Date Name Title Filing Type Shares Traded Price Total Held
Feb 15, 2024
Director, Bd. Co-Chair, President & CSO
Director, Bd. Co-Chair, President & CSO Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 123,601 $953.83 801,608
Dec 11, 2023
Director, Bd. Co-Chair, President & CSO
Director, Bd. Co-Chair, President & CSO Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 12,841 $844.09 752,486
Dec 30, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 130,714 $483.25 750,224
Dec 30, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 86,096 $483.25 822,207
Mar 09, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 50,545 $476.42 563,990
Mar 09, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 78,376 $476.42 635,614
Dec 12, 2019
Director, President and CSO
Director, President and CSO Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 49,405 $377.16 371,876
Dec 12, 2019
Director, President and CSO
Director, President and CSO Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 77,767 $377.16 444,109
Dec 13, 2018
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 76,863 $377.31 73,137
Dec 13, 2018
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 48,192 $377.31 118,993

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.