Date Name Title Filing Type Shares Traded Price Total Held
Dec 18, 2009
VP Regul Devel & Med Safety
VP Regul Devel & Med Safety Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 23,795 -- 23,795
Nov 17, 2014
SVP Commercial
SVP Commercial Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 23,810 $401.75 42,391
Aug 23, 2017
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 23,872 $479.45 23,689,302
Mar 07, 2014
Ten Percent Owner
Ten Percent Owner Form 4 Open market or private purchase of non-derivative or derivative security 23,881 $334.09 17,351,227
Nov 22, 2019
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Payment of exercise price or tax liability by delivering or withholding securities incident to the receipt, exercise or vesting of a security issued in accordance with Rule 16b-3 23,989 $358.33 362,727
Oct 31, 2006
SVP, Manufuring Operations
SVP, Manufuring Operations Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 24,000 $8.62 27,574
Oct 31, 2006
SVP, Manufuring Operations
SVP, Manufuring Operations Form 4 Open market or private sale of non-derivative or derivative security 24,000 $20.00 3,574
Oct 31, 2006
SVP, Manufuring Operations
SVP, Manufuring Operations Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 24,000 -- --
Feb 03, 2006
SVP, PreclinDevel & Biomol Sci
SVP, PreclinDevel & Biomol Sci Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 24,000 $7.41 27,127
Feb 03, 2006
SVP, PreclinDevel & Biomol Sci
SVP, PreclinDevel & Biomol Sci Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 24,000 -- --

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.