Date Name Title Filing Type Shares Traded Price Total Held
Jun 21, 2021
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 3,768 $536.37 57,718
Jun 21, 2021
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 4,154 $535.63 61,486
Jun 21, 2021
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 8,236 $534.48 65,640
Jun 21, 2021
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 7,494 $533.66 73,876
Jun 21, 2021
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 738 $532.89 81,370
Mar 10, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 7 $486.31 517,799
Mar 10, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 1,693 $485.63 517,806
Mar 10, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 345 $484.72 519,499
Mar 10, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 355 $483.80 519,844
Dec 30, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 130,714 $483.25 750,224

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.