Date Name Title Filing Type Shares Traded Price Total Held
Feb 25, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Other acquisition or disposition -- -- 5,791
Feb 25, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Other acquisition or disposition -- -- 57,465
Feb 25, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Other acquisition or disposition -- -- 500,000
Feb 24, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 118,123 $420.17 517,799
Dec 13, 2019
Director, President and CSO
Director, President and CSO Form 4 Other acquisition or disposition -- -- 5,791
Dec 13, 2019
Director, President and CSO
Director, President and CSO Form 4 Other acquisition or disposition -- -- 5,383
Dec 13, 2019
Director, President and CSO
Director, President and CSO Form 4 Other acquisition or disposition -- -- 14,000
Dec 12, 2019
Director, President and CSO
Director, President and CSO Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 95,295 $21.25 421,281
Dec 12, 2019
Director, President and CSO
Director, President and CSO Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 49,405 $377.16 371,876
Dec 12, 2019
Director, President and CSO
Director, President and CSO Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 150,000 $21.25 521,876

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.