Date Name Title Filing Type Shares Traded Price Total Held
Nov 17, 2006
VP, Regulatory Development
VP, Regulatory Development Form 4 Bona fide gift 8,352 -- 12,803
Dec 18, 2006
VP, Regulatory Development
VP, Regulatory Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 4,966 -- 4,966
Dec 18, 2006
VP, Regulatory Development
VP, Regulatory Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 25,034 -- 25,034
Nov 20, 2007
VP, Regul Devel & Clin Safety
VP, Regul Devel & Clin Safety Form 4 Bona fide gift 34,684 -- 34,684
Dec 17, 2007
VP, Regul Devel & Clin Safety
VP, Regul Devel & Clin Safety Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 4,562 -- 4,562
Dec 17, 2007
VP, Regul Devel & Clin Safety
VP, Regul Devel & Clin Safety Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 25,438 -- 25,438
Dec 19, 2007
VP, Regul Devel & Clin Safety
VP, Regul Devel & Clin Safety Form 4 Other acquisition or disposition -- -- 10,414
Dec 19, 2007
VP, Regul Devel & Clin Safety
VP, Regul Devel & Clin Safety Form 4 Other acquisition or disposition -- -- 2,798
Aug 20, 2008
VP, Regul Devel & Med Safety
VP, Regul Devel & Med Safety Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 34,840 $6.50 45,254
Aug 20, 2008
VP, Regul Devel & Med Safety
VP, Regul Devel & Med Safety Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 10,582 $21.40 24,102

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.