xlink:label="loc_us-gaap_ProjectMember_32CF519419305E714A1D5882EDB37663" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_5F78611DADF136D055DA5882EDB31177" xlink:to="loc_us-gaap_ProjectMember_32CF519419305E714A1D5882EDB37663" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_SanofiCollaborationAgreementMember" xlink:label="loc_regn_SanofiCollaborationAgreementMember_EFC0B67EAA96B5E32A7B5882EDB4026D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_32CF519419305E714A1D5882EDB37663" xlink:to="loc_regn_SanofiCollaborationAgreementMember_EFC0B67EAA96B5E32A7B5882EDB4026D" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_SanofiCollaborationAgreementAntibodyMember" xlink:label="loc_regn_SanofiCollaborationAgreementAntibodyMember_7AF62E84E9A19D72B21A5882EDB4323F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_32CF519419305E714A1D5882EDB37663" xlink:to="loc_regn_SanofiCollaborationAgreementAntibodyMember_7AF62E84E9A19D72B21A5882EDB4323F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_2B0D264DEF051577A2525882EDB5A1E9" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_1A2CC20E9014739742B65882EDB10403" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_2B0D264DEF051577A2525882EDB5A1E9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="loc_us-gaap_CommonStockSharesIssued_447CAC45DDF7C0B126EC5882EDB5C2BD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_2B0D264DEF051577A2525882EDB5A1E9" xlink:to="loc_us-gaap_CommonStockSharesIssued_447CAC45DDF7C0B126EC5882EDB5C2BD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromCollaborators" xlink:label="loc_us-gaap_ProceedsFromCollaborators_9AEA6027A8E2BA7228975882EDB6BF8C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_2B0D264DEF051577A2525882EDB5A1E9" xlink:to="loc_us-gaap_ProceedsFromCollaborators_9AEA6027A8E2BA7228975882EDB6BF8C" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_AnnualFundingMaximumOfResearchActivitiesPerAmendedAgreement" xlink:label="loc_regn_AnnualFundingMaximumOfResearchActivitiesPerAmendedAgreement_D7B4C2FDF62BB907D13E5882EDB6F1A2" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_2B0D264DEF051577A2525882EDB5A1E9" xlink:to="loc_regn_AnnualFundingMaximumOfResearchActivitiesPerAmendedAgreement_D7B4C2FDF62BB907D13E5882EDB6F1A2" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_PercentageOfTrialCostsBorneByCollaboratingParty" xlink:label="loc_regn_PercentageOfTrialCostsBorneByCollaboratingParty_1DE34BBB4C98D720B3225882EDB64A58" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_2B0D264DEF051577A2525882EDB5A1E9" xlink:to="loc_regn_PercentageOfTrialCostsBorneByCollaboratingParty_1DE34BBB4C98D720B3225882EDB64A58" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_PercentageOfTrialCostsBorneByEntity" xlink:label="loc_regn_PercentageOfTrialCostsBorneByEntity_4F1175A22A37C1DCEC645882EDB7652D" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_2B0D264DEF051577A2525882EDB5A1E9" xlink:to="loc_regn_PercentageOfTrialCostsBorneByEntity_4F1175A22A37C1DCEC645882EDB7652D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_89C2851FCDD2A7AA57A35882EDB7A1BA" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_2B0D264DEF051577A2525882EDB5A1E9" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_89C2851FCDD2A7AA57A35882EDB7A1BA" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Percentageofrepaymentofdevelopmentbalanceoutofprofits" xlink:label="loc_regn_Percentageofrepaymentofdevelopmentbalanceoutofprofits_F262582F60EA044FA14A5882EDB7DAF6" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_2B0D264DEF051577A2525882EDB5A1E9" xlink:to="loc_regn_Percentageofrepaymentofdevelopmentbalanceoutofprofits_F262582F60EA044FA14A5882EDB7DAF6" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_PercentageOfTrialCostsToBeReimbursedDueToProfitabilityOfAgreement" xlink:label="loc_regn_PercentageOfTrialCostsToBeReimbursedDueToProfitabilityOfAgreement_28358FD13BEC5490D9705882EDB761F1" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_2B0D264DEF051577A2525882EDB5A1E9" xlink:to="loc_regn_PercentageOfTrialCostsToBeReimbursedDueToProfitabilityOfAgreement_28358FD13BEC5490D9705882EDB761F1" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ExcessShareOfProfitNotRequiredToToBeAppliedToReimburseDevelopmentCost" xlink:label="loc_regn_ExcessShareOfProfitNotRequiredToToBeAppliedToReimburseDevelopmentCost_28DBE80A0AD445C1D7745882EDB8410B" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_2B0D264DEF051577A2525882EDB5A1E9" xlink:to="loc_regn_ExcessShareOfProfitNotRequiredToToBeAppliedToReimburseDevelopmentCost_28DBE80A0AD445C1D7745882EDB8410B" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Contingentreimbursementobligation" xlink:label="loc_regn_Contingentreimbursementobligation_08B4CAB50F56060C6BAC5882EDB823EB" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_2B0D264DEF051577A2525882EDB5A1E9" xlink:to="loc_regn_Contingentreimbursementobligation_08B4CAB50F56060C6BAC5882EDB823EB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TreasuryStockSharesAcquired" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_BD682EA6DFA1742A833C5882EDB8A3AC" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_2B0D264DEF051577A2525882EDB5A1E9" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_BD682EA6DFA1742A833C5882EDB8A3AC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_25FE2689D0B625C5E7205882EDB8D157" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_2B0D264DEF051577A2525882EDB5A1E9" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_25FE2689D0B625C5E7205882EDB8D157" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_StartingShareOfProfitsOutsideUnitedStatesBasedOnSalesForCollaboratingParty" xlink:label="loc_regn_StartingShareOfProfitsOutsideUnitedStatesBasedOnSalesForCollaboratingParty_BEAEC7ADAF56E35DEAF45882EDB984C4" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_2B0D264DEF051577A2525882EDB5A1E9" xlink:to="loc_regn_StartingShareOfProfitsOutsideUnitedStatesBasedOnSalesForCollaboratingParty_BEAEC7ADAF56E35DEAF45882EDB984C4" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_StartingShareOfProfitsOutsideUnitedStatesBasedOnSalesForCompany" xlink:label="loc_regn_StartingShareOfProfitsOutsideUnitedStatesBasedOnSalesForCompany_D911B764418E041D98BE5882EDB9F8DA" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_2B0D264DEF051577A2525882EDB5A1E9" xlink:to="loc_regn_StartingShareOfProfitsOutsideUnitedStatesBasedOnSalesForCompany_D911B764418E041D98BE5882EDB9F8DA" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_EndingShareOfProfitsOutsideUnitedStatesBasedOnSalesForCollaboratingParty" xlink:label="loc_regn_EndingShareOfProfitsOutsideUnitedStatesBasedOnSalesForCollaboratingParty_941449034530E4DF0CA45882EDB96CF0" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_2B0D264DEF051577A2525882EDB5A1E9" xlink:to="loc_regn_EndingShareOfProfitsOutsideUnitedStatesBasedOnSalesForCollaboratingParty_941449034530E4DF0CA45882EDB96CF0" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_EndingShareOfProfitsOutsideUnitedStatesBasedOnSalesForCompany" xlink:label="loc_regn_EndingShareOfProfitsOutsideUnitedStatesBasedOnSalesForCompany_CE6E625EC974B2EAC6F05882EDBA3915" xlink:type="locator" />
    <link:presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_2B0D264DEF051577A2525882EDB5A1E9" xlink:to="loc_regn_EndingShareOfProfitsOutsideUnitedStatesBasedOnSalesForCompany_CE6E625EC974B2EAC6F05882EDBA3915" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ShareOfLossesOutsideUnitedStatesForCollaboratingParty" xlink:label="loc_regn_ShareOfLossesOutsideUnitedStatesForCollaboratingParty_40E3A0565D0582CABE5E5882EDBABE33" xlink:type="locator" />
    <link:presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_2B0D264DEF051577A2525882EDB5A1E9" xlink:to="loc_regn_ShareOfLossesOutsideUnitedStatesForCollaboratingParty_40E3A0565D0582CABE5E5882EDBABE33" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ShareOfLossesOutsideUnitedStatesForCompany" xlink:label="loc_regn_ShareOfLossesOutsideUnitedStatesForCompany_FA1679F57ACC8275EF415882EDBA7A99" xlink:type="locator" />
    <link:presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_2B0D264DEF051577A2525882EDB5A1E9" xlink:to="loc_regn_ShareOfLossesOutsideUnitedStatesForCompany_FA1679F57ACC8275EF415882EDBA7A99" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_MaximumAmountOfSalesMilestonePaymentsIfTotalSalesAchieveSpecificLevels" xlink:label="loc_regn_MaximumAmountOfSalesMilestonePaymentsIfTotalSalesAchieveSpecificLevels_C9D8FC9D7E160247B9ED5882EDBBEDD1" xlink:type="locator" />
    <link:presentationArc order="19" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_2B0D264DEF051577A2525882EDB5A1E9" xlink:to="loc_regn_MaximumAmountOfSalesMilestonePaymentsIfTotalSalesAchieveSpecificLevels_C9D8FC9D7E160247B9ED5882EDBBEDD1" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Levelsoftwelvemonthsalesatwhichsalesmilestonepaymentswouldbereceived" xlink:label="loc_regn_Levelsoftwelvemonthsalesatwhichsalesmilestonepaymentswouldbereceived_F3BE061B7EBF00C666DF5882EDBB3C8F" xlink:type="locator" />
    <link:presentationArc order="20" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_2B0D264DEF051577A2525882EDB5A1E9" xlink:to="loc_regn_Levelsoftwelvemonthsalesatwhichsalesmilestonepaymentswouldbereceived_F3BE061B7EBF00C666DF5882EDBB3C8F" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_PeriodForAchievingSalesTargetForMilestonePaymentRollingBasis" xlink:label="loc_regn_PeriodForAchievingSalesTargetForMilestonePaymentRollingBasis_6EC8BE445002EF58E19E5882EDBB3103" xlink:type="locator" />
    <link:presentationArc order="21" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_2B0D264DEF051577A2525882EDB5A1E9" xlink:to="loc_regn_PeriodForAchievingSalesTargetForMilestonePaymentRollingBasis_6EC8BE445002EF58E19E5882EDBB3103" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_PeriodOfNoticeToOptOutOfFurtherDevelopmentAndOrCommercialization" xlink:label="loc_regn_PeriodOfNoticeToOptOutOfFurtherDevelopmentAndOrCommercialization_ECA7DF42F72EEEE013AD5882EDBBBD7A" xlink:type="locator" />
    <link:presentationArc order="22" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_2B0D264DEF051577A2525882EDB5A1E9" xlink:to="loc_regn_PeriodOfNoticeToOptOutOfFurtherDevelopmentAndOrCommercialization_ECA7DF42F72EEEE013AD5882EDBBBD7A" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsSanofiImmunoOncologyNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_22F8D01A64F67CB96DC1C3CD9A978714" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTable" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_90416B4E3DF59F41E9B1C3CD9A975907" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_22F8D01A64F67CB96DC1C3CD9A978714" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_90416B4E3DF59F41E9B1C3CD9A975907" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerDurationAxis" xlink:label="loc_us-gaap_ContractWithCustomerDurationAxis_53B16B0D852E6A339FD8C3CD9A98D37F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_90416B4E3DF59F41E9B1C3CD9A975907" xlink:to="loc_us-gaap_ContractWithCustomerDurationAxis_53B16B0D852E6A339FD8C3CD9A98D37F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerDurationDomain" xlink:label="loc_us-gaap_ContractWithCustomerDurationDomain_17DB87C206F34363121DC3CD9A987207" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerDurationAxis_53B16B0D852E6A339FD8C3CD9A98D37F" xlink:to="loc_us-gaap_ContractWithCustomerDurationDomain_17DB87C206F34363121DC3CD9A987207" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ThroughDecember312023Member" xlink:label="loc_regn_ThroughDecember312023Member_6C2DF03D739EFD13BBBDC3CD9A981D0E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerDurationDomain_17DB87C206F34363121DC3CD9A987207" xlink:to="loc_regn_ThroughDecember312023Member_6C2DF03D739EFD13BBBDC3CD9A981D0E" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_January12024ThroughDecember312026Member" xlink:label="loc_regn_January12024ThroughDecember312026Member_5B41C5F61DD9EB353F04C3CD9A99E46F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContractWithCustomerDurationDomain_17DB87C206F34363121DC3CD9A987207" xlink:to="loc_regn_January12024ThroughDecember312026Member_5B41C5F61DD9EB353F04C3CD9A99E46F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis" xlink:label="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_62E242A456DB9CBA8D7FC3CD9A995715" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_90416B4E3DF59F41E9B1C3CD9A975907" xlink:to="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_62E242A456DB9CBA8D7FC3CD9A995715" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProjectMember" xlink:label="loc_us-gaap_ProjectMember_6ACAC617C8FBCE925CC7C3CD9A9916CA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_62E242A456DB9CBA8D7FC3CD9A995715" xlink:to="loc_us-gaap_ProjectMember_6ACAC617C8FBCE925CC7C3CD9A9916CA" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_SanofiCollaborationAgreementImmunooncologyMember" xlink:label="loc_regn_SanofiCollaborationAgreementImmunooncologyMember_38EF94A17C0872F5EA3DC3CD9A9A1269" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_6ACAC617C8FBCE925CC7C3CD9A9916CA" xlink:to="loc_regn_SanofiCollaborationAgreementImmunooncologyMember_38EF94A17C0872F5EA3DC3CD9A9A1269" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductAxis" xlink:label="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductAxis_B5D2884EF38361016B8BC3CD9A9A8492" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_90416B4E3DF59F41E9B1C3CD9A975907" xlink:to="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductAxis_B5D2884EF38361016B8BC3CD9A9A8492" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain" xlink:label="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_4C3CDDCD9D37F4CBE4BCC3CD9A9ACE4D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductAxis_B5D2884EF38361016B8BC3CD9A9A8492" xlink:to="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_4C3CDDCD9D37F4CBE4BCC3CD9A9ACE4D" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_IODiscoveryAgreementMember" xlink:label="loc_regn_IODiscoveryAgreementMember_9DABABA8125A6D61863EC3CD9A9B607D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_4C3CDDCD9D37F4CBE4BCC3CD9A9ACE4D" xlink:to="loc_regn_IODiscoveryAgreementMember_9DABABA8125A6D61863EC3CD9A9B607D" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_AmendedIODiscoveryAgreementMember" xlink:label="loc_regn_AmendedIODiscoveryAgreementMember_01EA4ADB68D912B20A37C3CD9A9BB889" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_4C3CDDCD9D37F4CBE4BCC3CD9A9ACE4D" xlink:to="loc_regn_AmendedIODiscoveryAgreementMember_01EA4ADB68D912B20A37C3CD9A9BB889" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_AmendedIODiscoveryAgreementBCMAxCD3ProgramMember" xlink:label="loc_regn_AmendedIODiscoveryAgreementBCMAxCD3ProgramMember_7B4840F4ED15EA55491BC3CD9A9B72E9" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_4C3CDDCD9D37F4CBE4BCC3CD9A9ACE4D" xlink:to="loc_regn_AmendedIODiscoveryAgreementBCMAxCD3ProgramMember_7B4840F4ED15EA55491BC3CD9A9B72E9" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_AmendedIODiscoveryAgreementMUC16xCD3ProgramMember" xlink:label="loc_regn_AmendedIODiscoveryAgreementMUC16xCD3ProgramMember_25048ABCFF53B9A50654C3CD9A9B167F" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_4C3CDDCD9D37F4CBE4BCC3CD9A9ACE4D" xlink:to="loc_regn_AmendedIODiscoveryAgreementMUC16xCD3ProgramMember_25048ABCFF53B9A50654C3CD9A9B167F" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_IOAgreementMember" xlink:label="loc_regn_IOAgreementMember_E631107F8548B70F849EC3CD9A9B7B28" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_4C3CDDCD9D37F4CBE4BCC3CD9A9ACE4D" xlink:to="loc_regn_IOAgreementMember_E631107F8548B70F849EC3CD9A9B7B28" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_IOLicenseandCollaborationAgreementMember" xlink:label="loc_regn_IOLicenseandCollaborationAgreementMember_C94E2981A3F591F85A56C3CD9A9C385F" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchAndDevelopmentArrangementContractToPerformForOthersByProductDomain_4C3CDDCD9D37F4CBE4BCC3CD9A9ACE4D" xlink:to="loc_regn_IOLicenseandCollaborationAgreementMember_C94E2981A3F591F85A56C3CD9A9C385F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductOrServiceAxis" xlink:label="loc_srt_ProductOrServiceAxis_09088F28CDA57BC0AE7DC3CD9A9C5C22" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_90416B4E3DF59F41E9B1C3CD9A975907" xlink:to="loc_srt_ProductOrServiceAxis_09088F28CDA57BC0AE7DC3CD9A9C5C22" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_BE4B3D80D784D7749072C3CD9A9CF092" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_09088F28CDA57BC0AE7DC3CD9A9C5C22" xlink:to="loc_srt_ProductsAndServicesDomain_BE4B3D80D784D7749072C3CD9A9CF092" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_PD1Member" xlink:label="loc_regn_PD1Member_FA4FF474EB897C5B133AC3CD9A9C5BFD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_BE4B3D80D784D7749072C3CD9A9CF092" xlink:to="loc_regn_PD1Member_FA4FF474EB897C5B133AC3CD9A9C5BFD" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_LIBTAYONetProductSalesMember" xlink:label="loc_regn_LIBTAYONetProductSalesMember_70FC6F9358C507ECF465C3CD9A9D2E51" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_BE4B3D80D784D7749072C3CD9A9CF092" xlink:to="loc_regn_LIBTAYONetProductSalesMember_70FC6F9358C507ECF465C3CD9A9D2E51" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_E7AFAA15A3A9C3F08D60C3CD9A9DBC59" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_90416B4E3DF59F41E9B1C3CD9A975907" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_E7AFAA15A3A9C3F08D60C3CD9A9DBC59" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Upfrontpaymentreceived" xlink:label="loc_regn_Upfrontpaymentreceived_1C2B6046420675DB32CCC3CD9A9D2945" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_E7AFAA15A3A9C3F08D60C3CD9A9DBC59" xlink:to="loc_regn_Upfrontpaymentreceived_1C2B6046420675DB32CCC3CD9A9D2945" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_PotentialfutureRDexpenses" xlink:label="loc_regn_PotentialfutureRDexpenses_B321FA2CE1D3B7837508C3CD9A9DF7D7" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_E7AFAA15A3A9C3F08D60C3CD9A9DBC59" xlink:to="loc_regn_PotentialfutureRDexpenses_B321FA2CE1D3B7837508C3CD9A9DF7D7" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_FundingMaximumofResearchActivitiesPerAgreement" xlink:label="loc_regn_FundingMaximumofResearchActivitiesPerAgreement_0381EF69E1FD073F29A4C3CD9A9D8D04" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_E7AFAA15A3A9C3F08D60C3CD9A9DBC59" xlink:to="loc_regn_FundingMaximumofResearchActivitiesPerAgreement_0381EF69E1FD073F29A4C3CD9A9D8D04" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Licenseagreementterm" xlink:label="loc_regn_Licenseagreementterm_A929DA271C7B42A9448CC3CD9A9EE083" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_E7AFAA15A3A9C3F08D60C3CD9A9DBC59" xlink:to="loc_regn_Licenseagreementterm_A929DA271C7B42A9448CC3CD9A9EE083" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Additionalyearstoextendtheagreement" xlink:label="loc_regn_Additionalyearstoextendtheagreement_D447DB107ECF3253E585C3CD9A9E16F5" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_E7AFAA15A3A9C3F08D60C3CD9A9DBC59" xlink:to="loc_regn_Additionalyearstoextendtheagreement_D447DB107ECF3253E585C3CD9A9E16F5" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_AggregatePaymentReceivedWithRegardsToAmendment" xlink:label="loc_regn_AggregatePaymentReceivedWithRegardsToAmendment_FBB82AFE62F05A9847F6C3D1C55B943C" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_E7AFAA15A3A9C3F08D60C3CD9A9DBC59" xlink:to="loc_regn_AggregatePaymentReceivedWithRegardsToAmendment_FBB82AFE62F05A9847F6C3D1C55B943C" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ExpenditureCostsCap" xlink:label="loc_regn_ExpenditureCostsCap_A0B49A00A139213823B2C3D33A114534" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_E7AFAA15A3A9C3F08D60C3CD9A9DBC59" xlink:to="loc_regn_ExpenditureCostsCap_A0B49A00A139213823B2C3D33A114534" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_PotentialMaximumExpenditure" xlink:label="loc_regn_PotentialMaximumExpenditure_2069D45EC40043190E08C3D46BCD86D2" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_E7AFAA15A3A9C3F08D60C3CD9A9DBC59" xlink:to="loc_regn_PotentialMaximumExpenditure_2069D45EC40043190E08C3D46BCD86D2" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_OptionalPaymentToIncreaseDevelopmentCostFunding" xlink:label="loc_regn_OptionalPaymentToIncreaseDevelopmentCostFunding_0830482A2E7665974B4AC3D52B4F3985" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_E7AFAA15A3A9C3F08D60C3CD9A9DBC59" xlink:to="loc_regn_OptionalPaymentToIncreaseDevelopmentCostFunding_0830482A2E7665974B4AC3D52B4F3985" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ExcessShareOfProfitNotRequiredToToBeAppliedToReimburseDevelopmentCost" xlink:label="loc_regn_ExcessShareOfProfitNotRequiredToToBeAppliedToReimburseDevelopmentCost_196C6AC74C4E08F80E61C3CD9A9E3D14" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_E7AFAA15A3A9C3F08D60C3CD9A9DBC59" xlink:to="loc_regn_ExcessShareOfProfitNotRequiredToToBeAppliedToReimburseDevelopmentCost_196C6AC74C4E08F80E61C3CD9A9E3D14" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Contingentreimbursementobligation" xlink:label="loc_regn_Contingentreimbursementobligation_2B13CEEDF94A006F2A7CC3CD9A9E187A" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_E7AFAA15A3A9C3F08D60C3CD9A9DBC59" xlink:to="loc_regn_Contingentreimbursementobligation_2B13CEEDF94A006F2A7CC3CD9A9E187A" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Maximumsharesthecollaboratorcouldsell" xlink:label="loc_regn_Maximumsharesthecollaboratorcouldsell_798C36FC814D4C39B2F0C3CD9A9E0819" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_E7AFAA15A3A9C3F08D60C3CD9A9DBC59" xlink:to="loc_regn_Maximumsharesthecollaboratorcouldsell_798C36FC814D4C39B2F0C3CD9A9E0819" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TreasuryStockSharesAcquired" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_E7BF923C266A49BF075FC3CD9A9EFAFA" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_E7AFAA15A3A9C3F08D60C3CD9A9DBC59" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_E7BF923C266A49BF075FC3CD9A9EFAFA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_E08B2F242C927B2BF6DCC3CD9A9F5585" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_E7AFAA15A3A9C3F08D60C3CD9A9DBC59" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_E08B2F242C927B2BF6DCC3CD9A9F5585" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_MaximumAmountOfSalesMilestonePaymentsIfTotalSalesAchieveSpecificLevels" xlink:label="loc_regn_MaximumAmountOfSalesMilestonePaymentsIfTotalSalesAchieveSpecificLevels_311C4E6926B3EA8EF597C3CD9A9F86D9" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_E7AFAA15A3A9C3F08D60C3CD9A9DBC59" xlink:to="loc_regn_MaximumAmountOfSalesMilestonePaymentsIfTotalSalesAchieveSpecificLevels_311C4E6926B3EA8EF597C3CD9A9F86D9" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Levelsoftwelvemonthsalesatwhichsalesmilestonepaymentswouldbereceived" xlink:label="loc_regn_Levelsoftwelvemonthsalesatwhichsalesmilestonepaymentswouldbereceived_9757300D908F2F32D949C3CD9A9FC870" xlink:type="locator" />
    <link:presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_E7AFAA15A3A9C3F08D60C3CD9A9DBC59" xlink:to="loc_regn_Levelsoftwelvemonthsalesatwhichsalesmilestonepaymentswouldbereceived_9757300D908F2F32D949C3CD9A9FC870" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_PeriodForAchievingSalesTargetForMilestonePaymentRollingBasis" xlink:label="loc_regn_PeriodForAchievingSalesTargetForMilestonePaymentRollingBasis_5A8C7B6DA4446A9B7CB0C3CD9A9FDEC9" xlink:type="locator" />
    <link:presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_E7AFAA15A3A9C3F08D60C3CD9A9DBC59" xlink:to="loc_regn_PeriodForAchievingSalesTargetForMilestonePaymentRollingBasis_5A8C7B6DA4446A9B7CB0C3CD9A9FDEC9" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_PeriodOfNoticeToOptOutOfFurtherDevelopmentAndOrCommercialization" xlink:label="loc_regn_PeriodOfNoticeToOptOutOfFurtherDevelopmentAndOrCommercialization_7AACA4D8ADAE14722AE5C3CD9A9F1301" xlink:type="locator" />
    <link:presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_E7AFAA15A3A9C3F08D60C3CD9A9DBC59" xlink:to="loc_regn_PeriodOfNoticeToOptOutOfFurtherDevelopmentAndOrCommercialization_7AACA4D8ADAE14722AE5C3CD9A9F1301" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_UpfrontPaymentMade" xlink:label="loc_regn_UpfrontPaymentMade_021B448FB6E220C607E7C3CD9AA06797" xlink:type="locator" />
    <link:presentationArc order="19" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_E7AFAA15A3A9C3F08D60C3CD9A9DBC59" xlink:to="loc_regn_UpfrontPaymentMade_021B448FB6E220C607E7C3CD9AA06797" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_PaymentsForRoyaltiesPercentage" xlink:label="loc_regn_PaymentsForRoyaltiesPercentage_1465A3E2D348A0FF973FC3CD9AA010A4" xlink:type="locator" />
    <link:presentationArc order="20" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_E7AFAA15A3A9C3F08D60C3CD9A9DBC59" xlink:to="loc_regn_PaymentsForRoyaltiesPercentage_1465A3E2D348A0FF973FC3CD9AA010A4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerAssetCumulativeCatchUpAdjustmentToRevenueModificationOfContract" xlink:label="loc_us-gaap_ContractWithCustomerAssetCumulativeCatchUpAdjustmentToRevenueModificationOfContract_1A56E4E1B8A21A1EBCAAC3CD9AA04B81" xlink:type="locator" />
    <link:presentationArc order="21" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_E7AFAA15A3A9C3F08D60C3CD9A9DBC59" xlink:to="loc_us-gaap_ContractWithCustomerAssetCumulativeCatchUpAdjustmentToRevenueModificationOfContract_1A56E4E1B8A21A1EBCAAC3CD9AA04B81" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueRemainingPerformanceObligation" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligation_B9195A9F2B6AE8FC0370C3CD9AA09C3A" xlink:type="locator" />
    <link:presentationArc order="22" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_E7AFAA15A3A9C3F08D60C3CD9A9DBC59" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligation_B9195A9F2B6AE8FC0370C3CD9AA09C3A" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsScheduleOfAccountsReceivableAndDeferredRevenueInformationAntibodyCollaborationDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_AE573297E3AA689A7F514EEDA9B4DAE6" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTable" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_3912BF2F177C57C312C24EEDA9B4558F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_AE573297E3AA689A7F514EEDA9B4DAE6" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_3912BF2F177C57C312C24EEDA9B4558F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis" xlink:label="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_20F0576E9B8234F95F1B4EEDA9B48AF6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_3912BF2F177C57C312C24EEDA9B4558F" xlink:to="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_20F0576E9B8234F95F1B4EEDA9B48AF6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProjectMember" xlink:label="loc_us-gaap_ProjectMember_0F137AFC5AF7F3C9C0764EEDA9B4D824" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_20F0576E9B8234F95F1B4EEDA9B48AF6" xlink:to="loc_us-gaap_ProjectMember_0F137AFC5AF7F3C9C0764EEDA9B4D824" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_SanofiCollaborationAgreementAntibodyMember" xlink:label="loc_regn_SanofiCollaborationAgreementAntibodyMember_2F5CBD988E73BE6B4A7F4EEDA9B4F319" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_0F137AFC5AF7F3C9C0764EEDA9B4D824" xlink:to="loc_regn_SanofiCollaborationAgreementAntibodyMember_2F5CBD988E73BE6B4A7F4EEDA9B4F319" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_C0204CD1734C4C320FA94EEDA9B4AA73" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_3912BF2F177C57C312C24EEDA9B4558F" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_C0204CD1734C4C320FA94EEDA9B4AA73" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsReceivableRelatedPartiesCurrent" xlink:label="loc_us-gaap_AccountsReceivableRelatedPartiesCurrent_C14BF32C28EAF2885BD24EEDA9B483D2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_C0204CD1734C4C320FA94EEDA9B4AA73" xlink:to="loc_us-gaap_AccountsReceivableRelatedPartiesCurrent_C14BF32C28EAF2885BD24EEDA9B483D2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerLiability" xlink:label="loc_us-gaap_ContractWithCustomerLiability_07B89A9EEFD2971F42484EEDA9B4A256" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_C0204CD1734C4C320FA94EEDA9B4AA73" xlink:to="loc_us-gaap_ContractWithCustomerLiability_07B89A9EEFD2971F42484EEDA9B4A256" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsScheduleOfAccountsReceivableAndDeferredRevenueInformationIoCollaborationDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_62480298C3E0E793F2C64EEDAE156198" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTable" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_4D9F06E9797F0FFBA8224EEDAE164867" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_62480298C3E0E793F2C64EEDAE156198" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_4D9F06E9797F0FFBA8224EEDAE164867" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis" xlink:label="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_57C88C6AEA1D323083514EEDAE161B4A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_4D9F06E9797F0FFBA8224EEDAE164867" xlink:to="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_57C88C6AEA1D323083514EEDAE161B4A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProjectMember" xlink:label="loc_us-gaap_ProjectMember_FD0FBED4B859D32D5E1D4EEDAE174046" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_57C88C6AEA1D323083514EEDAE161B4A" xlink:to="loc_us-gaap_ProjectMember_FD0FBED4B859D32D5E1D4EEDAE174046" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_SanofiCollaborationAgreementImmunooncologyMember" xlink:label="loc_regn_SanofiCollaborationAgreementImmunooncologyMember_31A345BE9FC757D02B5F4EEDAE1C7BA3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_FD0FBED4B859D32D5E1D4EEDAE174046" xlink:to="loc_regn_SanofiCollaborationAgreementImmunooncologyMember_31A345BE9FC757D02B5F4EEDAE1C7BA3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_1157FB0B16E76F433D884EEDAE1DC509" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_4D9F06E9797F0FFBA8224EEDAE164867" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_1157FB0B16E76F433D884EEDAE1DC509" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsReceivableRelatedPartiesCurrent" xlink:label="loc_us-gaap_AccountsReceivableRelatedPartiesCurrent_5EE53A787B9A6A88A9AC4EEDAE1E06A1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_1157FB0B16E76F433D884EEDAE1DC509" xlink:to="loc_us-gaap_AccountsReceivableRelatedPartiesCurrent_5EE53A787B9A6A88A9AC4EEDAE1E06A1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerLiability" xlink:label="loc_us-gaap_ContractWithCustomerLiability_DC6F388EFA43700903114EEDAE1E0F0C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_1157FB0B16E76F433D884EEDAE1DC509" xlink:to="loc_us-gaap_ContractWithCustomerLiability_DC6F388EFA43700903114EEDAE1E0F0C" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsScheduleOfAccountsReceivableAndDeferredRevenueInformationTevaCollaborationDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_6922060F8B7A30566DC84EEDB8B5D5C2" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTable" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_66526D7CB2D5885D135F4EEDB8C5445A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_6922060F8B7A30566DC84EEDB8B5D5C2" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_66526D7CB2D5885D135F4EEDB8C5445A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis" xlink:label="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_5043E938D398155102324EEDB8C5FF0B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_66526D7CB2D5885D135F4EEDB8C5445A" xlink:to="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_5043E938D398155102324EEDB8C5FF0B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProjectMember" xlink:label="loc_us-gaap_ProjectMember_B43E5E5922B5EE8A50344EEDB8C522C1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_5043E938D398155102324EEDB8C5FF0B" xlink:to="loc_us-gaap_ProjectMember_B43E5E5922B5EE8A50344EEDB8C522C1" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_TevaPharmaceuticalsCollaborationAgreementMember" xlink:label="loc_regn_TevaPharmaceuticalsCollaborationAgreementMember_7424BD1B0ED7406EFD8C4EEDB8C54656" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_B43E5E5922B5EE8A50344EEDB8C522C1" xlink:to="loc_regn_TevaPharmaceuticalsCollaborationAgreementMember_7424BD1B0ED7406EFD8C4EEDB8C54656" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_F72516C4EA25B90085CC4EEDB8C50CF3" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_66526D7CB2D5885D135F4EEDB8C5445A" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_F72516C4EA25B90085CC4EEDB8C50CF3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_471F8C2E8713018A3AD94EEDB8C5C0D4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_F72516C4EA25B90085CC4EEDB8C50CF3" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_471F8C2E8713018A3AD94EEDB8C5C0D4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerLiability" xlink:label="loc_us-gaap_ContractWithCustomerLiability_D528DBD89AA8C953938A4EEDB8C52B74" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_F72516C4EA25B90085CC4EEDB8C50CF3" xlink:to="loc_us-gaap_ContractWithCustomerLiability_D528DBD89AA8C953938A4EEDB8C52B74" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsScheduleOfCollaborationRevenueEarnedFromBayerDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_8A82628BDF33171BC012C3CD9A7A9BFE" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTable" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_9D2F7E0EBA2C2027A3F8C3CD9A7A2141" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_8A82628BDF33171BC012C3CD9A7A9BFE" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_9D2F7E0EBA2C2027A3F8C3CD9A7A2141" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_StatementGeographicalAxis" xlink:label="loc_srt_StatementGeographicalAxis_F78E1C52CBB1CA9B6BAAC3CD9A7A359E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_9D2F7E0EBA2C2027A3F8C3CD9A7A2141" xlink:to="loc_srt_StatementGeographicalAxis_F78E1C52CBB1CA9B6BAAC3CD9A7A359E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_SegmentGeographicalDomain" xlink:label="loc_srt_SegmentGeographicalDomain_D76378F5B6B285E07015C3CD9A7BA572" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_StatementGeographicalAxis_F78E1C52CBB1CA9B6BAAC3CD9A7A359E" xlink:to="loc_srt_SegmentGeographicalDomain_D76378F5B6B285E07015C3CD9A7BA572" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NonUsMember" xlink:label="loc_us-gaap_NonUsMember_232F2383A8332455C6A0C3CD9A7B3FD5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_SegmentGeographicalDomain_D76378F5B6B285E07015C3CD9A7BA572" xlink:to="loc_us-gaap_NonUsMember_232F2383A8332455C6A0C3CD9A7B3FD5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis" xlink:label="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_68FD88F059436576852AC3CD9A7BB05E" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_9D2F7E0EBA2C2027A3F8C3CD9A7A2141" xlink:to="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_68FD88F059436576852AC3CD9A7BB05E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProjectMember" xlink:label="loc_us-gaap_ProjectMember_40665D77B007FEC27035C3CD9A7B1A85" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_68FD88F059436576852AC3CD9A7BB05E" xlink:to="loc_us-gaap_ProjectMember_40665D77B007FEC27035C3CD9A7B1A85" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_BayerCollaborationAgreementMember" xlink:label="loc_regn_BayerCollaborationAgreementMember_04EE8957F36162FC1DE2C3CD9A7C2FBE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_40665D77B007FEC27035C3CD9A7B1A85" xlink:to="loc_regn_BayerCollaborationAgreementMember_04EE8957F36162FC1DE2C3CD9A7C2FBE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductOrServiceAxis" xlink:label="loc_srt_ProductOrServiceAxis_39358B8FA31DDD1FE79FC3CD9A7C57E4" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_9D2F7E0EBA2C2027A3F8C3CD9A7A2141" xlink:to="loc_srt_ProductOrServiceAxis_39358B8FA31DDD1FE79FC3CD9A7C57E4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_9A6231CE25BC982A1E01C3CD9A7DB5AB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_39358B8FA31DDD1FE79FC3CD9A7C57E4" xlink:to="loc_srt_ProductsAndServicesDomain_9A6231CE25BC982A1E01C3CD9A7DB5AB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProductAndServiceOtherMember" xlink:label="loc_us-gaap_ProductAndServiceOtherMember_B123968B554E52B7F02CC3CD9A7D6202" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_9A6231CE25BC982A1E01C3CD9A7DB5AB" xlink:to="loc_us-gaap_ProductAndServiceOtherMember_B123968B554E52B7F02CC3CD9A7D6202" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_NetProfitInConnectionWithCommercializationMember" xlink:label="loc_regn_NetProfitInConnectionWithCommercializationMember_C0677877C0AF0BD213C6C3CD9A7D87DD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductAndServiceOtherMember_B123968B554E52B7F02CC3CD9A7D6202" xlink:to="loc_regn_NetProfitInConnectionWithCommercializationMember_C0677877C0AF0BD213C6C3CD9A7D87DD" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ReimbursementOfResearchAndDevelopmentExpensesMember" xlink:label="loc_regn_ReimbursementOfResearchAndDevelopmentExpensesMember_D4356C214915C3775557C3CD9A7D9F2F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductAndServiceOtherMember_B123968B554E52B7F02CC3CD9A7D6202" xlink:to="loc_regn_ReimbursementOfResearchAndDevelopmentExpensesMember_D4356C214915C3775557C3CD9A7D9F2F" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_OtherMember" xlink:label="loc_regn_OtherMember_20D54E41C1DC8E0E6A36C3CD9A7E2FAD" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductAndServiceOtherMember_B123968B554E52B7F02CC3CD9A7D6202" xlink:to="loc_regn_OtherMember_20D54E41C1DC8E0E6A36C3CD9A7E2FAD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_5D4D81039666B4356039C3CD9A7E0ECC" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_9D2F7E0EBA2C2027A3F8C3CD9A7A2141" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_5D4D81039666B4356039C3CD9A7E0ECC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_6403452C12A2D0FF8BE2C3CD9A7ED264" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_5D4D81039666B4356039C3CD9A7E0ECC" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_6403452C12A2D0FF8BE2C3CD9A7ED264" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsScheduleOfCollaborationRevenueEarnedFromSanofiDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_3A02B12E1FACFA53AD874EEDA5A09933" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTable" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_0EE483B338C8472F88F24EEDA5A1022A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_3A02B12E1FACFA53AD874EEDA5A09933" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_0EE483B338C8472F88F24EEDA5A1022A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductOrServiceAxis" xlink:label="loc_srt_ProductOrServiceAxis_A09B77EAE7C93C6C129A4EEDA5A1AC17" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_0EE483B338C8472F88F24EEDA5A1022A" xlink:to="loc_srt_ProductOrServiceAxis_A09B77EAE7C93C6C129A4EEDA5A1AC17" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_B0F9101D92780A68A9134EEDA5A37752" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_A09B77EAE7C93C6C129A4EEDA5A1AC17" xlink:to="loc_srt_ProductsAndServicesDomain_B0F9101D92780A68A9134EEDA5A37752" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProductAndServiceOtherMember" xlink:label="loc_us-gaap_ProductAndServiceOtherMember_F74C05DFCBC0E5D59B994EEDA5A4C2DB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_B0F9101D92780A68A9134EEDA5A37752" xlink:to="loc_us-gaap_ProductAndServiceOtherMember_F74C05DFCBC0E5D59B994EEDA5A4C2DB" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ReimbursementOfResearchAndDevelopmentExpensesMember" xlink:label="loc_regn_ReimbursementOfResearchAndDevelopmentExpensesMember_F5A35AD1787E447EA73D4EEDA5AA4F64" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductAndServiceOtherMember_F74C05DFCBC0E5D59B994EEDA5A4C2DB" xlink:to="loc_regn_ReimbursementOfResearchAndDevelopmentExpensesMember_F5A35AD1787E447EA73D4EEDA5AA4F64" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ReimbursementOfCommercializationRelatedExpensesMember" xlink:label="loc_regn_ReimbursementOfCommercializationRelatedExpensesMember_658EF36D209944EACFFA4EEDA5AA4DEB" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductAndServiceOtherMember_F74C05DFCBC0E5D59B994EEDA5A4C2DB" xlink:to="loc_regn_ReimbursementOfCommercializationRelatedExpensesMember_658EF36D209944EACFFA4EEDA5AA4DEB" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ShareOfLossesInConnectionWithCommercializationMember" xlink:label="loc_regn_ShareOfLossesInConnectionWithCommercializationMember_23E6CE3C83ADF46248484EEDA5AB710D" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductAndServiceOtherMember_F74C05DFCBC0E5D59B994EEDA5A4C2DB" xlink:to="loc_regn_ShareOfLossesInConnectionWithCommercializationMember_23E6CE3C83ADF46248484EEDA5AB710D" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_OtherMember" xlink:label="loc_regn_OtherMember_66DECE89928A37A825FE4EEDA5AB9012" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProductAndServiceOtherMember_F74C05DFCBC0E5D59B994EEDA5A4C2DB" xlink:to="loc_regn_OtherMember_66DECE89928A37A825FE4EEDA5AB9012" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis" xlink:label="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_0C27C2C6C08F138177CD4EEDA5AC012D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_0EE483B338C8472F88F24EEDA5A1022A" xlink:to="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_0C27C2C6C08F138177CD4EEDA5AC012D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProjectMember" xlink:label="loc_us-gaap_ProjectMember_B9C1AAE53F5B48484F144EEDA5ADB5BD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_0C27C2C6C08F138177CD4EEDA5AC012D" xlink:to="loc_us-gaap_ProjectMember_B9C1AAE53F5B48484F144EEDA5ADB5BD" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_SanofiCollaborationAgreementAntibodyMember" xlink:label="loc_regn_SanofiCollaborationAgreementAntibodyMember_857E9C077B8AFE0F171A4EEDA5AD367F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_B9C1AAE53F5B48484F144EEDA5ADB5BD" xlink:to="loc_regn_SanofiCollaborationAgreementAntibodyMember_857E9C077B8AFE0F171A4EEDA5AD367F" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_SanofiCollaborationAgreementImmunooncologyMember" xlink:label="loc_regn_SanofiCollaborationAgreementImmunooncologyMember_B62C5E9AB9B0F11364C04EEDA5AE04F6" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_B9C1AAE53F5B48484F144EEDA5ADB5BD" xlink:to="loc_regn_SanofiCollaborationAgreementImmunooncologyMember_B62C5E9AB9B0F11364C04EEDA5AE04F6" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_SanofiCollaborationAgreementMember" xlink:label="loc_regn_SanofiCollaborationAgreementMember_2A18927BEB6BBF2C7AFB4EEDA5AED1F1" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_B9C1AAE53F5B48484F144EEDA5ADB5BD" xlink:to="loc_regn_SanofiCollaborationAgreementMember_2A18927BEB6BBF2C7AFB4EEDA5AED1F1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_D09D46A79711CB9947E44EEDA5AED973" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_0EE483B338C8472F88F24EEDA5A1022A" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_D09D46A79711CB9947E44EEDA5AED973" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_535AF26263F388F3A32F4EEDA5B44D8E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_D09D46A79711CB9947E44EEDA5AED973" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_535AF26263F388F3A32F4EEDA5B44D8E" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsScheduleOfSignificantChangesInDeferredRevenueBalancesAntibodyCollaborationDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_DEFC632C883EE34486F95882ED8BC5A0" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTable" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_5E1C82DEA372050AC6C45882ED8B4BB6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_DEFC632C883EE34486F95882ED8BC5A0" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_5E1C82DEA372050AC6C45882ED8B4BB6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis" xlink:label="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_8BF0707C08F829BBC84D5882ED8B5465" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_5E1C82DEA372050AC6C45882ED8B4BB6" xlink:to="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_8BF0707C08F829BBC84D5882ED8B5465" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProjectMember" xlink:label="loc_us-gaap_ProjectMember_35A6D846C6D30521FC315882ED8CB7B6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_8BF0707C08F829BBC84D5882ED8B5465" xlink:to="loc_us-gaap_ProjectMember_35A6D846C6D30521FC315882ED8CB7B6" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_SanofiCollaborationAgreementAntibodyMember" xlink:label="loc_regn_SanofiCollaborationAgreementAntibodyMember_BE111599EEC4FD364C2A5882ED8C6BD7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_35A6D846C6D30521FC315882ED8CB7B6" xlink:to="loc_regn_SanofiCollaborationAgreementAntibodyMember_BE111599EEC4FD364C2A5882ED8C6BD7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_DFB920861D98C0199E8D5882ED8D4A2F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_5E1C82DEA372050AC6C45882ED8B4BB6" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_DFB920861D98C0199E8D5882ED8D4A2F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_4094ECCDE7724E29E4875882ED8D7649" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_DFB920861D98C0199E8D5882ED8D4A2F" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_4094ECCDE7724E29E4875882ED8D7649" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerLiabilityRevenueRecognized" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_FEC739479A1EF9244AB55882ED8E7F70" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_DFB920861D98C0199E8D5882ED8D4A2F" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_FEC739479A1EF9244AB55882ED8E7F70" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsScheduleOfSignificantChangesInDeferredRevenueBalancesIoCollaborationDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_97E2D743544CCD6ED036BEA9C76BB2BA" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTable" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_16FEF0BCB0278745E47FBEA9C76B1EC1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_97E2D743544CCD6ED036BEA9C76BB2BA" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_16FEF0BCB0278745E47FBEA9C76B1EC1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsForNewAccountingPronouncementsAxis" xlink:label="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_A5487C94E9661A2D0D13BEA9C76C268D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_16FEF0BCB0278745E47FBEA9C76B1EC1" xlink:to="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_A5487C94E9661A2D0D13BEA9C76C268D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TypeOfAdoptionMember" xlink:label="loc_us-gaap_TypeOfAdoptionMember_0A0D13EF927748AD656ABEA9C76CD9C4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_A5487C94E9661A2D0D13BEA9C76C268D" xlink:to="loc_us-gaap_TypeOfAdoptionMember_0A0D13EF927748AD656ABEA9C76CD9C4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201409Member" xlink:label="loc_us-gaap_AccountingStandardsUpdate201409Member_75FA1B1D1498225C113CBEA9C76C49AE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfAdoptionMember_0A0D13EF927748AD656ABEA9C76CD9C4" xlink:to="loc_us-gaap_AccountingStandardsUpdate201409Member_75FA1B1D1498225C113CBEA9C76C49AE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis" xlink:label="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_82AB8FCBAEE6A1E99354BEA9C76D062E" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_16FEF0BCB0278745E47FBEA9C76B1EC1" xlink:to="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_82AB8FCBAEE6A1E99354BEA9C76D062E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProjectMember" xlink:label="loc_us-gaap_ProjectMember_26F64B240FC401D0228CBEA9C76DEA94" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_82AB8FCBAEE6A1E99354BEA9C76D062E" xlink:to="loc_us-gaap_ProjectMember_26F64B240FC401D0228CBEA9C76DEA94" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_SanofiCollaborationAgreementImmunooncologyMember" xlink:label="loc_regn_SanofiCollaborationAgreementImmunooncologyMember_EA1733742FA6A8A1C61ABEA9C76D1BBE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_26F64B240FC401D0228CBEA9C76DEA94" xlink:to="loc_regn_SanofiCollaborationAgreementImmunooncologyMember_EA1733742FA6A8A1C61ABEA9C76D1BBE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_DACCFB599F306735C841BEA9C76E7788" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_16FEF0BCB0278745E47FBEA9C76B1EC1" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_DACCFB599F306735C841BEA9C76E7788" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_6DEEFC1B0113988236AEBEA9C76E45D8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_DACCFB599F306735C841BEA9C76E7788" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_6DEEFC1B0113988236AEBEA9C76E45D8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerAssetCumulativeCatchUpAdjustmentToRevenueModificationOfContract" xlink:label="loc_us-gaap_ContractWithCustomerAssetCumulativeCatchUpAdjustmentToRevenueModificationOfContract_77A7043B052EEC7EAC2DBEA9C76EE767" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_DACCFB599F306735C841BEA9C76E7788" xlink:to="loc_us-gaap_ContractWithCustomerAssetCumulativeCatchUpAdjustmentToRevenueModificationOfContract_77A7043B052EEC7EAC2DBEA9C76EE767" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerLiabilityRevenueRecognized" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_BAFB1413AB7A8967CDD9BEA9C76E8F26" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_DACCFB599F306735C841BEA9C76E7788" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_BAFB1413AB7A8967CDD9BEA9C76E8F26" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsScheduleOfSignificantChangesInDeferredRevenueBalancesTevaCollaborationDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_6F7D9EB36CACFE960C195882ECCD22D0" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTable" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_D66D18E35A2605E1E90D5882ECCD8CE6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_6F7D9EB36CACFE960C195882ECCD22D0" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_D66D18E35A2605E1E90D5882ECCD8CE6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis" xlink:label="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_49249D93D5072E7E5F9F5882ECCE0A7F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_D66D18E35A2605E1E90D5882ECCD8CE6" xlink:to="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_49249D93D5072E7E5F9F5882ECCE0A7F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProjectMember" xlink:label="loc_us-gaap_ProjectMember_3066764D2C42EDDCB57F5882ECCF4817" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_49249D93D5072E7E5F9F5882ECCE0A7F" xlink:to="loc_us-gaap_ProjectMember_3066764D2C42EDDCB57F5882ECCF4817" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_TevaPharmaceuticalsCollaborationAgreementMember" xlink:label="loc_regn_TevaPharmaceuticalsCollaborationAgreementMember_FE39EB1A04DC1698BDD15882ECCF72BC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_3066764D2C42EDDCB57F5882ECCF4817" xlink:to="loc_regn_TevaPharmaceuticalsCollaborationAgreementMember_FE39EB1A04DC1698BDD15882ECCF72BC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsForNewAccountingPronouncementsAxis" xlink:label="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_A2B5FDA0C265136FE6425882ECD0B2EB" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_D66D18E35A2605E1E90D5882ECCD8CE6" xlink:to="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_A2B5FDA0C265136FE6425882ECD0B2EB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TypeOfAdoptionMember" xlink:label="loc_us-gaap_TypeOfAdoptionMember_38D7B110189392A43DA55882ECD0558F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_A2B5FDA0C265136FE6425882ECD0B2EB" xlink:to="loc_us-gaap_TypeOfAdoptionMember_38D7B110189392A43DA55882ECD0558F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201409Member" xlink:label="loc_us-gaap_AccountingStandardsUpdate201409Member_7F643795B41A38E2F4C75882ECD1E670" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfAdoptionMember_38D7B110189392A43DA55882ECD0558F" xlink:to="loc_us-gaap_AccountingStandardsUpdate201409Member_7F643795B41A38E2F4C75882ECD1E670" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_428CDAACA4ACE1CAE0D05882ECD15862" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_D66D18E35A2605E1E90D5882ECCD8CE6" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_428CDAACA4ACE1CAE0D05882ECD15862" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_CF96A21EACEBCF9D03AB5882ECD21DA9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_428CDAACA4ACE1CAE0D05882ECD15862" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_CF96A21EACEBCF9D03AB5882ECD21DA9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerAsset" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerAsset_BEF6EFBD884A3B345E4C5882ECD3CE59" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_428CDAACA4ACE1CAE0D05882ECD15862" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerAsset_BEF6EFBD884A3B345E4C5882ECD3CE59" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerLiabilityRevenueRecognized" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_C6E4FDF7444DE56F47A15882ECD3D77F" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_428CDAACA4ACE1CAE0D05882ECD15862" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_C6E4FDF7444DE56F47A15882ECD3D77F" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_19E67478E62A6C5C07634EEDA4A5DEC1" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTableTextBlock" xlink:label="loc_us-gaap_DisaggregationOfRevenueTableTextBlock_35E045A2397ABFB695244EEDA4A6C85F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_19E67478E62A6C5C07634EEDA4A5DEC1" xlink:to="loc_us-gaap_DisaggregationOfRevenueTableTextBlock_35E045A2397ABFB695244EEDA4A6C85F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerAssetAndLiabilityTableTextBlock" xlink:label="loc_us-gaap_ContractWithCustomerAssetAndLiabilityTableTextBlock_49201EC658E824B4EC114EEDA4A61788" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_19E67478E62A6C5C07634EEDA4A5DEC1" xlink:to="loc_us-gaap_ContractWithCustomerAssetAndLiabilityTableTextBlock_49201EC658E824B4EC114EEDA4A61788" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/CollaborationAndLicenseAgreementsTevaNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_F2D3C90FD34DEC7FE5414EEDB7D5E433" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTable" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_D58A89DCA33C909E1F814EEDB7D574E0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_F2D3C90FD34DEC7FE5414EEDB7D5E433" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_D58A89DCA33C909E1F814EEDB7D574E0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis" xlink:label="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_5E506EB0778AD16484474EEDB7D5BBF8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_D58A89DCA33C909E1F814EEDB7D574E0" xlink:to="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_5E506EB0778AD16484474EEDB7D5BBF8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProjectMember" xlink:label="loc_us-gaap_ProjectMember_EEC49B63238B2FE144E34EEDB7D54769" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_5E506EB0778AD16484474EEDB7D5BBF8" xlink:to="loc_us-gaap_ProjectMember_EEC49B63238B2FE144E34EEDB7D54769" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_TevaPharmaceuticalsCollaborationAgreementMember" xlink:label="loc_regn_TevaPharmaceuticalsCollaborationAgreementMember_29C31A1CFDB1CADC2FD54EEDB7D5CF21" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_EEC49B63238B2FE144E34EEDB7D54769" xlink:to="loc_regn_TevaPharmaceuticalsCollaborationAgreementMember_29C31A1CFDB1CADC2FD54EEDB7D5CF21" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_69CE82F40ECEDAD265DE4EEDB7D551E2" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_D58A89DCA33C909E1F814EEDB7D574E0" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_69CE82F40ECEDAD265DE4EEDB7D551E2" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Upfrontpaymentreceived" xlink:label="loc_regn_Upfrontpaymentreceived_3D3735A760CD380FCB314EEDB7D5F485" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_69CE82F40ECEDAD265DE4EEDB7D551E2" xlink:to="loc_regn_Upfrontpaymentreceived_3D3735A760CD380FCB314EEDB7D5F485" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized" xlink:label="loc_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_EEDF3B3BAB35F858026C4EEDB7D55827" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_69CE82F40ECEDAD265DE4EEDB7D551E2" xlink:to="loc_us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized_EEDF3B3BAB35F858026C4EEDB7D55827" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_AggregatefuturedevelopmentmilestonepaymentstheCompanyiseligibletoreceive" xlink:label="loc_regn_AggregatefuturedevelopmentmilestonepaymentstheCompanyiseligibletoreceive_BA6B1E235158441DB81A4EEDB7D56EF9" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_69CE82F40ECEDAD265DE4EEDB7D551E2" xlink:to="loc_regn_AggregatefuturedevelopmentmilestonepaymentstheCompanyiseligibletoreceive_BA6B1E235158441DB81A4EEDB7D56EF9" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_CollaborativeArrangementAdditionalEligibleAggregatePayments" xlink:label="loc_regn_CollaborativeArrangementAdditionalEligibleAggregatePayments_FCFA92DF89539D3F8FFB4EEDB7D5C8BC" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_69CE82F40ECEDAD265DE4EEDB7D551E2" xlink:to="loc_regn_CollaborativeArrangementAdditionalEligibleAggregatePayments_FCFA92DF89539D3F8FFB4EEDB7D5C8BC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_76DF29ABA2F8FF04919B4EEDB7E5C881" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_69CE82F40ECEDAD265DE4EEDB7D551E2" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_76DF29ABA2F8FF04919B4EEDB7E5C881" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueRemainingPerformanceObligation" xlink:label="loc_us-gaap_RevenueRemainingPerformanceObligation_B42803AF42290E277F624EEDB7E515A5" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_69CE82F40ECEDAD265DE4EEDB7D551E2" xlink:to="loc_us-gaap_RevenueRemainingPerformanceObligation_B42803AF42290E277F624EEDB7E515A5" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/CommitmentsAndContingencies" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_58E5DB0B678AFEA7B93C57AD2407C432" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsDisclosureTextBlock" xlink:label="loc_us-gaap_CommitmentsDisclosureTextBlock_6FB401A250D1966454C057AD240765AB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_58E5DB0B678AFEA7B93C57AD2407C432" xlink:to="loc_us-gaap_CommitmentsDisclosureTextBlock_6FB401A250D1966454C057AD240765AB" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/CommitmentsAndContingenciesLeasesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_FA842ED3B0A6FF2269CA8130BF3A110B" xlink:type="locator" />
    <link:loc xlink:href="regn-20181231.xsd#regn_FacilityPurchasePrice" xlink:label="loc_regn_FacilityPurchasePrice_080116F19A8E5F9747D28130BF40DDA8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_FA842ED3B0A6FF2269CA8130BF3A110B" xlink:to="loc_regn_FacilityPurchasePrice_080116F19A8E5F9747D28130BF40DDA8" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_PaymenttowardspurchasepriceofTarrytownfacility" xlink:label="loc_regn_PaymenttowardspurchasepriceofTarrytownfacility_88853FB7611B127C19E28130BF405557" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_FA842ED3B0A6FF2269CA8130BF3A110B" xlink:to="loc_regn_PaymenttowardspurchasepriceofTarrytownfacility_88853FB7611B127C19E28130BF405557" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Aggregatefundingadvancedbytheparticipants" xlink:label="loc_regn_Aggregatefundingadvancedbytheparticipants_2B49B9F6ADFBB51E8B2B8130BF41526F" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_FA842ED3B0A6FF2269CA8130BF3A110B" xlink:to="loc_regn_Aggregatefundingadvancedbytheparticipants_2B49B9F6ADFBB51E8B2B8130BF41526F" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ReimbursementreceivedbytheCompany" xlink:label="loc_regn_ReimbursementreceivedbytheCompany_B952AF95C3CC03F1431F8130BF417B10" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_FA842ED3B0A6FF2269CA8130BF3A110B" xlink:to="loc_regn_ReimbursementreceivedbytheCompany_B952AF95C3CC03F1431F8130BF417B10" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Initialtermoflease" xlink:label="loc_regn_Initialtermoflease_AD484533056A75FB95628130BF417A97" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_FA842ED3B0A6FF2269CA8130BF3A110B" xlink:to="loc_regn_Initialtermoflease_AD484533056A75FB95628130BF417A97" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Potentialextendedtermoflease" xlink:label="loc_regn_Potentialextendedtermoflease_81BAC0BF5E11386E90918130BF41D576" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_FA842ED3B0A6FF2269CA8130BF3A110B" xlink:to="loc_regn_Potentialextendedtermoflease_81BAC0BF5E11386E90918130BF41D576" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_3F7DAAC366E47FDEC5DD8130BF4149FA" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_FA842ED3B0A6FF2269CA8130BF3A110B" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_3F7DAAC366E47FDEC5DD8130BF4149FA" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Tarrytownfacilitycapitalandfacilityleaseobligations" xlink:label="loc_regn_Tarrytownfacilitycapitalandfacilityleaseobligations_6D50F1E202B6C9FA43548130BF42846A" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_FA842ED3B0A6FF2269CA8130BF3A110B" xlink:to="loc_regn_Tarrytownfacilitycapitalandfacilityleaseobligations_6D50F1E202B6C9FA43548130BF42846A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InterestExpenseLesseeAssetsUnderCapitalLease" xlink:label="loc_us-gaap_InterestExpenseLesseeAssetsUnderCapitalLease_0B332AD85798CA979CB3813EA615809A" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_FA842ED3B0A6FF2269CA8130BF3A110B" xlink:to="loc_us-gaap_InterestExpenseLesseeAssetsUnderCapitalLease_0B332AD85798CA979CB3813EA615809A" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/CommitmentsAndContingenciesResearchCollaborationAndLicensingAgreementsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_E8FEF2103257A8FAED8152B94C780C06" xlink:type="locator" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ResearchCollaborationAndLicensingArrangementsTable" xlink:label="loc_regn_ResearchCollaborationAndLicensingArrangementsTable_9471C9B426F3864CB00752B94C78777B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_E8FEF2103257A8FAED8152B94C780C06" xlink:to="loc_regn_ResearchCollaborationAndLicensingArrangementsTable_9471C9B426F3864CB00752B94C78777B" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ResearchCollaborationAndLicensingAgreementsAxis" xlink:label="loc_regn_ResearchCollaborationAndLicensingAgreementsAxis_92946E728B1C0E9AFD9552B94C78752E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchCollaborationAndLicensingArrangementsTable_9471C9B426F3864CB00752B94C78777B" xlink:to="loc_regn_ResearchCollaborationAndLicensingAgreementsAxis_92946E728B1C0E9AFD9552B94C78752E" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ResearchCollaborationAndLicensingAgreementsDomain" xlink:label="loc_regn_ResearchCollaborationAndLicensingAgreementsDomain_E26214FA74E0E16C183852B94C79C827" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchCollaborationAndLicensingAgreementsAxis_92946E728B1C0E9AFD9552B94C78752E" xlink:to="loc_regn_ResearchCollaborationAndLicensingAgreementsDomain_E26214FA74E0E16C183852B94C79C827" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RoyaltyAgreementTermsMember" xlink:label="loc_us-gaap_RoyaltyAgreementTermsMember_9FECE408258ECA40977C52B94C7918EC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchCollaborationAndLicensingAgreementsDomain_E26214FA74E0E16C183852B94C79C827" xlink:to="loc_us-gaap_RoyaltyAgreementTermsMember_9FECE408258ECA40977C52B94C7918EC" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ResearchCollaborationAndLicensingArrangementsLineItems" xlink:label="loc_regn_ResearchCollaborationAndLicensingArrangementsLineItems_72F9C18A0FA604B813FE52B94C791AA2" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchCollaborationAndLicensingArrangementsTable_9471C9B426F3864CB00752B94C78777B" xlink:to="loc_regn_ResearchCollaborationAndLicensingArrangementsLineItems_72F9C18A0FA604B813FE52B94C791AA2" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_RoyaltyRateMinimum" xlink:label="loc_regn_RoyaltyRateMinimum_F27C1DC7BED9DFD7E47452B94C7A0D57" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchCollaborationAndLicensingArrangementsLineItems_72F9C18A0FA604B813FE52B94C791AA2" xlink:to="loc_regn_RoyaltyRateMinimum_F27C1DC7BED9DFD7E47452B94C7A0D57" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_RoyaltyRateMaximum" xlink:label="loc_regn_RoyaltyRateMaximum_8D80BACFF197D1D4302752B94C7A8090" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchCollaborationAndLicensingArrangementsLineItems_72F9C18A0FA604B813FE52B94C791AA2" xlink:to="loc_regn_RoyaltyRateMaximum_8D80BACFF197D1D4302752B94C7A8090" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RoyaltyExpense" xlink:label="loc_us-gaap_RoyaltyExpense_CB17863CE569DC49447952B94C7A407A" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ResearchCollaborationAndLicensingArrangementsLineItems_72F9C18A0FA604B813FE52B94C791AA2" xlink:to="loc_us-gaap_RoyaltyExpense_CB17863CE569DC49447952B94C7A407A" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/CommitmentsAndContingenciesScheduleOfCommitmentsUnderCapitalAndFacilityLeaseObligationsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_CEA53192FA9228AF39BC8130BED76476" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDueCurrent" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueCurrent_6587AA030C3F7DD0C6068130BED8CA6C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_CEA53192FA9228AF39BC8130BED76476" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueCurrent_6587AA030C3F7DD0C6068130BED8CA6C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDueInTwoYears" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInTwoYears_97E5AC93F251AFCE62FD8130BED8F66E" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_CEA53192FA9228AF39BC8130BED76476" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInTwoYears_97E5AC93F251AFCE62FD8130BED8F66E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDueInThreeYears" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInThreeYears_0192D369CDF19FB477828130BED86950" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_CEA53192FA9228AF39BC8130BED76476" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInThreeYears_0192D369CDF19FB477828130BED86950" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDueInFourYears" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInFourYears_5EF6A5FF4832E50ED1CB8130BED991D8" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_CEA53192FA9228AF39BC8130BED76476" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInFourYears_5EF6A5FF4832E50ED1CB8130BED991D8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDueInFiveYears" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInFiveYears_78A5E6ABD77C1506976B8130BED9A305" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_CEA53192FA9228AF39BC8130BED76476" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueInFiveYears_78A5E6ABD77C1506976B8130BED9A305" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDueThereafter" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueThereafter_5663A71FA80C499B11448130BED90703" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_CEA53192FA9228AF39BC8130BED76476" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDueThereafter_5663A71FA80C499B11448130BED90703" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeasesFutureMinimumPaymentsDue" xlink:label="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDue_E31523AEA4399877393C8130BEDAD16B" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_CEA53192FA9228AF39BC8130BED76476" xlink:to="loc_us-gaap_CapitalLeasesFutureMinimumPaymentsDue_E31523AEA4399877393C8130BEDAD16B" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/CommitmentsAndContingenciesScheduleOfCommitmentsUnderOperatingLeasesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_5EE697272FA228867E858130BF163F20" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfOperatingLeasedAssetsTable" xlink:label="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_B78DEB4D2BB4EE3B7FA38130BF164EE3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_5EE697272FA228867E858130BF163F20" xlink:to="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_B78DEB4D2BB4EE3B7FA38130BF164EE3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_8363C5B320EFC1710C5E8130BF17698A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_B78DEB4D2BB4EE3B7FA38130BF164EE3" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_8363C5B320EFC1710C5E8130BF17698A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_64A9DAC20B98925693C78130BF17349A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_8363C5B320EFC1710C5E8130BF17698A" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_64A9DAC20B98925693C78130BF17349A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BuildingMember" xlink:label="loc_us-gaap_BuildingMember_3B7AED411182B8EF0FCD8130BF18708A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_64A9DAC20B98925693C78130BF17349A" xlink:to="loc_us-gaap_BuildingMember_3B7AED411182B8EF0FCD8130BF18708A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquipmentMember" xlink:label="loc_us-gaap_EquipmentMember_B6030369E27CDB457E748130BF1879C0" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_64A9DAC20B98925693C78130BF17349A" xlink:to="loc_us-gaap_EquipmentMember_B6030369E27CDB457E748130BF1879C0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasedAssetsLineItems" xlink:label="loc_us-gaap_OperatingLeasedAssetsLineItems_086B450D794E174FC4C88130BF19FD10" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_B78DEB4D2BB4EE3B7FA38130BF164EE3" xlink:to="loc_us-gaap_OperatingLeasedAssetsLineItems_086B450D794E174FC4C88130BF19FD10" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_CA795C43DAE7290469C78130BF19131B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_086B450D794E174FC4C88130BF19FD10" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_CA795C43DAE7290469C78130BF19131B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_583FF6F567751A058A3A8130BF1A5A2B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_086B450D794E174FC4C88130BF19FD10" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInTwoYears_583FF6F567751A058A3A8130BF1A5A2B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_D5AC675C829D5186E5DA8130BF1A5981" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_086B450D794E174FC4C88130BF19FD10" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInThreeYears_D5AC675C829D5186E5DA8130BF1A5981" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_37DC438E8A3A0602E2DB8130BF1A8D91" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_086B450D794E174FC4C88130BF19FD10" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFourYears_37DC438E8A3A0602E2DB8130BF1A8D91" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_1E024953806455E9E0578130BF1C1A81" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_086B450D794E174FC4C88130BF19FD10" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueInFiveYears_1E024953806455E9E0578130BF1C1A81" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter_C5EAF3E41288C5AAE2028130BF1CFECD" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_086B450D794E174FC4C88130BF19FD10" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueThereafter_C5EAF3E41288C5AAE2028130BF1CFECD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_74FD95699BC4DD3B78768130BF1C2CB2" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_086B450D794E174FC4C88130BF19FD10" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_74FD95699BC4DD3B78768130BF1C2CB2" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/CommitmentsAndContingenciesScheduleOfRentExpenseUnderOperatingLeasesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_73CBB890DEAA1C3EC18B52F7C6D27292" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfOperatingLeasedAssetsTable" xlink:label="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_65114C5DED909C3FCFA752F7CA65491D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_73CBB890DEAA1C3EC18B52F7C6D27292" xlink:to="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_65114C5DED909C3FCFA752F7CA65491D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_8BB8F65FFA8314F8F61152F7CAA09FCD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_65114C5DED909C3FCFA752F7CA65491D" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_8BB8F65FFA8314F8F61152F7CAA09FCD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_AF8B284B060402C0173B52F7CAA1CE0F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_8BB8F65FFA8314F8F61152F7CAA09FCD" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_AF8B284B060402C0173B52F7CAA1CE0F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BuildingMember" xlink:label="loc_us-gaap_BuildingMember_C3408CBFA17AD73E3B0E52F7CACEC7C4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_AF8B284B060402C0173B52F7CAA1CE0F" xlink:to="loc_us-gaap_BuildingMember_C3408CBFA17AD73E3B0E52F7CACEC7C4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquipmentMember" xlink:label="loc_us-gaap_EquipmentMember_494C6120D698A79B0C8A52F7CAE7478D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_AF8B284B060402C0173B52F7CAA1CE0F" xlink:to="loc_us-gaap_EquipmentMember_494C6120D698A79B0C8A52F7CAE7478D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasedAssetsLineItems" xlink:label="loc_us-gaap_OperatingLeasedAssetsLineItems_6B737F512B35FD36129652F7CA65BBA3" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_65114C5DED909C3FCFA752F7CA65491D" xlink:to="loc_us-gaap_OperatingLeasedAssetsLineItems_6B737F512B35FD36129652F7CA65BBA3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesRentExpenseNet" xlink:label="loc_us-gaap_OperatingLeasesRentExpenseNet_D244B4A3FBB62030D53E52F7CA834D2D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_6B737F512B35FD36129652F7CA65BBA3" xlink:to="loc_us-gaap_OperatingLeasesRentExpenseNet_D244B4A3FBB62030D53E52F7CA834D2D" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/CommitmentsAndContingenciesTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_DB6D86CEC9D6184B930252B94C9CE0BC" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfFutureMinimumRentalPaymentsForOperatingLeasesTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfFutureMinimumRentalPaymentsForOperatingLeasesTableTextBlock_3083E725971E045A09C652B94C9C3280" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_DB6D86CEC9D6184B930252B94C9CE0BC" xlink:to="loc_us-gaap_ScheduleOfFutureMinimumRentalPaymentsForOperatingLeasesTableTextBlock_3083E725971E045A09C652B94C9C3280" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfRentExpenseTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfRentExpenseTableTextBlock_F11D757F8870A2829C1B52B94C9C4217" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_DB6D86CEC9D6184B930252B94C9CE0BC" xlink:to="loc_us-gaap_ScheduleOfRentExpenseTableTextBlock_F11D757F8870A2829C1B52B94C9C4217" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfFutureMinimumLeasePaymentsForCapitalLeasesTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfFutureMinimumLeasePaymentsForCapitalLeasesTableTextBlock_FCB1BB22F22668F556C452FB8FC2B1A3" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_DB6D86CEC9D6184B930252B94C9CE0BC" xlink:to="loc_us-gaap_ScheduleOfFutureMinimumLeasePaymentsForCapitalLeasesTableTextBlock_FCB1BB22F22668F556C452FB8FC2B1A3" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/ConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_D5E0AD0E35BE820EABB9C3CD9BA6111D" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_181C8E0874A94B741AB3C3CD9BA69BA6" xlink:type="locator" />
