Date Name Title Filing Type Shares Traded Price Total Held
Dec 17, 2008
VP, Regul Devel & Med Safety
VP, Regul Devel & Med Safety Form 4 Grant, award or other acquisition pursuant to Rule 16b-3(d) 24,048 -- 24,048
Aug 22, 2008
VP, Regul Devel & Med Safety
VP, Regul Devel & Med Safety Form 4 Bona fide gift 24,102 -- 69,356
Aug 22, 2008
VP, Regul Devel & Med Safety
VP, Regul Devel & Med Safety Form 4 Bona fide gift 24,102 -- --
Oct 31, 2006
SVP, Therap & Clin Prog Dev
SVP, Therap & Clin Prog Dev Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 24,226 $10.56 33,873
Oct 31, 2006
SVP, Therap & Clin Prog Dev
SVP, Therap & Clin Prog Dev Form 4 Open market or private sale of non-derivative or derivative security 24,226 $20.00 9,647
Oct 31, 2006
SVP, Therap & Clin Prog Dev
SVP, Therap & Clin Prog Dev Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 24,226 -- 7,463
Jun 27, 2005
Director
Director Form 4 Bona fide gift 24,252 -- 440,968
Jul 10, 2018
Director, Chairman of the Board
Director, Chairman of the Board Form 4 Open market or private sale of non-derivative or derivative security 24,339 $366.49 432,057
Mar 16, 2015
SVP Commercial
SVP Commercial Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 24,375 $30.63 44,404
Mar 16, 2015
SVP Commercial
SVP Commercial Form 4 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 24,375 -- 29,236

* Represents the number of non-derivative securities directly held. (I) Indicates that some (or all) of these shares are held indirectly.