Date Name Title Filing Type Shares Traded Price Total Held
Jun 14, 2017
EVP Research and Development
EVP Research and Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 20,295 $21.25 44,245
Jun 14, 2017
EVP Research and Development
EVP Research and Development Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 906 $475.56 43,339
Jun 14, 2017
EVP Research and Development
EVP Research and Development Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 10,822 $475.56 32,517
Jun 14, 2017
EVP Research and Development
EVP Research and Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 20,295 -- --
Jun 05, 2017
EVP Research and Development
EVP Research and Development Form 4 Other acquisition or disposition -- -- 10,000
Jun 05, 2017
EVP Research and Development
EVP Research and Development Form 4 Other acquisition or disposition -- -- 5,000
Jun 05, 2017
EVP Research and Development
EVP Research and Development Form 4 Other acquisition or disposition -- -- 5,647
Jun 02, 2017
EVP Research and Development
EVP Research and Development Form 4 Open market or private sale of non-derivative or derivative security 100 $466.33 26,662
Jun 02, 2017
EVP Research and Development
EVP Research and Development Form 4 Open market or private sale of non-derivative or derivative security 100 $469.83 26,562
Jun 02, 2017
EVP Research and Development
EVP Research and Development Form 4 Open market or private sale of non-derivative or derivative security 100 $470.49 26,462

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.