Date Name Title Filing Type Shares Traded Price Total Held
Nov 21, 2012
SVP Res and Devel Sciences
SVP Res and Devel Sciences Form 4 Open market or private sale of non-derivative or derivative security 13,157 $174.47 61,121
Dec 19, 2005
VP, Gen Counsel & Secretary
VP, Gen Counsel & Secretary Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 13,184 -- 13,184
Feb 06, 2023
Director, President and Chief Scientific
Director, President and Chief Scientific Form 4 Open market or private sale of non-derivative or derivative security 13,189 $800.08 200,504
Jan 19, 2012
SVP Finance and Admin CFO Trea
SVP Finance and Admin CFO Trea Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 13,193 $79.53 106,544
Jul 10, 2018
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Open market or private sale of non-derivative or derivative security 13,194 $369.41 400,247
Oct 16, 2014
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 13,224 $332.38 22,564,891
Jan 11, 2017
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 13,226 $364.32 23,439,760
Jan 05, 2005
VP, Regulatory Development
VP, Regulatory Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 13,235 -- 13,235
Jun 26, 2003
Director
Director Form 4 Bona fide gift 13,237 $15.89 614,277
Nov 02, 2015
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Open market or private sale of non-derivative or derivative security 13,257 $580.18 355,836

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.