<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:28dc3cf1-83f9-43bc-972c-bdc1fdc5cd44,g:31547e34-7092-4c27-8273-7b6f04ece633-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.regeneron.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="regn-20251231.xsd#CONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_6767e5ee-c985-4d56-9e7a-044d0703f4bf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_f0d8de42-44f1-42af-979f-cf124a0ff5fc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_6767e5ee-c985-4d56-9e7a-044d0703f4bf" xlink:to="loc_us-gaap_StockholdersEquity_f0d8de42-44f1-42af-979f-cf124a0ff5fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_c645b5e1-ac60-4f17-aa81-0175e0deee58" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_6767e5ee-c985-4d56-9e7a-044d0703f4bf" xlink:to="loc_us-gaap_CommitmentsAndContingencies_c645b5e1-ac60-4f17-aa81-0175e0deee58" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_39a787f2-76c1-4311-8de4-1f15baeb2f57" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_6767e5ee-c985-4d56-9e7a-044d0703f4bf" xlink:to="loc_us-gaap_Liabilities_39a787f2-76c1-4311-8de4-1f15baeb2f57" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_1171f99d-dffc-43d1-a750-db960d4a338c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_7cd00942-0669-4454-baf6-19a0951ecfa4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_1171f99d-dffc-43d1-a750-db960d4a338c" xlink:to="loc_us-gaap_LiabilitiesCurrent_7cd00942-0669-4454-baf6-19a0951ecfa4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_9ad0b753-3a1d-4616-bba4-5daebfb6a84e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_1171f99d-dffc-43d1-a750-db960d4a338c" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_9ad0b753-3a1d-4616-bba4-5daebfb6a84e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_69fdde12-2f0f-40fa-9666-9dc7a753960c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_1171f99d-dffc-43d1-a750-db960d4a338c" xlink:to="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_69fdde12-2f0f-40fa-9666-9dc7a753960c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_eaaa254b-50dc-46d5-860b-474ac7cc0b40" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_1171f99d-dffc-43d1-a750-db960d4a338c" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_eaaa254b-50dc-46d5-860b-474ac7cc0b40" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_8032217e-66c1-4ff9-b556-2bfc34129a9d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_1171f99d-dffc-43d1-a750-db960d4a338c" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_8032217e-66c1-4ff9-b556-2bfc34129a9d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_e498e04d-e0ad-48bc-aff1-90a5fb758feb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_542e6d64-41e3-412a-a21f-0d841e283886" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_e498e04d-e0ad-48bc-aff1-90a5fb758feb" xlink:to="loc_us-gaap_AccountsPayableCurrent_542e6d64-41e3-412a-a21f-0d841e283886" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesAndOtherLiabilities_707d8147-c7ae-4334-ae1b-75aad832724c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccruedLiabilitiesAndOtherLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_e498e04d-e0ad-48bc-aff1-90a5fb758feb" xlink:to="loc_us-gaap_AccruedLiabilitiesAndOtherLiabilities_707d8147-c7ae-4334-ae1b-75aad832724c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_1ae9efc7-55d9-4913-9efb-0a66a99ff876" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_e498e04d-e0ad-48bc-aff1-90a5fb758feb" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_1ae9efc7-55d9-4913-9efb-0a66a99ff876" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_82b98dce-665c-4d4c-b627-48c1d71b7491" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_203dee38-4a10-4cb7-b149-8414d74c5ef8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_82b98dce-665c-4d4c-b627-48c1d71b7491" xlink:to="loc_us-gaap_AssetsCurrent_203dee38-4a10-4cb7-b149-8414d74c5ef8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesNoncurrent_a5c93de1-99cd-43ae-8f97-4a4e1996eb8a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_MarketableSecuritiesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_82b98dce-665c-4d4c-b627-48c1d71b7491" xlink:to="loc_us-gaap_MarketableSecuritiesNoncurrent_a5c93de1-99cd-43ae-8f97-4a4e1996eb8a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_de96358b-a0b4-4cd6-be38-0e2403f3d49d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_82b98dce-665c-4d4c-b627-48c1d71b7491" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_de96358b-a0b4-4cd6-be38-0e2403f3d49d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_faaff326-9760-4785-906a-c60778788ee3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_82b98dce-665c-4d4c-b627-48c1d71b7491" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_faaff326-9760-4785-906a-c60778788ee3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_4889d4ea-6286-45f1-9e9a-15100c183659" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_82b98dce-665c-4d4c-b627-48c1d71b7491" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_4889d4ea-6286-45f1-9e9a-15100c183659" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_5d3f5130-6bdf-46fa-a5a5-8cbb63d44d08" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_82b98dce-665c-4d4c-b627-48c1d71b7491" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_5d3f5130-6bdf-46fa-a5a5-8cbb63d44d08" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_62a02ed1-3ff0-4208-b2bd-4dbf083caf40" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_72e85399-6e59-4564-b4d5-3f95e4883a00" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_62a02ed1-3ff0-4208-b2bd-4dbf083caf40" xlink:to="loc_us-gaap_PreferredStockValue_72e85399-6e59-4564-b4d5-3f95e4883a00" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_71a2ea4c-2658-4152-b4de-da7416c5e78a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_62a02ed1-3ff0-4208-b2bd-4dbf083caf40" xlink:to="loc_us-gaap_CommonStockValue_71a2ea4c-2658-4152-b4de-da7416c5e78a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_df797c8f-6ccb-4729-8021-5bad954689f6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_62a02ed1-3ff0-4208-b2bd-4dbf083caf40" xlink:to="loc_us-gaap_AdditionalPaidInCapital_df797c8f-6ccb-4729-8021-5bad954689f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_84dd1c2e-a698-4676-ad6d-e71f2c984ec1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_62a02ed1-3ff0-4208-b2bd-4dbf083caf40" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_84dd1c2e-a698-4676-ad6d-e71f2c984ec1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_b51d002c-7a7c-41fd-ace3-04caac558ca0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_62a02ed1-3ff0-4208-b2bd-4dbf083caf40" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_b51d002c-7a7c-41fd-ace3-04caac558ca0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonValue_76810e98-570d-478c-8422-0fd17c0be191" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TreasuryStockCommonValue"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_62a02ed1-3ff0-4208-b2bd-4dbf083caf40" xlink:to="loc_us-gaap_TreasuryStockCommonValue_76810e98-570d-478c-8422-0fd17c0be191" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_1a0aebe1-ed17-46fd-95e7-87dd54056481" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_c980592c-03b1-41e9-b1d2-b5c39e11e03d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_1a0aebe1-ed17-46fd-95e7-87dd54056481" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_c980592c-03b1-41e9-b1d2-b5c39e11e03d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesCurrent_aa4fef87-3ac2-4bf7-b081-4144699ed519" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_MarketableSecuritiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_1a0aebe1-ed17-46fd-95e7-87dd54056481" xlink:to="loc_us-gaap_MarketableSecuritiesCurrent_aa4fef87-3ac2-4bf7-b081-4144699ed519" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_9360b4eb-dab2-4644-8333-ec6b4e0d2312" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_1a0aebe1-ed17-46fd-95e7-87dd54056481" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_9360b4eb-dab2-4644-8333-ec6b4e0d2312" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_18af3d64-b1df-4671-80ca-6d16c3a56a2b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_1a0aebe1-ed17-46fd-95e7-87dd54056481" xlink:to="loc_us-gaap_InventoryNet_18af3d64-b1df-4671-80ca-6d16c3a56a2b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_22468970-ef66-4842-8227-3a5822114891" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_1a0aebe1-ed17-46fd-95e7-87dd54056481" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_22468970-ef66-4842-8227-3a5822114891" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVEINCOME" xlink:type="simple" xlink:href="regn-20251231.xsd#CONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVEINCOME"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONSANDCOMPREHENSIVEINCOME" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_a5762e6f-4bc3-438a-90fe-699b3a7cb83c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_8daef057-4223-44c5-8757-4eefb66e52e5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_a5762e6f-4bc3-438a-90fe-699b3a7cb83c" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_8daef057-4223-44c5-8757-4eefb66e52e5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_b69857dd-43a8-4a33-a9f4-ee3179f356b2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostsAndExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_a5762e6f-4bc3-438a-90fe-699b3a7cb83c" xlink:to="loc_us-gaap_CostsAndExpenses_b69857dd-43a8-4a33-a9f4-ee3179f356b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_952eecad-172e-4527-a044-0a2d34ffb1a6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_8f2e7a49-d4b2-4eac-9aae-e4a3d115c7e7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_952eecad-172e-4527-a044-0a2d34ffb1a6" xlink:to="loc_us-gaap_OperatingIncomeLoss_8f2e7a49-d4b2-4eac-9aae-e4a3d115c7e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_d078f653-ef7b-4c6f-9486-58ba950120d9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_952eecad-172e-4527-a044-0a2d34ffb1a6" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_d078f653-ef7b-4c6f-9486-58ba950120d9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostsAndExpenses_01e24b92-77b3-498e-b4ac-6dc7cb57d897" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostsAndExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOperatingIncomeExpenseNet_e676b4fa-5dac-4a6d-b4e0-8fa1613f05b7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherOperatingIncomeExpenseNet"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_01e24b92-77b3-498e-b4ac-6dc7cb57d897" xlink:to="loc_us-gaap_OtherOperatingIncomeExpenseNet_e676b4fa-5dac-4a6d-b4e0-8fa1613f05b7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_AcquiredInProcessResearchAndDevelopment_be0d890a-e3ca-482c-9e01-deb94a901736" xlink:href="regn-20251231.xsd#regn_AcquiredInProcessResearchAndDevelopment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_01e24b92-77b3-498e-b4ac-6dc7cb57d897" xlink:to="loc_regn_AcquiredInProcessResearchAndDevelopment_be0d890a-e3ca-482c-9e01-deb94a901736" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_df9376d0-78ac-4bc6-8fa5-173b3eeac04a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_01e24b92-77b3-498e-b4ac-6dc7cb57d897" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_df9376d0-78ac-4bc6-8fa5-173b3eeac04a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_f42286bc-71b5-49dd-9233-941a4e6138b1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_01e24b92-77b3-498e-b4ac-6dc7cb57d897" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_f42286bc-71b5-49dd-9233-941a4e6138b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_85dbcc62-a75d-4c5a-bdea-3f7aa8178d65" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostsAndExpenses_01e24b92-77b3-498e-b4ac-6dc7cb57d897" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_85dbcc62-a75d-4c5a-bdea-3f7aa8178d65" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_10fa8fc7-b3e1-4ed0-ac35-2c668d72045d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_92499155-4b49-4340-8cdf-4a8f8475f5c7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_10fa8fc7-b3e1-4ed0-ac35-2c668d72045d" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_92499155-4b49-4340-8cdf-4a8f8475f5c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_86d295cb-c23d-45fd-a735-090a4ee26928" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_10fa8fc7-b3e1-4ed0-ac35-2c668d72045d" xlink:to="loc_us-gaap_NetIncomeLoss_86d295cb-c23d-45fd-a735-090a4ee26928" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_792eaeaf-0384-4a7e-846e-4877dfa1919f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_10fa8fc7-b3e1-4ed0-ac35-2c668d72045d" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationAdjustmentNetOfTaxPortionAttributableToParent_792eaeaf-0384-4a7e-846e-4877dfa1919f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_e71c2431-8341-442a-85f5-a2e67144dc40" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_871ca2ee-a70c-4f9a-b535-01a057d8fdf8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_e71c2431-8341-442a-85f5-a2e67144dc40" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_871ca2ee-a70c-4f9a-b535-01a057d8fdf8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_21874b5b-3cd5-4aeb-960c-e6f07804c9f8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_e71c2431-8341-442a-85f5-a2e67144dc40" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_21874b5b-3cd5-4aeb-960c-e6f07804c9f8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_8c72692c-c356-41b2-acc8-20a9810afceb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_d0814639-e5f1-4381-8ba1-4defcfa39e6b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_8c72692c-c356-41b2-acc8-20a9810afceb" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_d0814639-e5f1-4381-8ba1-4defcfa39e6b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_396cbef2-70ef-449a-aa5d-8dcc6df1fea7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_8c72692c-c356-41b2-acc8-20a9810afceb" xlink:to="loc_us-gaap_InterestExpenseNonoperating_396cbef2-70ef-449a-aa5d-8dcc6df1fea7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="regn-20251231.xsd#CONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0d17de39-a8a3-4d28-b24a-e3d8214fb129" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_2c532d4b-baeb-4bba-932c-eabf20f4b701" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0d17de39-a8a3-4d28-b24a-e3d8214fb129" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_2c532d4b-baeb-4bba-932c-eabf20f4b701" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_a44511ce-9cfd-4998-b381-a03fe3cc03f7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0d17de39-a8a3-4d28-b24a-e3d8214fb129" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_a44511ce-9cfd-4998-b381-a03fe3cc03f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_c16e5200-bd1a-497a-9870-ea63a05a1f47" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0d17de39-a8a3-4d28-b24a-e3d8214fb129" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_c16e5200-bd1a-497a-9870-ea63a05a1f47" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDividends_37678233-608b-45a3-99f8-a4272f67a248" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsOfDividends"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0d17de39-a8a3-4d28-b24a-e3d8214fb129" xlink:to="loc_us-gaap_PaymentsOfDividends_37678233-608b-45a3-99f8-a4272f67a248" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_d7d78ccb-7d25-4297-99a6-528a9e083f91" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0d17de39-a8a3-4d28-b24a-e3d8214fb129" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_d7d78ccb-7d25-4297-99a6-528a9e083f91" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_06ca70e6-85b7-494e-9dc6-edf8032ee068" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_PaymentsToAcquireIntangibleAssets1_18c32e95-ee8a-4acf-b80d-6a21e874087e" xlink:href="regn-20251231.xsd#regn_PaymentsToAcquireIntangibleAssets1"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_06ca70e6-85b7-494e-9dc6-edf8032ee068" xlink:to="loc_regn_PaymentsToAcquireIntangibleAssets1_18c32e95-ee8a-4acf-b80d-6a21e874087e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_8dfcdd78-25bb-44e7-81ab-5b7f70a02cb8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireMarketableSecurities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_06ca70e6-85b7-494e-9dc6-edf8032ee068" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_8dfcdd78-25bb-44e7-81ab-5b7f70a02cb8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireProductiveAssets_420a076f-8bed-4500-86ae-5a96b9fa7301" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireProductiveAssets"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_06ca70e6-85b7-494e-9dc6-edf8032ee068" xlink:to="loc_us-gaap_PaymentsToAcquireProductiveAssets_420a076f-8bed-4500-86ae-5a96b9fa7301" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_b5c95d10-9043-4b24-a71f-d60dd685822c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_06ca70e6-85b7-494e-9dc6-edf8032ee068" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_b5c95d10-9043-4b24-a71f-d60dd685822c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_96a31d8e-baed-4bc6-9d2f-648de1b0c8b7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_06ca70e6-85b7-494e-9dc6-edf8032ee068" xlink:to="loc_us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities_96a31d8e-baed-4bc6-9d2f-648de1b0c8b7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_08eb1460-5cb9-4f61-9459-254bc7fec3f0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_06ca70e6-85b7-494e-9dc6-edf8032ee068" xlink:to="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_08eb1460-5cb9-4f61-9459-254bc7fec3f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1cda3a3e-85a1-4bc2-80ab-07fa0a74214a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_3337687b-1ecb-42bf-8d3d-d7dd5a481843" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1cda3a3e-85a1-4bc2-80ab-07fa0a74214a" xlink:to="loc_us-gaap_NetIncomeLoss_3337687b-1ecb-42bf-8d3d-d7dd5a481843" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_da8d6ecc-8f33-4fae-a468-941bbcbf9fad" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_1cda3a3e-85a1-4bc2-80ab-07fa0a74214a" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_da8d6ecc-8f33-4fae-a468-941bbcbf9fad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_8a5aea23-3c60-484f-9146-c313225d33d2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_10976f50-4b3d-474a-b5d6-75f9c16ff7ed" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_8a5aea23-3c60-484f-9146-c313225d33d2" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_10976f50-4b3d-474a-b5d6-75f9c16ff7ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_ec8164ec-efe7-40b5-b5f4-3c60b1973cf5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_8a5aea23-3c60-484f-9146-c313225d33d2" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_ec8164ec-efe7-40b5-b5f4-3c60b1973cf5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e65dfd79-