Date Name Title Filing Type Shares Traded Price Total Held
Feb 11, 2005
Director
Director Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 20,000 -- 23,000
Jan 05, 2005
VP, Regulatory Development
VP, Regulatory Development Form 4 Disposition to the issuer of issuer equity securities pursuant to Rule 16b-3(e) 20,000 -- --
Oct 13, 2004
SVP, Manuf & Process Sciences
SVP, Manuf & Process Sciences Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 20,000 $4.25 31,391
Oct 13, 2004
SVP, Manuf & Process Sciences
SVP, Manuf & Process Sciences Form 4 Open market or private sale of non-derivative or derivative security 20,000 $8.00 11,391
Oct 13, 2004
SVP, Manuf & Process Sciences
SVP, Manuf & Process Sciences Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 20,000 -- 30,000
May 05, 2004
VP Clinical Programs
VP Clinical Programs Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 20,000 $7.44 32,530
May 05, 2004
VP Clinical Programs
VP Clinical Programs Form 4 Open market or private sale of non-derivative or derivative security 20,000 $13.50 12,530
May 05, 2004
VP Clinical Programs
VP Clinical Programs Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 20,000 -- 15,000
Feb 03, 2014
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 20,023 $281.14 16,034,304
Oct 15, 2014
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 20,062 $329.79 22,518,168

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.