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_D5E0AD0E35BE820EABB9C3CD9BA6111D" xlink:to="loc_us-gaap_StatementTable_181C8E0874A94B741AB3C3CD9BA69BA6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis" xlink:label="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_C3CC7524B9D71CC4CB35C3CD9BA7D283" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_181C8E0874A94B741AB3C3CD9BA69BA6" xlink:to="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_C3CC7524B9D71CC4CB35C3CD9BA7D283" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProjectMember" xlink:label="loc_us-gaap_ProjectMember_8D3A5A823A2E62EF555AC3CD9BA7FA09" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_C3CC7524B9D71CC4CB35C3CD9BA7D283" xlink:to="loc_us-gaap_ProjectMember_8D3A5A823A2E62EF555AC3CD9BA7FA09" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_SanofiCollaborationAgreementMember" xlink:label="loc_regn_SanofiCollaborationAgreementMember_3094C6F80180DD51B6A8C3CD9BA84E34" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_8D3A5A823A2E62EF555AC3CD9BA7FA09" xlink:to="loc_regn_SanofiCollaborationAgreementMember_3094C6F80180DD51B6A8C3CD9BA84E34" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_BayerTevaPharmaceuticalsAndOtherAgreementsMember" xlink:label="loc_regn_BayerTevaPharmaceuticalsAndOtherAgreementsMember_B5E104D2E6AB29DD4D9BC3CD9BA8D124" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_8D3A5A823A2E62EF555AC3CD9BA7FA09" xlink:to="loc_regn_BayerTevaPharmaceuticalsAndOtherAgreementsMember_B5E104D2E6AB29DD4D9BC3CD9BA8D124" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_D60598160E9E78D3BA84C3CD9BA8D700" xlink:type="locator" />
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_181C8E0874A94B741AB3C3CD9BA69BA6" xlink:to="loc_us-gaap_StatementClassOfStockAxis_D60598160E9E78D3BA84C3CD9BA8D700" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_376C02E7C6E21618C081C3CD9BA9EFD9" xlink:type="locator" />
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_D60598160E9E78D3BA84C3CD9BA8D700" xlink:to="loc_us-gaap_ClassOfStockDomain_376C02E7C6E21618C081C3CD9BA9EFD9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonClassAMember" xlink:label="loc_us-gaap_CommonClassAMember_0AF2B95C246AA5119F3EC3CD9BA9477F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_376C02E7C6E21618C081C3CD9BA9EFD9" xlink:to="loc_us-gaap_CommonClassAMember_0AF2B95C246AA5119F3EC3CD9BA9477F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_C1DA2D54AF4D68965EA1C3CD9BA93612" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_376C02E7C6E21618C081C3CD9BA9EFD9" xlink:to="loc_us-gaap_CommonStockMember_C1DA2D54AF4D68965EA1C3CD9BA93612" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_818A259EA164E3DCB3D3C3CD9BAAA116" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_181C8E0874A94B741AB3C3CD9BA69BA6" xlink:to="loc_us-gaap_StatementLineItems_818A259EA164E3DCB3D3C3CD9BAAA116" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsAbstract" xlink:label="loc_us-gaap_AssetsAbstract_FD0372B4CE74BBD609EAC3CD9BAA83F0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_818A259EA164E3DCB3D3C3CD9BAAA116" xlink:to="loc_us-gaap_AssetsAbstract_FD0372B4CE74BBD609EAC3CD9BAA83F0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsCurrentAbstract" xlink:label="loc_us-gaap_AssetsCurrentAbstract_71A155A3D3C4CF28542FC3CD9BAA18C7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_FD0372B4CE74BBD609EAC3CD9BAA83F0" xlink:to="loc_us-gaap_AssetsCurrentAbstract_71A155A3D3C4CF28542FC3CD9BAA18C7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_B9895911F95F8D0BA2F6C3CD9BAA2EEA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_71A155A3D3C4CF28542FC3CD9BAA18C7" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_B9895911F95F8D0BA2F6C3CD9BAA2EEA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MarketableSecuritiesCurrent" xlink:label="loc_us-gaap_MarketableSecuritiesCurrent_12D0C73C1B79592143D5C3CD9BAB7D04" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_71A155A3D3C4CF28542FC3CD9BAA18C7" xlink:to="loc_us-gaap_MarketableSecuritiesCurrent_12D0C73C1B79592143D5C3CD9BAB7D04" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsReceivableNetCurrent" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_BF3B8CDB6F1623A2EE89C3CD9BAB4229" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_71A155A3D3C4CF28542FC3CD9BAA18C7" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_BF3B8CDB6F1623A2EE89C3CD9BAB4229" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsReceivableRelatedPartiesCurrent" xlink:label="loc_us-gaap_AccountsReceivableRelatedPartiesCurrent_04A44192460AC577E166C3CD9BAB83BE" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_71A155A3D3C4CF28542FC3CD9BAA18C7" xlink:to="loc_us-gaap_AccountsReceivableRelatedPartiesCurrent_04A44192460AC577E166C3CD9BAB83BE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsAndNotesReceivableNet" xlink:label="loc_us-gaap_AccountsAndNotesReceivableNet_6D662B20A496511D902DC3CD9BABA581" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_71A155A3D3C4CF28542FC3CD9BAA18C7" xlink:to="loc_us-gaap_AccountsAndNotesReceivableNet_6D662B20A496511D902DC3CD9BABA581" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_A59C1C492DEF84561388C3CD9BABADC4" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_71A155A3D3C4CF28542FC3CD9BAA18C7" xlink:to="loc_us-gaap_InventoryNet_A59C1C492DEF84561388C3CD9BABADC4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_33127E9B1043264882ACC3CD9BAC0015" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_71A155A3D3C4CF28542FC3CD9BAA18C7" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_33127E9B1043264882ACC3CD9BAC0015" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsCurrent" xlink:label="loc_us-gaap_AssetsCurrent_B50D4E37C5556A996D77C3CD9BAC01A2" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_71A155A3D3C4CF28542FC3CD9BAA18C7" xlink:to="loc_us-gaap_AssetsCurrent_B50D4E37C5556A996D77C3CD9BAC01A2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MarketableSecuritiesNoncurrent" xlink:label="loc_us-gaap_MarketableSecuritiesNoncurrent_151BB0CACFBF425800B3C3CD9BAC223F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_FD0372B4CE74BBD609EAC3CD9BAA83F0" xlink:to="loc_us-gaap_MarketableSecuritiesNoncurrent_151BB0CACFBF425800B3C3CD9BAC223F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_820C19784A3C52863BA9C3CD9BACC761" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_FD0372B4CE74BBD609EAC3CD9BAA83F0" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_820C19784A3C52863BA9C3CD9BACC761" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredIncomeTaxAssetsNet" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_958DBCD024BB0DF02824C3CD9BACA551" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_FD0372B4CE74BBD609EAC3CD9BAA83F0" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_958DBCD024BB0DF02824C3CD9BACA551" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherAssetsNoncurrent" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_D02418A987EC372D1A5EC3CD9BADBD15" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_FD0372B4CE74BBD609EAC3CD9BAA83F0" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_D02418A987EC372D1A5EC3CD9BADBD15" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Assets" xlink:label="loc_us-gaap_Assets_923A9653B75471D20E47C3CD9BAD5A3B" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_FD0372B4CE74BBD609EAC3CD9BAA83F0" xlink:to="loc_us-gaap_Assets_923A9653B75471D20E47C3CD9BAD5A3B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_1BB7F45604E2B47D0887C3CD9BAD0EA0" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_818A259EA164E3DCB3D3C3CD9BAAA116" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_1BB7F45604E2B47D0887C3CD9BAD0EA0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_56854767DE9CB76108E4C3CD9BADAAF3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_1BB7F45604E2B47D0887C3CD9BAD0EA0" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_56854767DE9CB76108E4C3CD9BADAAF3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsPayableCurrent" xlink:label="loc_us-gaap_AccountsPayableCurrent_3D298174EBA4D1D7F285C3CD9BADCCF5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_56854767DE9CB76108E4C3CD9BADAAF3" xlink:to="loc_us-gaap_AccountsPayableCurrent_3D298174EBA4D1D7F285C3CD9BADCCF5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccruedLiabilitiesAndOtherLiabilities" xlink:label="loc_us-gaap_AccruedLiabilitiesAndOtherLiabilities_D7EF15B5B126749CE4C6C3CD9BAE6614" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_56854767DE9CB76108E4C3CD9BADAAF3" xlink:to="loc_us-gaap_AccruedLiabilitiesAndOtherLiabilities_D7EF15B5B126749CE4C6C3CD9BAE6614" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerLiabilityCurrent" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_0F8248B5CE59A09BD514C3CD9BAE164D" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_56854767DE9CB76108E4C3CD9BADAAF3" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_0F8248B5CE59A09BD514C3CD9BAE164D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesCurrent" xlink:label="loc_us-gaap_LiabilitiesCurrent_71E5B5E57031AAFFDEE8C3CD9BAE6517" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_56854767DE9CB76108E4C3CD9BADAAF3" xlink:to="loc_us-gaap_LiabilitiesCurrent_71E5B5E57031AAFFDEE8C3CD9BAE6517" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Capitalandfacilityleaseobligationsnoncurrent" xlink:label="loc_regn_Capitalandfacilityleaseobligationsnoncurrent_BAAEDC35BDD82FC89F63C3CD9BAE9ABE" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_1BB7F45604E2B47D0887C3CD9BAD0EA0" xlink:to="loc_regn_Capitalandfacilityleaseobligationsnoncurrent_BAAEDC35BDD82FC89F63C3CD9BAE9ABE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_ADEF32BE50F6D4A1FB9FC3CD9BAE5800" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_1BB7F45604E2B47D0887C3CD9BAD0EA0" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_ADEF32BE50F6D4A1FB9FC3CD9BAE5800" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_187A9698ED4802F55C89C3CD9BAFB1F7" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_1BB7F45604E2B47D0887C3CD9BAD0EA0" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_187A9698ED4802F55C89C3CD9BAFB1F7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Liabilities" xlink:label="loc_us-gaap_Liabilities_D7EAFFAFAC0345188E94C3CD9BAF7981" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_1BB7F45604E2B47D0887C3CD9BAD0EA0" xlink:to="loc_us-gaap_Liabilities_D7EAFFAFAC0345188E94C3CD9BAF7981" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingencies" xlink:label="loc_us-gaap_CommitmentsAndContingencies_C03430D4F79ED1E770BCC3CD9BAF2DA3" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_818A259EA164E3DCB3D3C3CD9BAAA116" xlink:to="loc_us-gaap_CommitmentsAndContingencies_C03430D4F79ED1E770BCC3CD9BAF2DA3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquityAbstract" xlink:label="loc_us-gaap_StockholdersEquityAbstract_67FB149E8FE0F87853FCC3CD9BAF4E86" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_818A259EA164E3DCB3D3C3CD9BAAA116" xlink:to="loc_us-gaap_StockholdersEquityAbstract_67FB149E8FE0F87853FCC3CD9BAF4E86" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PreferredStockValue" xlink:label="loc_us-gaap_PreferredStockValue_2A3061DAE04F1EEC6D13C3CD9BB0392C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_67FB149E8FE0F87853FCC3CD9BAF4E86" xlink:to="loc_us-gaap_PreferredStockValue_2A3061DAE04F1EEC6D13C3CD9BB0392C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockValue" xlink:label="loc_us-gaap_CommonStockValue_8D4832FD4F47E6EFAAA6C3CD9BB0DB95" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_67FB149E8FE0F87853FCC3CD9BAF4E86" xlink:to="loc_us-gaap_CommonStockValue_8D4832FD4F47E6EFAAA6C3CD9BB0DB95" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdditionalPaidInCapital" xlink:label="loc_us-gaap_AdditionalPaidInCapital_D19A9D0A24292A369E4AC3CD9BB0B684" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_67FB149E8FE0F87853FCC3CD9BAF4E86" xlink:to="loc_us-gaap_AdditionalPaidInCapital_D19A9D0A24292A369E4AC3CD9BB0B684" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_2C53F99472A1A77F4B03C3CD9BB0AD93" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_67FB149E8FE0F87853FCC3CD9BAF4E86" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_2C53F99472A1A77F4B03C3CD9BB0AD93" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_8336970953A55724029FC3CD9BB0481D" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_67FB149E8FE0F87853FCC3CD9BAF4E86" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_8336970953A55724029FC3CD9BB0481D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TreasuryStockValue" xlink:label="loc_us-gaap_TreasuryStockValue_22B49D4EF41F3CADBFA7C3CD9BB1DC42" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_67FB149E8FE0F87853FCC3CD9BAF4E86" xlink:to="loc_us-gaap_TreasuryStockValue_22B49D4EF41F3CADBFA7C3CD9BB1DC42" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_64DBCE77BB825278FFB1C3CD9BB114C3" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_67FB149E8FE0F87853FCC3CD9BAF4E86" xlink:to="loc_us-gaap_StockholdersEquity_64DBCE77BB825278FFB1C3CD9BB114C3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_D243A9A82D5A35BD0AA3C3CD9BB11CD3" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_818A259EA164E3DCB3D3C3CD9BAAA116" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_D243A9A82D5A35BD0AA3C3CD9BB11CD3" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/ConsolidatedBalanceSheetsParenthetical" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_7563585168AB9323E0EA4E182B59748E" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_609655260A01A3E2A1644E182B5946E7" xlink:type="locator" />
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_7563585168AB9323E0EA4E182B59748E" xlink:to="loc_us-gaap_StatementTable_609655260A01A3E2A1644E182B5946E7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_45C22E7BF29C30E7DAEB4E182B59BEC6" xlink:type="locator" />
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_609655260A01A3E2A1644E182B5946E7" xlink:to="loc_us-gaap_StatementClassOfStockAxis_45C22E7BF29C30E7DAEB4E182B59BEC6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_47CFF464D3B3A77BD77E4E182B59CAF2" xlink:type="locator" />
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_45C22E7BF29C30E7DAEB4E182B59BEC6" xlink:to="loc_us-gaap_ClassOfStockDomain_47CFF464D3B3A77BD77E4E182B59CAF2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonClassAMember" xlink:label="loc_us-gaap_CommonClassAMember_D3F0A342B2BCC005DC584E182B5A953A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_47CFF464D3B3A77BD77E4E182B59CAF2" xlink:to="loc_us-gaap_CommonClassAMember_D3F0A342B2BCC005DC584E182B5A953A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_E6DA64E0B4413F67EB834E182B5AA371" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_47CFF464D3B3A77BD77E4E182B59CAF2" xlink:to="loc_us-gaap_CommonStockMember_E6DA64E0B4413F67EB834E182B5AA371" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_3070AD7552F6A9E28F0A4E182B5A54C6" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_609655260A01A3E2A1644E182B5946E7" xlink:to="loc_us-gaap_StatementLineItems_3070AD7552F6A9E28F0A4E182B5A54C6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_3DF2E3F7306D042E37694E182B5A8A06" xlink:type="locator" />
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_3070AD7552F6A9E28F0A4E182B5A54C6" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_3DF2E3F7306D042E37694E182B5A8A06" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PreferredStockParOrStatedValuePerShare" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_95E5DA8C4872C5E06D304E182B5BF181" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_3DF2E3F7306D042E37694E182B5A8A06" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_95E5DA8C4872C5E06D304E182B5BF181" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PreferredStockSharesAuthorized" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_92FDB2C9ACF1ED738FCE4E182B5BA300" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_3DF2E3F7306D042E37694E182B5A8A06" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_92FDB2C9ACF1ED738FCE4E182B5BA300" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PreferredStockSharesIssued" xlink:label="loc_us-gaap_PreferredStockSharesIssued_A0EEECC31232D66140A74E182B5B6970" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_3DF2E3F7306D042E37694E182B5A8A06" xlink:to="loc_us-gaap_PreferredStockSharesIssued_A0EEECC31232D66140A74E182B5B6970" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PreferredStockSharesOutstanding" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_C9F030911F4140AAE82A4E182B5BC379" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_3DF2E3F7306D042E37694E182B5A8A06" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_C9F030911F4140AAE82A4E182B5BC379" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_A06CE894DDE217E772414E182B5CC7B3" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_3DF2E3F7306D042E37694E182B5A8A06" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_A06CE894DDE217E772414E182B5CC7B3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockSharesAuthorized" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_B007E425AED95638B39B4E182B5C6B10" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_3DF2E3F7306D042E37694E182B5A8A06" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_B007E425AED95638B39B4E182B5C6B10" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockSharesIssued" xlink:label="loc_us-gaap_CommonStockSharesIssued_99383B11EFBC961335B34E182B5C2F6A" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_3DF2E3F7306D042E37694E182B5A8A06" xlink:to="loc_us-gaap_CommonStockSharesIssued_99383B11EFBC961335B34E182B5C2F6A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockSharesOutstanding" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_16B6539A2BF7AB5B05994E182B5CCDB8" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_3DF2E3F7306D042E37694E182B5A8A06" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_16B6539A2BF7AB5B05994E182B5CCDB8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TreasuryStockShares" xlink:label="loc_us-gaap_TreasuryStockShares_FACE4AE2A8A01BD0B2B34E182B5CEA30" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_3DF2E3F7306D042E37694E182B5A8A06" xlink:to="loc_us-gaap_TreasuryStockShares_FACE4AE2A8A01BD0B2B34E182B5CEA30" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/ConsolidatedStatementsOfCashFlows" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementOfCashFlowsAbstract" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_E08AE3DBE76914272EB64E182B1127C0" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_CE22FA8E49E5354D60C54E182B119990" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_E08AE3DBE76914272EB64E182B1127C0" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_CE22FA8E49E5354D60C54E182B119990" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_DD6DFED8291F02B33ACE4E182B116F17" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_CE22FA8E49E5354D60C54E182B119990" xlink:to="loc_us-gaap_NetIncomeLoss_DD6DFED8291F02B33ACE4E182B116F17" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_E915011B68E964694D6E4E182B117AF2" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_CE22FA8E49E5354D60C54E182B119990" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_E915011B68E964694D6E4E182B117AF2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_D9EEF619219CEB6F41314E182B1174DE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_E915011B68E964694D6E4E182B117AF2" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_D9EEF619219CEB6F41314E182B1174DE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensation" xlink:label="loc_us-gaap_ShareBasedCompensation_AE4C60C68A8A00099C724E182B11067F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_E915011B68E964694D6E4E182B117AF2" xlink:to="loc_us-gaap_ShareBasedCompensation_AE4C60C68A8A00099C724E182B11067F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherNoncashIncomeExpense" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_161D0B558B2764F375A84E182B11028C" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_E915011B68E964694D6E4E182B117AF2" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_161D0B558B2764F375A84E182B11028C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredIncomeTaxes" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_688D72764C6F7F6555694E182B1121A4" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_E915011B68E964694D6E4E182B117AF2" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_688D72764C6F7F6555694E182B1121A4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_31015E55A59E76D47C984E182B114D6C" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_E915011B68E964694D6E4E182B117AF2" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_31015E55A59E76D47C984E182B114D6C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_6C70FA321A59395BE98D4E182B118177" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_31015E55A59E76D47C984E182B114D6C" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_6C70FA321A59395BE98D4E182B118177" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInInventories" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_11B711DEEC53A596252F4E182B11909D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_31015E55A59E76D47C984E182B114D6C" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_11B711DEEC53A596252F4E182B11909D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_A8977E70FEBD0BB47E7B4E182B110B34" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_31015E55A59E76D47C984E182B114D6C" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_A8977E70FEBD0BB47E7B4E182B110B34" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_1C72592EC345ADE9E6534E182B112ECC" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_31015E55A59E76D47C984E182B114D6C" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_1C72592EC345ADE9E6534E182B112ECC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_E6289654BC0BE49911984E182B11684A" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_31015E55A59E76D47C984E182B114D6C" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_E6289654BC0BE49911984E182B11684A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_97889435DBCC82AD69E44E182B1163D3" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_E915011B68E964694D6E4E182B117AF2" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_97889435DBCC82AD69E44E182B1163D3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_DD620FF000AF2692A4934E182B113D71" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_CE22FA8E49E5354D60C54E182B119990" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_DD620FF000AF2692A4934E182B113D71" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_0DAAF828E955F20F4C2B4E182B11D2BE" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_E08AE3DBE76914272EB64E182B1127C0" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_0DAAF828E955F20F4C2B4E182B11D2BE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireMarketableSecurities" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_B854870D45E486580AD34E182B11C520" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_0DAAF828E955F20F4C2B4E182B11D2BE" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_B854870D45E486580AD34E182B11C520" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_C90F6367112A819FD5774E182B11806B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_0DAAF828E955F20F4C2B4E182B11D2BE" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_C90F6367112A819FD5774E182B11806B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireProductiveAssets" xlink:label="loc_us-gaap_PaymentsToAcquireProductiveAssets_058BCC5D14FD121E2FFC4E182B11519E" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_0DAAF828E955F20F4C2B4E182B11D2BE" xlink:to="loc_us-gaap_PaymentsToAcquireProductiveAssets_058BCC5D14FD121E2FFC4E182B11519E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_4D0A31E36EFA0C6ADD8F4E52C7D116DA" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_0DAAF828E955F20F4C2B4E182B11D2BE" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_4D0A31E36EFA0C6ADD8F4E52C7D116DA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_130361784108781689494E182B116165" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_0DAAF828E955F20F4C2B4E182B11D2BE" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_130361784108781689494E182B116165" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_00527BD2370DD3FA57E24E182B114935" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_E08AE3DBE76914272EB64E182B1127C0" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_00527BD2370DD3FA57E24E182B114935" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromRepaymentsOfLongTermDebtAndCapitalSecurities" xlink:label="loc_us-gaap_ProceedsFromRepaymentsOfLongTermDebtAndCapitalSecurities_25F16624A576321048764E182B111CC8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_00527BD2370DD3FA57E24E182B114935" xlink:to="loc_us-gaap_ProceedsFromRepaymentsOfLongTermDebtAndCapitalSecurities_25F16624A576321048764E182B111CC8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RepaymentsOfLongTermDebtAndCapitalSecurities" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebtAndCapitalSecurities_BCE353B1B5AB8B0251684E182B11D965" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_00527BD2370DD3FA57E24E182B114935" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebtAndCapitalSecurities_BCE353B1B5AB8B0251684E182B11D965" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RepaymentsOfConvertibleDebt" xlink:label="loc_us-gaap_RepaymentsOfConvertibleDebt_9DAD0CA98023D650A9DA4E182B11D978" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_00527BD2370DD3FA57E24E182B114935" xlink:to="loc_us-gaap_RepaymentsOfConvertibleDebt_9DAD0CA98023D650A9DA4E182B11D978" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsForRepurchaseOfWarrants" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfWarrants_9AF72C14A85C8CE571A94E182B11BC9F" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_00527BD2370DD3FA57E24E182B114935" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfWarrants_9AF72C14A85C8CE571A94E182B11BC9F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_BD56D90FC285EC87E4F44E182B11E63A" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_00527BD2370DD3FA57E24E182B114935" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_BD56D90FC285EC87E4F44E182B11E63A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_BBFBAD7000822335FA114E182B111411" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_00527BD2370DD3FA57E24E182B114935" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_BBFBAD7000822335FA114E182B111411" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_4CA3C70816CE96F195584E553EF4CAD1" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_00527BD2370DD3FA57E24E182B114935" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_4CA3C70816CE96F195584E553EF4CAD1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0879F618133D95299C894E182B1179FE" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_00527BD2370DD3FA57E24E182B114935" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0879F618133D95299C894E182B1179FE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease" xlink:label="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_350A444DF084AC1938834E182B1175BF" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_E08AE3DBE76914272EB64E182B1127C0" xlink:to="loc_us-gaap_CashAndCashEquivalentsPeriodIncreaseDecrease_350A444DF084AC1938834E182B1175BF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_32C9003EA37BFB7796674E5669C7B1AB" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_E08AE3DBE76914272EB64E182B1127C0" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_32C9003EA37BFB7796674E5669C7B1AB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_9D87FA374EF422BCAF154E5D970DCFF0" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_E08AE3DBE76914272EB64E182B1127C0" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_9D87FA374EF422BCAF154E5D970DCFF0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SupplementalCashFlowInformationAbstract" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_73516B4CB8B8E2CF2B5D4E726B48583D" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_E08AE3DBE76914272EB64E182B1127C0" xlink:to="loc_us-gaap_SupplementalCashFlowInformationAbstract_73516B4CB8B8E2CF2B5D4E726B48583D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InterestPaidNet" xlink:label="loc_us-gaap_InterestPaidNet_CD72CFE298544EABC0B74E182B119171" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_73516B4CB8B8E2CF2B5D4E726B48583D" xlink:to="loc_us-gaap_InterestPaidNet_CD72CFE298544EABC0B74E182B119171" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxesPaidNet" xlink:label="loc_us-gaap_IncomeTaxesPaidNet_A967E3DB1DA5288FD7A94E182B11D92C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_73516B4CB8B8E2CF2B5D4E726B48583D" xlink:to="loc_us-gaap_IncomeTaxesPaidNet_A967E3DB1DA5288FD7A94E182B11D92C" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/ConsolidatedStatementsOfOperationsAndComprehensiveIncome" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract" xlink:label="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_10778BC3D328E2B5204CC3CD9B7F3C23" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_7554FF9872A7B6332DD1C3CD9B7F48EB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_10778BC3D328E2B5204CC3CD9B7F3C23" xlink:to="loc_us-gaap_StatementTable_7554FF9872A7B6332DD1C3CD9B7F48EB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis" xlink:label="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_791AC0C7E3B5B9403F1FC3CD9B7FEE21" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_7554FF9872A7B6332DD1C3CD9B7F48EB" xlink:to="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_791AC0C7E3B5B9403F1FC3CD9B7FEE21" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProjectMember" xlink:label="loc_us-gaap_ProjectMember_61F14490DB73650151ACC3CD9B7F197D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_791AC0C7E3B5B9403F1FC3CD9B7FEE21" xlink:to="loc_us-gaap_ProjectMember_61F14490DB73650151ACC3CD9B7F197D" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_SanofiCollaborationAgreementMember" xlink:label="loc_regn_SanofiCollaborationAgreementMember_4336E5E256E02AB20009C3CD9B80B15B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_61F14490DB73650151ACC3CD9B7F197D" xlink:to="loc_regn_SanofiCollaborationAgreementMember_4336E5E256E02AB20009C3CD9B80B15B" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_BayerCollaborationAgreementMember" xlink:label="loc_regn_BayerCollaborationAgreementMember_46025869370F4C977A20C3CD9B805E36" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_61F14490DB73650151ACC3CD9B7F197D" xlink:to="loc_regn_BayerCollaborationAgreementMember_46025869370F4C977A20C3CD9B805E36" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_OtherCollaborationAgreementsMember" xlink:label="loc_regn_OtherCollaborationAgreementsMember_00E023A547C70FA8922DC3CD9B80C9EC" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_61F14490DB73650151ACC3CD9B7F197D" xlink:to="loc_regn_OtherCollaborationAgreementsMember_00E023A547C70FA8922DC3CD9B80C9EC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductOrServiceAxis" xlink:label="loc_srt_ProductOrServiceAxis_181C9BF6979B2AEC13B3C3CD9B806000" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_7554FF9872A7B6332DD1C3CD9B7F48EB" xlink:to="loc_srt_ProductOrServiceAxis_181C9BF6979B2AEC13B3C3CD9B806000" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_8C887F0E62B6B3BA1FAFC3CD9B814534" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_181C9BF6979B2AEC13B3C3CD9B806000" xlink:to="loc_srt_ProductsAndServicesDomain_8C887F0E62B6B3BA1FAFC3CD9B814534" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProductMember" xlink:label="loc_us-gaap_ProductMember_48F79E0EF03186588149C3CD9B81D149" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_8C887F0E62B6B3BA1FAFC3CD9B814534" xlink:to="loc_us-gaap_ProductMember_48F79E0EF03186588149C3CD9B81D149" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProductAndServiceOtherMember" xlink:label="loc_us-gaap_ProductAndServiceOtherMember_50E534E5595B41EA67F4C3CD9B813E69" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_8C887F0E62B6B3BA1FAFC3CD9B814534" xlink:to="loc_us-gaap_ProductAndServiceOtherMember_50E534E5595B41EA67F4C3CD9B813E69" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_CollaborationandContractManufacturingMember" xlink:label="loc_regn_CollaborationandContractManufacturingMember_1819F7434BC59F360202C3CD9B82DC81" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_8C887F0E62B6B3BA1FAFC3CD9B814534" xlink:to="loc_regn_CollaborationandContractManufacturingMember_1819F7434BC59F360202C3CD9B82DC81" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_8C700CF593A5C1AD5F1CC3CD9B828F3B" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_7554FF9872A7B6332DD1C3CD9B7F48EB" xlink:to="loc_us-gaap_StatementLineItems_8C700CF593A5C1AD5F1CC3CD9B828F3B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeStatementAbstract" xlink:label="loc_us-gaap_IncomeStatementAbstract_FE38099DEB09830E0B62C3CD9B82A2B8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8C700CF593A5C1AD5F1CC3CD9B828F3B" xlink:to="loc_us-gaap_IncomeStatementAbstract_FE38099DEB09830E0B62C3CD9B82A2B8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenuesAbstract" xlink:label="loc_us-gaap_RevenuesAbstract_54A1A75CD3CA35D71ECCC3CD9B827680" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_FE38099DEB09830E0B62C3CD9B82A2B8" xlink:to="loc_us-gaap_RevenuesAbstract_54A1A75CD3CA35D71ECCC3CD9B827680" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_9A81A02FD3C65F860D87C3CD9B839EE9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesAbstract_54A1A75CD3CA35D71ECCC3CD9B827680" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_9A81A02FD3C65F860D87C3CD9B839EE9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CostsAndExpensesAbstract" xlink:label="loc_us-gaap_CostsAndExpensesAbstract_4BCE4E8717D27A99972AC3CD9B83B4AD" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_FE38099DEB09830E0B62C3CD9B82A2B8" xlink:to="loc_us-gaap_CostsAndExpensesAbstract_4BCE4E8717D27A99972AC3CD9B83B4AD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_0FEBB1758E8819094D22C3CD9B83A0B0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_4BCE4E8717D27A99972AC3CD9B83B4AD" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_0FEBB1758E8819094D22C3CD9B83A0B0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_9F59209609EEDA68724AC3CD9B841677" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_4BCE4E8717D27A99972AC3CD9B83B4AD" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_9F59209609EEDA68724AC3CD9B841677" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_B13E21B67733C4FC1862C3CD9B84F0FE" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_4BCE4E8717D27A99972AC3CD9B83B4AD" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_B13E21B67733C4FC1862C3CD9B84F0FE