Date Name Title Filing Type Shares Traded Price Total Held
Aug 28, 2012
SVP Research and Development S
SVP Research and Development S Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 17,099 $145.70 76,005
Nov 20, 2012
SVP Res and Devel Sciences
SVP Res and Devel Sciences Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 17,000 $16.80 76,121
Aug 05, 2022
EVP Research and Development
EVP Research and Development Form 4 Open market or private sale of non-derivative or derivative security 176 $606.78 76,401
Aug 04, 2022
EVP Research and Development
EVP Research and Development Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 71,218 $613.00 76,577
Nov 05, 2015
EVP Research and Development
EVP Research and Development Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 935 $567.63 77,442
Nov 05, 2015
EVP Research and Development
EVP Research and Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 25,000 $21.25 78,377
Feb 14, 2012
SVP Research and Development S
SVP Research and Development S Form 4 Open market or private sale of non-derivative or derivative security 600 $113.47 80,203
Feb 12, 2014
SVP Research and Development S
SVP Research and Development S Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 40,000 -- 80,295
Dec 16, 2014
SVP Research and Development S
SVP Research and Development S Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 80,750 -- 80,750
Feb 14, 2012
SVP Research and Development S
SVP Research and Development S Form 4 Open market or private sale of non-derivative or derivative security 1,115 $112.10 80,803

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.