Date Name Title Filing Type Shares Traded Price Total Held
Aug 04, 2022
Director
Director Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 2,479 -- --
Aug 04, 2022
Director
Director Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 3,613 -- --
Aug 04, 2022
EVP Research and Development
EVP Research and Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 95,000 $270.43 147,795
Aug 04, 2022
EVP Research and Development
EVP Research and Development Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 71,218 $613.00 76,577
Aug 04, 2022
EVP Research and Development
EVP Research and Development Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 95,000 -- --
Aug 05, 2022
EVP Research and Development
EVP Research and Development Form 4 Open market or private sale of non-derivative or derivative security 176 $606.78 76,401
Aug 05, 2022
EVP Research and Development
EVP Research and Development Form 4 Open market or private sale of non-derivative or derivative security 724 $607.47 75,677
Aug 05, 2022
EVP Research and Development
EVP Research and Development Form 4 Open market or private sale of non-derivative or derivative security 610 $608.70 75,067
Aug 05, 2022
EVP Research and Development
EVP Research and Development Form 4 Open market or private sale of non-derivative or derivative security 3,044 $609.62 72,023
Aug 05, 2022
EVP Research and Development
EVP Research and Development Form 4 Open market or private sale of non-derivative or derivative security 3,931 $610.49 68,092

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.