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CostsAndExpenses" xlink:label="loc_us-gaap_CostsAndExpenses_ED27466668C9DE484018C3CD9B84BDEA" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CostsAndExpensesAbstract_4BCE4E8717D27A99972AC3CD9B83B4AD" xlink:to="loc_us-gaap_CostsAndExpenses_ED27466668C9DE484018C3CD9B84BDEA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingIncomeLoss" xlink:label="loc_us-gaap_OperatingIncomeLoss_E33E9B0F5D246B647D74C3CD9B84B307" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_FE38099DEB09830E0B62C3CD9B82A2B8" xlink:to="loc_us-gaap_OperatingIncomeLoss_E33E9B0F5D246B647D74C3CD9B84B307" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NonoperatingIncomeExpenseAbstract" xlink:label="loc_us-gaap_NonoperatingIncomeExpenseAbstract_E2D16D775749E3169F6AC3CD9B8462D7" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_FE38099DEB09830E0B62C3CD9B82A2B8" xlink:to="loc_us-gaap_NonoperatingIncomeExpenseAbstract_E2D16D775749E3169F6AC3CD9B8462D7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_115AF8AD8EAD97102CCDC3CD9B84B360" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_E2D16D775749E3169F6AC3CD9B8462D7" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_115AF8AD8EAD97102CCDC3CD9B84B360" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InterestExpense" xlink:label="loc_us-gaap_InterestExpense_94814085C36654E952A3C3CD9B857CA0" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_E2D16D775749E3169F6AC3CD9B8462D7" xlink:to="loc_us-gaap_InterestExpense_94814085C36654E952A3C3CD9B857CA0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NonoperatingIncomeExpense" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_275B0565EA0ABB26C215C3CD9B853251" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NonoperatingIncomeExpenseAbstract_E2D16D775749E3169F6AC3CD9B8462D7" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_275B0565EA0ABB26C215C3CD9B853251" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_9A8AF477C76CB337A060C3CD9B85619B" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_FE38099DEB09830E0B62C3CD9B82A2B8" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_9A8AF477C76CB337A060C3CD9B85619B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_FB1E9263A1250533690DC3CD9B86C6D2" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_FE38099DEB09830E0B62C3CD9B82A2B8" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_FB1E9263A1250533690DC3CD9B86C6D2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_560FC2C2BEDA9317CF66C3CD9B86FA30" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_FE38099DEB09830E0B62C3CD9B82A2B8" xlink:to="loc_us-gaap_NetIncomeLoss_560FC2C2BEDA9317CF66C3CD9B86FA30" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareBasic" xlink:label="loc_us-gaap_EarningsPerShareBasic_7E3AC5E00956F9927A07C3CD9B86ABD0" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_FE38099DEB09830E0B62C3CD9B82A2B8" xlink:to="loc_us-gaap_EarningsPerShareBasic_7E3AC5E00956F9927A07C3CD9B86ABD0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareDiluted" xlink:label="loc_us-gaap_EarningsPerShareDiluted_71D5CB5D6ACA512DF57EC3CD9B86AC84" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_FE38099DEB09830E0B62C3CD9B82A2B8" xlink:to="loc_us-gaap_EarningsPerShareDiluted_71D5CB5D6ACA512DF57EC3CD9B86AC84" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_ED2242631B13BB203D5DC3CD9B87595D" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_FE38099DEB09830E0B62C3CD9B82A2B8" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_ED2242631B13BB203D5DC3CD9B87595D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_EFBBE49FB04C653CB46AC3CD9B873EED" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_FE38099DEB09830E0B62C3CD9B82A2B8" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_EFBBE49FB04C653CB46AC3CD9B873EED" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTaxAbstract" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTaxAbstract_89C351112FE7AA4A1EC6C3CD9B8719AD" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_8C700CF593A5C1AD5F1CC3CD9B828F3B" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTaxAbstract_89C351112FE7AA4A1EC6C3CD9B8719AD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_0BE807BDD700A5A02A60C3CD9B87ADA9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxAbstract_89C351112FE7AA4A1EC6C3CD9B8719AD" xlink:to="loc_us-gaap_NetIncomeLoss_0BE807BDD700A5A02A60C3CD9B87ADA9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_BA131C0C4BA999D26752C3CD9B8868BD" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxAbstract_89C351112FE7AA4A1EC6C3CD9B8719AD" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_BA131C0C4BA999D26752C3CD9B8868BD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_D3940FE4C055B365E2ABC3CD9B88A8E8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_BA131C0C4BA999D26752C3CD9B8868BD" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_D3940FE4C055B365E2ABC3CD9B88A8E8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_2E6A6B7EB34165D568D6C3CD9B88E8AB" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParentAbstract_BA131C0C4BA999D26752C3CD9B8868BD" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedGainLossOnDerivativesArisingDuringPeriodNetOfTax_2E6A6B7EB34165D568D6C3CD9B88E8AB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_EB1BBC5BCB1DFEF6BC90C3CD9B89F3CA" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTaxAbstract_89C351112FE7AA4A1EC6C3CD9B8719AD" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_EB1BBC5BCB1DFEF6BC90C3CD9B89F3CA" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/ConsolidatedStatementsOfStockholdersEquity" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementOfStockholdersEquityAbstract" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_E6429A6F726CA6F7802EC8C1C218F939" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementTable" xlink:label="loc_us-gaap_StatementTable_54AD29603F6FE40FA9CCC8C1C229C381" xlink:type="locator" />
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_E6429A6F726CA6F7802EC8C1C218F939" xlink:to="loc_us-gaap_StatementTable_54AD29603F6FE40FA9CCC8C1C229C381" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis" xlink:label="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_726B00340DA146184AD9C8C1C22F6EB4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_54AD29603F6FE40FA9CCC8C1C229C381" xlink:to="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_726B00340DA146184AD9C8C1C22F6EB4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ChangeInAccountingPrincipleMember" xlink:label="loc_us-gaap_ChangeInAccountingPrincipleMember_46A30A90C988C2D92D0DC8C1C230F1ED" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsForChangeInAccountingPrincipleAxis_726B00340DA146184AD9C8C1C22F6EB4" xlink:to="loc_us-gaap_ChangeInAccountingPrincipleMember_46A30A90C988C2D92D0DC8C1C230F1ED" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_AccountingStandardsUpdate201409And201601Member" xlink:label="loc_regn_AccountingStandardsUpdate201409And201601Member_30553A09F4537FFEB4FFC8C1C230D314" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ChangeInAccountingPrincipleMember_46A30A90C988C2D92D0DC8C1C230F1ED" xlink:to="loc_regn_AccountingStandardsUpdate201409And201601Member_30553A09F4537FFEB4FFC8C1C230D314" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201601Member" xlink:label="loc_us-gaap_AccountingStandardsUpdate201601Member_4DAD331EE760EAE30848C8C1C232EA39" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ChangeInAccountingPrincipleMember_46A30A90C988C2D92D0DC8C1C230F1ED" xlink:to="loc_us-gaap_AccountingStandardsUpdate201601Member_4DAD331EE760EAE30848C8C1C232EA39" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_94597CE35CA4593C715EC8C1C233E504" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_54AD29603F6FE40FA9CCC8C1C229C381" xlink:to="loc_us-gaap_StatementClassOfStockAxis_94597CE35CA4593C715EC8C1C233E504" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_C3776DD09389AF42D1C1C8C1C2334D7D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_94597CE35CA4593C715EC8C1C233E504" xlink:to="loc_us-gaap_ClassOfStockDomain_C3776DD09389AF42D1C1C8C1C2334D7D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonClassAMember" xlink:label="loc_us-gaap_CommonClassAMember_CCB1C7C4FE503F28C8BAC8C1C23465B7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_C3776DD09389AF42D1C1C8C1C2334D7D" xlink:to="loc_us-gaap_CommonClassAMember_CCB1C7C4FE503F28C8BAC8C1C23465B7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_8F7DB1E0B00225DFFF3DC8C1C23EDF88" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_C3776DD09389AF42D1C1C8C1C2334D7D" xlink:to="loc_us-gaap_CommonStockMember_8F7DB1E0B00225DFFF3DC8C1C23EDF88" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedStockMember" xlink:label="loc_us-gaap_RestrictedStockMember_3C6368BFF4B7F896AF41C8C1C23EC075" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_C3776DD09389AF42D1C1C8C1C2334D7D" xlink:to="loc_us-gaap_RestrictedStockMember_3C6368BFF4B7F896AF41C8C1C23EC075" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_9E534C06121AD58EC338C8C1C23FBD65" xlink:type="locator" />
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_54AD29603F6FE40FA9CCC8C1C229C381" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_9E534C06121AD58EC338C8C1C23FBD65" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_C12468A9E7E98D36056CC8C1C23FFFCC" xlink:type="locator" />
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_9E534C06121AD58EC338C8C1C23FBD65" xlink:to="loc_us-gaap_EquityComponentDomain_C12468A9E7E98D36056CC8C1C23FFFCC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_D774E3967A02B46E0EF5C8C1C240EDED" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_C12468A9E7E98D36056CC8C1C23FFFCC" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_D774E3967A02B46E0EF5C8C1C240EDED" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RetainedEarningsMember" xlink:label="loc_us-gaap_RetainedEarningsMember_F21CFA8DE7F31E3E2547C8C1C241DAC9" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_C12468A9E7E98D36056CC8C1C23FFFCC" xlink:to="loc_us-gaap_RetainedEarningsMember_F21CFA8DE7F31E3E2547C8C1C241DAC9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_FA6A95F882496A19FA9AC8C1C241D2FF" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_C12468A9E7E98D36056CC8C1C23FFFCC" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_FA6A95F882496A19FA9AC8C1C241D2FF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TreasuryStockMember" xlink:label="loc_us-gaap_TreasuryStockMember_C98AB6EEDF070082E9B2C8C1C2421DCF" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_C12468A9E7E98D36056CC8C1C23FFFCC" xlink:to="loc_us-gaap_TreasuryStockMember_C98AB6EEDF070082E9B2C8C1C2421DCF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementLineItems" xlink:label="loc_us-gaap_StatementLineItems_3007925EB98E84B3C902C8C1C2426C6B" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_54AD29603F6FE40FA9CCC8C1C229C381" xlink:to="loc_us-gaap_StatementLineItems_3007925EB98E84B3C902C8C1C2426C6B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_D36D3262CC36C7D73A22C8C1C2425280" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_3007925EB98E84B3C902C8C1C2426C6B" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_D36D3262CC36C7D73A22C8C1C2425280" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharesOutstanding" xlink:label="loc_us-gaap_SharesOutstanding_A0025DCC58B1FACD18F0C8C1C248C87C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_D36D3262CC36C7D73A22C8C1C2425280" xlink:to="loc_us-gaap_SharesOutstanding_A0025DCC58B1FACD18F0C8C1C248C87C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_1B8357F449A7870C24C0C8C1C2484FE5" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_D36D3262CC36C7D73A22C8C1C2425280" xlink:to="loc_us-gaap_StockholdersEquity_1B8357F449A7870C24C0C8C1C2484FE5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_FAA66227A61C2D714CFDC8C1C2493387" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_D36D3262CC36C7D73A22C8C1C2425280" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_FAA66227A61C2D714CFDC8C1C2493387" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_FEFD8AD5DAF872D5C568C8C1C2493E3E" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_D36D3262CC36C7D73A22C8C1C2425280" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_FEFD8AD5DAF872D5C568C8C1C2493E3E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation" xlink:label="loc_us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation_CAEAD14F5310126AAB09C8C1C24A8F67" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_D36D3262CC36C7D73A22C8C1C2425280" xlink:to="loc_us-gaap_SharesPaidForTaxWithholdingForShareBasedCompensation_CAEAD14F5310126AAB09C8C1C24A8F67" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation" xlink:label="loc_us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_173CF81AC2B5A9B69A5CC8C1C24AFCAE" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_D36D3262CC36C7D73A22C8C1C2425280" xlink:to="loc_us-gaap_AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation_173CF81AC2B5A9B69A5CC8C1C24AFCAE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtConversionConvertedInstrumentSharesIssued1" xlink:label="loc_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_0462E1CD5FB1703F477AC8C1C24BEE5B" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_D36D3262CC36C7D73A22C8C1C2425280" xlink:to="loc_us-gaap_DebtConversionConvertedInstrumentSharesIssued1_0462E1CD5FB1703F477AC8C1C24BEE5B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_8C250E90CD9D6D807158C8C1C24BD72A" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_D36D3262CC36C7D73A22C8C1C2425280" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueConversionOfConvertibleSecurities_8C250E90CD9D6D807158C8C1C24BD72A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_3E8D19025EBD15DEA6E5C8C1C24B3A85" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_D36D3262CC36C7D73A22C8C1C2425280" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesRestrictedStockAwardNetOfForfeitures_3E8D19025EBD15DEA6E5C8C1C24B3A85" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardGross" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardGross_00E0B1A9C3C2A8E57196C8C1C24CAE99" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_D36D3262CC36C7D73A22C8C1C2425280" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueRestrictedStockAwardGross_00E0B1A9C3C2A8E57196C8C1C24CAE99" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeBenefitPlan" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeBenefitPlan_5C918380C0B22EFF5E86C8C1C24C075E" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_D36D3262CC36C7D73A22C8C1C2425280" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeBenefitPlan_5C918380C0B22EFF5E86C8C1C24C075E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueEmployeeBenefitPlan" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeBenefitPlan_04F2968EA8A0628436AFC8C1C24CFE5B" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_D36D3262CC36C7D73A22C8C1C2425280" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeBenefitPlan_04F2968EA8A0628436AFC8C1C24CFE5B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_470C9B7ADDA09CCDBFB2C8C1C25266B4" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_D36D3262CC36C7D73A22C8C1C2425280" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_470C9B7ADDA09CCDBFB2C8C1C25266B4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TreasuryStockSharesAcquired" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_9692B9544166D045E57AC8C1C252832C" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_D36D3262CC36C7D73A22C8C1C2425280" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_9692B9544166D045E57AC8C1C252832C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_33C2FA40ABE88CF73BF8C8C1C253B4A0" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_D36D3262CC36C7D73A22C8C1C2425280" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_33C2FA40ABE88CF73BF8C8C1C253B4A0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalOther" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalOther_CB4652095189D60411C1C8C1C253ED54" xlink:type="locator" />
    <link:presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_D36D3262CC36C7D73A22C8C1C2425280" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalOther_CB4652095189D60411C1C8C1C253ED54" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebtSubsequentAdjustments" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebtSubsequentAdjustments_71EA0CF531595EB7225FC8C1C254BC1A" xlink:type="locator" />
    <link:presentationArc order="17" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_D36D3262CC36C7D73A22C8C1C2425280" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebtSubsequentAdjustments_71EA0CF531595EB7225FC8C1C254BC1A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CumulativeEffectOnRetainedEarningsNetOfTax1" xlink:label="loc_us-gaap_CumulativeEffectOnRetainedEarningsNetOfTax1_7978A3EA2B76C2D7F62BC8C1C2544F19" xlink:type="locator" />
    <link:presentationArc order="18" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_D36D3262CC36C7D73A22C8C1C2425280" xlink:to="loc_us-gaap_CumulativeEffectOnRetainedEarningsNetOfTax1_7978A3EA2B76C2D7F62BC8C1C2544F19" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_BE8E903695F01EB93193C8C1C25490AD" xlink:type="locator" />
    <link:presentationArc order="19" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_D36D3262CC36C7D73A22C8C1C2425280" xlink:to="loc_us-gaap_NetIncomeLoss_BE8E903695F01EB93193C8C1C25490AD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_3820CFC9B5D875232C64C8C1C254A717" xlink:type="locator" />
    <link:presentationArc order="20" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_D36D3262CC36C7D73A22C8C1C2425280" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_3820CFC9B5D875232C64C8C1C254A717" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharesOutstanding" xlink:label="loc_us-gaap_SharesOutstanding_B9DD2DD8D57C33845541C8C1C255BF10" xlink:type="locator" />
    <link:presentationArc order="21" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_D36D3262CC36C7D73A22C8C1C2425280" xlink:to="loc_us-gaap_SharesOutstanding_B9DD2DD8D57C33845541C8C1C255BF10" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquity" xlink:label="loc_us-gaap_StockholdersEquity_336C77CDE9332AAED902C8C1C2560138" xlink:type="locator" />
    <link:presentationArc order="22" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_D36D3262CC36C7D73A22C8C1C2425280" xlink:to="loc_us-gaap_StockholdersEquity_336C77CDE9332AAED902C8C1C2560138" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/Debt" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtDisclosureAbstract" xlink:label="loc_us-gaap_DebtDisclosureAbstract_48D9246BBFC247D80DC957AD24251948" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtDisclosureTextBlock" xlink:label="loc_us-gaap_DebtDisclosureTextBlock_FC1C2CA8BD55F573DD4357AD2426B82B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_48D9246BBFC247D80DC957AD24251948" xlink:to="loc_us-gaap_DebtDisclosureTextBlock_FC1C2CA8BD55F573DD4357AD2426B82B" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/DebtNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtDisclosureAbstract" xlink:label="loc_us-gaap_DebtDisclosureAbstract_25CE99EA53D6AD853010BFDE93F458A2" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentTable" xlink:label="loc_us-gaap_DebtInstrumentTable_E0A962960DFEDFE77B6EBFDE93F7332E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_25CE99EA53D6AD853010BFDE93F458A2" xlink:to="loc_us-gaap_DebtInstrumentTable_E0A962960DFEDFE77B6EBFDE93F7332E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CreditFacilityAxis" xlink:label="loc_us-gaap_CreditFacilityAxis_73C94D13D260824A19AABFDE93F9C056" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_E0A962960DFEDFE77B6EBFDE93F7332E" xlink:to="loc_us-gaap_CreditFacilityAxis_73C94D13D260824A19AABFDE93F9C056" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CreditFacilityDomain" xlink:label="loc_us-gaap_CreditFacilityDomain_129F50C9636BF204425EBFDE93F99E92" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CreditFacilityAxis_73C94D13D260824A19AABFDE93F9C056" xlink:to="loc_us-gaap_CreditFacilityDomain_129F50C9636BF204425EBFDE93F99E92" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevolvingCreditFacilityMember" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_777E9A0FCE8645815118BFDE93FA7E12" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CreditFacilityDomain_129F50C9636BF204425EBFDE93F99E92" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_777E9A0FCE8645815118BFDE93FA7E12" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LetterOfCreditMember" xlink:label="loc_us-gaap_LetterOfCreditMember_29DCB18703CB32207E02BFDE93FA2D2D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CreditFacilityDomain_129F50C9636BF204425EBFDE93F99E92" xlink:to="loc_us-gaap_LetterOfCreditMember_29DCB18703CB32207E02BFDE93FA2D2D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementEquityComponentsAxis" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_BF2A08697052E996B1FABFDE93FB67D8" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_E0A962960DFEDFE77B6EBFDE93F7332E" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_BF2A08697052E996B1FABFDE93FB67D8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityComponentDomain" xlink:label="loc_us-gaap_EquityComponentDomain_9BE3E87CD992D346F4E2BFDE93FB899A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_BF2A08697052E996B1FABFDE93FB67D8" xlink:to="loc_us-gaap_EquityComponentDomain_9BE3E87CD992D346F4E2BFDE93FB899A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TreasuryStockMember" xlink:label="loc_us-gaap_TreasuryStockMember_B16B0C7CAF0B06DE539BBFDE93FBF9DA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_9BE3E87CD992D346F4E2BFDE93FB899A" xlink:to="loc_us-gaap_TreasuryStockMember_B16B0C7CAF0B06DE539BBFDE93FBF9DA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeAxis" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_A467170FF0B1832EC1D3BFDE93FC06AF" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_E0A962960DFEDFE77B6EBFDE93F7332E" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_A467170FF0B1832EC1D3BFDE93FC06AF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeDomain" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_7C23B84915C05CFF11D1BFDE93FC1ABA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_A467170FF0B1832EC1D3BFDE93FC06AF" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_7C23B84915C05CFF11D1BFDE93FC1ABA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConvertibleDebtMember" xlink:label="loc_us-gaap_ConvertibleDebtMember_B90F7B383EA0CF0D4B3CBFDE93FD0251" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_7C23B84915C05CFF11D1BFDE93FC1ABA" xlink:to="loc_us-gaap_ConvertibleDebtMember_B90F7B383EA0CF0D4B3CBFDE93FD0251" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCreditMember" xlink:label="loc_us-gaap_LineOfCreditMember_0B18A8A353ECCA8E7541BFDE93FDF805" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_7C23B84915C05CFF11D1BFDE93FC1ABA" xlink:to="loc_us-gaap_LineOfCreditMember_0B18A8A353ECCA8E7541BFDE93FDF805" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightAxis" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_EB0F455373F209353A75BFDE93FD9CCA" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_E0A962960DFEDFE77B6EBFDE93F7332E" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_EB0F455373F209353A75BFDE93FD9CCA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightDomain" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_7BC3A68890D518447B0FBFDE93FEC9C7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_EB0F455373F209353A75BFDE93FD9CCA" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_7BC3A68890D518447B0FBFDE93FEC9C7" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_November2016AgreementMember" xlink:label="loc_regn_November2016AgreementMember_6C5912E6DB47C1FA00BFBFDE93FE6120" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_7BC3A68890D518447B0FBFDE93FEC9C7" xlink:to="loc_regn_November2016AgreementMember_6C5912E6DB47C1FA00BFBFDE93FE6120" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantMember" xlink:label="loc_us-gaap_WarrantMember_880E4F05CC49992D19BCBFDE93FF9A5B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_7BC3A68890D518447B0FBFDE93FEC9C7" xlink:to="loc_us-gaap_WarrantMember_880E4F05CC49992D19BCBFDE93FF9A5B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentLineItems" xlink:label="loc_us-gaap_DebtInstrumentLineItems_DE06426FA3BC7E989B55BFDE93FF8CB9" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_E0A962960DFEDFE77B6EBFDE93F7332E" xlink:to="loc_us-gaap_DebtInstrumentLineItems_DE06426FA3BC7E989B55BFDE93FF8CB9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentFaceAmount" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_47E9E77738CE3BC33307BFDE93FFF7FD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_DE06426FA3BC7E989B55BFDE93FF8CB9" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_47E9E77738CE3BC33307BFDE93FFF7FD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_2DCBCADC5A1FFBB39324BFDE93FFC97D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_DE06426FA3BC7E989B55BFDE93FF8CB9" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_2DCBCADC5A1FFBB39324BFDE93FFC97D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_21FB02B46AB9BEDE9111BFDE94008603" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_DE06426FA3BC7E989B55BFDE93FF8CB9" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_21FB02B46AB9BEDE9111BFDE94008603" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RepaymentsOfConvertibleDebt" xlink:label="loc_us-gaap_RepaymentsOfConvertibleDebt_E79A4C32EB31526DCFB7BFDE9400ED13" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_DE06426FA3BC7E989B55BFDE93FF8CB9" xlink:to="loc_us-gaap_RepaymentsOfConvertibleDebt_E79A4C32EB31526DCFB7BFDE9400ED13" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_B887507C4F1EAA469C35BFDE94006A31" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_DE06426FA3BC7E989B55BFDE93FF8CB9" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_B887507C4F1EAA469C35BFDE94006A31" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebtSubsequentAdjustments" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebtSubsequentAdjustments_A002693D4CD6404FC618BFDE94007522" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_DE06426FA3BC7E989B55BFDE93FF8CB9" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebtSubsequentAdjustments_A002693D4CD6404FC618BFDE94007522" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TreasuryStockSharesAcquired" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_4F66AEAD6351E953D60ABFDE94013E99" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_DE06426FA3BC7E989B55BFDE93FF8CB9" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_4F66AEAD6351E953D60ABFDE94013E99" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_8C9DA433751036490FC8BFDE940148EF" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_DE06426FA3BC7E989B55BFDE93FF8CB9" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_8C9DA433751036490FC8BFDE940148EF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsForRepurchaseOfWarrants" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfWarrants_04D268453F40BB2C9DF5BFDE94015E75" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_DE06426FA3BC7E989B55BFDE93FF8CB9" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfWarrants_04D268453F40BB2C9DF5BFDE94015E75" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantsAndRightsOutstanding" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding_8DB440E19F2315EEE822BFDE94017E95" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_DE06426FA3BC7E989B55BFDE93FF8CB9" xlink:to="loc_us-gaap_WarrantsAndRightsOutstanding_8DB440E19F2315EEE822BFDE94017E95" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_AFE8EC4624B14971215ABFDE9401AC01" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_DE06426FA3BC7E989B55BFDE93FF8CB9" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_AFE8EC4624B14971215ABFDE9401AC01" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCreditFacilityExpirationPeriod" xlink:label="loc_us-gaap_LineOfCreditFacilityExpirationPeriod_EBC4A1C01156362FE6C0BFDEF191464C" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_DE06426FA3BC7E989B55BFDE93FF8CB9" xlink:to="loc_us-gaap_LineOfCreditFacilityExpirationPeriod_EBC4A1C01156362FE6C0BFDEF191464C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LineOfCredit" xlink:label="loc_us-gaap_LineOfCredit_50B4D816DBE07FCA53EBBFDE94022496" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_DE06426FA3BC7E989B55BFDE93FF8CB9" xlink:to="loc_us-gaap_LineOfCredit_50B4D816DBE07FCA53EBBFDE94022496" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_LineofCreditFacilityIncreaseLimit" xlink:label="loc_regn_LineofCreditFacilityIncreaseLimit_4AEB0CCBB576910F2B84BFDE9402EB6E" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_DE06426FA3BC7E989B55BFDE93FF8CB9" xlink:to="loc_regn_LineofCreditFacilityIncreaseLimit_4AEB0CCBB576910F2B84BFDE9402EB6E" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/DeferredRevenue" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_5D51AF3E064E7B3D873757AD243B64C7" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerTextBlock" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerTextBlock_260F75598B9128DBB7BC57AD243B42E3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_5D51AF3E064E7B3D873757AD243B64C7" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerTextBlock_260F75598B9128DBB7BC57AD243B42E3" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/DeferredRevenueScheduleOfDeferredRevenueDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_39FF42717695F486B192C3CD99AE84D9" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTable" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_47209E03E280E28376BBC3CD99AFAE02" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_39FF42717695F486B192C3CD99AE84D9" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_47209E03E280E28376BBC3CD99AFAE02" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis" xlink:label="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_72637CB6FE93FD6BF720C3CD99AF9F49" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_47209E03E280E28376BBC3CD99AFAE02" xlink:to="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_72637CB6FE93FD6BF720C3CD99AF9F49" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProjectMember" xlink:label="loc_us-gaap_ProjectMember_761C7742D0F7139B76D5C3CD99AF753C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_72637CB6FE93FD6BF720C3CD99AF9F49" xlink:to="loc_us-gaap_ProjectMember_761C7742D0F7139B76D5C3CD99AF753C" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_SanofiCollaborationAgreementMember" xlink:label="loc_regn_SanofiCollaborationAgreementMember_85385A61890956813531C3CD99B018A7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_761C7742D0F7139B76D5C3CD99AF753C" xlink:to="loc_regn_SanofiCollaborationAgreementMember_85385A61890956813531C3CD99B018A7" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_BayerCollaborationAgreementMember" xlink:label="loc_regn_BayerCollaborationAgreementMember_BA74A7A8F7E99D7FC8B1C3CD99B0040C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_761C7742D0F7139B76D5C3CD99AF753C" xlink:to="loc_regn_BayerCollaborationAgreementMember_BA74A7A8F7E99D7FC8B1C3CD99B0040C" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_TevaPharmaceuticalsCollaborationAgreementMember" xlink:label="loc_regn_TevaPharmaceuticalsCollaborationAgreementMember_91C3CB38631DCA07833CC3CD99B0956F" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_761C7742D0F7139B76D5C3CD99AF753C" xlink:to="loc_regn_TevaPharmaceuticalsCollaborationAgreementMember_91C3CB38631DCA07833CC3CD99B0956F" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_OtherAgreementsMember" xlink:label="loc_regn_OtherAgreementsMember_3409BDECA51CA9C258F1C3CD99B097D4" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_761C7742D0F7139B76D5C3CD99AF753C" xlink:to="loc_regn_OtherAgreementsMember_3409BDECA51CA9C258F1C3CD99B097D4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_137AC6A7AEAFB7689285C3CD99B1C4C5" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_47209E03E280E28376BBC3CD99AFAE02" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_137AC6A7AEAFB7689285C3CD99B1C4C5" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ContractWithCustomerLiabilityCurrentAbstract" xlink:label="loc_regn_ContractWithCustomerLiabilityCurrentAbstract_C09FDC3024DDA73F096FC3CD99B1572D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_137AC6A7AEAFB7689285C3CD99B1C4C5" xlink:to="loc_regn_ContractWithCustomerLiabilityCurrentAbstract_C09FDC3024DDA73F096FC3CD99B1572D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerLiabilityCurrent" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_37B8D6DA8A1F8F91A3BCC3CD99B1A8D7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ContractWithCustomerLiabilityCurrentAbstract_C09FDC3024DDA73F096FC3CD99B1572D" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_37B8D6DA8A1F8F91A3BCC3CD99B1A8D7" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ContractWithCustomerLiabilityNoncurrentAbstract" xlink:label="loc_regn_ContractWithCustomerLiabilityNoncurrentAbstract_7939062171104BDBF2C7C3CD99B2977E" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_137AC6A7AEAFB7689285C3CD99B1C4C5" xlink:to="loc_regn_ContractWithCustomerLiabilityNoncurrentAbstract_7939062171104BDBF2C7C3CD99B2977E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_2EF9F2C5AA60B6726A6FC3CD99B20730" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ContractWithCustomerLiabilityNoncurrentAbstract_7939062171104BDBF2C7C3CD99B2977E" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_2EF9F2C5AA60B6726A6FC3CD99B20730" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/DeferredRevenueTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerAbstract" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerAbstract_244033CD7A40DD80A02B52A93AD2A1A9" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerAssetAndLiabilityTableTextBlock" xlink:label="loc_us-gaap_ContractWithCustomerAssetAndLiabilityTableTextBlock_268B1B928B8B2A917CB852A93AE255CB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerAbstract_244033CD7A40DD80A02B52A93AD2A1A9" xlink:to="loc_us-gaap_ContractWithCustomerAssetAndLiabilityTableTextBlock_268B1B928B8B2A917CB852A93AE255CB" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/DerivativeInstrumentsAndHedgingActivities" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_AB041EC1673AF156F76F57AD27B13F81" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_94C48E32BD37F24B9EFB57AD27B13FEE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_AB041EC1673AF156F76F57AD27B13F81" xlink:to="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureTextBlock_94C48E32BD37F24B9EFB57AD27B13FEE" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/DerivativeInstrumentsAndHedgingActivitiesScheduleOfNotionalAmountsOfOutstandingDerivativePositionsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_4B77A92CD2D66F01966057AD27A50FE0" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeTable" xlink:label="loc_us-gaap_DerivativeTable_B95CE79A194391D3759557AD27A5B623" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_4B77A92CD2D66F01966057AD27A50FE0" xlink:to="loc_us-gaap_DerivativeTable_B95CE79A194391D3759557AD27A5B623" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_14983F4DD1B0CE55BA0E57AD27A65725" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_B95CE79A194391D3759557AD27A5B623" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_14983F4DD1B0CE55BA0E57AD27A65725" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeContractTypeDomain" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_E6CDD9DD90995FD4390457AD27A683C5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_14983F4DD1B0CE55BA0E57AD27A65725" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_E6CDD9DD90995FD4390457AD27A683C5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InterestRateSwapMember" xlink:label="loc_us-gaap_InterestRateSwapMember_1EDCDCE9CF83D315AAD757AD27A6D8E7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_E6CDD9DD90995FD4390457AD27A683C5" xlink:to="loc_us-gaap_InterestRateSwapMember_1EDCDCE9CF83D315AAD757AD27A6D8E7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InterestRateCapMember" xlink:label="loc_us-gaap_InterestRateCapMember_DD52B7A4E01AEBE946D857AD27A75D51" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_E6CDD9DD90995FD4390457AD27A683C5" xlink:to="loc_us-gaap_InterestRateCapMember_DD52B7A4E01AEBE946D857AD27A75D51" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeLineItems" xlink:label="loc_us-gaap_DerivativeLineItems_B06EB99B9D91FD218A8257AD27A7B75A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeTable_B95CE79A194391D3759557AD27A5B623" xlink:to="loc_us-gaap_DerivativeLineItems_B06EB99B9D91FD218A8257AD27A7B75A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_DerivativeNotionalAmount" xlink:label="loc_invest_DerivativeNotionalAmount_EAAB2068EAF162149D5F57AD27A76E73" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_B06EB99B9D91FD218A8257AD27A7B75A" xlink:to="loc_invest_DerivativeNotionalAmount_EAAB2068EAF162149D5F57AD27A76E73" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GainLossOnInterestRateCashFlowHedgeIneffectiveness" xlink:label="loc_us-gaap_GainLossOnInterestRateCashFlowHedgeIneffectiveness_BE5CACEED47C4572268257AD27A8520E" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeLineItems_B06EB99B9D91FD218A8257AD27A7B75A" xlink:to="loc_us-gaap_GainLossOnInterestRateCashFlowHedgeIneffectiveness_BE5CACEED47C4572268257AD27A8520E" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/DerivativeInstrumentsAndHedgingActivitiesTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_81E05A044E1703A123B457AD27AC9282" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfNotionalAmountsOfOutstandingDerivativePositionsTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfNotionalAmountsOfOutstandingDerivativePositionsTableTextBlock_CF375862ACF6020AAE8757AD27AC62EE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosureAbstract_81E05A044E1703A123B457AD27AC9282" xlink:to="loc_us-gaap_ScheduleOfNotionalAmountsOfOutstandingDerivativePositionsTableTextBlock_CF375862ACF6020AAE8757AD27AC62EE" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/DocumentAndEntityInformation" xlink:type="extended">