b0d7-4daf-bc10-5785c529e630" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_8a5aea23-3c60-484f-9146-c313225d33d2" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_e65dfd79-b0d7-4daf-bc10-5785c529e630" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_649829e2-e9e9-4396-b1ce-37c5531ea8c1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_8a5aea23-3c60-484f-9146-c313225d33d2" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_649829e2-e9e9-4396-b1ce-37c5531ea8c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_6fe390ae-4305-499b-ab29-1becba8daa1e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_eb8b13be-0077-4dc0-9bd5-110b10b60c92" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_6fe390ae-4305-499b-ab29-1becba8daa1e" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_eb8b13be-0077-4dc0-9bd5-110b10b60c92" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_6d4955c4-3184-4521-b08b-536ef2350ccb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_6fe390ae-4305-499b-ab29-1becba8daa1e" xlink:to="loc_us-gaap_ShareBasedCompensation_6d4955c4-3184-4521-b08b-536ef2350ccb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_MarketableAndOtherSecuritiesGainLoss_0edb5370-5b97-4fda-9982-9c09dd4fc44e" xlink:href="regn-20251231.xsd#regn_MarketableAndOtherSecuritiesGainLoss"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_6fe390ae-4305-499b-ab29-1becba8daa1e" xlink:to="loc_regn_MarketableAndOtherSecuritiesGainLoss_0edb5370-5b97-4fda-9982-9c09dd4fc44e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_7c10066c-6fb0-45a7-b2e7-7d28e0961f09" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_6fe390ae-4305-499b-ab29-1becba8daa1e" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_7c10066c-6fb0-45a7-b2e7-7d28e0961f09" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_8f3a7f28-7da4-4186-9b7d-038c0274386d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInDeferredIncomeTaxes"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_6fe390ae-4305-499b-ab29-1becba8daa1e" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_8f3a7f28-7da4-4186-9b7d-038c0274386d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_5d1c108f-1b47-4a72-ad48-f2b27f052407" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_6fe390ae-4305-499b-ab29-1becba8daa1e" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_5d1c108f-1b47-4a72-ad48-f2b27f052407" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_6d826595-98f3-41e1-8673-fea4f23f7470" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_6fe390ae-4305-499b-ab29-1becba8daa1e" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_6d826595-98f3-41e1-8673-fea4f23f7470" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_b635201a-4c96-4daf-9a63-776348b3d8a8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_6fe390ae-4305-499b-ab29-1becba8daa1e" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_b635201a-4c96-4daf-9a63-776348b3d8a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_7bb53589-3494-44e0-ba7b-69939eff4b72" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_6fe390ae-4305-499b-ab29-1becba8daa1e" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_7bb53589-3494-44e0-ba7b-69939eff4b72" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_236df4ee-007e-4108-8f19-79ba25585ac0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivities_6fe390ae-4305-499b-ab29-1becba8daa1e" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_236df4ee-007e-4108-8f19-79ba25585ac0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/MarketableSecuritiesScheduleofInvestmentsinAvailableForSaleDebtSecuritiesDetails" xlink:type="simple" xlink:href="regn-20251231.xsd#MarketableSecuritiesScheduleofInvestmentsinAvailableForSaleDebtSecuritiesDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/MarketableSecuritiesScheduleofInvestmentsinAvailableForSaleDebtSecuritiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_d3695b8d-09dc-4488-bc28-4c92fbf54f9e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_869ac5e2-051a-4626-9c54-4a5c742d01f6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_d3695b8d-09dc-4488-bc28-4c92fbf54f9e" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_869ac5e2-051a-4626-9c54-4a5c742d01f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_4914817b-ee49-45ad-adeb-fe4cc060a2e4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_d3695b8d-09dc-4488-bc28-4c92fbf54f9e" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_4914817b-ee49-45ad-adeb-fe4cc060a2e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_e4b70a16-c03f-4774-a6b9-697e4ece5d59" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_d3695b8d-09dc-4488-bc28-4c92fbf54f9e" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_e4b70a16-c03f-4774-a6b9-697e4ece5d59" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/MarketableSecuritiesScheduleofDebtSecuritiesBasedonContractualMaturityDatesDetails" xlink:type="simple" xlink:href="regn-20251231.xsd#MarketableSecuritiesScheduleofDebtSecuritiesBasedonContractualMaturityDatesDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/MarketableSecuritiesScheduleofDebtSecuritiesBasedonContractualMaturityDatesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_4540dd65-f8ec-4b17-befc-53889427b19a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_fcdc94dd-d64e-4571-9dbd-77159b205bba" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_4540dd65-f8ec-4b17-befc-53889427b19a" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearFairValue_fcdc94dd-d64e-4571-9dbd-77159b205bba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_75ad3600-38df-433b-8e6a-23a963acc161" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_4540dd65-f8ec-4b17-befc-53889427b19a" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughFiveYearsFairValue_75ad3600-38df-433b-8e6a-23a963acc161" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYear5_a418b29f-770b-4fcb-839a-90c4b67bd8d9" xlink:href="regn-20251231.xsd#regn_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYear5"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_4540dd65-f8ec-4b17-befc-53889427b19a" xlink:to="loc_regn_DebtSecuritiesAvailableForSaleFairValueMaturityAllocatedAndSingleMaturityDateAfterYear5_a418b29f-770b-4fcb-839a-90c4b67bd8d9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/FairValueMeasurementsScheduleofAssetsMeasuredatFairValueonaRecurringBasisDetails" xlink:type="simple" xlink:href="regn-20251231.xsd#FairValueMeasurementsScheduleofAssetsMeasuredatFairValueonaRecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/FairValueMeasurementsScheduleofAssetsMeasuredatFairValueonaRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_be9d9ff3-b25d-4830-a187-dc89a2a37977" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_57c73415-7507-4b19-a6b8-b375333a9fa4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_be9d9ff3-b25d-4830-a187-dc89a2a37977" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_57c73415-7507-4b19-a6b8-b375333a9fa4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFVNINoncurrent_d4d5db6c-ab12-4710-b6df-9edcb8898fab" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquitySecuritiesFVNINoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_be9d9ff3-b25d-4830-a187-dc89a2a37977" xlink:to="loc_us-gaap_EquitySecuritiesFVNINoncurrent_d4d5db6c-ab12-4710-b6df-9edcb8898fab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_a011c31e-0bd2-4e35-8194-c4930049a0d3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_be9d9ff3-b25d-4830-a187-dc89a2a37977" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_a011c31e-0bd2-4e35-8194-c4930049a0d3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/FairValueMeasurementsScheduleofUnrealizedGainsOnInvestmentsDetails" xlink:type="simple" xlink:href="regn-20251231.xsd#FairValueMeasurementsScheduleofUnrealizedGainsOnInvestmentsDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/FairValueMeasurementsScheduleofUnrealizedGainsOnInvestmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiGainLoss_c894a607-4d23-41e5-8240-d3b2dcf48763" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquitySecuritiesFvNiGainLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiRealizedGainLoss_6e20ba18-0f29-4688-b48f-4897777b7083" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquitySecuritiesFvNiRealizedGainLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EquitySecuritiesFvNiGainLoss_c894a607-4d23-41e5-8240-d3b2dcf48763" xlink:to="loc_us-gaap_EquitySecuritiesFvNiRealizedGainLoss_6e20ba18-0f29-4688-b48f-4897777b7083" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss_0900da18-ce0c-46b2-a654-0c13331da047" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EquitySecuritiesFvNiGainLoss_c894a607-4d23-41e5-8240-d3b2dcf48763" xlink:to="loc_us-gaap_EquitySecuritiesFvNiUnrealizedGainLoss_0900da18-ce0c-46b2-a654-0c13331da047" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/InventoriesScheduleofInventoriesDetails" xlink:type="simple" xlink:href="regn-20251231.xsd#InventoriesScheduleofInventoriesDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/InventoriesScheduleofInventoriesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_4d0d8319-29aa-492a-bc7d-2ecd8072845e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_a9582548-d3ab-49e5-b65f-210fe8e5bd67" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_4d0d8319-29aa-492a-bc7d-2ecd8072845e" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_a9582548-d3ab-49e5-b65f-210fe8e5bd67" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_1ce29b90-1c7a-4b62-9df6-78eb5b4