Date Name Title Filing Type Shares Traded Price Total Held
Dec 31, 2014
SVP Clinical Development & Reg
SVP Clinical Development & Reg Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 25,000 $52.03 35,711
Dec 31, 2014
SVP Clinical Development & Reg
SVP Clinical Development & Reg Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 25,000 -- 37,079
Nov 18, 2011
Director
Director Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 25,000 -- 25,000
Sep 14, 2011
Director
Director Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 25,000 $20.97 35,000
Sep 14, 2011
Director
Director Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 25,000 -- --
Jul 25, 2011
SVP Clinical Development
SVP Clinical Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 25,000 $15.64 25,000
Jul 25, 2011
SVP Clinical Development
SVP Clinical Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 25,000 -- 49,428
Nov 12, 2010
Director
Director Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 25,000 -- 25,000
Sep 29, 2008
SVP, Research & Devel Sciences
SVP, Research & Devel Sciences Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 25,000 $8.77 25,350
Sep 29, 2008
SVP, Research & Devel Sciences
SVP, Research & Devel Sciences Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 25,000 -- --

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.