Date Name Title Filing Type Shares Traded Price Total Held
Sep 16, 2008
VP, Regul Devel & Med Safety
VP, Regul Devel & Med Safety Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 4,947 $21.16 79,048
Jan 10, 2012
VP Regulatory Development and
VP Regulatory Development and Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 7,543 $73.92 79,039
Sep 06, 2011
VP Regulatory Development and
VP Regulatory Development and Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 3,800 $11.64 77,259
Jan 18, 2011
VP Regul Devel & Med Safety
VP Regul Devel & Med Safety Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 10,000 $9.49 76,956
Jan 07, 2011
VP Regul Devel & Med Safety
VP Regul Devel & Med Safety Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 10,000 $9.49 76,956
Sep 01, 2009
VP Regul Devel & Med Safety
VP Regul Devel & Med Safety Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 10,000 $8.50 76,956
Jan 11, 2012
VP Regulatory Development and
VP Regulatory Development and Form 4 Open market or private sale of non-derivative or derivative security 2,885 $75.72 76,907
Dec 28, 2009
VP Regul Devel & Med Safety
VP Regul Devel & Med Safety Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 9,927 $8.50 76,883
Sep 06, 2011
VP Regulatory Development and
VP Regulatory Development and Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 4,513 $11.64 75,973
Jan 18, 2011
VP Regul Devel & Med Safety
VP Regul Devel & Med Safety Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 8,812 $9.49 75,768

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.