Date Name Title Filing Type Shares Traded Price Total Held
Aug 20, 2021
SVP Controller
SVP Controller Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 13,500 $179.13 32,520
Aug 20, 2021
SVP Controller
SVP Controller Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 13,500 -- --
Nov 13, 2023
EVP Research
EVP Research Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 13,508 $795.69 65,913
Sep 27, 2006
Director
Director Form 4 Bona fide gift 13,534 -- 359,642
Dec 19, 2005
VP, Regulatory Development
VP, Regulatory Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 13,537 -- 13,537
Jun 02, 2017
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 13,544 $470.73 23,522,172
Jan 20, 2012
SVP Finance and Admin CFO Trea
SVP Finance and Admin CFO Trea Form 4 Open market or private sale of non-derivative or derivative security 13,567 $77.86 92,977
Aug 24, 2017
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 13,638 $480.36 23,746,241
Dec 11, 2019
SVP Commercial
SVP Commercial Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 13,650 -- 13,650
Jan 05, 2005
VP, Regulatory Development
VP, Regulatory Development Form 4 Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) 13,650 -- --

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.