Date Name Title Filing Type Shares Traded Price Total Held
Aug 05, 2022
EVP Research and Development
EVP Research and Development Form 4 Open market or private sale of non-derivative or derivative security 535 $616.40 54,519
Aug 05, 2022
EVP Research and Development
EVP Research and Development Form 4 Open market or private sale of non-derivative or derivative security 424 $617.43 54,095
Aug 05, 2022
EVP Research and Development
EVP Research and Development Form 4 Open market or private sale of non-derivative or derivative security 521 $618.27 53,574
Aug 05, 2022
EVP Research and Development
EVP Research and Development Form 4 Open market or private sale of non-derivative or derivative security 502 $619.64 53,072
Aug 05, 2022
EVP Research and Development
EVP Research and Development Form 4 Open market or private sale of non-derivative or derivative security 177 $620.11 52,895
Aug 05, 2022
EVP Research and Development
EVP Research and Development Form 4 Open market or private sale of non-derivative or derivative security 100 $621.11 52,795
Aug 08, 2022
EVP Research and Development
EVP Research and Development Form 4 Other acquisition or disposition -- -- 5,814
Aug 08, 2022
EVP Research and Development
EVP Research and Development Form 4 Other acquisition or disposition -- -- 4,605
Nov 08, 2022
EVP Research and Development
EVP Research and Development Form 4 Bona fide gift 330 -- 52,465
Dec 09, 2022
EVP Research and Development
EVP Research and Development Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 466 $753.28 51,999

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.