d7e69" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_4d0d8319-29aa-492a-bc7d-2ecd8072845e" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_1ce29b90-1c7a-4b62-9df6-78eb5b4d7e69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_9b7ee0b1-1734-4464-b7cf-f8f9a428ad9e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_4d0d8319-29aa-492a-bc7d-2ecd8072845e" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_9b7ee0b1-1734-4464-b7cf-f8f9a428ad9e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherInventoryNetOfReserves_c50f34aa-d0b0-448c-be3c-25aba67eaa60" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherInventoryNetOfReserves"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_4d0d8319-29aa-492a-bc7d-2ecd8072845e" xlink:to="loc_us-gaap_OtherInventoryNetOfReserves_c50f34aa-d0b0-448c-be3c-25aba67eaa60" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/PropertyPlantandEquipmentScheduleofPropertyPlantandEquipmentDetails" xlink:type="simple" xlink:href="regn-20251231.xsd#PropertyPlantandEquipmentScheduleofPropertyPlantandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/PropertyPlantandEquipmentScheduleofPropertyPlantandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_ef269b58-3dd3-4d42-891e-489d86908063" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization_fd51fa1e-75fb-4d49-86e8-135e3fe3bd55" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_ef269b58-3dd3-4d42-891e-489d86908063" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetBeforeAccumulatedDepreciationAndAmortization_fd51fa1e-75fb-4d49-86e8-135e3fe3bd55" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization_25d4fefa-d66f-464b-9146-a018ca3eaaa7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAfterAccumulatedDepreciationAndAmortization_ef269b58-3dd3-4d42-891e-489d86908063" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentAndFinanceLeaseRightOfUseAssetAccumulatedDepreciationAndAmortization_25d4fefa-d66f-464b-9146-a018ca3eaaa7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/IntangibleAssetsScheduleofIntangibleAssetsDetails" xlink:type="simple" xlink:href="regn-20251231.xsd#IntangibleAssetsScheduleofIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/IntangibleAssetsScheduleofIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_f8c14887-5c39-4b40-8f9c-be167ef9c401" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_e504f00f-6f20-4ebb-88b9-d704825a36a7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_f8c14887-5c39-4b40-8f9c-be167ef9c401" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_e504f00f-6f20-4ebb-88b9-d704825a36a7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_62edb476-d5fd-4509-b232-5bfb1f685719" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_f8c14887-5c39-4b40-8f9c-be167ef9c401" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_62edb476-d5fd-4509-b232-5bfb1f685719" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_4aea9ba7-f5fb-4c62-9cba-75221ee00188" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_c45f8b61-dbee-4794-bd0f-91a48ee34f74" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_4aea9ba7-f5fb-4c62-9cba-75221ee00188" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_c45f8b61-dbee-4794-bd0f-91a48ee34f74" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_e64acd7a-d3c4-4259-b59e-403ba62b8f92" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_4aea9ba7-f5fb-4c62-9cba-75221ee00188" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_e64acd7a-d3c4-4259-b59e-403ba62b8f92" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/AccruedExpensesandOtherCurrentLiabilitiesScheduleofAccruedExpensesandOtherCurrentLiabilitiesDetails" xlink:type="simple" xlink:href="regn-20251231.xsd#AccruedExpensesandOtherCurrentLiabilitiesScheduleofAccruedExpensesandOtherCurrentLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/AccruedExpensesandOtherCurrentLiabilitiesScheduleofAccruedExpensesandOtherCurrentLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_4c5e7011-30b2-4034-b528-2d1bf203c863" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_0324999e-8925-430b-9c4c-0704557098da" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_4c5e7011-30b2-4034-b528-2d1bf203c863" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_0324999e-8925-430b-9c4c-0704557098da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_d904a29f-48fe-4870-bbd1-4f76532867b1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_4c5e7011-30b2-4034-b528-2d1bf203c863" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_d904a29f-48fe-4870-bbd1-4f76532867b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxesPayableCurrent_e0b061d4-0604-4958-88ee-461f8f4301b2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_TaxesPayableCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_4c5e7011-30b2-4034-b528-2d1bf203c863" xlink:to="loc_us-gaap_TaxesPayableCurrent_e0b061d4-0604-4958-88ee-461f8f4301b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_AccruedClinicalTrialExpenseCurrent_25ddd8dc-a913-49e5-81df-186c34a86ee4" xlink:href="regn-20251231.xsd#regn_AccruedClinicalTrialExpenseCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_4c5e7011-30b2-4034-b528-2d1bf203c863" xlink:to="loc_regn_AccruedClinicalTrialExpenseCurrent_25ddd8dc-a913-49e5-81df-186c34a86ee4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_AccrualForSalesRelatedCostsCurrent_92d1c272-2453-4ef1-8a92-d66d7198bce6" xlink:href="regn-20251231.xsd#regn_AccrualForSalesRelatedCostsCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccountsPayableAndAccruedLiabilitiesCurrent_4c5e7011-30b2-4034-b528-2d1bf203c863" xlink:to="loc_regn_AccrualForSalesRelatedCostsCurrent_92d1c272-2453-4ef1-8a92-d66d7198bce6" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/LeasesAmountsrecognizedinCondensedConsolidatedBalanceSheetDetails" xlink:type="simple" xlink:href="regn-20251231.xsd#LeasesAmountsrecognizedinCondensedConsolidatedBalanceSheetDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/LeasesAmountsrecognizedinCondensedConsolidatedBalanceSheetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_regn_LeaseLiability_c5906a10-a707-4f7c-81fd-07005a409eba" xlink:href="regn-20251231.xsd#regn_LeaseLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_e2de32a4-119f-434c-85f3-b02fb4d4a91d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiability_c5906a10-a707-4f7c-81fd-07005a409eba" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_e2de32a4-119f-434c-85f3-b02fb4d4a91d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_71a43f9e-2d13-4432-9534-5408b5de192e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiability_c5906a10-a707-4f7c-81fd-07005a409eba" xlink:to="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_71a43f9e-2d13-4432-9534-5408b5de192e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_2544d86b-4220-48b2-a54f-41ed9ea2aa14" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiability_c5906a10-a707-4f7c-81fd-07005a409eba" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_2544d86b-4220-48b2-a54f-41ed9ea2aa14" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_LeaseRightofUseAsset_eb7a6377-57ac-4da7-a362-a16782adc47a" xlink:href="regn-20251231.xsd#regn_LeaseRightofUseAsset"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAsset_dcd884f0-5357-47cc-ae3c-09d2b3947a71" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseRightOfUseAsset"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseRightofUseAsset_eb7a6377-57ac-4da7-a362-a16782adc47a" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAsset_dcd884f0-5357-47cc-ae3c-09d2b3947a71" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_1446672d-2f15-447c-baa7-bcb17c89c6b7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseRightofUseAsset_eb7a6377-57ac-4da7-a362-a16782adc47a" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_1446672d-2f15-447c-baa7-bcb17c89c6b7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/LeasesFinanceleasecostsDetails" xlink:type="simple" xlink:href="regn-20251231.xsd#LeasesFinanceleasecostsDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/LeasesFinanceleasecostsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_regn_FinanceLeaseCost_645c8eaa-5ea2-443d-884a-c580caa5db1a" xlink:href="regn-20251231.xsd#regn_FinanceLeaseCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseInterestExpense_0933eb97-6e0d-4a00-8e19-0a53767bfcbc" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseInterestExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_FinanceLeaseCost_645c8eaa-5ea2-443d-884a-c580caa5db1a" xlink:to="loc_us-gaap_FinanceLeaseInterestExpense_0933eb97-6e0d-4a00-8e19-0a53767bfcbc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAssetAmortization_81990053-08b4-4dc7-83fa-f92b228ae83a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseRightOfUseAssetAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_FinanceLeaseCost_645c8eaa-5ea2-443d-884a-c580caa5db1a" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAssetAmortization_81990053-08b4-4dc7-83fa-f92b228ae83a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCost_76b82dc3-51ac-458e-914b-74f367da2d8c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LeaseCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseCost_97fc07f2-a472-4420-b113-104f5ea20872" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_76b82dc3-51ac-458e-914b-74f367da2d8c" xlink:to="loc_us-gaap_OperatingLeaseCost_97fc07f2-a472-4420-b113-104f5ea20872" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_FinanceLeaseCost_1f75d463-6b3f-4678-a4bd-8f070e72baaa" xlink