Date Name Title Filing Type Shares Traded Price Total Held
May 16, 2016
SVP Clinical Development & Reg
SVP Clinical Development & Reg Form 4 Bona fide gift 2,459 -- 2,459
May 16, 2016
SVP Clinical Development & Reg
SVP Clinical Development & Reg Form 4 Bona fide gift 2,459 -- --
May 16, 2016
SVP Clinical Development & Reg
SVP Clinical Development & Reg Form 4 Bona fide gift 2,459 -- 2,459
May 16, 2016
SVP Clinical Development & Reg
SVP Clinical Development & Reg Form 4 Bona fide gift 2,459 -- 2,459
Dec 16, 2015
SVP Clinical Development & Reg
SVP Clinical Development & Reg Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 1,921 $52.03 17,742
Dec 16, 2015
SVP Clinical Development & Reg
SVP Clinical Development & Reg Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 1,921 -- --
Aug 13, 2015
SVP Clinical Development & Reg
SVP Clinical Development & Reg Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 10,000 $270.43 25,821
Aug 13, 2015
SVP Clinical Development & Reg
SVP Clinical Development & Reg Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 14,625 $179.13 33,030
Aug 13, 2015
SVP Clinical Development & Reg
SVP Clinical Development & Reg Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 23,000 $52.03 46,299
Aug 13, 2015
SVP Clinical Development & Reg
SVP Clinical Development & Reg Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 8,000 $52.03 41,439

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.