Date Name Title Filing Type Shares Traded Price Total Held
Aug 20, 2008
VP, Regul Devel & Med Safety
VP, Regul Devel & Med Safety Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 34,840 $6.50 45,254
Aug 20, 2008
VP, Regul Devel & Med Safety
VP, Regul Devel & Med Safety Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 34,840 -- 15,160
Nov 20, 2007
VP, Regul Devel & Clin Safety
VP, Regul Devel & Clin Safety Form 4 Bona fide gift 34,684 -- 34,684
Dec 14, 2012
VP Regulat Dev & Med Safety
VP Regulat Dev & Med Safety Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 30,000 -- 30,000
Dec 16, 2011
VP Regulatory Development and
VP Regulatory Development and Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 28,079 -- 28,079
Dec 14, 2010
VP Regul Devel & Med Safety
VP Regul Devel & Med Safety Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 26,736 -- 26,736
Nov 05, 2012
VP Regulat Dev & Med Safety
VP Regulat Dev & Med Safety Form 4 Bona fide gift 26,000 -- 16,644
Nov 05, 2012
VP Regulat Dev & Med Safety
VP Regulat Dev & Med Safety Form 4 Bona fide gift 26,000 -- 45,947
Jan 10, 2012
VP Regulatory Development and
VP Regulatory Development and Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 25,438 $21.92 86,582
Jan 10, 2012
VP Regulatory Development and
VP Regulatory Development and Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 25,438 -- --

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.