:href="regn-20251231.xsd#regn_FinanceLeaseCost"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_76b82dc3-51ac-458e-914b-74f367da2d8c" xlink:to="loc_regn_FinanceLeaseCost_1f75d463-6b3f-4678-a4bd-8f070e72baaa" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/LeasesAnalysisofleaseliabilitymaturitiesDetails" xlink:type="simple" xlink:href="regn-20251231.xsd#LeasesAnalysisofleaseliabilitymaturitiesDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/LeasesAnalysisofleaseliabilitymaturitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_regn_LeaseLiabilityPaymentsDue_b76b9b17-d28a-47f2-ac53-b153a5fd4d46" xlink:href="regn-20251231.xsd#regn_LeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_LeaseLiabilityToBePaidYearOne_ca91b2e6-5b3d-4586-b3ac-480d7ed83913" xlink:href="regn-20251231.xsd#regn_LeaseLiabilityToBePaidYearOne"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiabilityPaymentsDue_b76b9b17-d28a-47f2-ac53-b153a5fd4d46" xlink:to="loc_regn_LeaseLiabilityToBePaidYearOne_ca91b2e6-5b3d-4586-b3ac-480d7ed83913" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_LeaseLiabilityToBePaidYearTwo_4dc533c2-8e8f-475d-8669-3701103cfe7b" xlink:href="regn-20251231.xsd#regn_LeaseLiabilityToBePaidYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiabilityPaymentsDue_b76b9b17-d28a-47f2-ac53-b153a5fd4d46" xlink:to="loc_regn_LeaseLiabilityToBePaidYearTwo_4dc533c2-8e8f-475d-8669-3701103cfe7b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_LeaseLiabilityToBePaidYearThree_830b3029-cf05-41c9-b4ca-e90c67c37339" xlink:href="regn-20251231.xsd#regn_LeaseLiabilityToBePaidYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiabilityPaymentsDue_b76b9b17-d28a-47f2-ac53-b153a5fd4d46" xlink:to="loc_regn_LeaseLiabilityToBePaidYearThree_830b3029-cf05-41c9-b4ca-e90c67c37339" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_LeaseLiabilityToBePaidYearFour_1a2d41d4-a92a-4951-8909-85450fc22654" xlink:href="regn-20251231.xsd#regn_LeaseLiabilityToBePaidYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiabilityPaymentsDue_b76b9b17-d28a-47f2-ac53-b153a5fd4d46" xlink:to="loc_regn_LeaseLiabilityToBePaidYearFour_1a2d41d4-a92a-4951-8909-85450fc22654" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_LeaseLiabilityToBePaidYearFive_9e9befae-f84d-4e6c-8087-9fced09cfa9d" xlink:href="regn-20251231.xsd#regn_LeaseLiabilityToBePaidYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiabilityPaymentsDue_b76b9b17-d28a-47f2-ac53-b153a5fd4d46" xlink:to="loc_regn_LeaseLiabilityToBePaidYearFive_9e9befae-f84d-4e6c-8087-9fced09cfa9d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_LeaseLiabilityToBePaidAfterYearFive_019bbd28-375a-7711-a94d-e677796149b8" xlink:href="regn-20251231.xsd#regn_LeaseLiabilityToBePaidAfterYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiabilityPaymentsDue_b76b9b17-d28a-47f2-ac53-b153a5fd4d46" xlink:to="loc_regn_LeaseLiabilityToBePaidAfterYearFive_019bbd28-375a-7711-a94d-e677796149b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_LeaseLiabilityToBePaidYearFive_019b3847-a2a3-71c1-b32a-883e4bf09678" xlink:href="regn-20251231.xsd#regn_LeaseLiabilityToBePaidYearFive"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive_019b3847-a2a4-7661-a392-0c1b4e40c989" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiabilityToBePaidYearFive_019b3847-a2a3-71c1-b32a-883e4bf09678" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive_019b3847-a2a4-7661-a392-0c1b4e40c989" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_019b3847-a2a4-7689-b259-53069820798b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiabilityToBePaidYearFive_019b3847-a2a3-71c1-b32a-883e4bf09678" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_019b3847-a2a4-7689-b259-53069820798b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_LeaseLiabilityToBePaidAfterYearFive_019bbd28-4692-7063-8f2c-45c85bd7f4e3" xlink:href="regn-20251231.xsd#regn_LeaseLiabilityToBePaidAfterYearFive"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive_019bbd28-4692-7def-be0b-b624fb191d79" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiabilityToBePaidAfterYearFive_019bbd28-4692-7063-8f2c-45c85bd7f4e3" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive_019bbd28-4692-7def-be0b-b624fb191d79" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_019bbd28-4692-77bc-8ed2-293a2db33145" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiabilityToBePaidAfterYearFive_019bbd28-4692-7063-8f2c-45c85bd7f4e3" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_019bbd28-4692-77bc-8ed2-293a2db33145" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_LeaseLiabilityToBePaidYearOne_019b3847-3de2-7054-ae6b-cc78fa317cb4" xlink:href="regn-20251231.xsd#regn_LeaseLiabilityToBePaidYearOne"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths_019b3847-3de2-752a-98a3-cdcae3175482" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiabilityToBePaidYearOne_019b3847-3de2-7054-ae6b-cc78fa317cb4" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths_019b3847-3de2-752a-98a3-cdcae3175482" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019b3847-3de2-7df6-a5b6-95528d9d586c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiabilityToBePaidYearOne_019b3847-3de2-7054-ae6b-cc78fa317cb4" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019b3847-3de2-7df6-a5b6-95528d9d586c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_LeaseLiabilityUndiscountedExcessAmount_019b3847-b3f2-7604-894b-fa7fb06efd99" xlink:href="regn-20251231.xsd#regn_LeaseLiabilityUndiscountedExcessAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount_019b3847-b3f2-749f-9f7b-24baf6083521" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiabilityUndiscountedExcessAmount_019b3847-b3f2-7604-894b-fa7fb06efd99" xlink:to="loc_us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount_019b3847-b3f2-749f-9f7b-24baf6083521" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019b3847-b3f2-7e40-9da1-69eb4ed67fd0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiabilityUndiscountedExcessAmount_019b3847-b3f2-7604-894b-fa7fb06efd99" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019b3847-b3f2-7e40-9da1-69eb4ed67fd0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_LeaseLiabilityToBePaidYearTwo_019b3847-76dd-7a60-beb6-bd77bcd85ad6" xlink:href="regn-20251231.xsd#regn_LeaseLiabilityToBePaidYearTwo"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo_019b3847-76dd-7d15-8b6d-b91cdee6c181" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiabilityToBePaidYearTwo_019b3847-76dd-7a60-beb6-bd77bcd85ad6" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo_019b3847-76dd-7d15-8b6d-b91cdee6c181" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019b3847-76dd-7872-8274-75322bf2a099" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiabilityToBePaidYearTwo_019b3847-76dd-7a60-beb6-bd77bcd85ad6" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019b3847-76dd-7872-8274-75322bf2a099" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_f2b77601-46aa-47d0-9447-0ba965e289c8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiability_a0c8db03-1587-41ec-ac5d-606dbbbc56c8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_f2b77601-46aa-47d0-9447-0ba965e289c8" xlink:to="loc_us-gaap_FinanceLeaseLiability_a0c8db03-1587-41ec-ac5d-606dbbbc56c8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount_73ab98cf-d168-4767-a05c-1fe0c5d39722" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_f2b77601-46aa-47d0-9447-0ba965e289c8" xlink:to="loc_us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount_73ab98cf-d168-4767-a05c-1fe0c5d39722" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_a976ac56-63bd-4bac-9b7a-0dc7887fe506" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_fa8d5c9f-4540-4613-b984-ccab286cf08e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_a976ac56-63bd-4bac-9b7a-0dc7887fe506" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_fa8d5c9f-4540-4613-b984-ccab286cf08e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_e92bba34-2d1c-46e2-842d-0105bfa43586" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_a976ac56-63bd-4bac-9b7a-0dc7887fe506" xlink:to="loc_us-gaap_OperatingLeaseLiability_e92bba34-2d1c-46e2-842d-0105bfa43586" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_LeaseLiabilityToBePaidYearFour_019b3847-9411-706d-a83b-3a1ab34f77be" xlink:href="regn-20251231.xsd#regn_LeaseLiabilityToBePaidYearFour"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour_019b3847-9411-7960-89a8-c68e3e07b847" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiabilityToBePaidYearFour_019b3847-9411-706d-a83b-3a1ab34f77be" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour_019b3847-9411-7960-89a8-c68e3e07b847" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_019b3847-9411-7397-b115-02130b08dbd0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiabilityToBePaidYearFour_019b3847-9411-706d-a83b-3a1ab34f77be" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_019b3847-9411-7397-b115-02130b08dbd0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_LeaseLiabilityToBePaidYearThree_019b3847-85b5-7a19-a099-7412291ef938" xlink:href="regn-20251231.xsd#regn_LeaseLiabilityToBePaidYearThree"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree_019b3847-85b5-792d-8e84-7d128b52af57" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiabilityToBePaidYearThree_019b3847-85b5-7a19-a099-7412291ef938" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree_019b3847-85b5-792d-8e84-7d128b52af57" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019