Date Name Title Filing Type Shares Traded Price Total Held
Nov 05, 2015
EVP Research and Development
EVP Research and Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 75,000 $30.63 97,029
Nov 05, 2015
EVP Research and Development
EVP Research and Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 75,000 -- 46,736
Dec 16, 2014
SVP Research and Development S
SVP Research and Development S Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 75,000 -- 123,079
Dec 13, 2013
SVP Research and Development S
SVP Research and Development S Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 75,000 -- 121,736
Dec 14, 2012
SVP Res and Devel Sciences
SVP Res and Devel Sciences Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 75,000 -- 120,295
Dec 16, 2011
SVP Research and Development S
SVP Research and Development S Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 75,000 -- 119,048
Aug 04, 2022
EVP Research and Development
EVP Research and Development Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 71,218 $613.00 76,577
Dec 16, 2015
EVP Research and Development
EVP Research and Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 68,638 -- 68,638
Feb 13, 2012
SVP Research and Development S
SVP Research and Development S Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 63,234 $8.50 122,355
Feb 13, 2012
SVP Research and Development S
SVP Research and Development S Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 63,234 -- 3,432

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.