    <link:loc xlink:href="regn-20181231.xsd#regn_DocumentAndEntityInformationAbstract" xlink:label="loc_regn_DocumentAndEntityInformationAbstract_2C4A9BCD616FC99560C18130C44AF97D" xlink:type="locator" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntitiesTable" xlink:label="loc_dei_EntitiesTable_E223E6929631A7B95E2C8130C44BD340" xlink:type="locator" />
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_DocumentAndEntityInformationAbstract_2C4A9BCD616FC99560C18130C44AF97D" xlink:to="loc_dei_EntitiesTable_E223E6929631A7B95E2C8130C44BD340" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_DB229C44D1AF7CE762A48130C44B2DF4" xlink:type="locator" />
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntitiesTable_E223E6929631A7B95E2C8130C44BD340" xlink:to="loc_us-gaap_StatementClassOfStockAxis_DB229C44D1AF7CE762A48130C44B2DF4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_740C282C124ACDFC96188130C44B0635" xlink:type="locator" />
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_DB229C44D1AF7CE762A48130C44B2DF4" xlink:to="loc_us-gaap_ClassOfStockDomain_740C282C124ACDFC96188130C44B0635" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_64FC9585F290C20ED0FC8130C44C6726" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_740C282C124ACDFC96188130C44B0635" xlink:to="loc_us-gaap_CommonStockMember_64FC9585F290C20ED0FC8130C44C6726" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonClassAMember" xlink:label="loc_us-gaap_CommonClassAMember_A6B5551BC3ABA51BEA318130C44CE23D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_740C282C124ACDFC96188130C44B0635" xlink:to="loc_us-gaap_CommonClassAMember_A6B5551BC3ABA51BEA318130C44CE23D" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityInformationLineItems" xlink:label="loc_dei_EntityInformationLineItems_FD8451215361DC605BE28130C44CF262" xlink:type="locator" />
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntitiesTable_E223E6929631A7B95E2C8130C44BD340" xlink:to="loc_dei_EntityInformationLineItems_FD8451215361DC605BE28130C44CF262" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityRegistrantName" xlink:label="loc_dei_EntityRegistrantName_580EDF50E496C70893178130C44C9CD7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_FD8451215361DC605BE28130C44CF262" xlink:to="loc_dei_EntityRegistrantName_580EDF50E496C70893178130C44C9CD7" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityCentralIndexKey" xlink:label="loc_dei_EntityCentralIndexKey_C283AE22252995B82E488130C44D08F2" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_FD8451215361DC605BE28130C44CF262" xlink:to="loc_dei_EntityCentralIndexKey_C283AE22252995B82E488130C44D08F2" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_CurrentFiscalYearEndDate" xlink:label="loc_dei_CurrentFiscalYearEndDate_65C644BB24477EB2463E8130C44D0704" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_FD8451215361DC605BE28130C44CF262" xlink:to="loc_dei_CurrentFiscalYearEndDate_65C644BB24477EB2463E8130C44D0704" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityFilerCategory" xlink:label="loc_dei_EntityFilerCategory_6FEB56F8F103F683F5058130C44D4219" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_FD8451215361DC605BE28130C44CF262" xlink:to="loc_dei_EntityFilerCategory_6FEB56F8F103F683F5058130C44D4219" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_DocumentType" xlink:label="loc_dei_DocumentType_33696DE309B61CB5DC988130C44D05FE" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_FD8451215361DC605BE28130C44CF262" xlink:to="loc_dei_DocumentType_33696DE309B61CB5DC988130C44D05FE" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_DocumentPeriodEndDate" xlink:label="loc_dei_DocumentPeriodEndDate_1A4FE966CA62AEC7E8718130C44D7D41" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_FD8451215361DC605BE28130C44CF262" xlink:to="loc_dei_DocumentPeriodEndDate_1A4FE966CA62AEC7E8718130C44D7D41" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_DocumentFiscalYearFocus" xlink:label="loc_dei_DocumentFiscalYearFocus_67C04A57EBB8EFF39D3A8130C44E623E" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_FD8451215361DC605BE28130C44CF262" xlink:to="loc_dei_DocumentFiscalYearFocus_67C04A57EBB8EFF39D3A8130C44E623E" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_DocumentFiscalPeriodFocus" xlink:label="loc_dei_DocumentFiscalPeriodFocus_937BE2CE2E1C522573E18130C44E8D9B" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_FD8451215361DC605BE28130C44CF262" xlink:to="loc_dei_DocumentFiscalPeriodFocus_937BE2CE2E1C522573E18130C44E8D9B" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_AmendmentFlag" xlink:label="loc_dei_AmendmentFlag_F3754CD1A05192B7F5F68130C44E5BB5" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_FD8451215361DC605BE28130C44CF262" xlink:to="loc_dei_AmendmentFlag_F3754CD1A05192B7F5F68130C44E5BB5" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityEmergingGrowthCompany" xlink:label="loc_dei_EntityEmergingGrowthCompany_AE63B7C92C8501FFD3BA8130C44E3855" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_FD8451215361DC605BE28130C44CF262" xlink:to="loc_dei_EntityEmergingGrowthCompany_AE63B7C92C8501FFD3BA8130C44E3855" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntitySmallBusiness" xlink:label="loc_dei_EntitySmallBusiness_6B791518E46511A93C018130C44E20ED" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_FD8451215361DC605BE28130C44CF262" xlink:to="loc_dei_EntitySmallBusiness_6B791518E46511A93C018130C44E20ED" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityShellCompany" xlink:label="loc_dei_EntityShellCompany_7A3AE692BC535DF2012B81905DD7DDBE" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_FD8451215361DC605BE28130C44CF262" xlink:to="loc_dei_EntityShellCompany_7A3AE692BC535DF2012B81905DD7DDBE" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityCommonStockSharesOutstanding" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_3A4529F1004CAFFFAA7D8130C44FFC6A" xlink:type="locator" />
    <link:presentationArc order="13" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_FD8451215361DC605BE28130C44CF262" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_3A4529F1004CAFFFAA7D8130C44FFC6A" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityWellKnownSeasonedIssuer" xlink:label="loc_dei_EntityWellKnownSeasonedIssuer_FDDA318CC7EA86655B1D8130C44FABE8" xlink:type="locator" />
    <link:presentationArc order="14" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_FD8451215361DC605BE28130C44CF262" xlink:to="loc_dei_EntityWellKnownSeasonedIssuer_FDDA318CC7EA86655B1D8130C44FABE8" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityVoluntaryFilers" xlink:label="loc_dei_EntityVoluntaryFilers_4CF08C34ABB4A0A886E08130C44FBD04" xlink:type="locator" />
    <link:presentationArc order="15" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_FD8451215361DC605BE28130C44CF262" xlink:to="loc_dei_EntityVoluntaryFilers_4CF08C34ABB4A0A886E08130C44FBD04" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityCurrentReportingStatus" xlink:label="loc_dei_EntityCurrentReportingStatus_B97EAD2470CA6E08F0048130C44F258F" xlink:type="locator" />
    <link:presentationArc order="16" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_FD8451215361DC605BE28130C44CF262" xlink:to="loc_dei_EntityCurrentReportingStatus_B97EAD2470CA6E08F0048130C44F258F" xlink:type="arc" />
    <link:loc xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityPublicFloat" xlink:label="loc_dei_EntityPublicFloat_54279A7CD08A2318D6C48130C44F4F99" xlink:type="locator" />
    <link:presentationArc order="17" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityInformationLineItems_FD8451215361DC605BE28130C44CF262" xlink:to="loc_dei_EntityPublicFloat_54279A7CD08A2318D6C48130C44F4F99" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/EmployeeSavingsPlan" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CompensationAndRetirementDisclosureAbstract" xlink:label="loc_us-gaap_CompensationAndRetirementDisclosureAbstract_E79307049479C9B2E1E757AD232B85E7" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PensionAndOtherPostretirementBenefitsDisclosureTextBlock" xlink:label="loc_us-gaap_PensionAndOtherPostretirementBenefitsDisclosureTextBlock_40F4B2F883F7C24201DC57AD232B9425" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CompensationAndRetirementDisclosureAbstract_E79307049479C9B2E1E757AD232B85E7" xlink:to="loc_us-gaap_PensionAndOtherPostretirementBenefitsDisclosureTextBlock_40F4B2F883F7C24201DC57AD232B9425" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/EmployeeSavingsPlanNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CompensationAndRetirementDisclosureAbstract" xlink:label="loc_us-gaap_CompensationAndRetirementDisclosureAbstract_7B7CE8D633259EFCD5D052B94C0FE57E" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DefinedContributionPlanCostRecognized" xlink:label="loc_us-gaap_DefinedContributionPlanCostRecognized_1EFC8250BFA522B9CEEF52B94C120CB8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CompensationAndRetirementDisclosureAbstract_7B7CE8D633259EFCD5D052B94C0FE57E" xlink:to="loc_us-gaap_DefinedContributionPlanCostRecognized_1EFC8250BFA522B9CEEF52B94C120CB8" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/FairValueMeasurements" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_E1F669C741E0C100C17F57AD279F82CA" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueDisclosuresTextBlock" xlink:label="loc_us-gaap_FairValueDisclosuresTextBlock_AA66C34F7CB6E0E2BEEF57AD279F7B73" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_E1F669C741E0C100C17F57AD279F82CA" xlink:to="loc_us-gaap_FairValueDisclosuresTextBlock_AA66C34F7CB6E0E2BEEF57AD279F7B73" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/FairValueMeasurementsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_C1C8D3AC5B33A524E5FC57AD26103C1D" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_E230E3DBB7E1B274527557AD26107280" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_C1C8D3AC5B33A524E5FC57AD26103C1D" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_E230E3DBB7E1B274527557AD26107280" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_CEC29A699E3A18E20FCC57AD2611A25F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_E230E3DBB7E1B274527557AD26107280" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_CEC29A699E3A18E20FCC57AD2611A25F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_17331F9E4EEA3D3B9FE157AD26112654" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_CEC29A699E3A18E20FCC57AD2611A25F" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_17331F9E4EEA3D3B9FE157AD26112654" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_5BC67310F7393B60E34657AD26128561" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_17331F9E4EEA3D3B9FE157AD26112654" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_5BC67310F7393B60E34657AD26128561" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_80F6B0EEA1A7BCB0C8D757AD26124A60" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_E230E3DBB7E1B274527557AD26107280" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_80F6B0EEA1A7BCB0C8D757AD26124A60" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ImpairmentOfInvestments" xlink:label="loc_us-gaap_ImpairmentOfInvestments_56189162C4AB73AC2E6357AD2612EFD0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_80F6B0EEA1A7BCB0C8D757AD26124A60" xlink:to="loc_us-gaap_ImpairmentOfInvestments_56189162C4AB73AC2E6357AD2612EFD0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SecuritiesOwnedNotReadilyMarketable" xlink:label="loc_us-gaap_SecuritiesOwnedNotReadilyMarketable_43D9C52616C6516D64A657AD2613AB2E" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_80F6B0EEA1A7BCB0C8D757AD26124A60" xlink:to="loc_us-gaap_SecuritiesOwnedNotReadilyMarketable_43D9C52616C6516D64A657AD2613AB2E" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/FairValueMeasurementsScheduleOfAssetsMeasuredAtFairValueOnRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_3A70E389C0C7DEA60FEEB963643B8242" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_D549DF10D81104D96B13B963643B8F0B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_3A70E389C0C7DEA60FEEB963643B8242" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_D549DF10D81104D96B13B963643B8F0B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_62B0AA32D88860E5AF0CB969BCB8CA9F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_D549DF10D81104D96B13B963643B8F0B" xlink:to="loc_us-gaap_FinancialInstrumentAxis_62B0AA32D88860E5AF0CB969BCB8CA9F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1DABF8A71EF8AB3DF116B969BCC10074" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_62B0AA32D88860E5AF0CB969BCB8CA9F" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1DABF8A71EF8AB3DF116B969BCC10074" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CorporateBondSecuritiesMember" xlink:label="loc_us-gaap_CorporateBondSecuritiesMember_524537330FDFB8DC3402B96A13D80B2E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1DABF8A71EF8AB3DF116B969BCC10074" xlink:to="loc_us-gaap_CorporateBondSecuritiesMember_524537330FDFB8DC3402B96A13D80B2E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_USTreasuryAndGovernmentMember" xlink:label="loc_us-gaap_USTreasuryAndGovernmentMember_ED2041B5F7171ED42259B96F5E020DA3" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1DABF8A71EF8AB3DF116B969BCC10074" xlink:to="loc_us-gaap_USTreasuryAndGovernmentMember_ED2041B5F7171ED42259B96F5E020DA3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SovereignDebtSecuritiesMember" xlink:label="loc_us-gaap_SovereignDebtSecuritiesMember_297B966139773F6C6E41B96B7D72E410" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1DABF8A71EF8AB3DF116B969BCC10074" xlink:to="loc_us-gaap_SovereignDebtSecuritiesMember_297B966139773F6C6E41B96B7D72E410" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_MunicipalBondsAndSovereignDebtSecuritiesMember" xlink:label="loc_regn_MunicipalBondsAndSovereignDebtSecuritiesMember_87505B5B168467270CCDB96BEC3B3850" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1DABF8A71EF8AB3DF116B969BCC10074" xlink:to="loc_regn_MunicipalBondsAndSovereignDebtSecuritiesMember_87505B5B168467270CCDB96BEC3B3850" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommercialPaperMember" xlink:label="loc_us-gaap_CommercialPaperMember_BB50F14301283033A521B96C2C791F51" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1DABF8A71EF8AB3DF116B969BCC10074" xlink:to="loc_us-gaap_CommercialPaperMember_BB50F14301283033A521B96C2C791F51" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CertificatesOfDepositMember" xlink:label="loc_us-gaap_CertificatesOfDepositMember_9C53F0C7CFA3AEC5B143B96C70552A1C" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_1DABF8A71EF8AB3DF116B969BCC10074" xlink:to="loc_us-gaap_CertificatesOfDepositMember_9C53F0C7CFA3AEC5B143B96C70552A1C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueByMeasurementBasisAxis" xlink:label="loc_us-gaap_FairValueByMeasurementBasisAxis_8644928CDB5208FBBAD3B963643B37EF" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_D549DF10D81104D96B13B963643B8F0B" xlink:to="loc_us-gaap_FairValueByMeasurementBasisAxis_8644928CDB5208FBBAD3B963643B37EF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueDisclosureItemAmountsDomain" xlink:label="loc_us-gaap_FairValueDisclosureItemAmountsDomain_9D47EF2B78CAE1DE80AFB963643BFB1D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementBasisAxis_8644928CDB5208FBBAD3B963643B37EF" xlink:to="loc_us-gaap_FairValueDisclosureItemAmountsDomain_9D47EF2B78CAE1DE80AFB963643BFB1D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PortionAtFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_9C29870092C689701BCCB963643CF8C2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_9D47EF2B78CAE1DE80AFB963643BFB1D" xlink:to="loc_us-gaap_PortionAtFairValueFairValueDisclosureMember_9C29870092C689701BCCB963643CF8C2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EstimateOfFairValueFairValueDisclosureMember" xlink:label="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_AEDE1E818564C9CF7F2FB963643C93AD" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosureItemAmountsDomain_9D47EF2B78CAE1DE80AFB963643BFB1D" xlink:to="loc_us-gaap_EstimateOfFairValueFairValueDisclosureMember_AEDE1E818564C9CF7F2FB963643C93AD" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ClassificationOfInvestmentAxis" xlink:label="loc_regn_ClassificationOfInvestmentAxis_29A274F73A5571317BF0B963643D4830" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_D549DF10D81104D96B13B963643B8F0B" xlink:to="loc_regn_ClassificationOfInvestmentAxis_29A274F73A5571317BF0B963643D4830" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ClassificationOfInvestmentDomain" xlink:label="loc_regn_ClassificationOfInvestmentDomain_26C7E423ABFEC2A426B1B963643D5714" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ClassificationOfInvestmentAxis_29A274F73A5571317BF0B963643D4830" xlink:to="loc_regn_ClassificationOfInvestmentDomain_26C7E423ABFEC2A426B1B963643D5714" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_UnrestrictedMember" xlink:label="loc_regn_UnrestrictedMember_8F4A95FD35AB01721B23B963643DFAD5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ClassificationOfInvestmentDomain_26C7E423ABFEC2A426B1B963643D5714" xlink:to="loc_regn_UnrestrictedMember_8F4A95FD35AB01721B23B963643DFAD5" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_RestrictedMember" xlink:label="loc_regn_RestrictedMember_0D7D495709BB48E7E494B963643D26C5" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ClassificationOfInvestmentDomain_26C7E423ABFEC2A426B1B963643D5714" xlink:to="loc_regn_RestrictedMember_0D7D495709BB48E7E494B963643D26C5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_DB9204DD5B97F73048E2B963643ED81C" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_D549DF10D81104D96B13B963643B8F0B" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_DB9204DD5B97F73048E2B963643ED81C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_21C3EAC4878B70D689CDB963643E68FB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_DB9204DD5B97F73048E2B963643ED81C" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_21C3EAC4878B70D689CDB963643E68FB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_CC8C0189B685C6337A67B963643EF134" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_21C3EAC4878B70D689CDB963643E68FB" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_CC8C0189B685C6337A67B963643EF134" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_B7DD89C8E14793BE9CC0B963643F39D4" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_D549DF10D81104D96B13B963643B8F0B" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_B7DD89C8E14793BE9CC0B963643F39D4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_84456D7634743EA4F07EB963643F02CA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_B7DD89C8E14793BE9CC0B963643F39D4" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_84456D7634743EA4F07EB963643F02CA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueInputsLevel1Member" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_ACA48E23887EA92EBB2BB963643F7D71" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_84456D7634743EA4F07EB963643F02CA" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_ACA48E23887EA92EBB2BB963643F7D71" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueInputsLevel2Member" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_A809C6CAF5E2EA861650B963643F6F34" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_84456D7634743EA4F07EB963643F02CA" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_A809C6CAF5E2EA861650B963643F6F34" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_F123A14B971809EA3A62B9636440A74F" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_D549DF10D81104D96B13B963643B8F0B" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_F123A14B971809EA3A62B9636440A74F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleSecuritiesAbstract" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesAbstract_F31F4C1E5B14B2A569CCB9636440397D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_F123A14B971809EA3A62B9636440A74F" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesAbstract_F31F4C1E5B14B2A569CCB9636440397D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_24D6103CC4CA2E9301EAB9686FA5084B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesAbstract_F31F4C1E5B14B2A569CCB9636440397D" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_24D6103CC4CA2E9301EAB9686FA5084B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquitySecuritiesFvNi" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_27661A953D6C613CB13AB96364427485" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_F123A14B971809EA3A62B9636440A74F" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_27661A953D6C613CB13AB96364427485" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MarketableSecurities" xlink:label="loc_us-gaap_MarketableSecurities_5B73CBBDA5DE98FFC41FB96364438F8C" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_F123A14B971809EA3A62B9636440A74F" xlink:to="loc_us-gaap_MarketableSecurities_5B73CBBDA5DE98FFC41FB96364438F8C" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/FairValueMeasurementsTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueDisclosuresAbstract" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_35045D581301DE19704C57AD279ADD00" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringAndNonrecurringBasisTableTextBlock" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringAndNonrecurringBasisTableTextBlock_B6FBE7F14B493C1A266957AD279B2C81" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_35045D581301DE19704C57AD279ADD00" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringAndNonrecurringBasisTableTextBlock_B6FBE7F14B493C1A266957AD279B2C81" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/IncomeTaxes" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_6C1D41E8628A96AD481B57AD23228BA7" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxDisclosureTextBlock" xlink:label="loc_us-gaap_IncomeTaxDisclosureTextBlock_73BF3B73A70EC6A490A857AD2322D3D9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_6C1D41E8628A96AD481B57AD23228BA7" xlink:to="loc_us-gaap_IncomeTaxDisclosureTextBlock_73BF3B73A70EC6A490A857AD2322D3D9" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/IncomeTaxesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_CFDCE9250634C18F6FCF9B197A811CBA" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_E7B4199547F280B2131F9B197A85A65B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_CFDCE9250634C18F6FCF9B197A811CBA" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_E7B4199547F280B2131F9B197A85A65B" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_TaxCutsAndJobsActOf2017IncompleteAccountingProvisionalIncomeTaxExpenseBenefit" xlink:label="loc_regn_TaxCutsAndJobsActOf2017IncompleteAccountingProvisionalIncomeTaxExpenseBenefit_A14F5FA552BA0B6CF4079B197A863353" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_CFDCE9250634C18F6FCF9B197A811CBA" xlink:to="loc_regn_TaxCutsAndJobsActOf2017IncompleteAccountingProvisionalIncomeTaxExpenseBenefit_A14F5FA552BA0B6CF4079B197A863353" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_TaxCutsandJobsActof2017IncompleteAccountingChangeinTaxRateProvisionalIncomeTaxExpenseBenefit" xlink:label="loc_regn_TaxCutsandJobsActof2017IncompleteAccountingChangeinTaxRateProvisionalIncomeTaxExpenseBenefit_41119EF7F2B77CB0DF629B197A869D04" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_CFDCE9250634C18F6FCF9B197A811CBA" xlink:to="loc_regn_TaxCutsandJobsActof2017IncompleteAccountingChangeinTaxRateProvisionalIncomeTaxExpenseBenefit_41119EF7F2B77CB0DF629B197A869D04" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_TaxCutsandJobsActof2017MeasurementPeriodAdjustmentIncomeTaxExpenseBenefit" xlink:label="loc_regn_TaxCutsandJobsActof2017MeasurementPeriodAdjustmentIncomeTaxExpenseBenefit_5B73194AA3BA70AD64F39B197A86991A" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_CFDCE9250634C18F6FCF9B197A811CBA" xlink:to="loc_regn_TaxCutsandJobsActof2017MeasurementPeriodAdjustmentIncomeTaxExpenseBenefit_5B73194AA3BA70AD64F39B197A86991A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_45304429614FED1A26B49B197A86AF26" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_CFDCE9250634C18F6FCF9B197A811CBA" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_45304429614FED1A26B49B197A86AF26" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate_D5327DCBF172BBD0754B9B197A87D213" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_CFDCE9250634C18F6FCF9B197A811CBA" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate_D5327DCBF172BBD0754B9B197A87D213" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/IncomeTaxesScheduleOfComponentsOfIncomeTaxExpenseDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_A86D41C6490E6F44061D819882060310" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_6F8EE8649DFF663983F08198820649E2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_A86D41C6490E6F44061D819882060310" xlink:to="loc_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_6F8EE8649DFF663983F08198820649E2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CurrentFederalTaxExpenseBenefit" xlink:label="loc_us-gaap_CurrentFederalTaxExpenseBenefit_E303BBCE11C3FA5F35D8819882077A72" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_6F8EE8649DFF663983F08198820649E2" xlink:to="loc_us-gaap_CurrentFederalTaxExpenseBenefit_E303BBCE11C3FA5F35D8819882077A72" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CurrentStateAndLocalTaxExpenseBenefit" xlink:label="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_66F3F9EFFB9E3805BC12819882073E55" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_6F8EE8649DFF663983F08198820649E2" xlink:to="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_66F3F9EFFB9E3805BC12819882073E55" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CurrentForeignTaxExpenseBenefit" xlink:label="loc_us-gaap_CurrentForeignTaxExpenseBenefit_EB3B2CC6E29719A56D98819882071222" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_6F8EE8649DFF663983F08198820649E2" xlink:to="loc_us-gaap_CurrentForeignTaxExpenseBenefit_EB3B2CC6E29719A56D98819882071222" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_870F272111965912A81E81988208BD15" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_6F8EE8649DFF663983F08198820649E2" xlink:to="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_870F272111965912A81E81988208BD15" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract_FFA2B00F50A6A5C887AA8198820824E7" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_A86D41C6490E6F44061D819882060310" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract_FFA2B00F50A6A5C887AA8198820824E7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredFederalIncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_457919747C51B6DF9E44819882089266" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract_FFA2B00F50A6A5C887AA8198820824E7" xlink:to="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_457919747C51B6DF9E44819882089266" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_E67B502ACC38ACBE24AD819882080F09" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract_FFA2B00F50A6A5C887AA8198820824E7" xlink:to="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_E67B502ACC38ACBE24AD819882080F09" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredForeignIncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_E9B18265FDAF5DDEE58281988209A1F4" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract_FFA2B00F50A6A5C887AA8198820824E7" xlink:to="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_E9B18265FDAF5DDEE58281988209A1F4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_897BEA47E2104E8917178198820935E7" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract_FFA2B00F50A6A5C887AA8198820824E7" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_897BEA47E2104E8917178198820935E7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_2DD6570542B5ADBB3202819882098B3A" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_A86D41C6490E6F44061D819882060310" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_2DD6570542B5ADBB3202819882098B3A" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/IncomeTaxesScheduleOfDeferredTaxAssetsAndLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_4D7A18BB163E1977724DB05E86D95E1C" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ComponentsOfDeferredTaxAssetsAbstract" xlink:label="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_C7EA19C989AFB733D4C5B05E86E5252C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_4D7A18BB163E1977724DB05E86D95E1C" xlink:to="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_C7EA19C989AFB733D4C5B05E86E5252C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefits" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefits_12E36378CE83145F1A0FB05E86F15B95" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_C7EA19C989AFB733D4C5B05E86E5252C" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefits_12E36378CE83145F1A0FB05E86F15B95" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsPropertyPlantAndEquipment" xlink:label="loc_us-gaap_DeferredTaxAssetsPropertyPlantAndEquipment_6F5CE744D11A1DA40E3BB05E86F4491A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_C7EA19C989AFB733D4C5B05E86E5252C" xlink:to="loc_us-gaap_DeferredTaxAssetsPropertyPlantAndEquipment_6F5CE744D11A1DA40E3BB05E86F4491A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsDeferredIncome" xlink:label="loc_us-gaap_DeferredTaxAssetsDeferredIncome_8658A692364846BBA187B05E86F4DFD5" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_C7EA19C989AFB733D4C5B05E86E5252C" xlink:to="loc_us-gaap_DeferredTaxAssetsDeferredIncome_8658A692364846BBA187B05E86F4DFD5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities_E9B42BC804F663E43C1EB05E86F55E57" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_C7EA19C989AFB733D4C5B05E86E5252C" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities_E9B42BC804F663E43C1EB05E86F55E57" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsOther" xlink:label="loc_us-gaap_DeferredTaxAssetsOther_6D6314EC4E375AA9A358B05E86F54A93" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_C7EA19C989AFB733D4C5B05E86E5252C" xlink:to="loc_us-gaap_DeferredTaxAssetsOther_6D6314EC4E375AA9A358B05E86F54A93" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsGross" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_467359E75F8600D7D54CB05E86F6BD74" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_C7EA19C989AFB733D4C5B05E86E5252C" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_467359E75F8600D7D54CB05E86F6BD74" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsValuationAllowance" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_7D6C419B113E9175140BB05E86F60658" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_C7EA19C989AFB733D4C5B05E86E5252C" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_7D6C419B113E9175140BB05E86F60658" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsNet" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_6EE94AF0BFE2060391DDB05E86F7301A" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxAssetsAbstract_C7EA19C989AFB733D4C5B05E86E5252C" xlink:to="loc_us-gaap_DeferredTaxAssetsNet_6EE94AF0BFE2060391DDB05E86F7301A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ComponentsOfDeferredTaxLiabilitiesAbstract" xlink:label="loc_us-gaap_ComponentsOfDeferredTaxLiabilitiesAbstract_F9794F60DEFAE2DAF830B05E86F72AA1" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_4D7A18BB163E1977724DB05E86D95E1C" xlink:to="loc_us-gaap_ComponentsOfDeferredTaxLiabilitiesAbstract_F9794F60DEFAE2DAF830B05E86F72AA1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_1B116E908706F0F2A503B05E86F8B04A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxLiabilitiesAbstract_F9794F60DEFAE2DAF830B05E86F72AA1" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesPropertyPlantAndEquipment_1B116E908706F0F2A503B05E86F8B04A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxLiabilitiesOther" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesOther_6AF6C676ED8C466FFA95B05E86F9A719" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxLiabilitiesAbstract_F9794F60DEFAE2DAF830B05E86F72AA1" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesOther_6AF6C676ED8C466FFA95B05E86F9A719" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_4310095D443B94E3BB7BB05E86F9AEDA" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ComponentsOfDeferredTaxLiabilitiesAbstract_F9794F60DEFAE2DAF830B05E86F72AA1" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilities_4310095D443B94E3BB7BB05E86F9AEDA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNet" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_C08DB57D1767AA47E943B05E86FA8522" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_4D7A18BB163E1977724DB05E86D95E1C" xlink:to="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_C08DB57D1767AA47E943B05E86FA8522" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/IncomeTaxesScheduleOfEffectiveIncomeTaxRateReconciliationDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_C79352D1001317B5DC6096B3ADE087E0" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_548D61A5EEAB645BD24496B3ADE0D51A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_C79352D1001317B5DC6096B3ADE087E0" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_548D61A5EEAB645BD24496B3ADE0D51A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationChangeInEnactedTaxRate" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInEnactedTaxRate_5351833F3B8B73FEEB2096B3ADE1EABC" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_C79352D1001317B5DC6096B3ADE087E0" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInEnactedTaxRate_5351833F3B8B73FEEB2096B3ADE1EABC" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_EffectiveIncomeTaxRateReconciliationSaleOfNonInventoryRelatedAssetsBetweenForeignSubsidiariesPercent" xlink:label="loc_regn_EffectiveIncomeTaxRateReconciliationSaleOfNonInventoryRelatedAssetsBetweenForeignSubsidiariesPercent_E6CCF07F66C514B4F56496B3ADE198A6" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_C79352D1001317B5DC6096B3ADE087E0" xlink:to="loc_regn_EffectiveIncomeTaxRateReconciliationSaleOfNonInventoryRelatedAssetsBetweenForeignSubsidiariesPercent_E6CCF07F66C514B4F56496B3ADE198A6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost_15BFC7AD645749DE8B5596B3ADE18EB9" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_C79352D1001317B5DC6096B3ADE087E0" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost_15BFC7AD645749DE8B5596B3ADE18EB9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_C7DBB15B91A948BF485196B3ADE2A052" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_C79352D1001317B5DC6096B3ADE087E0" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_C7DBB15B91A948BF485196B3ADE2A052" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationTaxCredits" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCredits_60BB24DDEF504C8DB12396B3ADE73F41" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_C79352D1001317B5DC6096B3ADE087E0" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCredits_60BB24DDEF504C8DB12396B3ADE73F41" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationDeductionsMedicarePrescriptionDrugBenefit" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationDeductionsMedicarePrescriptionDrugBenefit_A1CEFB225E9873C90E3196B3ADE8D102" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_C79352D1001317B5DC6096B3ADE087E0" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationDeductionsMedicarePrescriptionDrugBenefit_A1CEFB225E9873C90E3196B3ADE8D102" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_EffectiveIncomeTaxRateReconciliationDeductionForeignIntangibleIncomePercent" xlink