Date Name Title Filing Type Shares Traded Price Total Held
Jun 18, 2012
SVP Res & Dev Sciences
SVP Res & Dev Sciences Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 95,079 $20.32 154,200
Aug 04, 2022
EVP Research and Development
EVP Research and Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 95,000 $270.43 147,795
Apr 04, 2011
SVP Res and Dev Sciences
SVP Res and Dev Sciences Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 92,308 $13.00 142,658
Feb 14, 2012
SVP Research and Development S
SVP Research and Development S Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 50,000 $16.80 140,323
Jun 18, 2012
SVP Res & Dev Sciences
SVP Res & Dev Sciences Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 16,757 $115.29 137,443
Sep 06, 2011
SVP Research and Development S
SVP Research and Development S Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 82,818 $11.64 133,168
Feb 14, 2012
SVP Research and Development S
SVP Research and Development S Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 7,566 $111.01 132,757
Dec 16, 2014
SVP Research and Development S
SVP Research and Development S Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 75,000 -- 123,079
Feb 13, 2012
SVP Research and Development S
SVP Research and Development S Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 63,234 $8.50 122,355
Dec 13, 2013
SVP Research and Development S
SVP Research and Development S Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 75,000 -- 121,736

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.