Date Name Title Filing Type Shares Traded Price Total Held
Dec 17, 2018
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Other acquisition or disposition -- -- 400,000
Dec 14, 2018
Director, President and CSO
Director, President and CSO Form 4 Other acquisition or disposition -- -- 5,728
Dec 13, 2018
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Bona fide gift 118,993 -- --
Dec 13, 2018
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Bona fide gift 118,993 -- 602,594
Dec 13, 2018
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 150,000 -- 94,048
Dec 13, 2018
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 94,048 -- --
Dec 12, 2018
Director, President and CSO
Director, President and CSO Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 129,013 -- 129,013
Nov 16, 2018
Director, President and CSO
Director, President and CSO Form 4 Bona fide gift 1,176 -- 483,601
Nov 01, 2018
Director, President and CSO
Director, President and CSO Form 4 Bona fide gift 24,643 -- --
Aug 22, 2018
Director, President and CSO
Director, President and CSO Form 4 Bona fide gift 3,211 -- 484,777

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.