:label="loc_regn_EffectiveIncomeTaxRateReconciliationDeductionForeignIntangibleIncomePercent_7F7EFA026A9787901DB296B3ADE8E89A" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_C79352D1001317B5DC6096B3ADE087E0" xlink:to="loc_regn_EffectiveIncomeTaxRateReconciliationDeductionForeignIntangibleIncomePercent_7F7EFA026A9787901DB296B3ADE8E89A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationDeductionsQualifiedProductionActivities" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationDeductionsQualifiedProductionActivities_83380753B3D91A03169096B3ADE87C5A" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_C79352D1001317B5DC6096B3ADE087E0" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationDeductionsQualifiedProductionActivities_83380753B3D91A03169096B3ADE87C5A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_0E45C4BD585AF14CFA4096B3ADE2E294" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_C79352D1001317B5DC6096B3ADE087E0" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_0E45C4BD585AF14CFA4096B3ADE2E294" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther_C851D58697119F295C5496B3ADE9667C" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_C79352D1001317B5DC6096B3ADE087E0" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther_C851D58697119F295C5496B3ADE9667C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_16644626486CFFA1F0CB96B3ADE9ACEC" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_C79352D1001317B5DC6096B3ADE087E0" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_16644626486CFFA1F0CB96B3ADE9ACEC" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/IncomeTaxesScheduleOfIncomeBeforeIncomeTaxDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_623D6A3B38C70BB891F157AD2314EB5F" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLossCarryforwardsTable" xlink:label="loc_us-gaap_OperatingLossCarryforwardsTable_DEEA452D6DCAAC29206E57AD231451A1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_623D6A3B38C70BB891F157AD2314EB5F" xlink:to="loc_us-gaap_OperatingLossCarryforwardsTable_DEEA452D6DCAAC29206E57AD231451A1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxAuthorityAxis" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_6E1FA29B2FEDC0807EBC57AD23159177" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_DEEA452D6DCAAC29206E57AD231451A1" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_6E1FA29B2FEDC0807EBC57AD23159177" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_F54FEC36624282E509BA57AD2315643D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_6E1FA29B2FEDC0807EBC57AD23159177" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_F54FEC36624282E509BA57AD2315643D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DomesticCountryMember" xlink:label="loc_us-gaap_DomesticCountryMember_1C7A18DF337EB2C3BBF957AD23161019" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_F54FEC36624282E509BA57AD2315643D" xlink:to="loc_us-gaap_DomesticCountryMember_1C7A18DF337EB2C3BBF957AD23161019" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ForeignCountryMember" xlink:label="loc_us-gaap_ForeignCountryMember_3AE156F6CEC000739B8357AD2316B42B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_F54FEC36624282E509BA57AD2315643D" xlink:to="loc_us-gaap_ForeignCountryMember_3AE156F6CEC000739B8357AD2316B42B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLossCarryforwardsLineItems" xlink:label="loc_us-gaap_OperatingLossCarryforwardsLineItems_D5436CAA8687817B5D2257AD23168671" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_DEEA452D6DCAAC29206E57AD231451A1" xlink:to="loc_us-gaap_OperatingLossCarryforwardsLineItems_D5436CAA8687817B5D2257AD23168671" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_0A4F1471DE1F850BE28D57AD2316C3D5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_D5436CAA8687817B5D2257AD23168671" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_0A4F1471DE1F850BE28D57AD2316C3D5" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/IncomeTaxesScheduleOfUnrecognizedTaxBenefitsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_8DC485E8AB4AF6AA8AF1BFE14027EBBB" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward" xlink:label="loc_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward_39A896E502D217B0F5D2BFE140278CFF" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_8DC485E8AB4AF6AA8AF1BFE14027EBBB" xlink:to="loc_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward_39A896E502D217B0F5D2BFE140278CFF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UnrecognizedTaxBenefits" xlink:label="loc_us-gaap_UnrecognizedTaxBenefits_674436AB7EE0F97B1AAFBFE14027D0F7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward_39A896E502D217B0F5D2BFE140278CFF" xlink:to="loc_us-gaap_UnrecognizedTaxBenefits_674436AB7EE0F97B1AAFBFE14027D0F7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions_30CDE072ABEBAD225A72BFE1402BF2F6" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward_39A896E502D217B0F5D2BFE140278CFF" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions_30CDE072ABEBAD225A72BFE1402BF2F6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsPeriodIncreaseDecrease" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsPeriodIncreaseDecrease_E20DBCF54EC57C39338EBFE1402B3251" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward_39A896E502D217B0F5D2BFE140278CFF" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsPeriodIncreaseDecrease_E20DBCF54EC57C39338EBFE1402B3251" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_UnrecognizedTaxBenefitsDecreaseResultingFromSettlementsWithTaxingAuthoritiesAndReductionResultingFromLapseOfApplicableStatuteOfLimitations" xlink:label="loc_regn_UnrecognizedTaxBenefitsDecreaseResultingFromSettlementsWithTaxingAuthoritiesAndReductionResultingFromLapseOfApplicableStatuteOfLimitations_6DBBCBB0539F7D64F336BFE1433FE0C3" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward_39A896E502D217B0F5D2BFE140278CFF" xlink:to="loc_regn_UnrecognizedTaxBenefitsDecreaseResultingFromSettlementsWithTaxingAuthoritiesAndReductionResultingFromLapseOfApplicableStatuteOfLimitations_6DBBCBB0539F7D64F336BFE1433FE0C3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UnrecognizedTaxBenefits" xlink:label="loc_us-gaap_UnrecognizedTaxBenefits_2B7E7E3DEA97C070A938BFE1402CC1D4" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward_39A896E502D217B0F5D2BFE140278CFF" xlink:to="loc_us-gaap_UnrecognizedTaxBenefits_2B7E7E3DEA97C070A938BFE1402CC1D4" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/IncomeTaxesTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_150E4A7C7C8289581D5B52B94C058E8B" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfIncomeBeforeIncomeTaxDomesticAndForeignTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfIncomeBeforeIncomeTaxDomesticAndForeignTableTextBlock_17543E0A89F730D3499052B94C062121" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_150E4A7C7C8289581D5B52B94C058E8B" xlink:to="loc_us-gaap_ScheduleOfIncomeBeforeIncomeTaxDomesticAndForeignTableTextBlock_17543E0A89F730D3499052B94C062121" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock_1104FAF1A8FA93E6907C52B94C0696DC" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_150E4A7C7C8289581D5B52B94C058E8B" xlink:to="loc_us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock_1104FAF1A8FA93E6907C52B94C0696DC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock_AC8B2C03D69437A4008352B94C06C226" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_150E4A7C7C8289581D5B52B94C058E8B" xlink:to="loc_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock_AC8B2C03D69437A4008352B94C06C226" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock_12A15DF52CF498A54C5C52B94C06ACF9" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_150E4A7C7C8289581D5B52B94C058E8B" xlink:to="loc_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock_12A15DF52CF498A54C5C52B94C06ACF9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfUnrecognizedTaxBenefitsRollForwardTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfUnrecognizedTaxBenefitsRollForwardTableTextBlock_FC55E1E9BABB4F3663FF52B94C0737C0" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_150E4A7C7C8289581D5B52B94C058E8B" xlink:to="loc_us-gaap_ScheduleOfUnrecognizedTaxBenefitsRollForwardTableTextBlock_FC55E1E9BABB4F3663FF52B94C0737C0" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/Inventories" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryDisclosureAbstract" xlink:label="loc_us-gaap_InventoryDisclosureAbstract_007B96EFA1976101187957AD24814D00" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryDisclosureTextBlock" xlink:label="loc_us-gaap_InventoryDisclosureTextBlock_44CB795C410298878D1557AD24816564" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_007B96EFA1976101187957AD24814D00" xlink:to="loc_us-gaap_InventoryDisclosureTextBlock_44CB795C410298878D1557AD24816564" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/InventoriesScheduleOfInventoriesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryDisclosureAbstract" xlink:label="loc_us-gaap_InventoryDisclosureAbstract_B6C3CC618D41C4371FD057AD2476D484" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryRawMaterialsNetOfReserves" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_DEB7DF5BFD6FDEF2F27757AD24767EF9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_B6C3CC618D41C4371FD057AD2476D484" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_DEB7DF5BFD6FDEF2F27757AD24767EF9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryWorkInProcessNetOfReserves" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_670FC7D19F4224296CBD57AD2477D105" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_B6C3CC618D41C4371FD057AD2476D484" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_670FC7D19F4224296CBD57AD2477D105" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_EB4C704940A5C7DAB14D57AD247700AB" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_B6C3CC618D41C4371FD057AD2476D484" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_EB4C704940A5C7DAB14D57AD247700AB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherInventoryNetOfReserves" xlink:label="loc_us-gaap_OtherInventoryNetOfReserves_A3FFF5FDD7F9EBDD067457AD2477B47C" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_B6C3CC618D41C4371FD057AD2476D484" xlink:to="loc_us-gaap_OtherInventoryNetOfReserves_A3FFF5FDD7F9EBDD067457AD2477B47C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryNet" xlink:label="loc_us-gaap_InventoryNet_6EEE01A772B3CA1A054457AD24774171" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_B6C3CC618D41C4371FD057AD2476D484" xlink:to="loc_us-gaap_InventoryNet_6EEE01A772B3CA1A054457AD24774171" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/InventoriesTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryDisclosureAbstract" xlink:label="loc_us-gaap_InventoryDisclosureAbstract_DE6ABD8EBEDBC0AEE98657AD247C5C2B" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfInventoryCurrentTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfInventoryCurrentTableTextBlock_D41484177B45E61D0D8757AD247C0E24" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InventoryDisclosureAbstract_DE6ABD8EBEDBC0AEE98657AD247C5C2B" xlink:to="loc_us-gaap_ScheduleOfInventoryCurrentTableTextBlock_D41484177B45E61D0D8757AD247C0E24" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/LegalMatters" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_C1BF2ECC4E68904B5B1C57AD22795A48" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LegalMattersAndContingenciesTextBlock" xlink:label="loc_us-gaap_LegalMattersAndContingenciesTextBlock_567CDE2DCC91EA54288357AD227A50B2" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_C1BF2ECC4E68904B5B1C57AD22795A48" xlink:to="loc_us-gaap_LegalMattersAndContingenciesTextBlock_567CDE2DCC91EA54288357AD227A50B2" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/LegalMattersNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_10E10B23CCA8094E302457AD2269EDAD" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LossContingenciesTable" xlink:label="loc_us-gaap_LossContingenciesTable_CACB8426EF7B4DB5FECD57AD2269B22E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_10E10B23CCA8094E302457AD2269EDAD" xlink:to="loc_us-gaap_LossContingenciesTable_CACB8426EF7B4DB5FECD57AD2269B22E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_LitigationCaseAxis" xlink:label="loc_srt_LitigationCaseAxis_6FBB8B35AF0C9CBE65D957AD226AD3A0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesTable_CACB8426EF7B4DB5FECD57AD2269B22E" xlink:to="loc_srt_LitigationCaseAxis_6FBB8B35AF0C9CBE65D957AD226AD3A0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_LitigationCaseTypeDomain" xlink:label="loc_srt_LitigationCaseTypeDomain_6B094206BE303E8E51F857AD226AC185" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_LitigationCaseAxis_6FBB8B35AF0C9CBE65D957AD226AD3A0" xlink:to="loc_srt_LitigationCaseTypeDomain_6B094206BE303E8E51F857AD226AC185" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Regeneronv.s.MerusN.V.Member" xlink:label="loc_regn_Regeneronv.s.MerusN.V.Member_231CDFE18EAC5B7D19C757AD226BEE58" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_LitigationCaseTypeDomain_6B094206BE303E8E51F857AD226AC185" xlink:to="loc_regn_Regeneronv.s.MerusN.V.Member_231CDFE18EAC5B7D19C757AD226BEE58" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Amgenv.s.RegeneronMember" xlink:label="loc_regn_Amgenv.s.RegeneronMember_02277DA8168FBBEB90BF57AD226CF5B0" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_LitigationCaseTypeDomain_6B094206BE303E8E51F857AD226AC185" xlink:to="loc_regn_Amgenv.s.RegeneronMember_02277DA8168FBBEB90BF57AD226CF5B0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LitigationStatusAxis" xlink:label="loc_us-gaap_LitigationStatusAxis_AFC1983340BD627971D257AD226CD3F7" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesTable_CACB8426EF7B4DB5FECD57AD2269B22E" xlink:to="loc_us-gaap_LitigationStatusAxis_AFC1983340BD627971D257AD226CD3F7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LitigationStatusDomain" xlink:label="loc_us-gaap_LitigationStatusDomain_097BD1B642AF8F120D5157AD226C2524" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LitigationStatusAxis_AFC1983340BD627971D257AD226CD3F7" xlink:to="loc_us-gaap_LitigationStatusDomain_097BD1B642AF8F120D5157AD226C2524" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SettledLitigationMember" xlink:label="loc_us-gaap_SettledLitigationMember_701385D53826AAC28EB657AD226DC76F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LitigationStatusDomain_097BD1B642AF8F120D5157AD226C2524" xlink:to="loc_us-gaap_SettledLitigationMember_701385D53826AAC28EB657AD226DC76F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PendingLitigationMember" xlink:label="loc_us-gaap_PendingLitigationMember_37F2FB913594256032A457AD226D1868" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LitigationStatusDomain_097BD1B642AF8F120D5157AD226C2524" xlink:to="loc_us-gaap_PendingLitigationMember_37F2FB913594256032A457AD226D1868" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LossContingenciesLineItems" xlink:label="loc_us-gaap_LossContingenciesLineItems_E00E32DA7181A4549D6C57AD226DD7F1" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesTable_CACB8426EF7B4DB5FECD57AD2269B22E" xlink:to="loc_us-gaap_LossContingenciesLineItems_E00E32DA7181A4549D6C57AD226DD7F1" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_LitigationSettlementConsiderationTransferredCommonStockPurchasedShares" xlink:label="loc_regn_LitigationSettlementConsiderationTransferredCommonStockPurchasedShares_8C4282AEA7758DE8B20457AD226E3F9E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_E00E32DA7181A4549D6C57AD226DD7F1" xlink:to="loc_regn_LitigationSettlementConsiderationTransferredCommonStockPurchasedShares_8C4282AEA7758DE8B20457AD226E3F9E" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_LitigationSettlementConsiderationTransferredCommonStockPurchasedAmount" xlink:label="loc_regn_LitigationSettlementConsiderationTransferredCommonStockPurchasedAmount_87ECEA185EBCE173697C57AD226EA23C" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_E00E32DA7181A4549D6C57AD226DD7F1" xlink:to="loc_regn_LitigationSettlementConsiderationTransferredCommonStockPurchasedAmount_87ECEA185EBCE173697C57AD226EA23C" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_LossContingencyDamagesSoughtperunitproduced." xlink:label="loc_regn_LossContingencyDamagesSoughtperunitproduced._54A818309B57F44406B957AD226EA05D" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_E00E32DA7181A4549D6C57AD226DD7F1" xlink:to="loc_regn_LossContingencyDamagesSoughtperunitproduced._54A818309B57F44406B957AD226EA05D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LossContingencyDamagesSoughtValue" xlink:label="loc_us-gaap_LossContingencyDamagesSoughtValue_0D311252869EDB54086057AD226F93DF" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LossContingenciesLineItems_E00E32DA7181A4549D6C57AD226DD7F1" xlink:to="loc_us-gaap_LossContingencyDamagesSoughtValue_0D311252869EDB54086057AD226F93DF" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/LongTermIncentivePlans" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_76E870161F0F186A2C2257AD23AC6A91" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_BE2F2189F321132A526157AD23ACCB08" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_76E870161F0F186A2C2257AD23AC6A91" xlink:to="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_BE2F2189F321132A526157AD23ACCB08" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/LongTermIncentivePlansNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_C450F14DAE6F52D209DE57AD2394A8F9" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_C48E5D341BE6B67B22A857AD2394544A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_C450F14DAE6F52D209DE57AD2394A8F9" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_C48E5D341BE6B67B22A857AD2394544A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PlanNameAxis" xlink:label="loc_us-gaap_PlanNameAxis_9CDE40DD62D592CFB07B57AD23946290" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_C48E5D341BE6B67B22A857AD2394544A" xlink:to="loc_us-gaap_PlanNameAxis_9CDE40DD62D592CFB07B57AD23946290" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PlanNameDomain" xlink:label="loc_us-gaap_PlanNameDomain_C4C8305503C6A71370F357AD239590E5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameAxis_9CDE40DD62D592CFB07B57AD23946290" xlink:to="loc_us-gaap_PlanNameDomain_C4C8305503C6A71370F357AD239590E5" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_LongTermIncentivePlan2000Member" xlink:label="loc_regn_LongTermIncentivePlan2000Member_DCCCF3F274971323C13757AD23952F88" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_C4C8305503C6A71370F357AD239590E5" xlink:to="loc_regn_LongTermIncentivePlan2000Member_DCCCF3F274971323C13757AD23952F88" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_AmendedRestatedLongTermIncentivePlan2014Member" xlink:label="loc_regn_AmendedRestatedLongTermIncentivePlan2014Member_5BF2466017E4DADC5AC957AD239691C0" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_C4C8305503C6A71370F357AD239590E5" xlink:to="loc_regn_AmendedRestatedLongTermIncentivePlan2014Member_5BF2466017E4DADC5AC957AD239691C0" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_LongTermIncentivePlan2014Member" xlink:label="loc_regn_LongTermIncentivePlan2014Member_2B08769FB2574ADCB34257AD23968C99" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_C4C8305503C6A71370F357AD239590E5" xlink:to="loc_regn_LongTermIncentivePlan2014Member_2B08769FB2574ADCB34257AD23968C99" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_4F9E5B9654CFC1616E3857AD23962559" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_C48E5D341BE6B67B22A857AD2394544A" xlink:to="loc_us-gaap_AwardTypeAxis_4F9E5B9654CFC1616E3857AD23962559" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_673A334F6F5364A4A76657AD239700FD" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_4F9E5B9654CFC1616E3857AD23962559" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_673A334F6F5364A4A76657AD239700FD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeStockOptionMember" xlink:label="loc_us-gaap_EmployeeStockOptionMember_E03AE029E84451E3E2AE57AD23974393" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_673A334F6F5364A4A76657AD239700FD" xlink:to="loc_us-gaap_EmployeeStockOptionMember_E03AE029E84451E3E2AE57AD23974393" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_NonPerformanceBasedStockOptionsMember" xlink:label="loc_regn_NonPerformanceBasedStockOptionsMember_1D84B75BC2789951DF4B57AD239893A9" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_673A334F6F5364A4A76657AD239700FD" xlink:to="loc_regn_NonPerformanceBasedStockOptionsMember_1D84B75BC2789951DF4B57AD239893A9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PhantomShareUnitsPSUsMember" xlink:label="loc_us-gaap_PhantomShareUnitsPSUsMember_6F93EAA9DE8AAB9081A157AD2398764D" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_673A334F6F5364A4A76657AD239700FD" xlink:to="loc_us-gaap_PhantomShareUnitsPSUsMember_6F93EAA9DE8AAB9081A157AD2398764D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedStockMember" xlink:label="loc_us-gaap_RestrictedStockMember_94F09BB463E95082432857AD23983917" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_673A334F6F5364A4A76657AD239700FD" xlink:to="loc_us-gaap_RestrictedStockMember_94F09BB463E95082432857AD23983917" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis" xlink:label="loc_srt_RangeAxis_8DA6E80A9DADD4344CA457AD239975EB" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_C48E5D341BE6B67B22A857AD2394544A" xlink:to="loc_srt_RangeAxis_8DA6E80A9DADD4344CA457AD239975EB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember" xlink:label="loc_srt_RangeMember_0F236CCB2F9B748F8B4357AD2399E80D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_8DA6E80A9DADD4344CA457AD239975EB" xlink:to="loc_srt_RangeMember_0F236CCB2F9B748F8B4357AD2399E80D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MinimumMember" xlink:label="loc_srt_MinimumMember_7C3D6A655C5B445544D057AD239A3183" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_0F236CCB2F9B748F8B4357AD2399E80D" xlink:to="loc_srt_MinimumMember_7C3D6A655C5B445544D057AD239A3183" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember" xlink:label="loc_srt_MaximumMember_86ACCD276B667C4282D657AD239A046E" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_0F236CCB2F9B748F8B4357AD2399E80D" xlink:to="loc_srt_MaximumMember_86ACCD276B667C4282D657AD239A046E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_D350F5E5C448EC42173657AD239A10D5" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_C48E5D341BE6B67B22A857AD2394544A" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_D350F5E5C448EC42173657AD239A10D5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_D531D6C1CC4A12FE684457AD239A8867" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_D350F5E5C448EC42173657AD239A10D5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_D531D6C1CC4A12FE684457AD239A8867" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_AdditionalSharesRegistered" xlink:label="loc_regn_AdditionalSharesRegistered_3C35F708131A157CA29457AD239B790A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_D350F5E5C448EC42173657AD239A10D5" xlink:to="loc_regn_AdditionalSharesRegistered_3C35F708131A157CA29457AD239B790A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_142C3674197DD32E99B357AD239B00AF" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_D350F5E5C448EC42173657AD239A10D5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_142C3674197DD32E99B357AD239B00AF" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ShareBasedCompensationArrangementByShareBasedPaymentAwardExpiration" xlink:label="loc_regn_ShareBasedCompensationArrangementByShareBasedPaymentAwardExpiration_3577B797C0FE91D228C857AD239BD6FE" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_D350F5E5C448EC42173657AD239A10D5" xlink:to="loc_regn_ShareBasedCompensationArrangementByShareBasedPaymentAwardExpiration_3577B797C0FE91D228C857AD239BD6FE" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ShareBasedCompensationArrangementByShareBasedPaymentAwardPeriodFromVestingDateAwardsMayBeReceived" xlink:label="loc_regn_ShareBasedCompensationArrangementByShareBasedPaymentAwardPeriodFromVestingDateAwardsMayBeReceived_0817C01DE54CAC4ED14057AD239C7A76" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_D350F5E5C448EC42173657AD239A10D5" xlink:to="loc_regn_ShareBasedCompensationArrangementByShareBasedPaymentAwardPeriodFromVestingDateAwardsMayBeReceived_0817C01DE54CAC4ED14057AD239C7A76" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_5FB3A2A9666632CF61B057AD239C5B63" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_D350F5E5C448EC42173657AD239A10D5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_5FB3A2A9666632CF61B057AD239C5B63" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_3EEDA091BA73B8457A6757AD239CE6E9" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_D350F5E5C448EC42173657AD239A10D5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_3EEDA091BA73B8457A6757AD239CE6E9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpense" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_53654DC76C8B40A137C357AD239D7064" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_D350F5E5C448EC42173657AD239A10D5" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_53654DC76C8B40A137C357AD239D7064" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount_C7E7C6D49645DF6C1D5E57AD239D1E7A" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_D350F5E5C448EC42173657AD239A10D5" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsCapitalizedAmount_C7E7C6D49645DF6C1D5E57AD239D1E7A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_3041B97A908AAFEF4EDB57AD239D5A65" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_D350F5E5C448EC42173657AD239A10D5" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_3041B97A908AAFEF4EDB57AD239D5A65" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_FA9FF9F6D83123F7C89B57AD239DB706" xlink:type="locator" />
    <link:presentationArc order="11" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_D350F5E5C448EC42173657AD239A10D5" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_FA9FF9F6D83123F7C89B57AD239DB706" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_4ECEADAE9F5A11ED8CCE57AD239DF734" xlink:type="locator" />
    <link:presentationArc order="12" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_D350F5E5C448EC42173657AD239A10D5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_4ECEADAE9F5A11ED8CCE57AD239DF734" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/LongTermIncentivePlansSummaryOfActivityRelatedToRestrictedStockAwardsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_7C2B9DD95696031A48415CD752AE3020" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_C6AD211A8DE8A6DAED075CD752AE192F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_7C2B9DD95696031A48415CD752AE3020" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_C6AD211A8DE8A6DAED075CD752AE192F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_C79BE01F6B136C88F8065CD752AF9C33" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_C6AD211A8DE8A6DAED075CD752AE192F" xlink:to="loc_us-gaap_AwardTypeAxis_C79BE01F6B136C88F8065CD752AF9C33" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_DFE7B85D69801678B82B5CD752AFA645" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_C79BE01F6B136C88F8065CD752AF9C33" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_DFE7B85D69801678B82B5CD752AFA645" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedStockMember" xlink:label="loc_us-gaap_RestrictedStockMember_D9E3ACA6B75D42133BD15CD752AF8E66" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_DFE7B85D69801678B82B5CD752AFA645" xlink:to="loc_us-gaap_RestrictedStockMember_D9E3ACA6B75D42133BD15CD752AF8E66" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_83B8D5BD2B6F45315ADD5CD752B01BC8" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_C6AD211A8DE8A6DAED075CD752AE192F" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_83B8D5BD2B6F45315ADD5CD752B01BC8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_7DDF7E0A6850859532185CD752B00A79" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_83B8D5BD2B6F45315ADD5CD752B01BC8" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_7DDF7E0A6850859532185CD752B00A79" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_D40A309F2886CDF269B45CD752B03F4C" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_7DDF7E0A6850859532185CD752B00A79" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_D40A309F2886CDF269B45CD752B03F4C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_9D00FE960A011735CAE45CD752B0E731" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_7DDF7E0A6850859532185CD752B00A79" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_9D00FE960A011735CAE45CD752B0E731" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_104D0E013AAD9CB7D7B05CD752B10DD9" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_7DDF7E0A6850859532185CD752B00A79" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_104D0E013AAD9CB7D7B05CD752B10DD9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_1659DCF5D8FA184FAC3A5CD752B197DD" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_7DDF7E0A6850859532185CD752B00A79" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_1659DCF5D8FA184FAC3A5CD752B197DD" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_B5B568E4A98779E671505CD752B1AD91" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_7DDF7E0A6850859532185CD752B00A79" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_B5B568E4A98779E671505CD752B1AD91" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_B07D78120B3CE98CE7F35CD752B1C10D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_83B8D5BD2B6F45315ADD5CD752B01BC8" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_B07D78120B3CE98CE7F35CD752B1C10D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_2DF0941067F4113482245CD752B10092" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_B07D78120B3CE98CE7F35CD752B1C10D" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_2DF0941067F4113482245CD752B10092" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_0E2157C05829AAAB9F795CD752C2B407" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_B07D78120B3CE98CE7F35CD752B1C10D" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_0E2157C05829AAAB9F795CD752C2B407" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_E911BDBB5F0E8D0A3F295CD752C2FA93" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_B07D78120B3CE98CE7F35CD752B1C10D" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_E911BDBB5F0E8D0A3F295CD752C2FA93" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresIntrinsicValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresIntrinsicValue_6C5A97A5F4267654A8A15CD752C2CA58" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_B07D78120B3CE98CE7F35CD752B1C10D" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresIntrinsicValue_6C5A97A5F4267654A8A15CD752C2CA58" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_0FE3DFC58829FB5AF97A5CD752C3AC97" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_B07D78120B3CE98CE7F35CD752B1C10D" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_0FE3DFC58829FB5AF97A5CD752C3AC97" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/LongTermIncentivePlansSummaryOfTransactionsInvolvingStockOptionAwardsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_635C9A9F9D18102AE703538D21BAFEBB" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_C0647687F51C615BF1FB538D28413D25" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_635C9A9F9D18102AE703538D21BAFEBB" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_C0647687F51C615BF1FB538D28413D25" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_32C2E295C983B5AAEC08538D28414363" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_C0647687F51C615BF1FB538D28413D25" xlink:to="loc_us-gaap_AwardTypeAxis_32C2E295C983B5AAEC08538D28414363" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_4948C3FA98279E695FF7538D28412CE3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_32C2E295C983B5AAEC08538D28414363" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_4948C3FA98279E695FF7538D28412CE3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeStockOptionMember" xlink:label="loc_us-gaap_EmployeeStockOptionMember_5CBB44520021F5402CBF538D2ED0ACA1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_4948C3FA98279E695FF7538D28412CE3" xlink:to="loc_us-gaap_EmployeeStockOptionMember_5CBB44520021F5402CBF538D2ED0ACA1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_A4DD17D1AC9A0A3D3763538D2851D2EF" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_C0647687F51C615BF1FB538D28413D25" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_A4DD17D1AC9A0A3D3763538D2851D2EF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_0733C907CEE3E70F265C539ACC91CA66" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_A4DD17D1AC9A0A3D3763538D2851D2EF" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_0733C907CEE3E70F265C539ACC91CA66" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_DD921546AC3ECD30BB5D538D28A5ACC6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_0733C907CEE3E70F265C539ACC91CA66" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_DD921546AC3ECD30BB5D538D28A5ACC6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod_F8DFF22C146461DD73D1538D2997183D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_0733C907CEE3E70F265C539ACC91CA66" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod_F8DFF22C146461DD73D1538D2997183D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_50F177DD3790DF3F15CC538D2A29F80E" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_0733C907CEE3E70F265C539ACC91CA66" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_50F177DD3790DF3F15CC538D2A29F80E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod_54BEE4A8F7693E0F016C538D2ABED856" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_0733C907CEE3E70F265C539ACC91CA66" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod_54BEE4A8F7693E0F016C538D2ABED856" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_22A4D7775F00DBFE3984538D2B62E3A9" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_0733C907CEE3E70F265C539ACC91CA66" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_22A4D7775F00DBFE3984538D2B62E3A9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_78F266E56C6D41691862539BFADA8FD1" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_0733C907CEE3E70F265C539ACC91CA66" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_78F266E56C6D41691862539BFADA8FD1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber_D5AAE3985BC245B78343538D2C09D3D4" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_0733C907CEE3E70F265C539ACC91CA66" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber_D5AAE3985BC245B78343538D2C09D3D4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_666287F31BA889FEF2C6538D2D5F3F5E" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_0733C907CEE3E70F265C539ACC91CA66" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_666287F31BA889FEF2C6538D2D5F3F5E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_5953AB795E633DCA920953A0BE490A7F" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_A4DD17D1AC9A0A3D3763538D2851D2EF" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_5953AB795E633DCA920953A0BE490A7F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_43450E629D8D54BC3034538D28D5A8B3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_5953AB795E633DCA920953A0BE490A7F" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_43450E629D8D54BC3034538D28D5A8B3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_F8DF18594368FE6335BB538D29E10C79" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_5953AB795E633DCA920953A0BE490A7F" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_F8DF18594368FE6335BB538D29E10C79" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_F0A21137727F9118BFED538D2A75BE59" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_5953AB795E633DCA920953A0BE490A7F" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_F0A21137727F9118BFED538D2A75BE59" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice_E6C4B9003D45569BD410538D2B15E56F" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_5953AB795E633DCA920953A0BE490A7F" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice_E6C4B9003D45569BD410538D2B15E56F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_1F9A56B240F290C6AAEB538D2BB04C02" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_5953AB795E633DCA920953A0BE490A7F" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_1F9A56B240F290C6AAEB538D2BB04C02" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_7DC6E8C79290DBD3538B53A8A555E56C" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_5953AB795E633DCA920953A0BE490A7F" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_7DC6E8C79290DBD3538B53A8A555E56C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice_612D05BD59389A188817538D2C59EBE6" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_5953AB795