Date Name Title Filing Type Shares Traded Price Total Held
Feb 08, 2023
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Other acquisition or disposition -- -- 569,653
Feb 08, 2023
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Other acquisition or disposition -- -- 5,869
Feb 08, 2023
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Other acquisition or disposition -- -- 200,000
Feb 08, 2023
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Other acquisition or disposition -- -- 250,000
Feb 12, 2023
EVP Commercial
EVP Commercial Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 1,276 $751.78 20,803
Feb 14, 2023
EVP Commercial
EVP Commercial Form 4 Other acquisition or disposition -- -- 138
Feb 22, 2023
Director
Director Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 42,500 $270.43 366,583
Feb 22, 2023
Director
Director Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 29,005 $750.16 337,578
Feb 22, 2023
Director
Director Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 42,500 -- 85,000
Feb 24, 2023
Director
Director Form 4 Other acquisition or disposition -- -- 1,963

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.