<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2023 Workiva-->
<!--r:869d1957-475f-43f7-bc1f-072037384a1f,g:218f34b2-e669-47f4-8a06-cd86419caea1-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.regeneron.com/role/Cover" xlink:type="simple" xlink:href="regn-20230504.xsd#Cover"/>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_b94ef991-2e38-4f9b-86e2-784f5ae737c4" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_e1b3b0a4-8145-40ff-ba7d-af45a80d6d38" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b94ef991-2e38-4f9b-86e2-784f5ae737c4" xlink:to="loc_dei_DocumentType_e1b3b0a4-8145-40ff-ba7d-af45a80d6d38" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_a09ed41b-6eb0-4dff-addb-8922443a78ec" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b94ef991-2e38-4f9b-86e2-784f5ae737c4" xlink:to="loc_dei_EntityRegistrantName_a09ed41b-6eb0-4dff-addb-8922443a78ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_552dbeeb-6402-4123-9c7d-519281f563f8" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b94ef991-2e38-4f9b-86e2-784f5ae737c4" xlink:to="loc_dei_DocumentPeriodEndDate_552dbeeb-6402-4123-9c7d-519281f563f8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_15c8bf5d-c024-4c1a-9358-46dc74384892" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b94ef991-2e38-4f9b-86e2-784f5ae737c4" xlink:to="loc_dei_EntityIncorporationStateCountryCode_15c8bf5d-c024-4c1a-9358-46dc74384892" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_ee45953c-81fc-403f-b49a-9eb8d0e2ac3a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b94ef991-2e38-4f9b-86e2-784f5ae737c4" xlink:to="loc_dei_EntityFileNumber_ee45953c-81fc-403f-b49a-9eb8d0e2ac3a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_7f544ee3-262c-4609-b582-7b34ded656c3" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b94ef991-2e38-4f9b-86e2-784f5ae737c4" xlink:to="loc_dei_EntityTaxIdentificationNumber_7f544ee3-262c-4609-b582-7b34ded656c3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_ddcf440f-279b-41c5-a949-6431fcb40718" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b94ef991-2e38-4f9b-86e2-784f5ae737c4" xlink:to="loc_dei_EntityAddressAddressLine1_ddcf440f-279b-41c5-a949-6431fcb40718" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_a2bc3d85-6341-4c6d-89e5-f51738538fee" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b94ef991-2e38-4f9b-86e2-784f5ae737c4" xlink:to="loc_dei_EntityAddressCityOrTown_a2bc3d85-6341-4c6d-89e5-f51738538fee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_3720c1c7-1413-4dbf-b9bd-1d09a87fb28a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b94ef991-2e38-4f9b-86e2-784f5ae737c4" xlink:to="loc_dei_EntityAddressStateOrProvince_3720c1c7-1413-4dbf-b9bd-1d09a87fb28a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_640d899b-6d36-4d10-80e9-a5dbf333d78f" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b94ef991-2e38-4f9b-86e2-784f5ae737c4" xlink:to="loc_dei_EntityAddressPostalZipCode_640d899b-6d36-4d10-80e9-a5dbf333d78f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_caa9efe4-24a5-4425-8219-caa008db1968" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b94ef991-2e38-4f9b-86e2-784f5ae737c4" xlink:to="loc_dei_CityAreaCode_caa9efe4-24a5-4425-8219-caa008db1968" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_f94bfe57-46d5-490a-b89f-8946e8e81197" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b94ef991-2e38-4f9b-86e2-784f5ae737c4" xlink:to="loc_dei_LocalPhoneNumber_f94bfe57-46d5-490a-b89f-8946e8e81197" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_dea03cde-5e32-4803-8496-a9a226c0ffe8" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b94ef991-2e38-4f9b-86e2-784f5ae737c4" xlink:to="loc_dei_WrittenCommunications_dea03cde-5e32-4803-8496-a9a226c0ffe8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_a4f9c190-90f6-4c3f-897c-7064dca44e10" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b94ef991-2e38-4f9b-86e2-784f5ae737c4" xlink:to="loc_dei_SolicitingMaterial_a4f9c190-90f6-4c3f-897c-7064dca44e10" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_2e643e57-331a-4daf-bd1c-257ab0c07104" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b94ef991-2e38-4f9b-86e2-784f5ae737c4" xlink:to="loc_dei_PreCommencementTenderOffer_2e643e57-331a-4daf-bd1c-257ab0c07104" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_3b83cec7-f241-4498-8e16-a04336b8735d" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b94ef991-2e38-4f9b-86e2-784f5ae737c4" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_3b83cec7-f241-4498-8e16-a04336b8735d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_8c0da44d-f947-469f-ad5e-eb374096e1cb" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b94ef991-2e38-4f9b-86e2-784f5ae737c4" xlink:to="loc_dei_Security12bTitle_8c0da44d-f947-469f-ad5e-eb374096e1cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_3c6d0406-2c86-4eea-b4f7-3e79ded32f8a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b94ef991-2e38-4f9b-86e2-784f5ae737c4" xlink:to="loc_dei_SecurityExchangeName_3c6d0406-2c86-4eea-b4f7-3e79ded32f8a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_50d033a4-9257-43e4-99a6-524a5cd7ce46" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b94ef991-2e38-4f9b-86e2-784f5ae737c4" xlink:to="loc_dei_EntityEmergingGrowthCompany_50d033a4-9257-43e4-99a6-524a5cd7ce46" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_1c9e297c-d80f-4d79-bc00-f44fa98de52c" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_b94ef991-2e38-4f9b-86e2-784f5ae737c4" xlink:to="loc_dei_TradingSymbol_1c9e297c-d80f-4d79-bc00-f44fa98de52c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.regeneron.com/role/Cover_1" xlink:type="simple" xlink:href="regn-20230504.xsd#Cover_1"/>
  <link:presentationLink xlink:role="http://www.regeneron.com/role/Cover_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_33c7ea32-8960-4a66-acf5-bcf193f7f01b" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_5dd86975-0408-4742-8d37-1454a1c652d1" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_33c7ea32-8960-4a66-acf5-bcf193f7f01b" xlink:to="loc_dei_EntityCentralIndexKey_5dd86975-0408-4742-8d37-1454a1c652d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_dc2c6029-9450-4f69-b10a-3c2919ea5d70" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_33c7ea32-8960-4a66-acf5-bcf193f7f01b" xlink:to="loc_dei_AmendmentFlag_dc2c6029-9450-4f69-b10a-3c2919ea5d70" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