E633DCA920953A0BE490A7F" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice_612D05BD59389A188817538D2C59EBE6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_6341DABA0B42BE98B3A4538D2DB937D4" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_5953AB795E633DCA920953A0BE490A7F" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_6341DABA0B42BE98B3A4538D2DB937D4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_AFBD0390F2F9E5F0FA8B53A25B09FC9F" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_A4DD17D1AC9A0A3D3763538D2851D2EF" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_AFBD0390F2F9E5F0FA8B53A25B09FC9F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_56024A616BEF7075970B538D29199E83" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_AFBD0390F2F9E5F0FA8B53A25B09FC9F" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_56024A616BEF7075970B538D29199E83" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1_A3D248DEEBEC8769AC04538D2CAC93E0" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_AFBD0390F2F9E5F0FA8B53A25B09FC9F" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1_A3D248DEEBEC8769AC04538D2CAC93E0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_5414A9CA232C5FDA7CFD538D2E125591" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_AFBD0390F2F9E5F0FA8B53A25B09FC9F" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_5414A9CA232C5FDA7CFD538D2E125591" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_ADADBECB77FC6075EBC2538D295D1C7A" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_AFBD0390F2F9E5F0FA8B53A25B09FC9F" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_ADADBECB77FC6075EBC2538D295D1C7A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue_0982A3ED525D6A79A40F538D2D08C4FB" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_AFBD0390F2F9E5F0FA8B53A25B09FC9F" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue_0982A3ED525D6A79A40F538D2D08C4FB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_B9018DF182ED859F40E5538D2E6FA3DF" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_AFBD0390F2F9E5F0FA8B53A25B09FC9F" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_B9018DF182ED859F40E5538D2E6FA3DF" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/LongTermIncentivePlansSummaryOfWeightedAverageExercisePricesAndWeightedAverageGrantDateFairValuesOfOptionsIssuedDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_19B86EE209A78DE81DCC5391F049567B" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7ACCFBB0CAE5D1426D555391FA454F17" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_19B86EE209A78DE81DCC5391F049567B" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7ACCFBB0CAE5D1426D555391FA454F17" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_50FBFEC42DED107C4A6C5391FA553CF5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7ACCFBB0CAE5D1426D555391FA454F17" xlink:to="loc_us-gaap_AwardTypeAxis_50FBFEC42DED107C4A6C5391FA553CF5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_80F4848A5A28CBED20385391FA569646" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_50FBFEC42DED107C4A6C5391FA553CF5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_80F4848A5A28CBED20385391FA569646" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeStockOptionMember" xlink:label="loc_us-gaap_EmployeeStockOptionMember_0C594F731C03DA3E77E35391FCFF8463" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_80F4848A5A28CBED20385391FA569646" xlink:to="loc_us-gaap_EmployeeStockOptionMember_0C594F731C03DA3E77E35391FCFF8463" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_19E03C3778D54B06838E5391FA6485D4" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_7ACCFBB0CAE5D1426D555391FA454F17" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_19E03C3778D54B06838E5391FA6485D4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod_687153DED21D75B4A5C35391FB03F9C5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_19E03C3778D54B06838E5391FA6485D4" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod_687153DED21D75B4A5C35391FB03F9C5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_9E5351FD0FA3A8F1E4A45391FBB115B6" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_19E03C3778D54B06838E5391FA6485D4" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_9E5351FD0FA3A8F1E4A45391FBB115B6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_D18193D1798D72D0F5AA5391FC6A6656" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_19E03C3778D54B06838E5391FA6485D4" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_D18193D1798D72D0F5AA5391FC6A6656" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/LongTermIncentivePlansSummaryOfWeightedAverageValuesOfAssumptionsUsedInComputingFairValueOfOptionGrantsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_F37B2516C338AC54C4D35393C91A64BB" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_40785EF7B4A570634ACE5393D3579131" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_F37B2516C338AC54C4D35393C91A64BB" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_40785EF7B4A570634ACE5393D3579131" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AwardTypeAxis" xlink:label="loc_us-gaap_AwardTypeAxis_B4768FB4D0F80C9861995393D36925A3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_40785EF7B4A570634ACE5393D3579131" xlink:to="loc_us-gaap_AwardTypeAxis_B4768FB4D0F80C9861995393D36925A3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_5E8566D29B16006FC5A55393D36ABD39" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_B4768FB4D0F80C9861995393D36925A3" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_5E8566D29B16006FC5A55393D36ABD39" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeStockOptionMember" xlink:label="loc_us-gaap_EmployeeStockOptionMember_C34F6565F17ECF1B799A5393D666B21D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_5E8566D29B16006FC5A55393D36ABD39" xlink:to="loc_us-gaap_EmployeeStockOptionMember_C34F6565F17ECF1B799A5393D666B21D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_F400F720ED22128F8A2B5393D3783ADC" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_40785EF7B4A570634ACE5393D3579131" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_F400F720ED22128F8A2B5393D3783ADC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_9BBE80E5C777DC9EE0975393D40AB715" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_F400F720ED22128F8A2B5393D3783ADC" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_9BBE80E5C777DC9EE0975393D40AB715" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_21EAE9F8909AA6E765925393D49F418A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_F400F720ED22128F8A2B5393D3783ADC" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_21EAE9F8909AA6E765925393D49F418A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_FF8547EC62DC7BC3A35F5393D52037C6" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_F400F720ED22128F8A2B5393D3783ADC" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_FF8547EC62DC7BC3A35F5393D52037C6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_BD0DE8E39192D2BE4EEF5393D5CE4C81" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_F400F720ED22128F8A2B5393D3783ADC" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_BD0DE8E39192D2BE4EEF5393D5CE4C81" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/LongTermIncentivePlansTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_0D3E5143F90BD5D392BA52B94C57E18E" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock_54AA333500CF2ABDFD7F52B94C589228" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_0D3E5143F90BD5D392BA52B94C57E18E" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock_54AA333500CF2ABDFD7F52B94C589228" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValueTableTextBlock" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValueTableTextBlock_841A301B1CEDBF934AF352B94C5815F2" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_0D3E5143F90BD5D392BA52B94C57E18E" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValueTableTextBlock_841A301B1CEDBF934AF352B94C5815F2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock_66B3C2FEBE1CC56D119052B94C589D9A" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_0D3E5143F90BD5D392BA52B94C57E18E" xlink:to="loc_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock_66B3C2FEBE1CC56D119052B94C589D9A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfSharebasedCompensationRestrictedStockAndRestrictedStockUnitsActivityTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfSharebasedCompensationRestrictedStockAndRestrictedStockUnitsActivityTableTextBlock_E0E9674871D1453ADC7E52B94C5800DE" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_0D3E5143F90BD5D392BA52B94C57E18E" xlink:to="loc_us-gaap_ScheduleOfSharebasedCompensationRestrictedStockAndRestrictedStockUnitsActivityTableTextBlock_E0E9674871D1453ADC7E52B94C5800DE" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/MarketableSecurities" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_533390DF7196507A5A5E57AD25B9EFF6" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentsInDebtAndMarketableEquitySecuritiesAndCertainTradingAssetsDisclosureTextBlock" xlink:label="loc_us-gaap_InvestmentsInDebtAndMarketableEquitySecuritiesAndCertainTradingAssetsDisclosureTextBlock_C6EA768BE56CCF8D2C5F57AD25B976CC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_533390DF7196507A5A5E57AD25B9EFF6" xlink:to="loc_us-gaap_InvestmentsInDebtAndMarketableEquitySecuritiesAndCertainTradingAssetsDisclosureTextBlock_C6EA768BE56CCF8D2C5F57AD25B976CC" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/MarketableSecuritiesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_25CD4E638E2A5D6A4BC9913952887FA2" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfGainLossOnInvestmentsTable" xlink:label="loc_us-gaap_ScheduleOfGainLossOnInvestmentsTable_21C58DED797D2F7B966291395288366D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_25CD4E638E2A5D6A4BC9913952887FA2" xlink:to="loc_us-gaap_ScheduleOfGainLossOnInvestmentsTable_21C58DED797D2F7B966291395288366D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_0339669A60B548EA8EB991395288C8D8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfGainLossOnInvestmentsTable_21C58DED797D2F7B966291395288366D" xlink:to="loc_us-gaap_FinancialInstrumentAxis_0339669A60B548EA8EB991395288C8D8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_57DED35A9E20F3BEF7209139528915EE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_0339669A60B548EA8EB991395288C8D8" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_57DED35A9E20F3BEF7209139528915EE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquitySecuritiesMember" xlink:label="loc_us-gaap_EquitySecuritiesMember_C61C94C82534168203C29139528AD865" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_57DED35A9E20F3BEF7209139528915EE" xlink:to="loc_us-gaap_EquitySecuritiesMember_C61C94C82534168203C29139528AD865" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfGainLossOnInvestmentsIncludingMarketableSecuritiesAndInvestmentsHeldAtCostIncomeStatementReportedAmountsSummaryLineItems" xlink:label="loc_us-gaap_ScheduleOfGainLossOnInvestmentsIncludingMarketableSecuritiesAndInvestmentsHeldAtCostIncomeStatementReportedAmountsSummaryLineItems_E251F54FFD39D171AD9B9139528AFB3A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfGainLossOnInvestmentsTable_21C58DED797D2F7B966291395288366D" xlink:to="loc_us-gaap_ScheduleOfGainLossOnInvestmentsIncludingMarketableSecuritiesAndInvestmentsHeldAtCostIncomeStatementReportedAmountsSummaryLineItems_E251F54FFD39D171AD9B9139528AFB3A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ImpairmentOfInvestments" xlink:label="loc_us-gaap_ImpairmentOfInvestments_2B6E69E796FDC7B682E79139528BC794" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfGainLossOnInvestmentsIncludingMarketableSecuritiesAndInvestmentsHeldAtCostIncomeStatementReportedAmountsSummaryLineItems_E251F54FFD39D171AD9B9139528AFB3A" xlink:to="loc_us-gaap_ImpairmentOfInvestments_2B6E69E796FDC7B682E79139528BC794" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss" xlink:label="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss_7734DC68B9F8D5A5C5929139528CFDF1" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_25CD4E638E2A5D6A4BC9913952887FA2" xlink:to="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss_7734DC68B9F8D5A5C5929139528CFDF1" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/MarketableSecuritiesScheduleOfDebtSecuritiesBasedOnContractualMaturityDatesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_2114C74910BF1B17E35C57AD259A831D" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_2722F781A4A2D674D7B557AD259ACE65" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_2114C74910BF1B17E35C57AD259A831D" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_2722F781A4A2D674D7B557AD259ACE65" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_FD0862B062942B1B17A657AD259B65BE" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_2114C74910BF1B17E35C57AD259A831D" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_FD0862B062942B1B17A657AD259B65BE" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_187C784125C57578991B57AD259B39A8" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_2114C74910BF1B17E35C57AD259A831D" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_187C784125C57578991B57AD259B39A8" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/MarketableSecuritiesScheduleOfFairValueAndUnrealizedLossesOfDebtSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_9790E3EC3B21C5B7CF40A610EC2B49EB" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleTable" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_82E68814D642D4D56838A610EC2BDB58" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_9790E3EC3B21C5B7CF40A610EC2B49EB" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_82E68814D642D4D56838A610EC2BDB58" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_98C32EC61981E977B024A610EC2B1899" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_82E68814D642D4D56838A610EC2BDB58" xlink:to="loc_us-gaap_FinancialInstrumentAxis_98C32EC61981E977B024A610EC2B1899" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_AC9F29FA862D4EB05D64A610EC2CBBA7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_98C32EC61981E977B024A610EC2B1899" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_AC9F29FA862D4EB05D64A610EC2CBBA7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CorporateBondSecuritiesMember" xlink:label="loc_us-gaap_CorporateBondSecuritiesMember_AD4A45C98252C4105A56A610EC2D2789" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_AC9F29FA862D4EB05D64A610EC2CBBA7" xlink:to="loc_us-gaap_CorporateBondSecuritiesMember_AD4A45C98252C4105A56A610EC2D2789" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_USTreasuryAndGovernmentMember" xlink:label="loc_us-gaap_USTreasuryAndGovernmentMember_CB1F20F787B0BD0042EBA610EC2D38FF" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_AC9F29FA862D4EB05D64A610EC2CBBA7" xlink:to="loc_us-gaap_USTreasuryAndGovernmentMember_CB1F20F787B0BD0042EBA610EC2D38FF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_499118572439A4D3A884A610EC2E3E8D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_82E68814D642D4D56838A610EC2BDB58" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_499118572439A4D3A884A610EC2E3E8D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_DB56DE26B973B5593949A610EC2E51E3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_499118572439A4D3A884A610EC2E3E8D" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months_DB56DE26B973B5593949A610EC2E51E3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_7269DB065255BE8C1586A610EC2E54E4" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_499118572439A4D3A884A610EC2E3E8D" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss_7269DB065255BE8C1586A610EC2E54E4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_525B3012CED9C8DEE111A610EC2FEAA0" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_499118572439A4D3A884A610EC2E3E8D" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLonger_525B3012CED9C8DEE111A610EC2FEAA0" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_5D903C3F2293D6A59A6AA610EC2F461E" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_499118572439A4D3A884A610EC2E3E8D" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPosition12MonthsOrLongerAccumulatedLoss_5D903C3F2293D6A59A6AA610EC2F461E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_124480EF9AC784EBD2FFA610EC2F829A" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_499118572439A4D3A884A610EC2E3E8D" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPosition_124480EF9AC784EBD2FFA610EC2F829A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_95F6E807A841043B3303A610EC30CA18" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_499118572439A4D3A884A610EC2E3E8D" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionAccumulatedLoss_95F6E807A841043B3303A610EC30CA18" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/MarketableSecuritiesScheduleOfInvestmentsInAvailableForSaleDebtSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_E99850EBE8260E3236BDA610EC47BD5A" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleTable" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_CF8AB43B4464ED36C7EEA610EC4863BA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_E99850EBE8260E3236BDA610EC47BD5A" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_CF8AB43B4464ED36C7EEA610EC4863BA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinancialInstrumentAxis" xlink:label="loc_us-gaap_FinancialInstrumentAxis_DA3E3E8A6DAEB7841229A610EC480A31" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_CF8AB43B4464ED36C7EEA610EC4863BA" xlink:to="loc_us-gaap_FinancialInstrumentAxis_DA3E3E8A6DAEB7841229A610EC480A31" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_D02749C50E1B5643F0F9A610EC4A92A9" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_DA3E3E8A6DAEB7841229A610EC480A31" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_D02749C50E1B5643F0F9A610EC4A92A9" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CorporateBondSecuritiesMember" xlink:label="loc_us-gaap_CorporateBondSecuritiesMember_CFF6829EA045224865A3A610EC4A4714" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_D02749C50E1B5643F0F9A610EC4A92A9" xlink:to="loc_us-gaap_CorporateBondSecuritiesMember_CFF6829EA045224865A3A610EC4A4714" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_USTreasuryAndGovernmentMember" xlink:label="loc_us-gaap_USTreasuryAndGovernmentMember_83BD3E951233CD94B744A610EC4B700A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_D02749C50E1B5643F0F9A610EC4A92A9" xlink:to="loc_us-gaap_USTreasuryAndGovernmentMember_83BD3E951233CD94B744A610EC4B700A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SovereignDebtSecuritiesMember" xlink:label="loc_us-gaap_SovereignDebtSecuritiesMember_AC3174C7DB95566AF1C2A611A43BB048" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_D02749C50E1B5643F0F9A610EC4A92A9" xlink:to="loc_us-gaap_SovereignDebtSecuritiesMember_AC3174C7DB95566AF1C2A611A43BB048" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_MunicipalBondsAndSovereignDebtSecuritiesMember" xlink:label="loc_regn_MunicipalBondsAndSovereignDebtSecuritiesMember_3125420333353A2E4DFDA61359882EDF" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_D02749C50E1B5643F0F9A610EC4A92A9" xlink:to="loc_regn_MunicipalBondsAndSovereignDebtSecuritiesMember_3125420333353A2E4DFDA61359882EDF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommercialPaperMember" xlink:label="loc_us-gaap_CommercialPaperMember_1F91B5FF4A6B85329239A610EC4BC069" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_D02749C50E1B5643F0F9A610EC4A92A9" xlink:to="loc_us-gaap_CommercialPaperMember_1F91B5FF4A6B85329239A610EC4BC069" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CertificatesOfDepositMember" xlink:label="loc_us-gaap_CertificatesOfDepositMember_231CAC234B2110CC15EEA610EC4C9CD0" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_D02749C50E1B5643F0F9A610EC4A92A9" xlink:to="loc_us-gaap_CertificatesOfDepositMember_231CAC234B2110CC15EEA610EC4C9CD0" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ClassificationOfInvestmentAxis" xlink:label="loc_regn_ClassificationOfInvestmentAxis_ABFDC15FE6BB13A4C7D6A610EC4C7382" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_CF8AB43B4464ED36C7EEA610EC4863BA" xlink:to="loc_regn_ClassificationOfInvestmentAxis_ABFDC15FE6BB13A4C7D6A610EC4C7382" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ClassificationOfInvestmentDomain" xlink:label="loc_regn_ClassificationOfInvestmentDomain_9AE9FEC5F4864CF4C047A610EC4CBC62" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ClassificationOfInvestmentAxis_ABFDC15FE6BB13A4C7D6A610EC4C7382" xlink:to="loc_regn_ClassificationOfInvestmentDomain_9AE9FEC5F4864CF4C047A610EC4CBC62" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_UnrestrictedMember" xlink:label="loc_regn_UnrestrictedMember_08890168E04F00F36AD6A610EC4DF77E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_regn_ClassificationOfInvestmentDomain_9AE9FEC5F4864CF4C047A610EC4CBC62" xlink:to="loc_regn_UnrestrictedMember_08890168E04F00F36AD6A610EC4DF77E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_804D72C589759F1E3752A610EC4DD697" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_CF8AB43B4464ED36C7EEA610EC4863BA" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_804D72C589759F1E3752A610EC4DD697" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_819287A847879C52A8F6A610EC4E5BE4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_804D72C589759F1E3752A610EC4DD697" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_819287A847879C52A8F6A610EC4E5BE4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_18C4995090FC9C249F11A610EC4EB07B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_804D72C589759F1E3752A610EC4DD697" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_18C4995090FC9C249F11A610EC4EB07B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_3D397334DDA8526BE1C6A610EC4FAAFB" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_804D72C589759F1E3752A610EC4DD697" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_3D397334DDA8526BE1C6A610EC4FAAFB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_10A44DD5387F083D8FFAA610EC4FD3E6" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_804D72C589759F1E3752A610EC4DD697" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_10A44DD5387F083D8FFAA610EC4FD3E6" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/MarketableSecuritiesTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract" xlink:label="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_84E106269AD75BDF3DEF57AD25B36FD5" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock_CC0C42BEABC290EEDED857AD25B302A5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_84E106269AD75BDF3DEF57AD25B36FD5" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock_CC0C42BEABC290EEDED857AD25B302A5" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentsClassifiedByContractualMaturityDateTableTextBlock" xlink:label="loc_us-gaap_InvestmentsClassifiedByContractualMaturityDateTableTextBlock_81CF811F403D8D31A87C57AD25B4D75A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_84E106269AD75BDF3DEF57AD25B36FD5" xlink:to="loc_us-gaap_InvestmentsClassifiedByContractualMaturityDateTableTextBlock_81CF811F403D8D31A87C57AD25B4D75A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionFairValueTableTextBlock" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionFairValueTableTextBlock_309B7D6D8D0517743ED557AD25B44B33" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentsDebtAndEquitySecuritiesAbstract_84E106269AD75BDF3DEF57AD25B36FD5" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleUnrealizedLossPositionFairValueTableTextBlock_309B7D6D8D0517743ED557AD25B44B33" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/NetIncomePerShare" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_2D50AA93B042ABE233ED57AD2251A545" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareTextBlock" xlink:label="loc_us-gaap_EarningsPerShareTextBlock_BBAEA4358FD2ECA98F9B57AD2252BDC5" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_2D50AA93B042ABE233ED57AD2251A545" xlink:to="loc_us-gaap_EarningsPerShareTextBlock_BBAEA4358FD2ECA98F9B57AD2252BDC5" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/NetIncomePerShareScheduleOfAntidilutiveSecuritiesExcludedFromComputationDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_434DAEBF085FD18EBFC557AD220B25ED" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_B20CF5E7F26D2AF6BE7257AD220B5FAC" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_434DAEBF085FD18EBFC557AD220B25ED" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_B20CF5E7F26D2AF6BE7257AD220B5FAC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_FD3990B3B6E2B2FB68D257AD220C991D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_B20CF5E7F26D2AF6BE7257AD220B5FAC" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_FD3990B3B6E2B2FB68D257AD220C991D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AntidilutiveSecuritiesNameDomain" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_58466A1BAEB845F2630C57AD220CFA2A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_FD3990B3B6E2B2FB68D257AD220C991D" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_58466A1BAEB845F2630C57AD220CFA2A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeStockOptionMember" xlink:label="loc_us-gaap_EmployeeStockOptionMember_456B3E81CC0DBA8D82DF57AD220C7C05" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_58466A1BAEB845F2630C57AD220CFA2A" xlink:to="loc_us-gaap_EmployeeStockOptionMember_456B3E81CC0DBA8D82DF57AD220C7C05" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_FD1AA59FD6F65F4E2C8257AD220D1C25" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_B20CF5E7F26D2AF6BE7257AD220B5FAC" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_FD1AA59FD6F65F4E2C8257AD220D1C25" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_FD18D47558479AD29D0957AD220D32DB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_FD1AA59FD6F65F4E2C8257AD220D1C25" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_FD18D47558479AD29D0957AD220D32DB" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/NetIncomePerShareScheduleOfBasicAndDilutedNetIncomePerShareDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_34AECC26AC545828B51581988199EDF9" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_DD94F9725C8C4767263C8198819ACED1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_34AECC26AC545828B51581988199EDF9" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_DD94F9725C8C4767263C8198819ACED1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_079666F1200139F1703D8198819AE574" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_DD94F9725C8C4767263C8198819ACED1" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_079666F1200139F1703D8198819AE574" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AntidilutiveSecuritiesNameDomain" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_A613BFFAB1A7B2E702358198819C1A2F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_079666F1200139F1703D8198819AE574" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_A613BFFAB1A7B2E702358198819C1A2F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeStockOptionMember" xlink:label="loc_us-gaap_EmployeeStockOptionMember_C2A9C065D1C8A4E9EB508198819D8EA4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_A613BFFAB1A7B2E702358198819C1A2F" xlink:to="loc_us-gaap_EmployeeStockOptionMember_C2A9C065D1C8A4E9EB508198819D8EA4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedStockMember" xlink:label="loc_us-gaap_RestrictedStockMember_9D0677D1789754D775648198819D7708" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_A613BFFAB1A7B2E702358198819C1A2F" xlink:to="loc_us-gaap_RestrictedStockMember_9D0677D1789754D775648198819D7708" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_0F13ED5FBE320FE2A22B8198819E6B3D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_DD94F9725C8C4767263C8198819ACED1" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_0F13ED5FBE320FE2A22B8198819E6B3D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_301450385E7F2B4D9E388198819E755D" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_0F13ED5FBE320FE2A22B8198819E6B3D" xlink:to="loc_us-gaap_NetIncomeLoss_301450385E7F2B4D9E388198819E755D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InterestOnConvertibleDebtNetOfTax" xlink:label="loc_us-gaap_InterestOnConvertibleDebtNetOfTax_8B5EAEB44658D10879738198819E82C2" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_0F13ED5FBE320FE2A22B8198819E6B3D" xlink:to="loc_us-gaap_InterestOnConvertibleDebtNetOfTax_8B5EAEB44658D10879738198819E82C2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLossAttributableToParentDiluted" xlink:label="loc_us-gaap_NetIncomeLossAttributableToParentDiluted_11064F32152857B132068198819FDCD3" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_0F13ED5FBE320FE2A22B8198819E6B3D" xlink:to="loc_us-gaap_NetIncomeLossAttributableToParentDiluted_11064F32152857B132068198819FDCD3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_766A3EDD288613E659B88198819FFF22" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_0F13ED5FBE320FE2A22B8198819E6B3D" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_766A3EDD288613E659B88198819FFF22" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustmentAbstract" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustmentAbstract_49EAB27198EE3057A7A28198819FCEFC" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_0F13ED5FBE320FE2A22B8198819E6B3D" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustmentAbstract_49EAB27198EE3057A7A28198819FCEFC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_9EFE60F9E2EA9D0BE79C8198819F110E" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustmentAbstract_49EAB27198EE3057A7A28198819FCEFC" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_9EFE60F9E2EA9D0BE79C8198819F110E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants_049772B5F1C01CF9DA32819881A0E74A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustmentAbstract_49EAB27198EE3057A7A28198819FCEFC" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants_049772B5F1C01CF9DA32819881A0E74A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment" xlink:label="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_076EC330518B17F61A0E819881A1E3D4" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustmentAbstract_49EAB27198EE3057A7A28198819FCEFC" xlink:to="loc_us-gaap_WeightedAverageNumberDilutedSharesOutstandingAdjustment_076EC330518B17F61A0E819881A1E3D4" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_B6A32BCAE92318C1B997819881A1FEBC" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_0F13ED5FBE320FE2A22B8198819E6B3D" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_B6A32BCAE92318C1B997819881A1FEBC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareBasic" xlink:label="loc_us-gaap_EarningsPerShareBasic_CA7B75445FC5D9D1AD12819881A13B1C" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_0F13ED5FBE320FE2A22B8198819E6B3D" xlink:to="loc_us-gaap_EarningsPerShareBasic_CA7B75445FC5D9D1AD12819881A13B1C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareDiluted" xlink:label="loc_us-gaap_EarningsPerShareDiluted_4E9140A5269A67D1E631819881A18DCF" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_0F13ED5FBE320FE2A22B8198819E6B3D" xlink:to="loc_us-gaap_EarningsPerShareDiluted_4E9140A5269A67D1E631819881A18DCF" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/NetIncomePerShareTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareAbstract" xlink:label="loc_us-gaap_EarningsPerShareAbstract_3BD439F0EDFB5D20C80157AD22426F29" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_539A95CCD6B21CEE907057AD2243D314" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_3BD439F0EDFB5D20C80157AD22426F29" xlink:to="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_539A95CCD6B21CEE907057AD2243D314" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_5249DD8D04862EAA4B1657AD2243A29A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareAbstract_3BD439F0EDFB5D20C80157AD22426F29" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_5249DD8D04862EAA4B1657AD2243A29A" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/ProductSales" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenuesAbstract" xlink:label="loc_us-gaap_RevenuesAbstract_D65FB4119FE396E0A42A57AD25EFD0C1" xlink:type="locator" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ProductSalesandConcentrationRiskTextBlock" xlink:label="loc_regn_ProductSalesandConcentrationRiskTextBlock_ED061A104E1A00F4581357AD25EF0E12" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesAbstract_D65FB4119FE396E0A42A57AD25EFD0C1" xlink:to="loc_regn_ProductSalesandConcentrationRiskTextBlock_ED061A104E1A00F4581357AD25EF0E12" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/ProductSalesScheduleOfConcentrationOfRiskByRiskFactorDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenuesAbstract" xlink:label="loc_us-gaap_RevenuesAbstract_6A2E66C2F1536A0201C157AD25D2943E" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskTable" xlink:label="loc_us-gaap_ConcentrationRiskTable_3688C738492CA83FC04C57AD25D26C01" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesAbstract_6A2E66C2F1536A0201C157AD25D2943E" xlink:to="loc_us-gaap_ConcentrationRiskTable_3688C738492CA83FC04C57AD25D26C01" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_67E114E7B4E64B746D8D57AD25D2C272" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_3688C738492CA83FC04C57AD25D26C01" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_67E114E7B4E64B746D8D57AD25D2C272" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_1857090E7BD25C43053D57AD25D38BA0" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_67E114E7B4E64B746D8D57AD25D2C272" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_1857090E7BD25C43053D57AD25D38BA0" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_GrossSalesRevenueMember" xlink:label="loc_regn_GrossSalesRevenueMember_14EA3903CE8553E303D757AD25D3B74A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_1857090E7BD25C43053D57AD25D38BA0" xlink:to="loc_regn_GrossSalesRevenueMember_14EA3903CE8553E303D757AD25D3B74A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskByTypeAxis" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_1E52927DFB03CA9879F957AD25D4073E" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_3688C738492CA83FC04C57AD25D26C01" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_1E52927DFB03CA9879F957AD25D4073E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_5BD36DAAA7B725B737A857AD25D47FEB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_1E52927DFB03CA9879F957AD25D4073E" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_5BD36DAAA7B725B737A857AD25D47FEB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CustomerConcentrationRiskMember" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember_6B239178B49AEC11CE3A57AD25D411AA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_5BD36DAAA7B725B737A857AD25D47FEB" xlink:to="loc_us-gaap_CustomerConcentrationRiskMember_6B239178B49AEC11CE3A57AD25D411AA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MajorCustomersAxis" xlink:label="loc_srt_MajorCustomersAxis_4213ED5AEED33CABB21157AD25D50D29" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_3688C738492CA83FC04C57AD25D26C01" xlink:to="loc_srt_MajorCustomersAxis_4213ED5AEED33CABB21157AD25D50D29" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_NameOfMajorCustomerDomain" xlink:label="loc_srt_NameOfMajorCustomerDomain_62EA7AF9576FBAC23B7957AD25D5B18B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_MajorCustomersAxis_4213ED5AEED33CABB21157AD25D50D29" xlink:to="loc_srt_NameOfMajorCustomerDomain_62EA7AF9576FBAC23B7957AD25D5B18B" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_BesseMedicalMember" xlink:label="loc_regn_BesseMedicalMember_DC33B7A1C60C2C12D3DD57AD25D53C0B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_NameOfMajorCustomerDomain_62EA7AF9576FBAC23B7957AD25D5B18B" xlink:to="loc_regn_BesseMedicalMember_DC33B7A1C60C2C12D3DD57AD25D53C0B" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_McKessonCorporationMember" xlink:label="loc_regn_McKessonCorporationMember_7024C644E787FB97F8E357AD25D69CCB" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_NameOfMajorCustomerDomain_62EA7AF9576FBAC23B7957AD25D5B18B" xlink:to="loc_regn_McKessonCorporationMember_7024C644E787FB97F8E357AD25D69CCB" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_CurascriptSDMember" xlink:label="loc_regn_CurascriptSDMember_8D3FD3A10E5745E96B8E57AD25D69FD3" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_NameOfMajorCustomerDomain_62EA7AF9576FBAC23B7957AD25D5B18B" xlink:to="loc_regn_CurascriptSDMember_8D3FD3A10E5745E96B8E57AD25D69FD3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskLineItems" xlink:label="loc_us-gaap_ConcentrationRiskLineItems_BC789EE5C07868D95A7457AD25D6996E" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_3688C738492CA83FC04C57AD25D26C01" xlink:to="loc_us-gaap_ConcentrationRiskLineItems_BC789EE5C07868D95A7457AD25D6996E" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskPercentage1" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_53C1D4DA3FFCC4FE3D4357AD25D6162F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_BC789EE5C07868D95A7457AD25D6996E" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_53C1D4DA3FFCC4FE3D4357AD25D6162F" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/ProductSalesScheduleOfNetProductSalesDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenuesAbstract" xlink:label="loc_us-gaap_RevenuesAbstract_739CA5B540E8829E063557AD25DF4F4D" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTable" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_AE506D3AD36080E015CB57AD25E01014" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesAbstract_739CA5B540E8829E063557AD25DF4F4D" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_AE506D3AD36080E015CB57AD25E01014" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_StatementGeographicalAxis" xlink:label="loc_srt_StatementGeographicalAxis_D8B4EB0C854F11D7533057AD25E0E869" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_AE506D3AD36080E015CB57AD25E01014" xlink:to="loc_srt_StatementGeographicalAxis_D8B4EB0C854F11D7533057AD25E0E869" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_SegmentGeographicalDomain" xlink:label="loc_srt_SegmentGeographicalDomain_1D53EABAD917812EE95657AD25E0C1DB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_StatementGeographicalAxis_D8B4EB0C854F11D7533057AD25E0E869" xlink:to="loc_srt_SegmentGeographicalDomain_1D53EABAD917812EE95657AD25E0C1DB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_US" xlink:label="loc_country_US_622FB80BBD7F53B8C9FC57AD25E135EB" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_SegmentGeographicalDomain_1D53EABAD917812EE95657AD25E0C1DB" xlink:to="loc_country_US_622FB80BBD7F53B8C9FC57AD25E135EB" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductOrServiceAxis" xlink:label="loc_srt_ProductOrServiceAxis_9BB7C0716E748F51CCEF57AD25E1CE10" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_AE506D3AD36080E015CB57AD25E01014" xlink:to="loc_srt_ProductOrServiceAxis_9BB7C0716E748F51CCEF57AD25E1CE10" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain" xlink:label="loc_srt_ProductsAndServicesDomain_49385870A56B52D5791157AD25E1E452" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_9BB7C0716E748F51CCEF57AD25E1CE10" xlink:to="loc_srt_ProductsAndServicesDomain_49385870A56B52D5791157AD25E1E452" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_EyleaNetProductSalesMember" xlink:label="loc_regn_EyleaNetProductSalesMember_3B0B142BADA365AB226D57AD25E2E421" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_49385870A56B52D5791157AD25E1E452" xlink:to="loc_regn_EyleaNetProductSalesMember_3B0B142BADA365AB226D57AD25E2E421" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_LIBTAYONetProductSalesMember" xlink:label="loc_regn_LIBTAYONetProductSalesMember_F7060D67224A623406CA57AD25E2F220" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_49385870A56B52D5791157AD25E1E452" xlink:to="loc_regn_LIBTAYONetProductSalesMember_F7060D67224A623406CA57AD25E2F220" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ArcalystNetProductSalesMember" xlink:label="loc_regn_ArcalystNetProductSalesMember_72AC8D4B9ECD8DB1B81F57AD25E2A32D" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_49385870A56B52D5791157AD25E1E452" xlink:to="loc_regn_ArcalystNetProductSalesMember_72AC8D4B9ECD8DB1B81F57AD25E2A32D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProductMember" xlink:label="loc_us-gaap_ProductMember_0F0ECFDD2229002FC1FF57AD25E3015D" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_49385870A56B52D5791157AD25E1E452" xlink:to="loc_us-gaap_ProductMember_0F0ECFDD2229002FC1FF57AD25E3015D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_4679CF0C866AB803DD7C57AD25E3D489" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_AE506D3AD36080E015CB57AD25E01014" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_4679CF0C866AB803DD7C57AD25E3D489" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_3193BC7F1F1AD120F3C357AD25E3962B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_4679CF0C866AB803DD7C57AD25E3D489" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_3193BC7F1F1AD120F3C357AD25E3962B" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/ProductSalesScheduleOfSalesRelatedDeductionsActivityDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenuesAbstract" xlink:label="loc_us-gaap_RevenuesAbstract_4838328B5B686B67FA805882EDEE0785" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ValuationAndQualifyingAccountsDisclosureTable" xlink:label="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_3EAB4243E6B2A2FA05C95882EDEF271A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesAbstract_4838328B5B686B67FA805882EDEE0785" xlink:to="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_3EAB4243E6B2A2FA05C95882EDEF271A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ValuationAllowancesAndReservesTypeAxis" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_BF8C8554EC6A13DBE1045882EDEF1289" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_3EAB4243E6B2A2FA05C95882EDEF271A" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_BF8C8554EC6A13DBE1045882EDEF1289" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ValuationAllowancesAndReservesDomain" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDomain_D011DF319D45C47784655882EDF0EF10" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_BF8C8554EC6A13DBE1045882EDEF1289" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDomain_D011DF319D45C47784655882EDF0EF10" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_RebatesAndChargebacksMember" xlink:label="loc_regn_RebatesAndChargebacksMember_5E2BDC484B909528A37E5882EDF1D444" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesDomain_D011DF319D45C47784655882EDF0EF10" xlink:to="loc_regn_RebatesAndChargebacksMember_5E2BDC484B909528A37E5882EDF1D444" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_DistributionRelatedFeesMember" xlink:label="loc_regn_DistributionRelatedFeesMember_5F2A63B3241DDFFE50245882EDF19FAD" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesDomain_D011DF319D45C47784655882EDF0EF10" xlink:to="loc_regn_DistributionRelatedFeesMember_5F2A63B3241DDFFE50245882EDF19FAD" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_OtherSalesRelatedDeductionsMember" xlink:label="loc_regn_OtherSalesRelatedDeductionsMember_47C3070C588F32D32BA55882EDF20296" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesDomain_D011DF319D45C47784655882EDF0EF10" xlink:to="loc_regn_OtherSalesRelatedDeductionsMember_47C3070C588F32D32BA55882EDF20296" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ValuationAndQualifyingAccountsDisclosureLineItems" xlink:label="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_EFBC8817C83E277C365F5882EDF23033" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_3EAB4243E6B2A2FA05C95882EDEF271A" xlink:to="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_EFBC8817C83E277C365F5882EDF23033" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ValuationAllowancesAndReservesBalance" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesBalance_45AF3ABBAFAC677A81E75882EDF27201" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_EFBC8817C83E277C365F5882EDF23033" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesBalance_45AF3ABBAFAC677A81E75882EDF27201" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ValuationAllowancesAndReservesChargedToOtherAccounts" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesChargedToOtherAccounts_B1F2FC4711F39FD4088A5882EDF3E06D" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_EFBC8817C83E277C365F5882EDF23033" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesChargedToOtherAccounts_B1F2FC4711F39FD4088A5882EDF3E06D" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ValuationAllowancesAndReservesDeductions" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDeductions_2CC64859B79A6ECFF8515882EDF433EA" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_EFBC8817C83E277C365F5882EDF23033" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDeductions_2CC64859B79A6ECFF8515882EDF433EA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ValuationAllowancesAndReservesBalance" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesBalance_1D0AC72E521776F3CBD75882EDF4391A" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_EFBC8817C83E277C365F5882EDF23033" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesBalance_1D0AC72E521776F3CBD75882EDF4391A" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/ProductSalesTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenuesAbstract" xlink:label="loc_us-gaap_RevenuesAbstract_8EDEA9E7EAE7F85FF81257AD25E8BDAE" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTableTextBlock" xlink:label="loc_us-gaap_DisaggregationOfRevenueTableTextBlock_AEAC8F6B4F6F4C800EBF57AD25E9E838" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesAbstract_8EDEA9E7EAE7F85FF81257AD25E8BDAE" xlink:to="loc_us-gaap_DisaggregationOfRevenueTableTextBlock_AEAC8F6B4F6F4C800EBF57AD25E9E838" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock" xlink:label="loc_us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock_9A85D5A7AE5340C0DFE057AD25E9C420" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesAbstract_8EDEA9E7EAE7F85FF81257AD25E8BDAE" xlink:to="loc_us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock_9A85D5A7AE5340C0DFE057AD25E9C420" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_ScheduleOfSalesRelatedDeductionsActivityTableTextBlock" xlink:label="loc_regn_ScheduleOfSalesRelatedDeductionsActivityTableTextBlock_52F325477E28DB821C3C57AD25EA9D7A" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesAbstract_8EDEA9E7EAE7F85FF81257AD25E8BDAE" xlink:to="loc_regn_ScheduleOfSalesRelatedDeductionsActivityTableTextBlock_52F325477E28DB821C3C57AD25EA9D7A" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/PropertyPlantAndEquipment" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAbstract" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_63BB9A4D8FB2F578E0DF57AD246E83C1" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock_8B19A502EBC082B9AF1157AD246FDA24" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_63BB9A4D8FB2F578E0DF57AD246E83C1" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock_8B19A502EBC082B9AF1157AD246FDA24" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/PropertyPlantAndEquipmentNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAbstract" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_B25D661F69B3AC1BDF9658826774899B" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_6EA2EFA2ADB017BC51A458826866C523" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_B25D661F69B3AC1BDF9658826774899B" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_6EA2EFA2ADB017BC51A458826866C523" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_StatementGeographicalAxis" xlink:label="loc_srt_StatementGeographicalAxis_ABFC958DFEA7FE665F97588268F995A6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_6EA2EFA2ADB017BC51A458826866C523" xlink:to="loc_srt_StatementGeographicalAxis_ABFC958DFEA7FE665F97588268F995A6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_SegmentGeographicalDomain" xlink:label="loc_srt_SegmentGeographicalDomain_274569140E9C17B0F0F158826C9A7F69" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_StatementGeographicalAxis_ABFC958DFEA7FE665F97588268F995A6" xlink:to="loc_srt_SegmentGeographicalDomain_274569140E9C17B0F0F158826C9A7F69" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_US" xlink:label="loc_country_US_7FB8059B668EF1A54FCB58826919D664" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_SegmentGeographicalDomain_274569140E9C17B0F0F158826C9A7F69" xlink:to="loc_country_US_7FB8059B668EF1A54FCB58826919D664" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_EuropeMember" xlink:label="loc_srt_EuropeMember_4565C421C2356DC5FA2858826931CF8A" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_SegmentGeographicalDomain_274569140E9C17B0F0F158826C9A7F69" xlink:to="loc_srt_EuropeMember_4565C421C2356DC5FA2858826931CF8A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_D8670A28A56DF98E05805882686FF342" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_6EA2EFA2ADB017BC51A458826866C523" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentLineItems_D8670A28A56DF98E05805882686FF342" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_246696B9D5F48798A61258826896EFB4" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_D8670A28A56DF98E05805882686FF342" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_246696B9D5F48798A61258826896EFB4" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_DepreciationDepletionAndAmortizationExcludingIntangibleAssets" xlink:label="loc_regn_DepreciationDepletionAndAmortizationExcludingIntangibleAssets_4D56A456F0990EFEDC62588268AFAA77" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_D8670A28A56DF98E05805882686FF342" xlink:to="loc_regn_DepreciationDepletionAndAmortizationExcludingIntangibleAssets_4D56A456F0990EFEDC62588268AFAA77" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_CapitalAndFacilityLeasesAtCost" xlink:label="loc_regn_CapitalAndFacilityLeasesAtCost_6FC45D5FD21AC3C1FE3C588268C5AA45" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_D8670A28A56DF98E05805882686FF342" xlink:to="loc_regn_CapitalAndFacilityLeasesAtCost_6FC45D5FD21AC3C1FE3C588268C5AA45" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_AccumulatedAmortizationOfCapitalAndFacilityLeases" xlink:label="loc_regn_AccumulatedAmortizationOfCapitalAndFacilityLeases_30F5580463243827E495588268DF300C" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_D8670A28A56DF98E05805882686FF342" xlink:to="loc_regn_AccumulatedAmortizationOfCapitalAndFacilityLeases_30F5580463243827E495588268DF300C" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/PropertyPlantAndEquipmentScheduleOfPropertyPlantAndEquipmentDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAbstract" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_CB802CC7D070C4884603588187CA0AD3" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_91055BE90B85EF5BE661588187CB8DC1" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_CB802CC7D070C4884603588187CA0AD3" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_91055BE90B85EF5BE661588187CB8DC1" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_A9BCB4C6E43E3A24FBD0588187D33073" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_91055BE90B85EF5BE661588187CB8DC1" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_A9BCB4C6E43E3A24FBD0588187D33073" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_E9C2D13BDF36957975F1588187D364E6" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_A9BCB4C6E43E3A24FBD0588187D33073" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_E9C2D13BDF36957975F1588187D364E6" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LandMember" xlink:label="loc_us-gaap_LandMember_5C0624E97CCF0B562AED588187D40CB8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_E9C2D13BDF36957975F1588187D364E6" xlink:to="loc_us-gaap_LandMember_5C0624E97CCF0B562AED588187D40CB8" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BuildingAndBuildingImprovementsMember" xlink:label="loc_us-gaap_BuildingAndBuildingImprovementsMember_FE94860560E1CFF991C4588187D46889" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_E9C2D13BDF36957975F1588187D364E6" xlink:to="loc_us-gaap_BuildingAndBuildingImprovementsMember_FE94860560E1CFF991C4588187D46889" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeaseholdImprovementsMember" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_5CC74A5D46E7184681CB588187D59DFF" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_E9C2D13BDF36957975F1588187D364E6" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_5CC74A5D46E7184681CB588187D59DFF" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConstructionInProgressMember" xlink:label="loc_us-gaap_ConstructionInProgressMember_E8CFA5BC874AA5053B38588187D58ABA" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_E9C2D13BDF36957975F1588187D364E6" xlink:to="loc_us-gaap_ConstructionInProgressMember_E8CFA5BC874AA5053B38588187D58ABA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquipmentMember" xlink:label="loc_us-gaap_EquipmentMember_1897EE08A5E877F152B2588187D50407" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_E9C2D13BDF36957975F1588187D364E6" xlink:to="loc_us-gaap_EquipmentMember_1897EE08A5E877F152B2588187D50407" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OfficeEquipmentMember" xlink:label="loc_us-gaap_OfficeEquipmentMember_F19B631D7F1EFF5E5B1B588187DB9E8C" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_E9C2D13BDF36957975F1588187D364E6" xlink:to="loc_us-gaap_OfficeEquipmentMember_F19B631D7F1EFF5E5B1B588187DB9E8C" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_31087D081656F971E111588187DB0865" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_91055BE90B85EF5BE661588187CB8DC1" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentLineItems_31087D081656F971E111588187DB0865" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_210EF04A4DC6FC01C01C588187DCD677" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_31087D081656F971E111588187DB0865" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_210EF04A4DC6FC01C01C588187DCD677" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_1BB4B9812D8A42AD6025588187DC50C2" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_31087D081656F971E111588187DB0865" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_1BB4B9812D8A42AD6025588187DC50C2" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_B12E028D4A45554DF542588187DCF3A6" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_31087D081656F971E111588187DB0865" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_B12E028D4A45554DF542588187DCF3A6" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/PropertyPlantAndEquipmentTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentAbstract" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_14D85B3DB149BE8D609E57AD246AB68C" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTextBlock" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_937FDCF753CBD05E0CCF57AD246AA6AE" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_14D85B3DB149BE8D609E57AD246AB68C" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_937FDCF753CBD05E0CCF57AD246AA6AE" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/StatementOfCashFlows" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SupplementalCashFlowInformationAbstract" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_E46AEDE15045041330D857AD260A123C" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashFlowSupplementalDisclosuresTextBlock" xlink:label="loc_us-gaap_CashFlowSupplementalDisclosuresTextBlock_931A6EFC7A2E6C68EF4D57AD260AF376" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_E46AEDE15045041330D857AD260A123C" xlink:to="loc_us-gaap_CashFlowSupplementalDisclosuresTextBlock_931A6EFC7A2E6C68EF4D57AD260AF376" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/StatementOfCashFlowsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SupplementalCashFlowInformationAbstract" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_9784633F94F795F6898F80B84550BC55" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CondensedCashFlowStatementTable" xlink:label="loc_srt_CondensedCashFlowStatementTable_1BF7EE885433F6AA44FA80B845516F28" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_9784633F94F795F6898F80B84550BC55" xlink:to="loc_srt_CondensedCashFlowStatementTable_1BF7EE885433F6AA44FA80B845516F28" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis" xlink:label="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_2D95BA52831E828E916980B84551393A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CondensedCashFlowStatementTable_1BF7EE885433F6AA44FA80B845516F28" xlink:to="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_2D95BA52831E828E916980B84551393A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProjectMember" xlink:label="loc_us-gaap_ProjectMember_94771CA63B068B8B95C480B845511537" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_2D95BA52831E828E916980B84551393A" xlink:to="loc_us-gaap_ProjectMember_94771CA63B068B8B95C480B845511537" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_SanofiCollaborationAgreementImmunooncologyMember" xlink:label="loc_regn_SanofiCollaborationAgreementImmunooncologyMember_8258B400A40574025FA580B84552E902" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_94771CA63B068B8B95C480B845511537" xlink:to="loc_regn_SanofiCollaborationAgreementImmunooncologyMember_8258B400A40574025FA580B84552E902" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CondensedCashFlowStatementsCaptionsLineItems" xlink:label="loc_srt_CondensedCashFlowStatementsCaptionsLineItems_B6191D40D66139F4050180B845520C79" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CondensedCashFlowStatementTable_1BF7EE885433F6AA44FA80B845516F28" xlink:to="loc_srt_CondensedCashFlowStatementsCaptionsLineItems_B6191D40D66139F4050180B845520C79" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_AccruedCapitalExpenditures" xlink:label="loc_regn_AccruedCapitalExpenditures_CD0D69538CE5134B34B780B84553EF8B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CondensedCashFlowStatementsCaptionsLineItems_B6191D40D66139F4050180B845520C79" xlink:to="loc_regn_AccruedCapitalExpenditures_CD0D69538CE5134B34B780B84553EF8B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TreasuryStockSharesAcquired" xlink:label="loc_us-gaap_TreasuryStockSharesAcquired_ED447D7D89CEB8C3E21780B84553B87B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CondensedCashFlowStatementsCaptionsLineItems_B6191D40D66139F4050180B845520C79" xlink:to="loc_us-gaap_TreasuryStockSharesAcquired_ED447D7D89CEB8C3E21780B84553B87B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TreasuryStockValueAcquiredCostMethod" xlink:label="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_36E8294B48153F788FD380B845535402" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CondensedCashFlowStatementsCaptionsLineItems_B6191D40D66139F4050180B845520C79" xlink:to="loc_us-gaap_TreasuryStockValueAcquiredCostMethod_36E8294B48153F788FD380B845535402" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalLeaseObligationsIncurred" xlink:label="loc_us-gaap_CapitalLeaseObligationsIncurred_8245A1AAF21D2107D17580B84553A703" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CondensedCashFlowStatementsCaptionsLineItems_B6191D40D66139F4050180B845520C79" xlink:to="loc_us-gaap_CapitalLeaseObligationsIncurred_8245A1AAF21D2107D17580B84553A703" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/StatementOfCashFlowsScheduleOfReconciliationOfCashCashEquivalentsAndRestrictedCashDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SupplementalCashFlowInformationAbstract" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_672232067AEDCF2BF12A57890D63FAEF" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_F221ECE0D402DC19CF4E57890D647C75" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_672232067AEDCF2BF12A57890D63FAEF" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_F221ECE0D402DC19CF4E57890D647C75" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedCash" xlink:label="loc_us-gaap_RestrictedCash_0A25894D9C9E9DE0E69457890D647FE7" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_672232067AEDCF2BF12A57890D63FAEF" xlink:to="loc_us-gaap_RestrictedCash_0A25894D9C9E9DE0E69457890D647FE7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_FCDF5EE38C929127120857890D642597" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/totalLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_672232067AEDCF2BF12A57890D63FAEF" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_FCDF5EE38C929127120857890D642597" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/StatementOfCashFlowsTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SupplementalCashFlowInformationAbstract" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_FA316E58540A5962FC0657890D0741C0" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfRestrictedCashAndCashEquivalentsTextBlock" xlink:label="loc_us-gaap_ScheduleOfRestrictedCashAndCashEquivalentsTextBlock_0509917834CBD44D2B0E57890D07CE22" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_FA316E58540A5962FC0657890D0741C0" xlink:to="loc_us-gaap_ScheduleOfRestrictedCashAndCashEquivalentsTextBlock_0509917834CBD44D2B0E57890D07CE22" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/StockholdersEquity" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_181226BEBC28E9285E5057AD23C3FDCB" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquityNoteDisclosureTextBlock" xlink:label="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_BC3A3A5FDB47B445541957AD23C38365" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_181226BEBC28E9285E5057AD23C3FDCB" xlink:to="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_BC3A3A5FDB47B445541957AD23C38365" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/StockholdersEquityNarrativeDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityAbstract" xlink:label="loc_us-gaap_EquityAbstract_E55CB83D54C88320F375C3CD98CB3FD7" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfStockByClassTable" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_E9B6835FC7B6E9E96453C3CD98CB32D7" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_E55CB83D54C88320F375C3CD98CB3FD7" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_E9B6835FC7B6E9E96453C3CD98CB32D7" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis" xlink:label="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_6A20F49FADC9800DA4C6C3CD98CB5C9A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_E9B6835FC7B6E9E96453C3CD98CB32D7" xlink:to="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_6A20F49FADC9800DA4C6C3CD98CB5C9A" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProjectMember" xlink:label="loc_us-gaap_ProjectMember_C32456D69EB4E3820866C3CD98CC9AAA" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProjectAxis_6A20F49FADC9800DA4C6C3CD98CB5C9A" xlink:to="loc_us-gaap_ProjectMember_C32456D69EB4E3820866C3CD98CC9AAA" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_SanofiCollaborationAgreementMember" xlink:label="loc_regn_SanofiCollaborationAgreementMember_F5D219EC15CFA1728078C3CD98CCF1B8" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_C32456D69EB4E3820866C3CD98CC9AAA" xlink:to="loc_regn_SanofiCollaborationAgreementMember_F5D219EC15CFA1728078C3CD98CCF1B8" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_BayerCollaborationAgreementMember" xlink:label="loc_regn_BayerCollaborationAgreementMember_EC55ED5939D7BB76333EC3CD98CCF1CF" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_C32456D69EB4E3820866C3CD98CC9AAA" xlink:to="loc_regn_BayerCollaborationAgreementMember_EC55ED5939D7BB76333EC3CD98CCF1CF" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_TevaPharmaceuticalsCollaborationAgreementMember" xlink:label="loc_regn_TevaPharmaceuticalsCollaborationAgreementMember_D7C99F2CFD041D35ECFBC3CD98CCC2CA" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ProjectMember_C32456D69EB4E3820866C3CD98CC9AAA" xlink:to="loc_regn_TevaPharmaceuticalsCollaborationAgreementMember_D7C99F2CFD041D35ECFBC3CD98CCC2CA" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementClassOfStockAxis" xlink:label="loc_us-gaap_StatementClassOfStockAxis_3C30DC353803FEE95494C3CD98CD4CEC" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_E9B6835FC7B6E9E96453C3CD98CB32D7" xlink:to="loc_us-gaap_StatementClassOfStockAxis_3C30DC353803FEE95494C3CD98CD4CEC" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockDomain" xlink:label="loc_us-gaap_ClassOfStockDomain_D401FBE41DDB12CF437EC3CD98CDAD89" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_3C30DC353803FEE95494C3CD98CD4CEC" xlink:to="loc_us-gaap_ClassOfStockDomain_D401FBE41DDB12CF437EC3CD98CDAD89" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonClassAMember" xlink:label="loc_us-gaap_CommonClassAMember_64D17E5AB14ECA46749EC3CD98CD1A7F" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_D401FBE41DDB12CF437EC3CD98CDAD89" xlink:to="loc_us-gaap_CommonClassAMember_64D17E5AB14ECA46749EC3CD98CD1A7F" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockMember" xlink:label="loc_us-gaap_CommonStockMember_EED0A16D7A32BEC4CEDCC3CD98CE629B" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_D401FBE41DDB12CF437EC3CD98CDAD89" xlink:to="loc_us-gaap_CommonStockMember_EED0A16D7A32BEC4CEDCC3CD98CE629B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfStockLineItems" xlink:label="loc_us-gaap_ClassOfStockLineItems_D436BC3EC7FFE1585052C3CD98CEDB99" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_E9B6835FC7B6E9E96453C3CD98CB32D7" xlink:to="loc_us-gaap_ClassOfStockLineItems_D436BC3EC7FFE1585052C3CD98CEDB99" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockSharesAuthorized" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_1EB2477851BF13C2BD90C3CD98CE7A0B" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_D436BC3EC7FFE1585052C3CD98CEDB99" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_1EB2477851BF13C2BD90C3CD98CE7A0B" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_3783474C7F19C6F37957C3CD995F19B7" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_D436BC3EC7FFE1585052C3CD98CEDB99" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_3783474C7F19C6F37957C3CD995F19B7" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_NumberOfVotesPerShare" xlink:label="loc_regn_NumberOfVotesPerShare_D023DB391F7B919B525EC3CD9960EB42" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_D436BC3EC7FFE1585052C3CD98CEDB99" xlink:to="loc_regn_NumberOfVotesPerShare_D023DB391F7B919B525EC3CD9960EB42" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PreferredStockSharesAuthorized" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_8DB94230C855BEB850C9C3CD9960E334" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_D436BC3EC7FFE1585052C3CD98CEDB99" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_8DB94230C855BEB850C9C3CD9960E334" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_NumberofNewlyIssuedSharesPurchased" xlink:label="loc_regn_NumberofNewlyIssuedSharesPurchased_E8DC32B524BA699F29C3C3CD99604545" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_D436BC3EC7FFE1585052C3CD98CEDB99" xlink:to="loc_regn_NumberofNewlyIssuedSharesPurchased_E8DC32B524BA699F29C3C3CD99604545" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_NumberOfDemandRightsToRequireTheCompanyToConductRegisteredUnderwrittenPublicOffering" xlink:label="loc_regn_NumberOfDemandRightsToRequireTheCompanyToConductRegisteredUnderwrittenPublicOffering_6156882177436F6847AFC3CD99603AC0" xlink:type="locator" />
    <link:presentationArc order="6" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_D436BC3EC7FFE1585052C3CD98CEDB99" xlink:to="loc_regn_NumberOfDemandRightsToRequireTheCompanyToConductRegisteredUnderwrittenPublicOffering_6156882177436F6847AFC3CD99603AC0" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_Maximumsharesthecollaboratorcouldsell" xlink:label="loc_regn_Maximumsharesthecollaboratorcouldsell_138C3D50D28099357492C3CD9961274B" xlink:type="locator" />
    <link:presentationArc order="7" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_D436BC3EC7FFE1585052C3CD98CEDB99" xlink:to="loc_regn_Maximumsharesthecollaboratorcouldsell_138C3D50D28099357492C3CD9961274B" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_MaximumPercentageOfOutstandingSharesThatMayBeAcquiredUnderStandstillProvisions" xlink:label="loc_regn_MaximumPercentageOfOutstandingSharesThatMayBeAcquiredUnderStandstillProvisions_6560D7ED8F9F2C42174AC3CD9961ECDC" xlink:type="locator" />
    <link:presentationArc order="8" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_D436BC3EC7FFE1585052C3CD98CEDB99" xlink:to="loc_regn_MaximumPercentageOfOutstandingSharesThatMayBeAcquiredUnderStandstillProvisions_6560D7ED8F9F2C42174AC3CD9961ECDC" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_PercentageOfOutstandingSharesOrVotingRightsUnderAmendedInvestorAgreement" xlink:label="loc_regn_PercentageOfOutstandingSharesOrVotingRightsUnderAmendedInvestorAgreement_D1155DDB13DD117D183EC3CD9961DEC7" xlink:type="locator" />
    <link:presentationArc order="9" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_D436BC3EC7FFE1585052C3CD98CEDB99" xlink:to="loc_regn_PercentageOfOutstandingSharesOrVotingRightsUnderAmendedInvestorAgreement_D1155DDB13DD117D183EC3CD9961DEC7" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_PercentageOfOutstandingSharesThatTheCompanyIsRequiredToAppointAnIndividualAgreedUponByTheCompanyAndTheCollaboratorToTheCompanysBoardOfDirectors" xlink:label="loc_regn_PercentageOfOutstandingSharesThatTheCompanyIsRequiredToAppointAnIndividualAgreedUponByTheCompanyAndTheCollaboratorToTheCompanysBoardOfDirectors_C406D7DBF5B01E0EB248C3CD99618001" xlink:type="locator" />
    <link:presentationArc order="10" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_D436BC3EC7FFE1585052C3CD98CEDB99" xlink:to="loc_regn_PercentageOfOutstandingSharesThatTheCompanyIsRequiredToAppointAnIndividualAgreedUponByTheCompanyAndTheCollaboratorToTheCompanysBoardOfDirectors_C406D7DBF5B01E0EB248C3CD99618001" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/UnauditedQuarterlyResults" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_QuarterlyFinancialInformationDisclosureAbstract" xlink:label="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_E821F07DCC389C1F588D57AD21FA6087" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_QuarterlyFinancialInformationTextBlock" xlink:label="loc_us-gaap_QuarterlyFinancialInformationTextBlock_BB304FAE37E94BC07AE657AD21FA8A4A" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_E821F07DCC389C1F588D57AD21FA6087" xlink:to="loc_us-gaap_QuarterlyFinancialInformationTextBlock_BB304FAE37E94BC07AE657AD21FA8A4A" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/UnauditedQuarterlyResultsScheduleOfUnauditedQuarterlyResultsDetails" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_QuarterlyFinancialInformationDisclosureAbstract" xlink:label="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_9458194CE3C7DB2F704957AD21DDEAFB" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_C4FF3CD0A580B5037DF057C3A652F4A3" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_9458194CE3C7DB2F704957AD21DDEAFB" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_C4FF3CD0A580B5037DF057C3A652F4A3" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss" xlink:label="loc_us-gaap_NetIncomeLoss_ACD1184DDC62E11AD68757AD21DE2504" xlink:type="locator" />
    <link:presentationArc order="2" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_9458194CE3C7DB2F704957AD21DDEAFB" xlink:to="loc_us-gaap_NetIncomeLoss_ACD1184DDC62E11AD68757AD21DE2504" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareBasic" xlink:label="loc_us-gaap_EarningsPerShareBasic_B7D689CC085B420D8FDD57AD21DFEE77" xlink:type="locator" />
    <link:presentationArc order="3" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_9458194CE3C7DB2F704957AD21DDEAFB" xlink:to="loc_us-gaap_EarningsPerShareBasic_B7D689CC085B420D8FDD57AD21DFEE77" xlink:type="arc" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareDiluted" xlink:label="loc_us-gaap_EarningsPerShareDiluted_CBD9803B1684F8E9F81957AD21E0EEE0" xlink:type="locator" />
    <link:presentationArc order="4" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_9458194CE3C7DB2F704957AD21DDEAFB" xlink:to="loc_us-gaap_EarningsPerShareDiluted_CBD9803B1684F8E9F81957AD21E0EEE0" xlink:type="arc" />
    <link:loc xlink:href="regn-20181231.xsd#regn_TaxCutsAndJobsActOf2017IncompleteAccountingProvisionalIncomeTaxExpenseBenefit" xlink:label="loc_regn_TaxCutsAndJobsActOf2017IncompleteAccountingProvisionalIncomeTaxExpenseBenefit_39337CC15558CC45CA5657AD21E0C3C2" xlink:type="locator" />
    <link:presentationArc order="5" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_9458194CE3C7DB2F704957AD21DDEAFB" xlink:to="loc_regn_TaxCutsAndJobsActOf2017IncompleteAccountingProvisionalIncomeTaxExpenseBenefit_39337CC15558CC45CA5657AD21E0C3C2" xlink:type="arc" />
  </link:presentationLink>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/UnauditedQuarterlyResultsTables" xlink:type="extended">
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_QuarterlyFinancialInformationDisclosureAbstract" xlink:label="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_C91D0869BB6A2D3BAA3FAE2D5C0C227A" xlink:type="locator" />
    <link:loc xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock" xlink:label="loc_us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock_FB748D64C83283DB3336AE2D5C0DCB90" xlink:type="locator" />
    <link:presentationArc order="1" preferredLabel="http://www.xbrl.org/2003/role/terseLabel" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_C91D0869BB6A2D3BAA3FAE2D5C0C227A" xlink:to="loc_us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock_FB748D64C83283DB3336AE2D5C0DCB90" xlink:type="arc" />
  </link:presentationLink>
</link:linkbase>
