Date Name Title Filing Type Shares Traded Price Total Held
Apr 15, 2021
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Bona fide gift 14,000 -- 14,000
Apr 15, 2021
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Bona fide gift 14,000 -- --
Apr 15, 2021
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Bona fide gift 5,383 -- --
Apr 15, 2021
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Bona fide gift 5,383 -- 5,383
May 07, 2021
EVP Commercial
EVP Commercial Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 1,000 $342.93 18,038
May 07, 2021
EVP Commercial
EVP Commercial Form 4 Open market or private sale of non-derivative or derivative security 1,000 $495.63 17,038
May 07, 2021
EVP Commercial
EVP Commercial Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 1,000 -- 17,000
May 10, 2021
EVP Commercial
EVP Commercial Form 4 Other acquisition or disposition -- -- 108
May 14, 2021
EVP Research and Development
EVP Research and Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 40,000 $179.13 64,280
May 14, 2021
EVP Research and Development
EVP Research and Development Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 27,775 $516.69 36,505

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.