Date Name Title Filing Type Shares Traded Price Total Held
Aug 14, 2015
SVP Clinical Development & Reg
SVP Clinical Development & Reg Form 4 Open market or private sale of non-derivative or derivative security 700 $575.47 21,583
Aug 14, 2015
SVP Clinical Development & Reg
SVP Clinical Development & Reg Form 4 Open market or private sale of non-derivative or derivative security 2,004 $576.65 19,579
Aug 14, 2015
SVP Clinical Development & Reg
SVP Clinical Development & Reg Form 4 Open market or private sale of non-derivative or derivative security 2,258 $577.75 17,321
Aug 14, 2015
SVP Clinical Development & Reg
SVP Clinical Development & Reg Form 4 Open market or private sale of non-derivative or derivative security 1,500 $578.63 15,821
Aug 13, 2015
SVP Clinical Development & Reg
SVP Clinical Development & Reg Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 10,000 $270.43 25,821
Aug 13, 2015
SVP Clinical Development & Reg
SVP Clinical Development & Reg Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 4,667 $579.35 21,154
Aug 13, 2015
SVP Clinical Development & Reg
SVP Clinical Development & Reg Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 2,749 $579.35 18,405
Aug 13, 2015
SVP Clinical Development & Reg
SVP Clinical Development & Reg Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 14,625 $179.13 33,030
Aug 13, 2015
SVP Clinical Development & Reg
SVP Clinical Development & Reg Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 4,521 $579.35 28,509
Aug 13, 2015
SVP Clinical Development & Reg
SVP Clinical Development & Reg Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 5,210 $579.35 23,299

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.