Date Name Title Filing Type Shares Traded Price Total Held
Nov 16, 2018
Director, President and CSO
Director, President and CSO Form 4 Bona fide gift 1,176 -- 483,601
Aug 22, 2018
Director, President and CSO
Director, President and CSO Form 4 Bona fide gift 3,211 -- 484,777
Dec 19, 2017
Director, President and CSO
Director, President and CSO Form 4 Bona fide gift 242,150 -- 486,820
Feb 23, 2021
Director
Director Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 248,079 $52.03 487,088
Aug 03, 2018
Director, President and CSO
Director, President and CSO Form 4 Bona fide gift 101,187 -- 487,141
Aug 21, 2018
Director, President and CSO
Director, President and CSO Form 4 Bona fide gift 847 -- 487,988
Dec 13, 2018
Director, President & CEO
Director, President & CEO Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 125,000 $16.80 488,014
May 12, 2020
Director, President & CEO
Director, President & CEO Form 4 Open market or private sale of non-derivative or derivative security 19,984 $572.47 493,465
May 20, 2020
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 77,309 $30.63 497,063
Mar 11, 2020
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Other acquisition or disposition -- -- 500,000

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.