Date Name Title Filing Type Shares Traded Price Total Held
Oct 31, 2006
SVP, Therap & Clin Prog Dev
SVP, Therap & Clin Prog Dev Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 48 -- --
Oct 31, 2006
SVP, Therap & Clin Prog Dev
SVP, Therap & Clin Prog Dev Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 18,311 -- --
Oct 19, 2006
Director
Director Form 4 Open market or private sale of non-derivative or derivative security 2,000 $19.50 32,000
Oct 18, 2006
Director
Director Form 4 Open market or private sale of non-derivative or derivative security 2,469 $18.00 34,000
Oct 18, 2006
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Other acquisition or disposition -- -- 900
Oct 18, 2006
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Other acquisition or disposition -- -- 900
Oct 18, 2006
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Other acquisition or disposition -- -- 1,710,790
Oct 18, 2006
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Other acquisition or disposition -- -- 29,275
Oct 18, 2006
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Other acquisition or disposition -- -- 29,275
Oct 17, 2006
Director
Director Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 10,000 $9.88 42,000

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.