Date Name Title Filing Type Shares Traded Price Total Held
Jan 02, 2013
Director
Director Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 15,000 -- 15,000
Jan 02, 2013
Director
Director Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 15,000 -- 15,000
Jan 02, 2013
Director
Director Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 15,000 -- 15,000
Jan 02, 2013
Director
Director Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 15,000 -- 15,000
Sep 18, 2012
SVP Clinical Development & Reg
SVP Clinical Development & Reg Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 15,000 $16.80 45,134
Sep 18, 2012
SVP Clinical Development & Reg
SVP Clinical Development & Reg Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 15,000 -- --
Aug 23, 2012
VP Regulatory Development and
VP Regulatory Development and Form 4 Open market or private sale of non-derivative or derivative security 15,000 $144.00 46,144
Aug 07, 2012
Director
Director Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 15,000 $15.80 15,000
Aug 07, 2012
Director
Director Form 4 Open market or private sale of non-derivative or derivative security 15,000 $139.56 --
Aug 07, 2012
Director
Director Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 15,000 -- --

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.