b3847-85b5-71dd-a923-7c9aa3ad501c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiabilityToBePaidYearThree_019b3847-85b5-7a19-a099-7412291ef938" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019b3847-85b5-71dd-a923-7c9aa3ad501c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_LeaseLiability_019b3847-c355-76b8-8f44-1c1756d4d9af" xlink:href="regn-20251231.xsd#regn_LeaseLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiability_019b3847-c355-7c27-bf0f-c401e67f399f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiability_019b3847-c355-76b8-8f44-1c1756d4d9af" xlink:to="loc_us-gaap_FinanceLeaseLiability_019b3847-c355-7c27-bf0f-c401e67f399f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019b3847-c355-714b-aa6d-53415b8bf2e4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiability_019b3847-c355-76b8-8f44-1c1756d4d9af" xlink:to="loc_us-gaap_OperatingLeaseLiability_019b3847-c355-714b-aa6d-53415b8bf2e4" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/LeasesAnalysisofleaseliabilitymaturitiesDetails_1" xlink:type="simple" xlink:href="regn-20251231.xsd#LeasesAnalysisofleaseliabilitymaturitiesDetails_1"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/LeasesAnalysisofleaseliabilitymaturitiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_2548d213-b4fe-4de9-a47f-7ab481e1236c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_f4274934-7592-4cfb-9c63-9ff777fb33c3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_2548d213-b4fe-4de9-a47f-7ab481e1236c" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_f4274934-7592-4cfb-9c63-9ff777fb33c3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_343db199-38f3-437c-9e88-e74ef99726a9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_2548d213-b4fe-4de9-a47f-7ab481e1236c" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_343db199-38f3-437c-9e88-e74ef99726a9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_2ec2c704-7f92-4635-8cde-88b4551619bd" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_2548d213-b4fe-4de9-a47f-7ab481e1236c" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_2ec2c704-7f92-4635-8cde-88b4551619bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_1cd5a67d-b74c-404e-b784-b56807008656" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_2548d213-b4fe-4de9-a47f-7ab481e1236c" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour_1cd5a67d-b74c-404e-b784-b56807008656" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_a4666ec3-c8da-4995-b4d6-4357c78a6eb0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_2548d213-b4fe-4de9-a47f-7ab481e1236c" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive_a4666ec3-c8da-4995-b4d6-4357c78a6eb0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_019bbd28-21b5-7b7a-94a1-32950a267078" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_2548d213-b4fe-4de9-a47f-7ab481e1236c" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive_019bbd28-21b5-7b7a-94a1-32950a267078" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_LeaseLiabilityPaymentsDue_2d938640-197f-4751-a558-502bc2a05cf3" xlink:href="regn-20251231.xsd#regn_LeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_LeaseLiability_6a216db5-79c0-417a-931b-dd8ee7e7ecf1" xlink:href="regn-20251231.xsd#regn_LeaseLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiabilityPaymentsDue_2d938640-197f-4751-a558-502bc2a05cf3" xlink:to="loc_regn_LeaseLiability_6a216db5-79c0-417a-931b-dd8ee7e7ecf1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_LeaseLiabilityUndiscountedExcessAmount_43cee28b-6baa-40f5-9a9a-fbca035c55fb" xlink:href="regn-20251231.xsd#regn_LeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_regn_LeaseLiabilityPaymentsDue_2d938640-197f-4751-a558-502bc2a05cf3" xlink:to="loc_regn_LeaseLiabilityUndiscountedExcessAmount_43cee28b-6baa-40f5-9a9a-fbca035c55fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_3933175b-03b0-4222-b8a7-85451c780b16" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths_252c54e4-6fbd-4711-8e8c-461c6b401936" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_3933175b-03b0-4222-b8a7-85451c780b16" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths_252c54e4-6fbd-4711-8e8c-461c6b401936" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo_859396fc-ef71-4eb4-9156-28971a6c9bf1" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_3933175b-03b0-4222-b8a7-85451c780b16" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo_859396fc-ef71-4eb4-9156-28971a6c9bf1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree_744d5186-b4ac-4f1e-836a-5e0c8edfd7c6" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_3933175b-03b0-4222-b8a7-85451c780b16" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree_744d5186-b4ac-4f1e-836a-5e0c8edfd7c6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour_3b68d722-4da2-4570-9477-f5301fe31d5f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_3933175b-03b0-4222-b8a7-85451c780b16" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFour_3b68d722-4da2-4570-9477-f5301fe31d5f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive_26b2b60d-cbd5-45d4-828f-d1bb533f9c29" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_3933175b-03b0-4222-b8a7-85451c780b16" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearFive_26b2b60d-cbd5-45d4-828f-d1bb533f9c29" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive_019bbd28-0f10-7481-a244-699fdc2472ca" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_3933175b-03b0-4222-b8a7-85451c780b16" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueAfterYearFive_019bbd28-0f10-7481-a244-699fdc2472ca" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/IncomeTaxesScheduleofincomebeforeincometaxDetails" xlink:type="simple" xlink:href="regn-20251231.xsd#IncomeTaxesScheduleofincomebeforeincometaxDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/IncomeTaxesScheduleofincomebeforeincometaxDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_c46d9317-f7b4-4b6a-ba4a-a3cabfa762eb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_4efcb9e4-8155-413f-a3cd-ec6bde0f3ba9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_c46d9317-f7b4-4b6a-ba4a-a3cabfa762eb" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesDomestic_4efcb9e4-8155-413f-a3cd-ec6bde0f3ba9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign_a98ac2bd-ef49-4f23-8a8d-d75bbc5b9364" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_c46d9317-f7b4-4b6a-ba4a-a3cabfa762eb" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign_a98ac2bd-ef49-4f23-8a8d-d75bbc5b9364" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/IncomeTaxesScheduleofcomponentsofincometaxexpenseDetails" xlink:type="simple" xlink:href="regn-20251231.xsd#IncomeTaxesScheduleofcomponentsofincometaxexpenseDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/IncomeTaxesScheduleofcomponentsofincometaxexpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_9eed70b9-adc1-4849-8cf5-53493c367ba8" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentFederalTaxExpenseBenefit_6bb83de4-0f89-4085-9369-7a8ad0209dfb" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CurrentFederalTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_9eed70b9-adc1-4849-8cf5-53493c367ba8" xlink:to="loc_us-gaap_CurrentFederalTaxExpenseBenefit_6bb83de4-0f89-4085-9369-7a8ad0209dfb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_80b79326-b1bd-4dc4-8982-9736a2b07302" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CurrentStateAndLocalTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_9eed70b9-adc1-4849-8cf5-53493c367ba8" xlink:to="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_80b79326-b1bd-4dc4-8982-9736a2b07302" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentForeignTaxExpenseBenefit_dfd21af1-7096-4100-bc93-27aa8bf34b6c" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CurrentForeignTaxExpenseBenefit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_9eed70b9-adc1-4849-8cf5-53493c367ba8" xlink:to="loc_us-gaap_CurrentForeignTaxExpenseBenefit_dfd21af1-7096-4100-bc93-27aa8bf34b6c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_f64d35c9-6e4a-481a-95ca-b71640a2bd3f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_fb833fcc-1b73-432d-b1ba-a4fa97c04509" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_f64d35c9-6e4a-481a-95ca-b71640a2bd3f" xlink:to="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_fb833fcc-1b73-432d-b1ba-a4fa97c04509" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_1731ea27-3c3e-4b35-8bca-389c7328ee76" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_f64d35c9-6e4a-481a-95ca-b71640a2bd3f" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_1731ea27-3c3e-4b35-8bca-389c7328ee76" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_c3895ac1-9bb1-47ac-af07-b4e224bbbe96" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_45adca80-e7c1-4f19-8e36-6c8a4cb41cc9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredFederalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_c3895ac1-9bb1-47ac-af07-b4e224bbbe96" xlink:to="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_45adca80-e7c1-4f19-8e36-6c8a4cb41cc9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_5a127d79-9684-493d-afe7-910ddb1ae058" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_c3895ac1-9bb1-47ac-af07-b4e224bbbe96" xlink:to="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_5a127d79-9684-493d-afe7-910ddb1ae058" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_a5915ce0-9827-4b7a-add1-0df2923d9098" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredForeignIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_c3895ac1-9bb1-47ac-af07-b4e224bbbe96" xlink:to="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_a5915ce0-9827-4b7a-add1-0df2923d9098" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/IncomeTaxesScheduleofcashpaidforincometaxesDetails" xlink:type="simple" xlink:href="regn-20251231.xsd#IncomeTaxesScheduleofcashpaidforincometaxesDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/IncomeTaxesScheduleofcashpaidforincometaxesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxesPaidNet_98e608d9-3166-4e60-8b16-c60417e52bad" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxesPaidNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxPaidFederalAfterRefundReceived_4b51be15-24d1-450c-be88-a9c71c7e1d20" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxPaidFederalAfterRefundReceived"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxesPaidNet_98e608d9-3166-4e60-8b16-c60417e52bad" xlink:to="loc_us-gaap_IncomeTaxPaidFederalAfterRefundReceived_4b51be15-24d1-450c-be88-a9c71c7e1d20" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxPaidStateAndLocalAfterRefundReceived_65eee89a-d492-49e3-b4d7-b7e24146133d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxPaidStateAndLocalAfterRefundReceived"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxesPaidNet_98e608d9-3166-4e60-8b16-c60417e52bad" xlink:to="loc_us-gaap_IncomeTaxPaidStateAndLocalAfterRefundReceived_65eee89a-d492-49e3-b4d7-b7e24146133d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxPaidForeignAfterRefundReceived_5d9bc39b-c2d9-4c26-b3bd-13b1138d4004" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxPaidForeignAfterRefundReceived"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxesPaidNet_98e608d9-3166-4e60-8b16-c60417e52bad" xlink:to="loc_us-gaap_IncomeTaxPaidForeignAfterRefundReceived_5d9bc39b-c2d9-4c26-b3bd-13b1138d4004" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/IncomeTaxesScheduleofeffectiveincometaxratereconciliationDetails" xlink:type="simple" xlink:href="regn-20251231.xsd#IncomeTaxesScheduleofeffectiveincometaxratereconciliationDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/IncomeTaxesScheduleofeffectiveincometaxratereconciliationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_b98c4ca8-b284-46cb-90bf-d631083256f3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_a6a847a5-0f5c-4820-9c70-73d93f990a6f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_b98c4ca8-b284-46cb-90bf-d631083256f3" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_a6a847a5-0f5c-4820-9c70-73d93f990a6f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_b1ca606a-8e90-4636-a704-45cad04e218d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_b98c4ca8-b284-46cb-90bf-d631083256f3" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_b1ca606a-8e90-4636-a704-45cad04e218d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherReconcilingItemsPercent_0c2d087f-6143-4769-a5d5-28c26b316aad" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationOtherReconcilingItemsPercent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_b98c4ca8-b284-46cb-90bf-d631083256f3" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherReconcilingItemsPercent_0c2d087f-6143-4769-a5d5-28c26b316aad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_e6129620-d124-47cd-9057-7d87f92b5295" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_b98c4ca8-b284-46cb-90bf-d631083256f3" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationOtherAdjustments_e6129620-d124-47cd-9057-7d87f92b5295" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCreditsResearch_2f075437-c6b3-477f-9d42-5877425b96c0" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationTaxCreditsResearch"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_b98c4ca8-b284-46cb-90bf-d631083256f3" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCreditsResearch_2f075437-c6b3-477f-9d42-5877425b96c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxContingencies_8dfaa295-989f-4670-98ce-21a54f73df37" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationTaxContingencies"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_b98c4ca8-b284-46cb-90bf-d631083256f3" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxContingencies_8dfaa295-989f-4670-98ce-21a54f73df37" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInEnactedTaxRate_9dd9645e-cb41-4a52-b70c-eba999d2f106" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationChangeInEnactedTaxRate"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_b98c4ca8-b284-46cb-90bf-d631083256f3" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationChangeInEnactedTaxRate_9dd9645e-cb41-4a52-b70c-eba999d2f106" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost_3d146654-30eb-4ef1-be73-9609bffc154b" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_b98c4ca8-b284-46cb-90bf-d631083256f3" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost_3d146654-30eb-4ef1-be73-9609bffc154b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther_f8fd34a5-176d-423c-bf06-56f4c51bef57" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_b98c4ca8-b284-46cb-90bf-d631083256f3" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther_f8fd34a5-176d-423c-bf06-56f4c51bef57" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_EffectiveIncomeTaxRateReconciliationNCTIPercent_b876730e-6af5-4581-aa5d-b88bce4e1964" xlink:href="regn-20251231.xsd#regn_EffectiveIncomeTaxRateReconciliationNCTIPercent"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_b98c4ca8-b284-46cb-90bf-d631083256f3" xlink:to="loc_regn_EffectiveIncomeTaxRateReconciliationNCTIPercent_b876730e-6af5-4581-aa5d-b88bce4e1964" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationFdiiPercent_dfa7512a-f433-4095-8de6-8e6616484cdf" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationFdiiPercent"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_b98c4ca8-b284-46cb-90bf-d631083256f3" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationFdiiPercent_dfa7512a-f433-4095-8de6-8e6616484cdf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationCrossBorderOtherPercent_019be647-3ce9-7b0e-9526-e0fdbdbbb38d" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationCrossBorderOtherPercent"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_b98c4ca8-b284-46cb-90bf-d631083256f3" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationCrossBorderOtherPercent_019be647-3ce9-7b0e-9526-e0fdbdbbb38d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_4fab88db-ca6e-4a7d-b7a1-692e77132446" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_d7fe7312-b957-4ef7-8d16-f8592f2c2320" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_4fab88db-ca6e-4a7d-b7a1-692e77132446" xlink:to="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_d7fe7312-b957-4ef7-8d16-f8592f2c2320" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationForeignIncomeTaxRateDifferential_12e9a722-16d8-4130-8453-8c511f1ce704" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationForeignIncomeTaxRateDifferential"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_4fab88db-ca6e-4a7d-b7a1-692e77132446" xlink:to="loc_us-gaap_IncomeTaxReconciliationForeignIncomeTaxRateDifferential_12e9a722-16d8-4130-8453-8c511f1ce704" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationOtherReconcilingItems_5519451b-35b0-4a6f-8ff1-ef07cadec8a9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationOtherReconcilingItems"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_4fab88db-ca6e-4a7d-b7a1-692e77132446" xlink:to="loc_us-gaap_IncomeTaxReconciliationOtherReconcilingItems_5519451b-35b0-4a6f-8ff1-ef07cadec8a9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_5f510125-27f2-4763-a5d5-bf44de052e31" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationOtherAdjustments"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_4fab88db-ca6e-4a7d-b7a1-692e77132446" xlink:to="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_5f510125-27f2-4763-a5d5-bf44de052e31" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxCreditsResearch_ccb83823-f18c-4d9b-a615-4fce10ceea2a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationTaxCreditsResearch"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_4fab88db-ca6e-4a7d-b7a1-692e77132446" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxCreditsResearch_ccb83823-f18c-4d9b-a615-4fce10ceea2a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxContingencies_11b33c4c-6740-400b-b5ae-3d6cffa20096" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationTaxContingencies"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_4fab88db-ca6e-4a7d-b7a1-692e77132446" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxContingencies_11b33c4c-6740-400b-b5ae-3d6cffa20096" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate_e6be8d37-1db5-42cf-bf97-f9f71dfbef02" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_4fab88db-ca6e-4a7d-b7a1-692e77132446" xlink:to="loc_us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate_e6be8d37-1db5-42cf-bf97-f9f71dfbef02" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_a9b113c6-1305-4d57-bd92-beb5c4bbf359" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_4fab88db-ca6e-4a7d-b7a1-692e77132446" xlink:to="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_a9b113c6-1305-4d57-bd92-beb5c4bbf359" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseOther_79e0f36c-352d-45c2-ac23-c6925132276a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpenseOther"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_4fab88db-ca6e-4a7d-b7a1-692e77132446" xlink:to="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseOther_79e0f36c-352d-45c2-ac23-c6925132276a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_EffectiveIncomeTaxRateReconciliationNCTIAmount_f6d7ce9c-3b42-49f8-897c-413a0d3f11c9" xlink:href="regn-20251231.xsd#regn_EffectiveIncomeTaxRateReconciliationNCTIAmount"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_4fab88db-ca6e-4a7d-b7a1-692e77132446" xlink:to="loc_regn_EffectiveIncomeTaxRateReconciliationNCTIAmount_f6d7ce9c-3b42-49f8-897c-413a0d3f11c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationFdiiAmount_bf709e1e-8b4b-431f-a9d2-235710309205" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationFdiiAmount"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_4fab88db-ca6e-4a7d-b7a1-692e77132446" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationFdiiAmount_bf709e1e-8b4b-431f-a9d2-235710309205" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationCrossBorderOtherAmount_019be647-2134-7e50-970e-cc8ab4317ce5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationCrossBorderOtherAmount"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_4fab88db-ca6e-4a7d-b7a1-692e77132446" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationCrossBorderOtherAmount_019be647-2134-7e50-970e-cc8ab4317ce5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/IncomeTaxesScheduleofeffectiveincometaxrateDetails" xlink:type="simple" xlink:href="regn-20251231.xsd#IncomeTaxesScheduleofeffectiveincometaxrateDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/IncomeTaxesScheduleofeffectiveincometaxrateDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_c07d9c24-2c29-4693-9dd2-b43c51abb9c9" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_5293dfd2-a79d-4d23-98c5-18ad79cc96c4" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_c07d9c24-2c29-4693-9dd2-b43c51abb9c9" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_5293dfd2-a79d-4d23-98c5-18ad79cc96c4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_183a6976-53a1-4d00-b23c-29428a49a684" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_c07d9c24-2c29-4693-9dd2-b43c51abb9c9" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationForeignIncomeTaxRateDifferential_183a6976-53a1-4d00-b23c-29428a49a684" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost_554ce286-99f2-42c1-8f2f-05a7358af1ad" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_c07d9c24-2c29-4693-9dd2-b43c51abb9c9" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseShareBasedCompensationCost_554ce286-99f2-42c1-8f2f-05a7358af1ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationFdiiPercent_387c808d-06db-40ff-9292-3f1faf8317f7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationFdiiPercent"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_c07d9c24-2c29-4693-9dd2-b43c51abb9c9" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationFdiiPercent_387c808d-06db-40ff-9292-3f1faf8317f7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCredits_a758305b-8969-4d52-97a1-a5af3e7fbf43" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationTaxCredits"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_c07d9c24-2c29-4693-9dd2-b43c51abb9c9" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationTaxCredits_a758305b-8969-4d52-97a1-a5af3e7fbf43" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther_3584f415-b9c3-46e1-9a90-394313ffc10e" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_c07d9c24-2c29-4693-9dd2-b43c51abb9c9" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateReconciliationNondeductibleExpenseOther_3584f415-b9c3-46e1-9a90-394313ffc10e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/IncomeTaxesScheduleofdeferredtaxassetsandliabilitiesDetails" xlink:type="simple" xlink:href="regn-20251231.xsd#IncomeTaxesScheduleofdeferredtaxassetsandliabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/IncomeTaxesScheduleofdeferredtaxassetsandliabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_291d612b-f569-4640-bf69-fcac340fce44" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefits_a792054c-f2eb-4712-85b3-68dca1769a87" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefits"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_291d612b-f569-4640-bf69-fcac340fce44" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefits_a792054c-f2eb-4712-85b3-68dca1769a87" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities_7c1e47d0-2332-4da7-8823-67fcb6fee240" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_291d612b-f569-4640-bf69-fcac340fce44" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities_7c1e47d0-2332-4da7-8823-67fcb6fee240" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsPropertyPlantAndEquipment_00bb211e-e0a6-452d-b0a2-205c0d25b215" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsPropertyPlantAndEquipment"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_291d612b-f569-4640-bf69-fcac340fce44" xlink:to="loc_us-gaap_DeferredTaxAssetsPropertyPlantAndEquipment_00bb211e-e0a6-452d-b0a2-205c0d25b215" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOther_7a8f9eeb-43dd-4331-83f7-76bb6a35a0a3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsOther"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_291d612b-f569-4640-bf69-fcac340fce44" xlink:to="loc_us-gaap_DeferredTaxAssetsOther_7a8f9eeb-43dd-4331-83f7-76bb6a35a0a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_regn_DeferredTaxAssetsCapitalizedResearchAndDevelopmentExpenses_8841c78e-c47b-45a0-978a-55a3d4db97bc" xlink:href="regn-20251231.xsd#regn_DeferredTaxAssetsCapitalizedResearchAndDevelopmentExpenses"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_291d612b-f569-4640-bf69-fcac340fce44" xlink:to="loc_regn_DeferredTaxAssetsCapitalizedResearchAndDevelopmentExpenses_8841c78e-c47b-45a0-978a-55a3d4db97bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards_45b4a5ae-3f95-49d7-90c8-2a5f49666e45" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsTaxCreditCarryforwards"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_291d612b-f569-4640-bf69-fcac340fce44" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards_45b4a5ae-3f95-49d7-90c8-2a5f49666e45" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_abf5f838-46b4-44d7-aa7c-87c478454480" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_f2a0e038-cf9f-4d79-a344-7ef819198e60" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_abf5f838-46b4-44d7-aa7c-87c478454480" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_f2a0e038-cf9f-4d79-a344-7ef819198e60" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesUnrealizedGainsOnTradingSecurities_028aed80-3139-423a-8091-a3b3c5e8fac5" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_DeferredTaxLiabilitiesUnrealizedGainsOnTradingSecurities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_abf5f838-46b4-44d7-aa7c-87c478454480" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesUnrealizedGainsOnTradingSecurities_028aed80-3139-423a-8091-a3b3c5e8fac5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/NetIncomePerShareScheduleofBasicandDilutedNetIncomePerShareDetails" xlink:type="simple" xlink:href="regn-20251231.xsd#NetIncomePerShareScheduleofBasicandDilutedNetIncomePerShareDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/NetIncomePerShareScheduleofBasicandDilutedNetIncomePerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_d3e3037d-a045-4596-992e-ced7dd9d3f0f" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_5fbffc6a-6d76-4360-a98e-a470d8b9df8a" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_d3e3037d-a045-4596-992e-ced7dd9d3f0f" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_5fbffc6a-6d76-4360-a98e-a470d8b9df8a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_83406c4b-c938-47f6-a922-08e7ba7e13b7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_d3e3037d-a045-4596-992e-ced7dd9d3f0f" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_83406c4b-c938-47f6-a922-08e7ba7e13b7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/StatementofCashFlowsScheduleofReconciliationofCashCashEquivalentsandRestrictedCashDetails" xlink:type="simple" xlink:href="regn-20251231.xsd#StatementofCashFlowsScheduleofReconciliationofCashCashEquivalentsandRestrictedCashDetails"/>
  <link:calculationLink xlink:role="http://www.regeneron.com/role/StatementofCashFlowsScheduleofReconciliationofCashCashEquivalentsandRestrictedCashDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_9b4f835b-0ef6-43b6-8047-6f69e3dc75c2" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashCurrent_74b2fbb9-1736-4438-9a9e-7070b9a46254" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_9b4f835b-0ef6-43b6-8047-6f69e3dc75c2" xlink:to="loc_us-gaap_RestrictedCashCurrent_74b2fbb9-1736-4438-9a9e-7070b9a46254" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_1d14660a-81c9-4146-ac73-1c792a0094d3" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_9b4f835b-0ef6-43b6-8047-6f69e3dc75c2" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_1d14660a-81c9-4146-ac73-1c792a0094d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_45b3fde4-4670-458c-9544-b984eee6ffe7" xlink:href="https://xbrl.fasb.org/us-gaap/2025/elts/us-gaap-2025.xsd#us-gaap_RestrictedCashNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_9b4f835b-0ef6-43b6-8047-6f69e3dc75c2" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_45b3fde4-4670-458c-9544-b984eee6ffe7" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
