Date Name Title Filing Type Shares Traded Price Total Held
Apr 27, 2009
VP Regul Devel & Clin Safety
VP Regul Devel & Clin Safety Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 15,160 -- --
Jun 02, 2017
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 15,197 $481.13 23,595,235
Mar 03, 2014
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 15,199 $336.19 16,787,795
Dec 16, 2022
EVP Research
EVP Research Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 15,238 -- 15,238
Sep 23, 2015
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 15,274 $538.31 23,002,051
Mar 12, 2014
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 15,296 $326.52 17,793,920
May 23, 2018
EVP Research and Development
EVP Research and Development Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 15,329 $293.68 43,380
Sep 09, 2016
Director
Director Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 15,353 -- 15,353
Sep 09, 2016
Director
Director Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 15,353 -- 15,353
Feb 14, 2012
Director, President & CEO
Director, President & CEO Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 15,384 $13.00 394,386

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.