Date Name Title Filing Type Shares Traded Price Total Held
Jun 02, 2017
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 18,311 $483.04 23,637,036
Mar 16, 2015
SVP General Counsel and Secret
SVP General Counsel and Secret Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 18,311 $59.20 28,311
Mar 16, 2015
SVP General Counsel and Secret
SVP General Counsel and Secret Form 4 Open market or private sale of non-derivative or derivative security 18,311 $450.00 10,000
Mar 16, 2015
SVP General Counsel and Secret
SVP General Counsel and Secret Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 18,311 -- 54,933
Oct 31, 2006
SVP, Therap & Clin Prog Dev
SVP, Therap & Clin Prog Dev Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 18,311 $10.56 22,198
Oct 31, 2006
SVP, Therap & Clin Prog Dev
SVP, Therap & Clin Prog Dev Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 18,311 -- --
Jan 28, 2014
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 18,379 $278.50 15,929,245
Aug 09, 2021
EVP & General Mgr, Industrial
EVP & General Mgr, Industrial Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 18,397 $617.68 33,534
Oct 02, 2013
VP Reg Dev & Med Safety
VP Reg Dev & Med Safety Form 5 Bona fide gift 18,399 -- 31,846
Nov 29, 2012
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Open market or private sale of non-derivative or derivative security 18,440 $178.71 105,834

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.