Date Name Title Type Shares Traded Price
Dec 19, 2007
VP, Regul Devel & Clin Safety
VP, Regul Devel & Clin Safety Other acquisition or disposition -- --
Dec 19, 2007
VP, Regul Devel & Clin Safety
VP, Regul Devel & Clin Safety Other acquisition or disposition -- --
Dec 17, 2007
VP, Regul Devel & Clin Safety
VP, Regul Devel & Clin Safety Grant, award or other acquisition pursuant to Rule 16b-3(d) 4,562 --
Dec 17, 2007
VP, Regul Devel & Clin Safety
VP, Regul Devel & Clin Safety Grant, award or other acquisition pursuant to Rule 16b-3(d) 25,438 --
Nov 20, 2007
VP, Regul Devel & Clin Safety
VP, Regul Devel & Clin Safety Bona fide gift 34,684 --
Dec 18, 2008
VP, Regul Devel & Med Safety
VP, Regul Devel & Med Safety Other acquisition or disposition -- --
Dec 18, 2008
VP, Regul Devel & Med Safety
VP, Regul Devel & Med Safety Other acquisition or disposition -- --
Dec 17, 2008
VP, Regul Devel & Med Safety
VP, Regul Devel & Med Safety Grant, award or other acquisition pursuant to Rule 16b-3(d) 5,952 --
Dec 17, 2008
VP, Regul Devel & Med Safety
VP, Regul Devel & Med Safety Grant, award or other acquisition pursuant to Rule 16b-3(d) 24,048 --
Dec 12, 2008
VP, Regul Devel & Med Safety
VP, Regul Devel & Med Safety Bona fide gift 2,400 --

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.