Date Name Title Filing Type Shares Traded Price Total Held
Oct 16, 2014
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 11,402 $333.49 22,576,293
May 24, 2018
EVP Research and Development
EVP Research and Development Form 4 Open market or private sale of non-derivative or derivative security 11,407 $295.09 31,973
May 21, 2020
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Open market or private sale of non-derivative or derivative security 11,447 $568.43 326,090
Feb 23, 2015
SVP Commercial
SVP Commercial Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 11,458 $427.94 31,202
Dec 08, 2023
EVP Research
EVP Research Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 11,473 -- 11,473
Dec 08, 2023
EVP & General Mgr, Industrial
EVP & General Mgr, Industrial Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 11,473 -- 11,473
Feb 11, 2014
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Open market or private sale of non-derivative or derivative security 11,475 $325.10 103,275
Nov 27, 2012
VP Regulat Dev & Med Safety
VP Regulat Dev & Med Safety Form 4 Bona fide gift 11,500 -- 11,500
Nov 27, 2012
VP Regulat Dev & Med Safety
VP Regulat Dev & Med Safety Form 4 Bona fide gift 11,500 -- 17,447
Mar 21, 2011
Director
Director Form 4 Open market or private sale of non-derivative or derivative security 11,505 $40.00 --

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.