Date Name Title Filing Type Shares Traded Price Total Held
Sep 27, 2018
Director
Director Form 4 Open market or private sale of non-derivative or derivative security 260 $395.42 --
Aug 22, 2018
Director
Director Form 4 Open market or private sale of non-derivative or derivative security 1,500 $380.49 --
Aug 22, 2018
Director
Director Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 1,500 -- --
Aug 21, 2018
Director, President and CSO
Director, President and CSO Form 4 Bona fide gift 847 -- --
Aug 02, 2018
Director
Director Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 2,000 -- --
Jul 09, 2018
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 153,274 -- --
May 23, 2018
EVP Research and Development
EVP Research and Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 26,736 -- --
Jan 02, 2018
Director
Director Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 15,000 -- --
Dec 13, 2017
Director, President & CEO
Director, President & CEO Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 250,000 -- --
Dec 13, 2017
Director, President & CSO
Director, President & CSO Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 195,438 -- --

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.