Date Name Title Filing Type Shares Traded Price Total Held
Dec 30, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 86,096 $483.25 822,207
Mar 10, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 100 $481.68 520,199
Mar 10, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 60 $480.34 520,299
Mar 10, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 1,651 $479.60 520,359
Mar 10, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 1,469 $478.43 522,010
Mar 10, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 4,735 $477.50 523,479
Mar 10, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 7,197 $476.51 528,214
Mar 09, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 50,545 $476.42 563,990
Mar 09, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 78,376 $476.42 635,614
Mar 10, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 4,223 $475.43 535,411

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.