Date Name Title Filing Type Shares Traded Price Total Held
Dec 13, 2018
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Bona fide gift 118,993 -- --
Dec 13, 2018
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Bona fide gift 118,993 -- 602,594
Nov 16, 2018
Director, President and CSO
Director, President and CSO Form 4 Bona fide gift 1,176 -- 483,601
Nov 01, 2018
Director, President and CSO
Director, President and CSO Form 4 Bona fide gift 24,643 -- --
Aug 22, 2018
Director, President and CSO
Director, President and CSO Form 4 Bona fide gift 3,211 -- 484,777
Aug 21, 2018
Director, President and CSO
Director, President and CSO Form 4 Bona fide gift 847 -- --
Aug 21, 2018
Director, President and CSO
Director, President and CSO Form 4 Bona fide gift 847 -- 487,988
Aug 03, 2018
Director, President and CSO
Director, President and CSO Form 4 Bona fide gift 101,187 -- 75,036
Aug 03, 2018
Director, President and CSO
Director, President and CSO Form 4 Bona fide gift 101,187 -- 487,141
Jul 24, 2018
Director, President and CSO
Director, President and CSO Form 4 Bona fide gift 299,134 -- 24,643

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.