Date Name Title Filing Type Shares Traded Price Total Held
Feb 28, 2005
Director
Director Form 4 Open market or private sale of non-derivative or derivative security 16,354 $6.29 17,975
Feb 28, 2005
Director
Director Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 16,354 -- 5,000
Dec 23, 2014
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 16,393 $393.99 22,752,324
Nov 07, 2006
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Open market or private sale of non-derivative or derivative security 16,400 $23.11 88,264
Dec 19, 2005
VP, Regulatory Development
VP, Regulatory Development Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 16,463 -- 16,463
Jan 05, 2005
VP, Gen Counsel & Secretary
VP, Gen Counsel & Secretary Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 16,569 -- 16,569
Sep 15, 2014
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 16,623 $342.92 22,298,053
Jul 01, 2014
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 16,683 $299.16 20,549,528
Nov 18, 2014
SVP Research and Development S
SVP Research and Development S Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 16,757 $115.29 30,284
Nov 18, 2014
SVP Research and Development S
SVP Research and Development S Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 16,757 -- --

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.