Date Name Title Filing Type Shares Traded Price Total Held
Apr 27, 2009
VP Regul Devel & Clin Safety
VP Regul Devel & Clin Safety Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 15,160 $6.50 82,116
Jan 11, 2012
VP Regulatory Development and
VP Regulatory Development and Form 4 Open market or private sale of non-derivative or derivative security 100 $73.99 83,192
Jan 10, 2012
VP Regulatory Development and
VP Regulatory Development and Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 7,009 $73.92 83,292
Sep 16, 2008
VP, Regul Devel & Med Safety
VP, Regul Devel & Med Safety Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 10,361 $21.16 83,995
Jan 10, 2012
VP Regulatory Development and
VP Regulatory Development and Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 25,438 $21.92 86,582
Jan 10, 2012
VP Regulatory Development and
VP Regulatory Development and Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 6,881 $73.92 90,301
Sep 16, 2008
VP, Regul Devel & Med Safety
VP, Regul Devel & Med Safety Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 25,000 $8.77 94,356
Jan 10, 2012
VP Regulatory Development and
VP Regulatory Development and Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 25,034 $20.32 97,182

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.