Date Name Title Filing Type Shares Traded Price Total Held
Dec 30, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 158,079 $52.03 908,303
Dec 30, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 86,096 $483.25 822,207
Dec 30, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 240,000 -- 158,079
Dec 30, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 158,079 -- --
Jul 27, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Bona fide gift 57,465 -- --
Mar 11, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Other acquisition or disposition -- -- 57,465
Mar 11, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Other acquisition or disposition -- -- 500,000
Mar 11, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Other acquisition or disposition -- -- 5,791
Mar 10, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 1,159 $461.79 634,455
Mar 10, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 3,317 $462.43 631,138

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.