Date Name Title Filing Type Shares Traded Price Total Held
Oct 18, 2006
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Other acquisition or disposition -- -- 1,710,790
Oct 18, 2006
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Other acquisition or disposition -- -- 29,275
Oct 18, 2006
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Other acquisition or disposition -- -- 29,275
Oct 17, 2006
Director
Director Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 10,000 $9.88 42,000
Oct 17, 2006
Director
Director Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 5,531 $17.85 36,469
Oct 17, 2006
Director
Director Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 10,000 -- --
Oct 17, 2006
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Open market or private sale of non-derivative or derivative security 28,656 $18.00 63,009
Oct 17, 2006
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Open market or private sale of non-derivative or derivative security 1,344 $18.05 61,665
Oct 02, 2006
SVP, Clinical Development
SVP, Clinical Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 25,572 -- 25,572
Oct 02, 2006
SVP, Clinical Development
SVP, Clinical Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 74,428 -- 74,428

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.