Date Name Title Filing Type Shares Traded Price Total Held
Sep 23, 2015
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 23,423 $536.26 22,966,047
Feb 22, 2012
SVP Clinical Development & Reg
SVP Clinical Development & Reg Form 4 Open market or private sale of non-derivative or derivative security 23,454 $96.45 25,944
Sep 02, 2011
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Open market or private sale of non-derivative or derivative security 23,458 $62.04 140,087
Jun 02, 2017
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 23,490 $482.08 23,618,725
Dec 18, 2009
VP Investor Relations & Commun
VP Investor Relations & Commun Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 23,500 -- 23,500
Nov 07, 2006
Director, Chief Exec Officer & President, Ten Percent Owner
Director, Chief Exec Officer & President, Ten Percent Owner Form 4 Open market or private sale of non-derivative or derivative security 23,600 $23.14 64,664
Oct 15, 2014
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 23,602 $328.01 22,455,659
Mar 21, 2014
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 23,644 $317.23 18,238,015
May 20, 2013
SVP Finance and Admin CFO and
SVP Finance and Admin CFO and Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 23,730 $266.64 80,878
Mar 07, 2014
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 23,743 $332.84 17,327,346

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.